Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE42_LEIMA

TriTrypDb:

LmjF.17.1470

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QE42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE42

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.681
CLV_PCSK_SKI1_1	58	62	PF00082	0.564
DEG_Nend_UBRbox_2	1	3	PF02207	0.493
DEG_ODPH_VHL_1	12	24	PF01847	0.479
DOC_USP7_MATH_1	108	112	PF00917	0.774
DOC_USP7_MATH_1	81	85	PF00917	0.739
DOC_USP7_UBL2_3	100	104	PF12436	0.759
DOC_WW_Pin1_4	154	159	PF00397	0.768
DOC_WW_Pin1_4	170	175	PF00397	0.618
DOC_WW_Pin1_4	193	198	PF00397	0.746
DOC_WW_Pin1_4	63	68	PF00397	0.746
DOC_WW_Pin1_4	73	78	PF00397	0.652
DOC_WW_Pin1_4	83	88	PF00397	0.768
LIG_14-3-3_CanoR_1	206	214	PF00244	0.603
LIG_FHA_1	179	185	PF00498	0.707
LIG_FHA_2	116	122	PF00498	0.648
LIG_FHA_2	129	135	PF00498	0.648
LIG_LIR_Gen_1	16	25	PF02991	0.408
LIG_LIR_Gen_1	2	12	PF02991	0.487
LIG_LIR_Nem_3	16	20	PF02991	0.498
LIG_LIR_Nem_3	2	7	PF02991	0.495
LIG_SH2_NCK_1	17	21	PF00017	0.386
LIG_SH2_SRC	17	20	PF00017	0.448
LIG_SH2_STAP1	17	21	PF00017	0.479
LIG_SH3_3	155	161	PF00018	0.832
LIG_SH3_3	3	9	PF00018	0.536
MOD_CDK_SPxK_1	154	160	PF00069	0.796
MOD_CDK_SPxxK_3	63	70	PF00069	0.749
MOD_CK1_1	192	198	PF00069	0.729
MOD_CK1_1	69	75	PF00069	0.755
MOD_GlcNHglycan	110	113	PF01048	0.533
MOD_GlcNHglycan	143	146	PF01048	0.544
MOD_GlcNHglycan	234	237	PF01048	0.481
MOD_GlcNHglycan	83	86	PF01048	0.553
MOD_GlcNHglycan	89	92	PF01048	0.521
MOD_GSK3_1	166	173	PF00069	0.774
MOD_GSK3_1	189	196	PF00069	0.715
MOD_GSK3_1	69	76	PF00069	0.788
MOD_GSK3_1	81	88	PF00069	0.719
MOD_N-GLC_1	154	159	PF02516	0.627
MOD_N-GLC_1	206	211	PF02516	0.513
MOD_NEK2_1	138	143	PF00069	0.753
MOD_NEK2_2	115	120	PF00069	0.585
MOD_PIKK_1	159	165	PF00454	0.772
MOD_PIKK_1	178	184	PF00454	0.715
MOD_Plk_1	115	121	PF00069	0.651
MOD_Plk_1	128	134	PF00069	0.669
MOD_Plk_2-3	128	134	PF00069	0.605
MOD_Plk_4	128	134	PF00069	0.645
MOD_ProDKin_1	154	160	PF00069	0.769
MOD_ProDKin_1	170	176	PF00069	0.616
MOD_ProDKin_1	193	199	PF00069	0.747
MOD_ProDKin_1	63	69	PF00069	0.749
MOD_ProDKin_1	73	79	PF00069	0.653
MOD_ProDKin_1	83	89	PF00069	0.769
TRG_DiLeu_BaEn_1	128	133	PF01217	0.652
TRG_DiLeu_BaEn_1	223	228	PF01217	0.720
TRG_DiLeu_BaEn_4	128	134	PF01217	0.586
TRG_DiLeu_BaEn_4	223	229	PF01217	0.720
TRG_ENDOCYTIC_2	17	20	PF00928	0.496
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR49	Leptomonas seymouri	45%	100%
A0A3Q8IE41	Leishmania donovani	86%	100%
A4H9A5	Leishmania braziliensis	60%	100%
A4HTR3	Leishmania infantum	85%	100%
A4HXM5	Leishmania infantum	86%	100%
C9ZUK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ARC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	83%
Q4QBZ4	Leishmania major	100%	100%