RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 27, putative

Species:

Leishmania major

UniProt:

Q4QE39_LEIMA

TriTrypDb:

LmjF.18.0030 , LMJLV39_180005400 , LMJSD75_180005400

Length:

344

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE39

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.539
CLV_NRD_NRD_1	216	218	PF00675	0.660
CLV_PCSK_KEX2_1	113	115	PF00082	0.609
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.609
CLV_PCSK_SKI1_1	218	222	PF00082	0.690
CLV_PCSK_SKI1_1	271	275	PF00082	0.539
DOC_CYCLIN_yCln2_LP_2	126	129	PF00134	0.613
DOC_MAPK_gen_1	112	123	PF00069	0.625
DOC_MAPK_gen_1	71	79	PF00069	0.476
DOC_PP1_RVXF_1	229	236	PF00149	0.519
DOC_PP1_RVXF_1	36	42	PF00149	0.581
DOC_PP2B_LxvP_1	126	129	PF13499	0.613
DOC_PP4_FxxP_1	54	57	PF00568	0.498
DOC_USP7_MATH_1	285	289	PF00917	0.547
DOC_USP7_MATH_1	316	320	PF00917	0.573
DOC_USP7_MATH_1	94	98	PF00917	0.759
DOC_WD40_RPTOR_TOS_1	327	332	PF00400	0.613
DOC_WW_Pin1_4	132	137	PF00397	0.529
DOC_WW_Pin1_4	207	212	PF00397	0.753
DOC_WW_Pin1_4	236	241	PF00397	0.563
DOC_WW_Pin1_4	53	58	PF00397	0.498
DOC_WW_Pin1_4	97	102	PF00397	0.761
LIG_APCC_ABBA_1	169	174	PF00400	0.595
LIG_APCC_ABBA_1	8	13	PF00400	0.423
LIG_Clathr_ClatBox_1	326	330	PF01394	0.696
LIG_FHA_1	116	122	PF00498	0.596
LIG_FHA_1	177	183	PF00498	0.488
LIG_FHA_1	188	194	PF00498	0.565
LIG_FHA_1	315	321	PF00498	0.600
LIG_LIR_Apic_2	196	200	PF02991	0.624
LIG_LIR_Apic_2	53	57	PF02991	0.498
LIG_LIR_Gen_1	170	180	PF02991	0.527
LIG_LIR_Gen_1	26	35	PF02991	0.476
LIG_LIR_Gen_1	264	275	PF02991	0.399
LIG_LIR_Nem_3	170	175	PF02991	0.525
LIG_LIR_Nem_3	248	254	PF02991	0.528
LIG_LIR_Nem_3	26	30	PF02991	0.467
LIG_LIR_Nem_3	264	270	PF02991	0.300
LIG_LIR_Nem_3	304	308	PF02991	0.588
LIG_NRBOX	188	194	PF00104	0.531
LIG_PCNA_PIPBox_1	165	174	PF02747	0.354
LIG_PCNA_yPIPBox_3	160	172	PF02747	0.457
LIG_PCNA_yPIPBox_3	334	343	PF02747	0.638
LIG_PDZ_Class_2	339	344	PF00595	0.634
LIG_SH2_CRK	340	344	PF00017	0.444
LIG_SH2_GRB2like	66	69	PF00017	0.553
LIG_SH2_NCK_1	84	88	PF00017	0.510
LIG_SH2_PTP2	9	12	PF00017	0.519
LIG_SH2_SRC	66	69	PF00017	0.484
LIG_SH2_STAP1	340	344	PF00017	0.444
LIG_SH2_STAP1	84	88	PF00017	0.566
LIG_SH2_STAT5	140	143	PF00017	0.595
LIG_SH2_STAT5	51	54	PF00017	0.562
LIG_SH2_STAT5	66	69	PF00017	0.418
LIG_SH2_STAT5	9	12	PF00017	0.487
LIG_SUMO_SIM_par_1	241	249	PF11976	0.525
LIG_SUMO_SIM_par_1	252	260	PF11976	0.577
LIG_SUMO_SIM_par_1	75	81	PF11976	0.515
LIG_TYR_ITIM	7	12	PF00017	0.513
MOD_CDK_SPxK_1	236	242	PF00069	0.593
MOD_CK1_1	210	216	PF00069	0.652
MOD_CK1_1	255	261	PF00069	0.514
MOD_CK1_1	288	294	PF00069	0.612
MOD_CK1_1	97	103	PF00069	0.759
MOD_Cter_Amidation	215	218	PF01082	0.665
MOD_GlcNHglycan	101	104	PF01048	0.775
MOD_GlcNHglycan	212	215	PF01048	0.700
MOD_GlcNHglycan	287	290	PF01048	0.553
MOD_GlcNHglycan	84	87	PF01048	0.654
MOD_GlcNHglycan	94	97	PF01048	0.741
MOD_GSK3_1	144	151	PF00069	0.651
MOD_GSK3_1	195	202	PF00069	0.530
MOD_GSK3_1	205	212	PF00069	0.612
MOD_GSK3_1	255	262	PF00069	0.459
MOD_GSK3_1	287	294	PF00069	0.624
MOD_GSK3_1	78	85	PF00069	0.455
MOD_NEK2_1	175	180	PF00069	0.469
MOD_NEK2_1	193	198	PF00069	0.669
MOD_PIKK_1	116	122	PF00454	0.412
MOD_PIKK_1	187	193	PF00454	0.581
MOD_PIKK_1	259	265	PF00454	0.549
MOD_PIKK_1	87	93	PF00454	0.667
MOD_PKA_2	115	121	PF00069	0.583
MOD_PKA_2	216	222	PF00069	0.630
MOD_PKB_1	114	122	PF00069	0.573
MOD_Plk_1	116	122	PF00069	0.412
MOD_ProDKin_1	132	138	PF00069	0.523
MOD_ProDKin_1	207	213	PF00069	0.754
MOD_ProDKin_1	236	242	PF00069	0.562
MOD_ProDKin_1	53	59	PF00069	0.498
MOD_ProDKin_1	97	103	PF00069	0.761
MOD_SUMO_rev_2	33	39	PF00179	0.477
TRG_ENDOCYTIC_2	172	175	PF00928	0.503
TRG_ENDOCYTIC_2	340	343	PF00928	0.437
TRG_ENDOCYTIC_2	51	54	PF00928	0.581
TRG_ENDOCYTIC_2	9	12	PF00928	0.519
TRG_NES_CRM1_1	167	181	PF08389	0.591
TRG_NES_CRM1_1	26	40	PF08389	0.562
TRG_NLS_MonoExtC_3	111	116	PF00514	0.510
TRG_NLS_MonoExtN_4	109	116	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR6	Leptomonas seymouri	44%	99%
A0A1X0P7J4	Trypanosomatidae	28%	96%
A0A3S7WUR3	Leishmania donovani	88%	100%
A0A422NWM0	Trypanosoma rangeli	30%	96%
A4H9A9	Leishmania braziliensis	65%	100%
A4HXM9	Leishmania infantum	87%	100%
C9ZZY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A069	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ARE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B9X5	Trypanosoma cruzi	29%	99%