DZANK-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type/Double zinc ribbon, putative

Species:

Leishmania major

UniProt:

Q4QE35_LEIMA

TriTrypDb:

LmjF.18.0070 , LMJLV39_180005900 , LMJSD75_180005900

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005815	microtubule organizing center	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0036064	ciliary basal body	3	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE35

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.335
CLV_NRD_NRD_1	145	147	PF00675	0.628
CLV_NRD_NRD_1	241	243	PF00675	0.321
CLV_NRD_NRD_1	266	268	PF00675	0.746
CLV_NRD_NRD_1	307	309	PF00675	0.685
CLV_NRD_NRD_1	415	417	PF00675	0.417
CLV_NRD_NRD_1	613	615	PF00675	0.440
CLV_NRD_NRD_1	654	656	PF00675	0.459
CLV_NRD_NRD_1	695	697	PF00675	0.292
CLV_PCSK_KEX2_1	145	147	PF00082	0.661
CLV_PCSK_KEX2_1	241	243	PF00082	0.468
CLV_PCSK_KEX2_1	325	327	PF00082	0.609
CLV_PCSK_KEX2_1	415	417	PF00082	0.217
CLV_PCSK_KEX2_1	612	614	PF00082	0.473
CLV_PCSK_KEX2_1	643	645	PF00082	0.561
CLV_PCSK_KEX2_1	654	656	PF00082	0.427
CLV_PCSK_KEX2_1	695	697	PF00082	0.404
CLV_PCSK_KEX2_1	721	723	PF00082	0.613
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.691
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.568
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.623
CLV_PCSK_SKI1_1	241	245	PF00082	0.271
CLV_PCSK_SKI1_1	267	271	PF00082	0.624
CLV_PCSK_SKI1_1	470	474	PF00082	0.445
CLV_PCSK_SKI1_1	501	505	PF00082	0.475
CLV_PCSK_SKI1_1	544	548	PF00082	0.694
CLV_PCSK_SKI1_1	613	617	PF00082	0.502
CLV_PCSK_SKI1_1	654	658	PF00082	0.461
CLV_PCSK_SKI1_1	98	102	PF00082	0.313
DEG_SCF_FBW7_1	546	552	PF00400	0.510
DEG_SPOP_SBC_1	312	316	PF00917	0.603
DOC_CKS1_1	546	551	PF01111	0.689
DOC_MAPK_gen_1	110	120	PF00069	0.477
DOC_PP2B_LxvP_1	676	679	PF13499	0.507
DOC_USP7_MATH_1	237	241	PF00917	0.292
DOC_USP7_MATH_1	313	317	PF00917	0.683
DOC_USP7_MATH_1	336	340	PF00917	0.562
DOC_USP7_MATH_1	381	385	PF00917	0.271
DOC_USP7_MATH_1	463	467	PF00917	0.707
DOC_USP7_MATH_1	529	533	PF00917	0.789
DOC_USP7_MATH_1	537	541	PF00917	0.593
DOC_USP7_MATH_1	549	553	PF00917	0.593
DOC_USP7_MATH_1	596	600	PF00917	0.292
DOC_USP7_MATH_1	631	635	PF00917	0.612
DOC_USP7_UBL2_3	305	309	PF12436	0.821
DOC_USP7_UBL2_3	643	647	PF12436	0.606
DOC_WW_Pin1_4	131	136	PF00397	0.756
DOC_WW_Pin1_4	151	156	PF00397	0.608
DOC_WW_Pin1_4	214	219	PF00397	0.671
DOC_WW_Pin1_4	262	267	PF00397	0.682
DOC_WW_Pin1_4	276	281	PF00397	0.588
DOC_WW_Pin1_4	282	287	PF00397	0.764
DOC_WW_Pin1_4	297	302	PF00397	0.509
DOC_WW_Pin1_4	400	405	PF00397	0.404
DOC_WW_Pin1_4	443	448	PF00397	0.624
DOC_WW_Pin1_4	454	459	PF00397	0.651
DOC_WW_Pin1_4	530	535	PF00397	0.579
DOC_WW_Pin1_4	545	550	PF00397	0.575
DOC_WW_Pin1_4	563	568	PF00397	0.564
LIG_14-3-3_CanoR_1	331	336	PF00244	0.601
LIG_14-3-3_CanoR_1	530	534	PF00244	0.649
LIG_14-3-3_CanoR_1	536	542	PF00244	0.625
LIG_14-3-3_CanoR_1	585	595	PF00244	0.292
LIG_14-3-3_CanoR_1	605	615	PF00244	0.332
LIG_14-3-3_CanoR_1	708	714	PF00244	0.500
LIG_BIR_III_4	427	431	PF00653	0.289
LIG_BRCT_BRCA1_1	239	243	PF00533	0.419
LIG_BRCT_BRCA1_1	649	653	PF00533	0.458
LIG_deltaCOP1_diTrp_1	645	653	PF00928	0.502
LIG_eIF4E_1	578	584	PF01652	0.426
LIG_FHA_1	160	166	PF00498	0.376
LIG_FHA_1	170	176	PF00498	0.316
LIG_FHA_1	483	489	PF00498	0.575
LIG_FHA_1	545	551	PF00498	0.740
LIG_FHA_2	283	289	PF00498	0.731
LIG_FHA_2	479	485	PF00498	0.536
LIG_FHA_2	502	508	PF00498	0.676
LIG_FHA_2	564	570	PF00498	0.710
LIG_FHA_2	670	676	PF00498	0.528
LIG_FHA_2	681	687	PF00498	0.455
LIG_Integrin_RGD_1	113	115	PF01839	0.403
LIG_LIR_Apic_2	319	324	PF02991	0.604
LIG_LIR_Gen_1	223	233	PF02991	0.428
LIG_LIR_Gen_1	81	91	PF02991	0.393
LIG_LIR_LC3C_4	246	250	PF02991	0.289
LIG_LIR_Nem_3	223	229	PF02991	0.439
LIG_LIR_Nem_3	572	578	PF02991	0.615
LIG_LIR_Nem_3	81	86	PF02991	0.376
LIG_MYND_1	157	161	PF01753	0.546
LIG_NBox_RRM_1	653	663	PF00076	0.568
LIG_NRP_CendR_1	721	723	PF00754	0.637
LIG_PTB_Apo_2	681	688	PF02174	0.602
LIG_PTB_Phospho_1	681	687	PF10480	0.609
LIG_SH2_STAP1	183	187	PF00017	0.425
LIG_SH2_STAP1	350	354	PF00017	0.376
LIG_SH2_STAT3	13	16	PF00017	0.360
LIG_SH2_STAT5	164	167	PF00017	0.278
LIG_SH2_STAT5	21	24	PF00017	0.295
LIG_SH2_STAT5	474	477	PF00017	0.450
LIG_SH2_STAT5	687	690	PF00017	0.289
LIG_SH3_2	257	262	PF14604	0.546
LIG_SH3_2	263	268	PF14604	0.569
LIG_SH3_2	404	409	PF14604	0.292
LIG_SH3_2	639	644	PF14604	0.671
LIG_SH3_2	716	721	PF14604	0.569
LIG_SH3_3	115	121	PF00018	0.565
LIG_SH3_3	152	158	PF00018	0.692
LIG_SH3_3	199	205	PF00018	0.491
LIG_SH3_3	254	260	PF00018	0.599
LIG_SH3_3	362	368	PF00018	0.378
LIG_SH3_3	401	407	PF00018	0.317
LIG_SH3_3	414	420	PF00018	0.213
LIG_SH3_3	46	52	PF00018	0.460
LIG_SH3_3	531	537	PF00018	0.637
LIG_SH3_3	543	549	PF00018	0.664
LIG_SH3_3	553	559	PF00018	0.610
LIG_SH3_3	56	62	PF00018	0.401
LIG_SH3_3	581	587	PF00018	0.383
LIG_SH3_3	636	642	PF00018	0.640
LIG_SH3_3	685	691	PF00018	0.385
LIG_SH3_3	710	716	PF00018	0.544
LIG_SH3_3	88	94	PF00018	0.404
LIG_SH3_CIN85_PxpxPR_1	214	219	PF14604	0.482
LIG_SH3_CIN85_PxpxPR_1	716	721	PF14604	0.569
LIG_TRAF2_1	567	570	PF00917	0.596
LIG_WW_1	678	681	PF00397	0.527
LIG_WW_3	718	722	PF00397	0.582
MOD_CDC14_SPxK_1	265	268	PF00782	0.662
MOD_CDK_SPK_2	214	219	PF00069	0.515
MOD_CDK_SPK_2	262	267	PF00069	0.606
MOD_CDK_SPK_2	297	302	PF00069	0.600
MOD_CDK_SPxK_1	262	268	PF00069	0.653
MOD_CDK_SPxK_1	530	536	PF00069	0.625
MOD_CK1_1	634	640	PF00069	0.699
MOD_CK2_1	214	220	PF00069	0.560
MOD_CK2_1	313	319	PF00069	0.738
MOD_CK2_1	395	401	PF00069	0.325
MOD_CK2_1	42	48	PF00069	0.468
MOD_CK2_1	535	541	PF00069	0.753
MOD_CK2_1	563	569	PF00069	0.672
MOD_DYRK1A_RPxSP_1	151	155	PF00069	0.601
MOD_DYRK1A_RPxSP_1	530	534	PF00069	0.512
MOD_GlcNHglycan	28	31	PF01048	0.336
MOD_GlcNHglycan	315	318	PF01048	0.708
MOD_GlcNHglycan	397	400	PF01048	0.325
MOD_GlcNHglycan	537	540	PF01048	0.628
MOD_GlcNHglycan	633	636	PF01048	0.690
MOD_GSK3_1	278	285	PF00069	0.678
MOD_GSK3_1	327	334	PF00069	0.696
MOD_GSK3_1	454	461	PF00069	0.599
MOD_GSK3_1	478	485	PF00069	0.578
MOD_GSK3_1	514	521	PF00069	0.682
MOD_GSK3_1	545	552	PF00069	0.625
MOD_N-GLC_1	237	242	PF02516	0.292
MOD_N-GLC_1	616	621	PF02516	0.549
MOD_N-GLC_2	371	373	PF02516	0.367
MOD_N-GLC_2	431	433	PF02516	0.289
MOD_N-GLC_2	563	565	PF02516	0.540
MOD_NEK2_1	369	374	PF00069	0.478
MOD_NEK2_1	386	391	PF00069	0.249
MOD_NEK2_1	616	621	PF00069	0.587
MOD_PIKK_1	42	48	PF00454	0.459
MOD_PIKK_1	606	612	PF00454	0.496
MOD_PIKK_1	634	640	PF00454	0.599
MOD_PIKK_1	85	91	PF00454	0.383
MOD_PKA_1	42	48	PF00069	0.459
MOD_PKA_2	327	333	PF00069	0.623
MOD_PKA_2	529	535	PF00069	0.659
MOD_Plk_1	483	489	PF00069	0.420
MOD_Plk_2-3	423	429	PF00069	0.335
MOD_Plk_2-3	569	575	PF00069	0.570
MOD_ProDKin_1	131	137	PF00069	0.757
MOD_ProDKin_1	151	157	PF00069	0.601
MOD_ProDKin_1	214	220	PF00069	0.668
MOD_ProDKin_1	262	268	PF00069	0.685
MOD_ProDKin_1	276	282	PF00069	0.589
MOD_ProDKin_1	297	303	PF00069	0.552
MOD_ProDKin_1	400	406	PF00069	0.404
MOD_ProDKin_1	443	449	PF00069	0.626
MOD_ProDKin_1	454	460	PF00069	0.652
MOD_ProDKin_1	530	536	PF00069	0.580
MOD_ProDKin_1	545	551	PF00069	0.574
MOD_ProDKin_1	563	569	PF00069	0.562
MOD_SUMO_for_1	601	604	PF00179	0.292
MOD_SUMO_rev_2	349	356	PF00179	0.504
MOD_SUMO_rev_2	466	472	PF00179	0.552
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.516
TRG_ENDOCYTIC_2	83	86	PF00928	0.505
TRG_ER_diArg_1	144	146	PF00400	0.768
TRG_ER_diArg_1	210	213	PF00400	0.546
TRG_ER_diArg_1	241	243	PF00400	0.333
TRG_ER_diArg_1	326	329	PF00400	0.616
TRG_ER_diArg_1	414	416	PF00400	0.246
TRG_ER_diArg_1	613	615	PF00400	0.523
TRG_ER_diArg_1	653	655	PF00400	0.464
TRG_ER_diArg_1	695	697	PF00400	0.404
TRG_ER_diArg_1	720	723	PF00400	0.603
TRG_NLS_Bipartite_1	308	329	PF00514	0.518
TRG_NLS_MonoCore_2	610	615	PF00514	0.557
TRG_NLS_MonoExtN_4	266	271	PF00514	0.599
TRG_NLS_MonoExtN_4	324	329	PF00514	0.585
TRG_NLS_MonoExtN_4	611	616	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	655	659	PF00026	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P519	Leptomonas seymouri	56%	97%
A0A1X0P6N6	Trypanosomatidae	47%	97%
A0A3Q8I9V6	Leishmania donovani	92%	100%
A0A3S5IS42	Trypanosoma rangeli	44%	96%
A4H9B2	Leishmania braziliensis	71%	100%
A4HXN3	Leishmania infantum	92%	100%
D0A010	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
E9ARE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BEH8	Trypanosoma cruzi	50%	100%