Diphosphomevalonate decarboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mevalonate-diphosphate decarboxylase, putative

Species:

Leishmania major

UniProt:

Q4QE40_LEIMA

TriTrypDb:

LmjF.18.0020 , LMJLV39_180005300 , LMJSD75_180005300

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	12
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QE40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE40

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	12
GO:0006084	acetyl-CoA metabolic process	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006629	lipid metabolic process	3	13
GO:0006637	acyl-CoA metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006694	steroid biosynthetic process	5	12
GO:0006695	cholesterol biosynthetic process	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006790	sulfur compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	13
GO:0008202	steroid metabolic process	4	12
GO:0008203	cholesterol metabolic process	5	12
GO:0008610	lipid biosynthetic process	4	13
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	13
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009240	isopentenyl diphosphate biosynthetic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009987	cellular process	1	13
GO:0016125	sterol metabolic process	4	12
GO:0016126	sterol biosynthetic process	5	12
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0035383	thioester metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044255	cellular lipid metabolic process	3	13
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046165	alcohol biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0046490	isopentenyl diphosphate metabolic process	5	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	13
GO:0072521	purine-containing compound metabolic process	4	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	13
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12
GO:1902652	secondary alcohol metabolic process	4	12
GO:1902653	secondary alcohol biosynthetic process	5	12
GO:0006720	isoprenoid metabolic process	4	1
GO:0008299	isoprenoid biosynthetic process	4	1
GO:0044249	cellular biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004163	diphosphomevalonate decarboxylase activity	5	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016829	lyase activity	2	13
GO:0016830	carbon-carbon lyase activity	3	13
GO:0016831	carboxy-lyase activity	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.393
CLV_PCSK_KEX2_1	23	25	PF00082	0.350
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.350
CLV_PCSK_SKI1_1	325	329	PF00082	0.265
CLV_PCSK_SKI1_1	95	99	PF00082	0.506
DEG_SPOP_SBC_1	198	202	PF00917	0.416
DOC_CKS1_1	74	79	PF01111	0.525
DOC_CYCLIN_yCln2_LP_2	378	381	PF00134	0.433
DOC_MAPK_DCC_7	305	313	PF00069	0.432
DOC_MAPK_gen_1	354	361	PF00069	0.432
DOC_MAPK_gen_1	45	55	PF00069	0.360
DOC_MAPK_MEF2A_6	179	186	PF00069	0.440
DOC_MAPK_MEF2A_6	305	313	PF00069	0.432
DOC_PP1_RVXF_1	323	329	PF00149	0.400
DOC_PP2B_LxvP_1	30	33	PF13499	0.336
DOC_PP2B_LxvP_1	378	381	PF13499	0.433
DOC_USP7_MATH_1	148	152	PF00917	0.535
DOC_USP7_MATH_1	224	228	PF00917	0.408
DOC_USP7_MATH_1	353	357	PF00917	0.553
DOC_USP7_MATH_1	46	50	PF00917	0.353
DOC_USP7_UBL2_3	19	23	PF12436	0.308
DOC_USP7_UBL2_3	192	196	PF12436	0.466
DOC_WW_Pin1_4	360	365	PF00397	0.432
DOC_WW_Pin1_4	73	78	PF00397	0.413
LIG_14-3-3_CanoR_1	225	233	PF00244	0.416
LIG_14-3-3_CanoR_1	48	54	PF00244	0.337
LIG_14-3-3_CanoR_1	6	10	PF00244	0.458
LIG_14-3-3_CanoR_1	78	83	PF00244	0.355
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_CaM_IQ_9	201	217	PF13499	0.385
LIG_EH1_1	270	278	PF00400	0.432
LIG_eIF4E_1	271	277	PF01652	0.432
LIG_FHA_1	132	138	PF00498	0.432
LIG_FHA_1	166	172	PF00498	0.370
LIG_FHA_1	27	33	PF00498	0.404
LIG_FHA_1	74	80	PF00498	0.440
LIG_FHA_1	92	98	PF00498	0.388
LIG_FHA_2	319	325	PF00498	0.450
LIG_FHA_2	49	55	PF00498	0.396
LIG_LIR_Gen_1	118	128	PF02991	0.432
LIG_LIR_Gen_1	237	246	PF02991	0.475
LIG_LIR_Gen_1	268	279	PF02991	0.432
LIG_LIR_Gen_1	321	331	PF02991	0.452
LIG_LIR_Gen_1	356	365	PF02991	0.498
LIG_LIR_Nem_3	118	123	PF02991	0.452
LIG_LIR_Nem_3	151	156	PF02991	0.487
LIG_LIR_Nem_3	178	184	PF02991	0.356
LIG_LIR_Nem_3	237	241	PF02991	0.435
LIG_LIR_Nem_3	268	274	PF02991	0.432
LIG_LIR_Nem_3	321	326	PF02991	0.412
LIG_LIR_Nem_3	345	349	PF02991	0.452
LIG_LIR_Nem_3	356	360	PF02991	0.465
LIG_Pex14_2	17	21	PF04695	0.309
LIG_Pex14_2	319	323	PF04695	0.484
LIG_SH2_CRK	120	124	PF00017	0.452
LIG_SH2_CRK	271	275	PF00017	0.432
LIG_SH2_CRK	340	344	PF00017	0.552
LIG_SH2_STAP1	291	295	PF00017	0.432
LIG_SH2_STAT5	100	103	PF00017	0.405
LIG_SH2_STAT5	120	123	PF00017	0.461
LIG_SH2_STAT5	291	294	PF00017	0.432
LIG_SH2_STAT5	371	374	PF00017	0.388
LIG_SH3_3	6	12	PF00018	0.303
LIG_SH3_4	260	267	PF00018	0.385
LIG_SUMO_SIM_anti_2	310	315	PF11976	0.482
LIG_SUMO_SIM_par_1	133	138	PF11976	0.542
LIG_SUMO_SIM_par_1	28	34	PF11976	0.294
LIG_UBA3_1	301	305	PF00899	0.441
MOD_CDK_SPK_2	73	78	PF00069	0.420
MOD_CK1_1	115	121	PF00069	0.443
MOD_CK1_1	138	144	PF00069	0.543
MOD_CK1_1	199	205	PF00069	0.450
MOD_CK1_1	207	213	PF00069	0.426
MOD_CK1_1	49	55	PF00069	0.336
MOD_CK1_1	57	63	PF00069	0.395
MOD_CK1_1	81	87	PF00069	0.400
MOD_CK2_1	48	54	PF00069	0.440
MOD_CK2_1	57	63	PF00069	0.495
MOD_Cter_Amidation	21	24	PF01082	0.312
MOD_Cter_Amidation	67	70	PF01082	0.557
MOD_GlcNHglycan	1	4	PF01048	0.615
MOD_GlcNHglycan	115	118	PF01048	0.244
MOD_GlcNHglycan	144	147	PF01048	0.254
MOD_GlcNHglycan	201	204	PF01048	0.185
MOD_GlcNHglycan	226	229	PF01048	0.215
MOD_GSK3_1	131	138	PF00069	0.432
MOD_GSK3_1	144	151	PF00069	0.432
MOD_GSK3_1	204	211	PF00069	0.446
MOD_GSK3_1	34	41	PF00069	0.357
MOD_N-GLC_1	34	39	PF02516	0.325
MOD_NEK2_1	113	118	PF00069	0.432
MOD_NEK2_1	204	209	PF00069	0.441
MOD_NEK2_1	300	305	PF00069	0.522
MOD_NEK2_1	38	43	PF00069	0.336
MOD_NEK2_2	148	153	PF00069	0.385
MOD_PIKK_1	170	176	PF00454	0.355
MOD_PK_1	217	223	PF00069	0.479
MOD_PK_1	78	84	PF00069	0.414
MOD_PKA_2	224	230	PF00069	0.438
MOD_PKA_2	256	262	PF00069	0.531
MOD_PKA_2	5	11	PF00069	0.467
MOD_PKB_1	215	223	PF00069	0.476
MOD_Plk_1	135	141	PF00069	0.432
MOD_Plk_1	267	273	PF00069	0.432
MOD_Plk_1	34	40	PF00069	0.323
MOD_Plk_4	135	141	PF00069	0.441
MOD_Plk_4	209	215	PF00069	0.422
MOD_Plk_4	217	223	PF00069	0.512
MOD_Plk_4	26	32	PF00069	0.300
MOD_Plk_4	374	380	PF00069	0.358
MOD_Plk_4	78	84	PF00069	0.411
MOD_ProDKin_1	360	366	PF00069	0.432
MOD_ProDKin_1	73	79	PF00069	0.406
MOD_SUMO_for_1	191	194	PF00179	0.501
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.508
TRG_ENDOCYTIC_2	120	123	PF00928	0.432
TRG_ENDOCYTIC_2	153	156	PF00928	0.523
TRG_ENDOCYTIC_2	271	274	PF00928	0.432
TRG_ENDOCYTIC_2	286	289	PF00928	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ7	Leptomonas seymouri	84%	99%
A0A0S4JH23	Bodo saltans	65%	99%
A0A1D8PC43	Candida albicans (strain SC5314 / ATCC MYA-2876)	42%	100%
A0A1X0P6N9	Trypanosomatidae	71%	100%
A0A3S7WUN8	Leishmania donovani	92%	100%
A0A422NWH3	Trypanosoma rangeli	67%	100%
A4H9A8	Leishmania braziliensis	87%	97%
A4HXM8	Leishmania infantum	92%	100%
C9ZZY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0A068	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
D0EAP4	Panax ginseng	37%	92%
D4GXZ3	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	29%	100%
E9ARD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
F4JCU3	Arabidopsis thaliana	40%	91%
F8QQQ7	Panax ginseng	37%	91%
G9BIY1	Ganoderma lucidum	39%	96%
I1S130	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	43%	100%
O13963	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	97%
O23722	Arabidopsis thaliana	37%	93%
P32377	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	97%
P53602	Homo sapiens	45%	96%
Q0P570	Bos taurus	44%	96%
Q4WNV9	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	39%	95%
Q54YQ9	Dictyostelium discoideum	43%	98%
Q5U403	Danio rerio	45%	96%
Q62967	Rattus norvegicus	45%	96%
Q6BY07	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	39%	99%
Q751D8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	42%	96%
Q97UL5	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	35%	100%
Q99JF5	Mus musculus	44%	96%
V5BEI4	Trypanosoma cruzi	66%	100%