Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QE44_LEIMA

TriTrypDb:

LmjF.17.1450 , LMJLV39_170022300 , LMJSD75_170022000

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.776
CLV_C14_Caspase3-7	122	126	PF00656	0.720
CLV_C14_Caspase3-7	252	256	PF00656	0.402
CLV_C14_Caspase3-7	401	405	PF00656	0.346
CLV_C14_Caspase3-7	418	422	PF00656	0.612
CLV_NRD_NRD_1	13	15	PF00675	0.508
CLV_NRD_NRD_1	248	250	PF00675	0.420
CLV_NRD_NRD_1	418	420	PF00675	0.448
CLV_NRD_NRD_1	70	72	PF00675	0.536
CLV_NRD_NRD_1	78	80	PF00675	0.535
CLV_NRD_NRD_1	88	90	PF00675	0.583
CLV_PCSK_FUR_1	68	72	PF00082	0.341
CLV_PCSK_KEX2_1	13	15	PF00082	0.529
CLV_PCSK_KEX2_1	248	250	PF00082	0.420
CLV_PCSK_KEX2_1	70	72	PF00082	0.540
CLV_PCSK_KEX2_1	78	80	PF00082	0.520
CLV_PCSK_SKI1_1	14	18	PF00082	0.492
CLV_PCSK_SKI1_1	284	288	PF00082	0.357
CLV_PCSK_SKI1_1	315	319	PF00082	0.355
CLV_PCSK_SKI1_1	368	372	PF00082	0.465
CLV_PCSK_SKI1_1	477	481	PF00082	0.426
DEG_MDM2_SWIB_1	38	46	PF02201	0.495
DEG_Nend_UBRbox_3	1	3	PF02207	0.532
DEG_ODPH_VHL_1	132	144	PF01847	0.563
DEG_SPOP_SBC_1	119	123	PF00917	0.712
DEG_SPOP_SBC_1	399	403	PF00917	0.321
DOC_CDC14_PxL_1	410	418	PF14671	0.367
DOC_CYCLIN_RxL_1	281	291	PF00134	0.279
DOC_CYCLIN_yClb1_LxF_4	1	7	PF00134	0.511
DOC_MAPK_gen_1	474	481	PF00069	0.444
DOC_MAPK_gen_1	89	97	PF00069	0.733
DOC_PP1_RVXF_1	157	163	PF00149	0.335
DOC_PP1_RVXF_1	313	319	PF00149	0.355
DOC_PP1_RVXF_1	91	98	PF00149	0.737
DOC_PP2B_LxvP_1	108	111	PF13499	0.647
DOC_PP2B_LxvP_1	49	52	PF13499	0.538
DOC_PP4_FxxP_1	27	30	PF00568	0.589
DOC_USP7_MATH_1	135	139	PF00917	0.588
DOC_USP7_MATH_1	222	226	PF00917	0.434
DOC_USP7_MATH_1	399	403	PF00917	0.532
DOC_WW_Pin1_4	14	19	PF00397	0.448
DOC_WW_Pin1_4	402	407	PF00397	0.564
DOC_WW_Pin1_4	84	89	PF00397	0.686
LIG_14-3-3_CanoR_1	13	17	PF00244	0.579
LIG_14-3-3_CanoR_1	150	154	PF00244	0.342
LIG_14-3-3_CanoR_1	159	163	PF00244	0.315
LIG_14-3-3_CanoR_1	248	258	PF00244	0.410
LIG_14-3-3_CanoR_1	329	335	PF00244	0.402
LIG_Actin_WH2_2	458	476	PF00022	0.584
LIG_APCC_ABBA_1	164	169	PF00400	0.376
LIG_BIR_III_2	106	110	PF00653	0.690
LIG_BIR_III_4	374	378	PF00653	0.536
LIG_BRCT_BRCA1_1	224	228	PF00533	0.447
LIG_CaM_IQ_9	276	291	PF13499	0.363
LIG_deltaCOP1_diTrp_1	67	73	PF00928	0.526
LIG_FHA_1	15	21	PF00498	0.527
LIG_FHA_1	386	392	PF00498	0.556
LIG_FHA_1	46	52	PF00498	0.458
LIG_FHA_2	120	126	PF00498	0.729
LIG_FHA_2	173	179	PF00498	0.426
LIG_FHA_2	298	304	PF00498	0.376
LIG_LIR_Apic_2	161	165	PF02991	0.402
LIG_LIR_Apic_2	24	30	PF02991	0.572
LIG_LIR_Gen_1	225	236	PF02991	0.415
LIG_LIR_Gen_1	337	347	PF02991	0.421
LIG_LIR_Gen_1	39	50	PF02991	0.471
LIG_LIR_Gen_1	463	473	PF02991	0.346
LIG_LIR_Nem_3	225	231	PF02991	0.388
LIG_LIR_Nem_3	233	239	PF02991	0.318
LIG_LIR_Nem_3	3	9	PF02991	0.466
LIG_LIR_Nem_3	337	342	PF02991	0.395
LIG_LIR_Nem_3	39	45	PF02991	0.371
LIG_LIR_Nem_3	463	469	PF02991	0.562
LIG_NRBOX	293	299	PF00104	0.447
LIG_PCNA_yPIPBox_3	289	302	PF02747	0.480
LIG_Pex14_1	331	335	PF04695	0.447
LIG_Pex14_1	40	44	PF04695	0.462
LIG_Pex14_2	228	232	PF04695	0.447
LIG_Pex14_2	318	322	PF04695	0.377
LIG_Pex14_2	38	42	PF04695	0.496
LIG_PTB_Apo_2	185	192	PF02174	0.480
LIG_PTB_Phospho_1	185	191	PF10480	0.480
LIG_SH2_GRB2like	265	268	PF00017	0.363
LIG_SH2_NCK_1	410	414	PF00017	0.327
LIG_SH2_PTP2	339	342	PF00017	0.505
LIG_SH2_STAP1	140	144	PF00017	0.472
LIG_SH2_STAP1	396	400	PF00017	0.522
LIG_SH2_STAP1	466	470	PF00017	0.578
LIG_SH2_STAT3	140	143	PF00017	0.522
LIG_SH2_STAT5	309	312	PF00017	0.334
LIG_SH2_STAT5	339	342	PF00017	0.435
LIG_SH2_STAT5	358	361	PF00017	0.393
LIG_SH3_1	420	426	PF00018	0.640
LIG_SH3_3	128	134	PF00018	0.587
LIG_SH3_3	420	426	PF00018	0.549
LIG_TYR_ITIM	234	239	PF00017	0.480
MOD_CDC14_SPxK_1	87	90	PF00782	0.647
MOD_CDK_SPK_2	84	89	PF00069	0.705
MOD_CDK_SPxK_1	84	90	PF00069	0.709
MOD_CDK_SPxxK_3	402	409	PF00069	0.563
MOD_CK1_1	101	107	PF00069	0.695
MOD_CK1_1	118	124	PF00069	0.491
MOD_CK1_1	136	142	PF00069	0.574
MOD_CK1_1	158	164	PF00069	0.402
MOD_CK1_1	402	408	PF00069	0.501
MOD_CK1_1	452	458	PF00069	0.510
MOD_CK2_1	181	187	PF00069	0.456
MOD_CK2_1	297	303	PF00069	0.381
MOD_CK2_1	80	86	PF00069	0.617
MOD_CK2_1	99	105	PF00069	0.705
MOD_Cter_Amidation	76	79	PF01082	0.558
MOD_GlcNHglycan	111	114	PF01048	0.747
MOD_GlcNHglycan	117	120	PF01048	0.757
MOD_GlcNHglycan	122	125	PF01048	0.642
MOD_GlcNHglycan	224	227	PF01048	0.474
MOD_GlcNHglycan	271	275	PF01048	0.487
MOD_GSK3_1	115	122	PF00069	0.510
MOD_GSK3_1	398	405	PF00069	0.440
MOD_GSK3_1	80	87	PF00069	0.662
MOD_GSK3_1	97	104	PF00069	0.688
MOD_N-GLC_1	351	356	PF02516	0.422
MOD_N-GLC_1	452	457	PF02516	0.490
MOD_NEK2_1	181	186	PF00069	0.466
MOD_NEK2_1	258	263	PF00069	0.320
MOD_NEK2_1	297	302	PF00069	0.363
MOD_NEK2_1	351	356	PF00069	0.386
MOD_NEK2_1	449	454	PF00069	0.413
MOD_NEK2_1	45	50	PF00069	0.474
MOD_NEK2_1	80	85	PF00069	0.591
MOD_NEK2_1	97	102	PF00069	0.738
MOD_NEK2_2	427	432	PF00069	0.585
MOD_PKA_2	12	18	PF00069	0.557
MOD_PKA_2	149	155	PF00069	0.356
MOD_PKA_2	158	164	PF00069	0.335
MOD_PKA_2	21	27	PF00069	0.483
MOD_PKA_2	449	455	PF00069	0.410
MOD_PKA_2	88	94	PF00069	0.753
MOD_Plk_1	136	142	PF00069	0.553
MOD_Plk_1	155	161	PF00069	0.245
MOD_Plk_1	2	8	PF00069	0.522
MOD_Plk_1	351	357	PF00069	0.374
MOD_Plk_1	427	433	PF00069	0.572
MOD_Plk_1	80	86	PF00069	0.603
MOD_Plk_2-3	369	375	PF00069	0.475
MOD_Plk_2-3	99	105	PF00069	0.792
MOD_Plk_4	181	187	PF00069	0.454
MOD_Plk_4	2	8	PF00069	0.510
MOD_Plk_4	297	303	PF00069	0.365
MOD_Plk_4	330	336	PF00069	0.407
MOD_ProDKin_1	14	20	PF00069	0.443
MOD_ProDKin_1	402	408	PF00069	0.559
MOD_ProDKin_1	84	90	PF00069	0.690
MOD_SUMO_for_1	57	60	PF00179	0.389
MOD_SUMO_rev_2	54	59	PF00179	0.575
TRG_AP2beta_CARGO_1	3	13	PF09066	0.498
TRG_DiLeu_BaEn_1	230	235	PF01217	0.402
TRG_DiLeu_BaEn_2	196	202	PF01217	0.355
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.335
TRG_ENDOCYTIC_2	183	186	PF00928	0.487
TRG_ENDOCYTIC_2	236	239	PF00928	0.394
TRG_ENDOCYTIC_2	244	247	PF00928	0.356
TRG_ENDOCYTIC_2	339	342	PF00928	0.491
TRG_ENDOCYTIC_2	466	469	PF00928	0.550
TRG_ER_diArg_1	247	249	PF00400	0.447
TRG_ER_diArg_1	69	71	PF00400	0.523
TRG_ER_diArg_1	78	80	PF00400	0.532
TRG_NES_CRM1_1	362	374	PF08389	0.534
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	210	214	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P848	Leptomonas seymouri	57%	100%
A0A0S4IV10	Bodo saltans	26%	84%
A0A3S7WUR8	Leishmania donovani	91%	100%
A0A422NB36	Trypanosoma rangeli	32%	99%
A4H9A3	Leishmania braziliensis	77%	100%
A4HXM3	Leishmania infantum	91%	100%
C9ZPB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	90%
E9ARB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BEU9	Trypanosoma cruzi	32%	97%