LeishMANIAdb
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Protein ZIP4 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Protein ZIP4 homolog
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QE37_LEIMA
TriTrypDb:
LmjF.18.0050 , LMJLV39_180005600 , LMJSD75_180005600 *
Length:
973

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4QE37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE37

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 44 48 PF00656 0.523
CLV_C14_Caspase3-7 497 501 PF00656 0.624
CLV_C14_Caspase3-7 640 644 PF00656 0.553
CLV_C14_Caspase3-7 691 695 PF00656 0.385
CLV_NRD_NRD_1 171 173 PF00675 0.485
CLV_NRD_NRD_1 388 390 PF00675 0.464
CLV_NRD_NRD_1 420 422 PF00675 0.483
CLV_NRD_NRD_1 725 727 PF00675 0.376
CLV_NRD_NRD_1 86 88 PF00675 0.384
CLV_NRD_NRD_1 935 937 PF00675 0.534
CLV_PCSK_KEX2_1 171 173 PF00082 0.408
CLV_PCSK_KEX2_1 388 390 PF00082 0.480
CLV_PCSK_KEX2_1 420 422 PF00082 0.450
CLV_PCSK_KEX2_1 725 727 PF00082 0.376
CLV_PCSK_KEX2_1 935 937 PF00082 0.534
CLV_PCSK_SKI1_1 128 132 PF00082 0.453
CLV_PCSK_SKI1_1 138 142 PF00082 0.377
CLV_PCSK_SKI1_1 280 284 PF00082 0.445
CLV_PCSK_SKI1_1 285 289 PF00082 0.470
CLV_PCSK_SKI1_1 290 294 PF00082 0.315
CLV_PCSK_SKI1_1 340 344 PF00082 0.566
CLV_PCSK_SKI1_1 434 438 PF00082 0.455
CLV_PCSK_SKI1_1 548 552 PF00082 0.430
CLV_PCSK_SKI1_1 62 66 PF00082 0.523
CLV_PCSK_SKI1_1 767 771 PF00082 0.549
CLV_PCSK_SKI1_1 88 92 PF00082 0.292
CLV_PCSK_SKI1_1 889 893 PF00082 0.594
CLV_Separin_Metazoa 417 421 PF03568 0.471
DEG_APCC_DBOX_1 697 705 PF00400 0.338
DEG_SPOP_SBC_1 316 320 PF00917 0.342
DEG_SPOP_SBC_1 391 395 PF00917 0.314
DOC_ANK_TNKS_1 811 818 PF00023 0.426
DOC_CYCLIN_RxL_1 542 554 PF00134 0.411
DOC_MAPK_gen_1 171 179 PF00069 0.447
DOC_MAPK_gen_1 698 705 PF00069 0.335
DOC_MAPK_gen_1 752 759 PF00069 0.394
DOC_MAPK_gen_1 941 948 PF00069 0.364
DOC_MAPK_MEF2A_6 325 334 PF00069 0.408
DOC_MAPK_MEF2A_6 480 487 PF00069 0.436
DOC_MAPK_MEF2A_6 62 69 PF00069 0.485
DOC_MAPK_MEF2A_6 698 705 PF00069 0.335
DOC_MAPK_MEF2A_6 752 759 PF00069 0.394
DOC_MAPK_NFAT4_5 698 706 PF00069 0.336
DOC_MIT_MIM_1 694 704 PF04212 0.357
DOC_PP1_RVXF_1 149 156 PF00149 0.457
DOC_PP2B_LxvP_1 639 642 PF13499 0.433
DOC_PP2B_LxvP_1 813 816 PF13499 0.459
DOC_PP4_MxPP_1 427 430 PF00568 0.290
DOC_USP7_MATH_1 236 240 PF00917 0.501
DOC_USP7_MATH_1 254 258 PF00917 0.485
DOC_USP7_MATH_1 317 321 PF00917 0.488
DOC_USP7_MATH_1 352 356 PF00917 0.374
DOC_USP7_MATH_1 366 370 PF00917 0.286
DOC_USP7_MATH_1 392 396 PF00917 0.398
DOC_USP7_MATH_1 678 682 PF00917 0.669
DOC_USP7_MATH_1 686 690 PF00917 0.624
DOC_USP7_MATH_1 71 75 PF00917 0.516
DOC_USP7_MATH_1 793 797 PF00917 0.371
DOC_WW_Pin1_4 592 597 PF00397 0.549
DOC_WW_Pin1_4 773 778 PF00397 0.519
DOC_WW_Pin1_4 811 816 PF00397 0.459
LIG_14-3-3_CanoR_1 142 152 PF00244 0.405
LIG_14-3-3_CanoR_1 171 179 PF00244 0.406
LIG_14-3-3_CanoR_1 206 215 PF00244 0.545
LIG_14-3-3_CanoR_1 340 349 PF00244 0.367
LIG_14-3-3_CanoR_1 351 361 PF00244 0.426
LIG_14-3-3_CanoR_1 389 397 PF00244 0.484
LIG_14-3-3_CanoR_1 408 415 PF00244 0.455
LIG_14-3-3_CanoR_1 420 429 PF00244 0.420
LIG_14-3-3_CanoR_1 442 448 PF00244 0.391
LIG_14-3-3_CanoR_1 453 461 PF00244 0.490
LIG_14-3-3_CanoR_1 561 570 PF00244 0.448
LIG_14-3-3_CanoR_1 572 576 PF00244 0.457
LIG_14-3-3_CanoR_1 752 758 PF00244 0.344
LIG_14-3-3_CanoR_1 95 101 PF00244 0.407
LIG_Actin_WH2_2 170 185 PF00022 0.410
LIG_Actin_WH2_2 24 42 PF00022 0.384
LIG_Actin_WH2_2 621 637 PF00022 0.368
LIG_APCC_ABBA_1 31 36 PF00400 0.398
LIG_APCC_ABBA_1 492 497 PF00400 0.375
LIG_deltaCOP1_diTrp_1 643 652 PF00928 0.344
LIG_deltaCOP1_diTrp_1 922 930 PF00928 0.309
LIG_EH1_1 605 613 PF00400 0.400
LIG_eIF4E_1 300 306 PF01652 0.378
LIG_eIF4E_1 653 659 PF01652 0.461
LIG_EVH1_2 428 432 PF00568 0.419
LIG_FHA_1 210 216 PF00498 0.523
LIG_FHA_1 341 347 PF00498 0.477
LIG_FHA_1 356 362 PF00498 0.277
LIG_FHA_1 392 398 PF00498 0.363
LIG_FHA_1 414 420 PF00498 0.462
LIG_FHA_1 486 492 PF00498 0.312
LIG_FHA_1 500 506 PF00498 0.423
LIG_FHA_1 566 572 PF00498 0.458
LIG_FHA_1 719 725 PF00498 0.421
LIG_FHA_1 746 752 PF00498 0.476
LIG_FHA_1 754 760 PF00498 0.329
LIG_FHA_1 842 848 PF00498 0.507
LIG_FHA_1 873 879 PF00498 0.442
LIG_FHA_1 948 954 PF00498 0.433
LIG_FHA_2 317 323 PF00498 0.364
LIG_FHA_2 42 48 PF00498 0.563
LIG_FHA_2 552 558 PF00498 0.583
LIG_FHA_2 638 644 PF00498 0.450
LIG_FHA_2 689 695 PF00498 0.481
LIG_FHA_2 705 711 PF00498 0.296
LIG_FHA_2 763 769 PF00498 0.474
LIG_FHA_2 774 780 PF00498 0.505
LIG_FHA_2 912 918 PF00498 0.481
LIG_GBD_Chelix_1 945 953 PF00786 0.398
LIG_LIR_Gen_1 176 185 PF02991 0.331
LIG_LIR_Gen_1 318 329 PF02991 0.374
LIG_LIR_Gen_1 458 467 PF02991 0.494
LIG_LIR_Gen_1 601 608 PF02991 0.440
LIG_LIR_Gen_1 706 717 PF02991 0.360
LIG_LIR_Gen_1 853 861 PF02991 0.431
LIG_LIR_Gen_1 927 938 PF02991 0.447
LIG_LIR_Gen_1 99 108 PF02991 0.321
LIG_LIR_Nem_3 176 182 PF02991 0.462
LIG_LIR_Nem_3 296 300 PF02991 0.326
LIG_LIR_Nem_3 318 324 PF02991 0.496
LIG_LIR_Nem_3 398 403 PF02991 0.365
LIG_LIR_Nem_3 458 464 PF02991 0.453
LIG_LIR_Nem_3 601 605 PF02991 0.442
LIG_LIR_Nem_3 648 653 PF02991 0.382
LIG_LIR_Nem_3 706 712 PF02991 0.312
LIG_LIR_Nem_3 853 858 PF02991 0.360
LIG_LIR_Nem_3 917 921 PF02991 0.373
LIG_LIR_Nem_3 927 933 PF02991 0.438
LIG_LIR_Nem_3 940 945 PF02991 0.372
LIG_LIR_Nem_3 99 103 PF02991 0.313
LIG_NRBOX 267 273 PF00104 0.309
LIG_NRBOX 700 706 PF00104 0.372
LIG_NRBOX 730 736 PF00104 0.441
LIG_NRBOX 846 852 PF00104 0.290
LIG_PCNA_yPIPBox_3 265 277 PF02747 0.378
LIG_PCNA_yPIPBox_3 399 408 PF02747 0.384
LIG_Pex14_1 646 650 PF04695 0.343
LIG_Pex14_1 96 100 PF04695 0.315
LIG_Pex14_2 437 441 PF04695 0.312
LIG_Pex14_2 602 606 PF04695 0.369
LIG_SH2_CRK 302 306 PF00017 0.382
LIG_SH2_CRK 321 325 PF00017 0.256
LIG_SH2_NCK_1 310 314 PF00017 0.373
LIG_SH2_STAP1 211 215 PF00017 0.415
LIG_SH2_STAP1 302 306 PF00017 0.480
LIG_SH2_STAP1 310 314 PF00017 0.421
LIG_SH2_STAP1 653 657 PF00017 0.396
LIG_SH2_STAT5 100 103 PF00017 0.399
LIG_SH2_STAT5 211 214 PF00017 0.483
LIG_SH2_STAT5 297 300 PF00017 0.328
LIG_SH2_STAT5 808 811 PF00017 0.505
LIG_SH3_3 247 253 PF00018 0.571
LIG_SH3_3 54 60 PF00018 0.432
LIG_SH3_3 671 677 PF00018 0.264
LIG_SUMO_SIM_anti_2 270 275 PF11976 0.317
LIG_SUMO_SIM_par_1 270 275 PF11976 0.450
LIG_SUMO_SIM_par_1 355 363 PF11976 0.529
LIG_SUMO_SIM_par_1 775 781 PF11976 0.467
LIG_SUMO_SIM_par_1 790 796 PF11976 0.282
LIG_SUMO_SIM_par_1 944 951 PF11976 0.518
LIG_TRAF2_1 110 113 PF00917 0.368
LIG_TRAF2_1 226 229 PF00917 0.428
LIG_TRAF2_1 377 380 PF00917 0.409
LIG_TRAF2_1 475 478 PF00917 0.427
LIG_TRAF2_1 501 504 PF00917 0.397
LIG_TYR_ITIM 98 103 PF00017 0.312
LIG_UBA3_1 130 138 PF00899 0.342
LIG_UBA3_1 272 280 PF00899 0.348
LIG_UBA3_1 850 859 PF00899 0.550
LIG_WRC_WIRS_1 566 571 PF05994 0.376
LIG_WRC_WIRS_1 709 714 PF05994 0.402
MOD_CK1_1 267 273 PF00069 0.445
MOD_CK1_1 355 361 PF00069 0.387
MOD_CK1_1 411 417 PF00069 0.327
MOD_CK1_1 456 462 PF00069 0.470
MOD_CK1_1 730 736 PF00069 0.516
MOD_CK1_1 811 817 PF00069 0.434
MOD_CK1_1 839 845 PF00069 0.350
MOD_CK1_1 951 957 PF00069 0.489
MOD_CK2_1 223 229 PF00069 0.496
MOD_CK2_1 242 248 PF00069 0.700
MOD_CK2_1 411 417 PF00069 0.368
MOD_CK2_1 473 479 PF00069 0.361
MOD_CK2_1 517 523 PF00069 0.399
MOD_CK2_1 551 557 PF00069 0.511
MOD_CK2_1 717 723 PF00069 0.431
MOD_CK2_1 734 740 PF00069 0.384
MOD_CK2_1 741 747 PF00069 0.539
MOD_CK2_1 911 917 PF00069 0.486
MOD_GlcNHglycan 173 176 PF01048 0.507
MOD_GlcNHglycan 238 241 PF01048 0.622
MOD_GlcNHglycan 256 259 PF01048 0.690
MOD_GlcNHglycan 394 397 PF01048 0.467
MOD_GlcNHglycan 443 446 PF01048 0.402
MOD_GlcNHglycan 455 458 PF01048 0.429
MOD_GlcNHglycan 49 52 PF01048 0.447
MOD_GlcNHglycan 519 522 PF01048 0.405
MOD_GlcNHglycan 577 580 PF01048 0.445
MOD_GlcNHglycan 795 798 PF01048 0.570
MOD_GlcNHglycan 847 850 PF01048 0.437
MOD_GlcNHglycan 9 12 PF01048 0.482
MOD_GSK3_1 202 209 PF00069 0.509
MOD_GSK3_1 455 462 PF00069 0.473
MOD_GSK3_1 561 568 PF00069 0.341
MOD_GSK3_1 571 578 PF00069 0.368
MOD_GSK3_1 704 711 PF00069 0.412
MOD_GSK3_1 71 78 PF00069 0.373
MOD_GSK3_1 730 737 PF00069 0.442
MOD_GSK3_1 741 748 PF00069 0.507
MOD_GSK3_1 811 818 PF00069 0.478
MOD_GSK3_1 835 842 PF00069 0.533
MOD_GSK3_1 868 875 PF00069 0.372
MOD_GSK3_1 947 954 PF00069 0.429
MOD_N-GLC_1 742 747 PF02516 0.659
MOD_N-GLC_1 75 80 PF02516 0.340
MOD_N-GLC_1 884 889 PF02516 0.471
MOD_N-GLC_1 924 929 PF02516 0.349
MOD_N-GLC_1 956 961 PF02516 0.509
MOD_NEK2_1 102 107 PF00069 0.393
MOD_NEK2_1 134 139 PF00069 0.460
MOD_NEK2_1 272 277 PF00069 0.332
MOD_NEK2_1 293 298 PF00069 0.327
MOD_NEK2_1 455 460 PF00069 0.274
MOD_NEK2_1 485 490 PF00069 0.441
MOD_NEK2_1 505 510 PF00069 0.446
MOD_NEK2_1 522 527 PF00069 0.217
MOD_NEK2_1 551 556 PF00069 0.522
MOD_NEK2_1 570 575 PF00069 0.321
MOD_NEK2_1 762 767 PF00069 0.449
MOD_NEK2_1 850 855 PF00069 0.426
MOD_NEK2_1 911 916 PF00069 0.493
MOD_NEK2_2 29 34 PF00069 0.452
MOD_PIKK_1 196 202 PF00454 0.407
MOD_PIKK_1 485 491 PF00454 0.463
MOD_PK_1 283 289 PF00069 0.332
MOD_PKA_1 171 177 PF00069 0.427
MOD_PKA_1 420 426 PF00069 0.439
MOD_PKA_2 143 149 PF00069 0.407
MOD_PKA_2 171 177 PF00069 0.407
MOD_PKA_2 205 211 PF00069 0.578
MOD_PKA_2 420 426 PF00069 0.396
MOD_PKA_2 441 447 PF00069 0.375
MOD_PKA_2 459 465 PF00069 0.454
MOD_PKA_2 571 577 PF00069 0.535
MOD_PKA_2 753 759 PF00069 0.329
MOD_Plk_1 29 35 PF00069 0.471
MOD_Plk_1 355 361 PF00069 0.377
MOD_Plk_1 411 417 PF00069 0.452
MOD_Plk_1 485 491 PF00069 0.374
MOD_Plk_1 505 511 PF00069 0.492
MOD_Plk_1 522 528 PF00069 0.425
MOD_Plk_1 746 752 PF00069 0.550
MOD_Plk_1 75 81 PF00069 0.358
MOD_Plk_1 762 768 PF00069 0.255
MOD_Plk_1 884 890 PF00069 0.485
MOD_Plk_1 924 930 PF00069 0.349
MOD_Plk_4 267 273 PF00069 0.469
MOD_Plk_4 293 299 PF00069 0.382
MOD_Plk_4 300 306 PF00069 0.328
MOD_Plk_4 378 384 PF00069 0.488
MOD_Plk_4 565 571 PF00069 0.465
MOD_Plk_4 730 736 PF00069 0.513
MOD_Plk_4 753 759 PF00069 0.337
MOD_Plk_4 787 793 PF00069 0.439
MOD_Plk_4 850 856 PF00069 0.370
MOD_Plk_4 911 917 PF00069 0.450
MOD_Plk_4 948 954 PF00069 0.559
MOD_Plk_4 96 102 PF00069 0.464
MOD_ProDKin_1 592 598 PF00069 0.544
MOD_ProDKin_1 773 779 PF00069 0.516
MOD_ProDKin_1 811 817 PF00069 0.455
MOD_SUMO_for_1 334 337 PF00179 0.453
MOD_SUMO_rev_2 736 744 PF00179 0.472
MOD_SUMO_rev_2 86 92 PF00179 0.498
TRG_DiLeu_BaEn_1 127 132 PF01217 0.341
TRG_DiLeu_BaEn_2 564 570 PF01217 0.383
TRG_DiLeu_BaLyEn_6 398 403 PF01217 0.381
TRG_DiLeu_BaLyEn_6 665 670 PF01217 0.537
TRG_DiLeu_BaLyEn_6 864 869 PF01217 0.410
TRG_DiLeu_BaLyEn_6 876 881 PF01217 0.331
TRG_DiLeu_BaLyEn_6 968 973 PF01217 0.543
TRG_ENDOCYTIC_2 100 103 PF00928 0.406
TRG_ENDOCYTIC_2 302 305 PF00928 0.499
TRG_ENDOCYTIC_2 321 324 PF00928 0.278
TRG_ENDOCYTIC_2 855 858 PF00928 0.330
TRG_ER_diArg_1 141 144 PF00400 0.451
TRG_ER_diArg_1 170 172 PF00400 0.480
TRG_ER_diArg_1 388 390 PF00400 0.540
TRG_ER_diArg_1 419 421 PF00400 0.482
TRG_ER_diArg_1 697 700 PF00400 0.357
TRG_ER_diArg_1 724 726 PF00400 0.376
TRG_ER_diArg_1 751 754 PF00400 0.395
TRG_NES_CRM1_1 21 37 PF08389 0.362
TRG_NES_CRM1_1 213 228 PF08389 0.283
TRG_NES_CRM1_1 363 373 PF08389 0.525
TRG_Pf-PMV_PEXEL_1 225 229 PF00026 0.624
TRG_Pf-PMV_PEXEL_1 351 356 PF00026 0.324
TRG_Pf-PMV_PEXEL_1 420 424 PF00026 0.369
TRG_Pf-PMV_PEXEL_1 867 872 PF00026 0.400
TRG_Pf-PMV_PEXEL_1 936 940 PF00026 0.429

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCQ0 Leptomonas seymouri 38% 98%
A0A1X0P6X9 Trypanosomatidae 22% 100%
A0A3S5IS41 Trypanosoma rangeli 23% 100%
A0A3S7WUQ3 Leishmania donovani 91% 100%
A4H9B0 Leishmania braziliensis 72% 100%
A4HXN1 Leishmania infantum 91% 100%
D0A008 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 21% 98%
E9ARE2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5AQ00 Trypanosoma cruzi 22% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS