Putative major facilitator superfamily protein (MFS)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily protein (MFS), putative

Species:

Leishmania major

UniProt:

Q4QE38_LEIMA

TriTrypDb:

LmjF.18.0040 , LMJLV39_180005500 , LMJSD75_180005500

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QE38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE38

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.340
CLV_C14_Caspase3-7	446	450	PF00656	0.651
CLV_C14_Caspase3-7	71	75	PF00656	0.202
CLV_NRD_NRD_1	486	488	PF00675	0.528
CLV_PCSK_FUR_1	484	488	PF00082	0.546
CLV_PCSK_KEX2_1	486	488	PF00082	0.527
CLV_PCSK_KEX2_1	533	535	PF00082	0.694
CLV_PCSK_KEX2_1	83	85	PF00082	0.552
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.694
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.552
CLV_PCSK_SKI1_1	39	43	PF00082	0.310
CLV_PCSK_SKI1_1	461	465	PF00082	0.241
CLV_PCSK_SKI1_1	56	60	PF00082	0.441
CLV_PCSK_SKI1_1	84	88	PF00082	0.526
DEG_APCC_DBOX_1	460	468	PF00400	0.441
DEG_ODPH_VHL_1	233	245	PF01847	0.513
DOC_CDC14_PxL_1	194	202	PF14671	0.345
DOC_CKS1_1	35	40	PF01111	0.322
DOC_CKS1_1	505	510	PF01111	0.526
DOC_MAPK_MEF2A_6	112	119	PF00069	0.491
DOC_MAPK_MEF2A_6	461	468	PF00069	0.451
DOC_MAPK_NFAT4_5	112	120	PF00069	0.513
DOC_MAPK_NFAT4_5	461	469	PF00069	0.533
DOC_PP1_RVXF_1	37	44	PF00149	0.421
DOC_PP2B_LxvP_1	12	15	PF13499	0.752
DOC_PP2B_LxvP_1	288	291	PF13499	0.202
DOC_PP2B_LxvP_1	473	476	PF13499	0.292
DOC_PP4_FxxP_1	408	411	PF00568	0.458
DOC_PP4_FxxP_1	472	475	PF00568	0.417
DOC_USP7_MATH_1	108	112	PF00917	0.524
DOC_USP7_MATH_1	15	19	PF00917	0.712
DOC_USP7_MATH_1	248	252	PF00917	0.402
DOC_USP7_MATH_1	492	496	PF00917	0.446
DOC_USP7_MATH_1	62	66	PF00917	0.303
DOC_WW_Pin1_4	201	206	PF00397	0.328
DOC_WW_Pin1_4	237	242	PF00397	0.493
DOC_WW_Pin1_4	34	39	PF00397	0.281
DOC_WW_Pin1_4	407	412	PF00397	0.461
DOC_WW_Pin1_4	504	509	PF00397	0.519
DOC_WW_Pin1_4	74	79	PF00397	0.346
DOC_WW_Pin1_4	96	101	PF00397	0.340
LIG_14-3-3_CanoR_1	169	173	PF00244	0.487
LIG_14-3-3_CanoR_1	56	61	PF00244	0.310
LIG_Actin_WH2_2	448	463	PF00022	0.586
LIG_APCC_ABBA_1	50	55	PF00400	0.388
LIG_BIR_III_4	447	451	PF00653	0.509
LIG_BRCT_BRCA1_1	417	421	PF00533	0.531
LIG_BRCT_BRCA1_1	98	102	PF00533	0.340
LIG_BRCT_MDC1_1	534	538	PF00533	0.358
LIG_Clathr_ClatBox_1	298	302	PF01394	0.238
LIG_Clathr_ClatBox_1	51	55	PF01394	0.421
LIG_EH1_1	335	343	PF00400	0.493
LIG_FHA_1	1	7	PF00498	0.714
LIG_FHA_1	134	140	PF00498	0.357
LIG_FHA_1	154	160	PF00498	0.324
LIG_FHA_1	168	174	PF00498	0.399
LIG_FHA_1	210	216	PF00498	0.330
LIG_FHA_1	23	29	PF00498	0.472
LIG_FHA_1	238	244	PF00498	0.508
LIG_FHA_1	247	253	PF00498	0.462
LIG_FHA_1	270	276	PF00498	0.381
LIG_FHA_1	292	298	PF00498	0.299
LIG_FHA_1	323	329	PF00498	0.505
LIG_FHA_1	353	359	PF00498	0.342
LIG_FHA_1	361	367	PF00498	0.233
LIG_FHA_1	373	379	PF00498	0.145
LIG_FHA_1	42	48	PF00498	0.316
LIG_FHA_1	489	495	PF00498	0.441
LIG_FHA_1	8	14	PF00498	0.721
LIG_FHA_2	156	162	PF00498	0.293
LIG_FXI_DFP_1	405	409	PF00024	0.279
LIG_GBD_Chelix_1	308	316	PF00786	0.288
LIG_HP1_1	219	223	PF01393	0.438
LIG_LIR_Apic_2	276	281	PF02991	0.340
LIG_LIR_Apic_2	33	38	PF02991	0.558
LIG_LIR_Apic_2	407	411	PF02991	0.460
LIG_LIR_Gen_1	132	143	PF02991	0.255
LIG_LIR_Gen_1	149	160	PF02991	0.262
LIG_LIR_Gen_1	266	275	PF02991	0.396
LIG_LIR_Gen_1	396	405	PF02991	0.474
LIG_LIR_Nem_3	132	138	PF02991	0.245
LIG_LIR_Nem_3	149	155	PF02991	0.204
LIG_LIR_Nem_3	170	175	PF02991	0.465
LIG_LIR_Nem_3	195	200	PF02991	0.281
LIG_LIR_Nem_3	204	209	PF02991	0.201
LIG_LIR_Nem_3	266	271	PF02991	0.391
LIG_LIR_Nem_3	396	400	PF02991	0.478
LIG_LIR_Nem_3	479	485	PF02991	0.359
LIG_LIR_Nem_3	48	53	PF02991	0.380
LIG_LYPXL_yS_3	197	200	PF13949	0.333
LIG_MLH1_MIPbox_1	417	421	PF16413	0.582
LIG_MLH1_MIPbox_1	98	102	PF16413	0.238
LIG_PCNA_yPIPBox_3	24	36	PF02747	0.539
LIG_PCNA_yPIPBox_3	379	391	PF02747	0.293
LIG_Pex14_1	172	176	PF04695	0.293
LIG_Pex14_1	206	210	PF04695	0.241
LIG_Pex14_2	360	364	PF04695	0.294
LIG_Pex14_2	440	444	PF04695	0.581
LIG_Pex14_2	468	472	PF04695	0.349
LIG_Pex14_2	50	54	PF04695	0.421
LIG_PTB_Apo_2	252	259	PF02174	0.441
LIG_PTB_Phospho_1	252	258	PF10480	0.451
LIG_REV1ctd_RIR_1	418	427	PF16727	0.591
LIG_REV1ctd_RIR_1	99	109	PF16727	0.238
LIG_SH2_CRK	135	139	PF00017	0.291
LIG_SH2_CRK	177	181	PF00017	0.306
LIG_SH2_CRK	258	262	PF00017	0.362
LIG_SH2_CRK	268	272	PF00017	0.247
LIG_SH2_NCK_1	177	181	PF00017	0.306
LIG_SH2_SRC	226	229	PF00017	0.438
LIG_SH2_STAP1	135	139	PF00017	0.262
LIG_SH2_STAP1	393	397	PF00017	0.441
LIG_SH2_STAT5	135	138	PF00017	0.333
LIG_SH2_STAT5	210	213	PF00017	0.438
LIG_SH2_STAT5	226	229	PF00017	0.421
LIG_SH2_STAT5	268	271	PF00017	0.322
LIG_SH2_STAT5	470	473	PF00017	0.352
LIG_SH2_STAT5	53	56	PF00017	0.421
LIG_SH2_STAT5	95	98	PF00017	0.407
LIG_SH3_3	238	244	PF00018	0.558
LIG_SH3_3	505	511	PF00018	0.525
LIG_SH3_3	94	100	PF00018	0.388
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.309
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.340
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.331
LIG_SUMO_SIM_par_1	155	161	PF11976	0.340
LIG_TRFH_1	231	235	PF08558	0.513
LIG_TYR_ITIM	133	138	PF00017	0.309
LIG_WRC_WIRS_1	42	47	PF05994	0.421
MOD_CDK_SPK_2	34	39	PF00069	0.293
MOD_CDK_SPxK_1	201	207	PF00069	0.328
MOD_CK1_1	104	110	PF00069	0.399
MOD_CK1_1	324	330	PF00069	0.460
MOD_CK1_1	381	387	PF00069	0.360
MOD_CK1_1	65	71	PF00069	0.293
MOD_CK1_1	7	13	PF00069	0.749
MOD_CK2_1	515	521	PF00069	0.505
MOD_GlcNHglycan	106	109	PF01048	0.345
MOD_GlcNHglycan	305	308	PF01048	0.421
MOD_GlcNHglycan	493	497	PF01048	0.574
MOD_GlcNHglycan	534	537	PF01048	0.553
MOD_GlcNHglycan	88	91	PF01048	0.319
MOD_GSK3_1	104	111	PF00069	0.459
MOD_GSK3_1	129	136	PF00069	0.411
MOD_GSK3_1	160	167	PF00069	0.481
MOD_GSK3_1	244	251	PF00069	0.498
MOD_GSK3_1	269	276	PF00069	0.388
MOD_GSK3_1	4	11	PF00069	0.706
MOD_GSK3_1	41	48	PF00069	0.418
MOD_GSK3_1	488	495	PF00069	0.363
MOD_GSK3_1	500	507	PF00069	0.448
MOD_GSK3_1	61	68	PF00069	0.113
MOD_GSK3_1	70	77	PF00069	0.215
MOD_GSK3_1	96	103	PF00069	0.460
MOD_N-GLC_1	15	20	PF02516	0.534
MOD_N-GLC_1	378	383	PF02516	0.362
MOD_N-GLC_1	74	79	PF02516	0.552
MOD_NEK2_1	101	106	PF00069	0.293
MOD_NEK2_1	133	138	PF00069	0.284
MOD_NEK2_1	155	160	PF00069	0.306
MOD_NEK2_1	175	180	PF00069	0.113
MOD_NEK2_1	193	198	PF00069	0.341
MOD_NEK2_1	246	251	PF00069	0.533
MOD_NEK2_1	360	365	PF00069	0.266
MOD_NEK2_1	372	377	PF00069	0.260
MOD_NEK2_1	421	426	PF00069	0.445
MOD_NEK2_1	45	50	PF00069	0.375
MOD_NEK2_1	86	91	PF00069	0.303
MOD_PIKK_1	4	10	PF00454	0.710
MOD_PKA_2	104	110	PF00069	0.438
MOD_PKA_2	168	174	PF00069	0.492
MOD_Plk_1	378	384	PF00069	0.362
MOD_Plk_1	500	506	PF00069	0.469
MOD_Plk_1	8	14	PF00069	0.745
MOD_Plk_4	133	139	PF00069	0.352
MOD_Plk_4	155	161	PF00069	0.317
MOD_Plk_4	168	174	PF00069	0.422
MOD_Plk_4	175	181	PF00069	0.113
MOD_Plk_4	248	254	PF00069	0.468
MOD_Plk_4	263	269	PF00069	0.186
MOD_Plk_4	308	314	PF00069	0.382
MOD_Plk_4	31	37	PF00069	0.438
MOD_Plk_4	378	384	PF00069	0.336
MOD_Plk_4	395	401	PF00069	0.411
MOD_Plk_4	8	14	PF00069	0.735
MOD_ProDKin_1	201	207	PF00069	0.328
MOD_ProDKin_1	237	243	PF00069	0.493
MOD_ProDKin_1	34	40	PF00069	0.281
MOD_ProDKin_1	407	413	PF00069	0.465
MOD_ProDKin_1	504	510	PF00069	0.520
MOD_ProDKin_1	74	80	PF00069	0.346
MOD_ProDKin_1	96	102	PF00069	0.340
TRG_DiLeu_BaEn_1	9	14	PF01217	0.746
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.313
TRG_ENDOCYTIC_2	135	138	PF00928	0.241
TRG_ENDOCYTIC_2	177	180	PF00928	0.293
TRG_ENDOCYTIC_2	197	200	PF00928	0.291
TRG_ENDOCYTIC_2	258	261	PF00928	0.293
TRG_ENDOCYTIC_2	268	271	PF00928	0.262
TRG_ENDOCYTIC_2	397	400	PF00928	0.477
TRG_ENDOCYTIC_2	470	473	PF00928	0.350
TRG_ER_diArg_1	483	486	PF00400	0.298
TRG_Pf-PMV_PEXEL_1	426	431	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT4	Leptomonas seymouri	63%	100%
A0A0S4JAJ6	Bodo saltans	43%	100%
A0A1X0P6Q0	Trypanosomatidae	45%	100%
A0A3R7NQ56	Trypanosoma rangeli	46%	98%
A0A3R7R683	Trypanosoma rangeli	23%	70%
A0A3S5H721	Leishmania donovani	87%	100%
A2CER7	Danio rerio	25%	100%
A2SWM2	Danio rerio	24%	100%
A4HXN0	Leishmania infantum	87%	100%
A8WGF7	Xenopus tropicalis	26%	100%
B0JZE1	Xenopus tropicalis	25%	100%
C9ZZY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A070	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ARE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
F4IKF6	Arabidopsis thaliana	28%	100%
Q08DX7	Bos taurus	25%	100%
Q2YDU8	Rattus norvegicus	25%	100%
Q5XGK0	Xenopus laevis	26%	100%
Q6NMN6	Arabidopsis thaliana	26%	100%
Q7ZU13	Danio rerio	26%	100%
Q8IVW8	Homo sapiens	27%	98%
Q8R0G7	Mus musculus	25%	100%
Q91VM4	Mus musculus	27%	98%
Q9D232	Mus musculus	23%	100%
Q9FLG8	Arabidopsis thaliana	29%	100%
Q9GQQ0	Drosophila melanogaster	24%	89%
Q9H2V7	Homo sapiens	25%	100%
V5B601	Trypanosoma cruzi	23%	72%
V5D5S9	Trypanosoma cruzi	43%	100%