Putative alpha glucosidase II subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha glucosidase II subunit, putative

Species:

Leishmania major

UniProt:

Q4QE33_LEIMA

TriTrypDb:

LmjF.18.0090 , LMJLV39_180006100 , LMJSD75_180006100

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 0
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE33

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	7
GO:0009100	glycoprotein metabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	7
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:0005975	carbohydrate metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	12
GO:0004558	alpha-1,4-glucosidase activity	7	7
GO:0005488	binding	1	12
GO:0015926	glucosidase activity	5	8
GO:0016787	hydrolase activity	2	12
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	12
GO:0030246	carbohydrate binding	2	12
GO:0032450	maltose alpha-glucosidase activity	8	7
GO:0090599	alpha-glucosidase activity	6	8
GO:0033919	glucan 1,3-alpha-glucosidase activity	8	1
GO:0090600	alpha-1,3-glucosidase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.658
CLV_NRD_NRD_1	317	319	PF00675	0.252
CLV_NRD_NRD_1	547	549	PF00675	0.251
CLV_NRD_NRD_1	678	680	PF00675	0.328
CLV_NRD_NRD_1	794	796	PF00675	0.379
CLV_PCSK_FUR_1	676	680	PF00082	0.317
CLV_PCSK_KEX2_1	2	4	PF00082	0.543
CLV_PCSK_KEX2_1	329	331	PF00082	0.285
CLV_PCSK_KEX2_1	546	548	PF00082	0.250
CLV_PCSK_KEX2_1	678	680	PF00082	0.328
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.285
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.244
CLV_PCSK_SKI1_1	100	104	PF00082	0.238
CLV_PCSK_SKI1_1	294	298	PF00082	0.251
CLV_PCSK_SKI1_1	307	311	PF00082	0.251
CLV_PCSK_SKI1_1	319	323	PF00082	0.194
CLV_PCSK_SKI1_1	446	450	PF00082	0.377
CLV_PCSK_SKI1_1	466	470	PF00082	0.172
CLV_PCSK_SKI1_1	562	566	PF00082	0.266
CLV_PCSK_SKI1_1	568	572	PF00082	0.266
CLV_PCSK_SKI1_1	591	595	PF00082	0.277
CLV_PCSK_SKI1_1	635	639	PF00082	0.302
CLV_PCSK_SKI1_1	717	721	PF00082	0.332
CLV_PCSK_SKI1_1	767	771	PF00082	0.382
DEG_Nend_UBRbox_1	1	4	PF02207	0.550
DEG_SPOP_SBC_1	361	365	PF00917	0.312
DOC_CDC14_PxL_1	569	577	PF14671	0.266
DOC_CKS1_1	779	784	PF01111	0.428
DOC_CYCLIN_RxL_1	588	596	PF00134	0.284
DOC_MAPK_FxFP_2	127	130	PF00069	0.361
DOC_MAPK_gen_1	316	323	PF00069	0.251
DOC_MAPK_gen_1	795	801	PF00069	0.371
DOC_PP1_RVXF_1	633	640	PF00149	0.182
DOC_PP2B_PxIxI_1	613	619	PF00149	0.394
DOC_PP4_FxxP_1	127	130	PF00568	0.355
DOC_PP4_FxxP_1	191	194	PF00568	0.394
DOC_PP4_FxxP_1	222	225	PF00568	0.266
DOC_PP4_FxxP_1	303	306	PF00568	0.251
DOC_PP4_FxxP_1	516	519	PF00568	0.244
DOC_PP4_MxPP_1	94	97	PF00568	0.366
DOC_USP7_MATH_1	206	210	PF00917	0.511
DOC_USP7_MATH_1	312	316	PF00917	0.285
DOC_USP7_MATH_1	361	365	PF00917	0.251
DOC_USP7_MATH_1	388	392	PF00917	0.430
DOC_USP7_MATH_1	417	421	PF00917	0.459
DOC_USP7_MATH_1	598	602	PF00917	0.279
DOC_USP7_UBL2_3	50	54	PF12436	0.425
DOC_WW_Pin1_4	225	230	PF00397	0.266
DOC_WW_Pin1_4	4	9	PF00397	0.437
DOC_WW_Pin1_4	778	783	PF00397	0.430
LIG_14-3-3_CanoR_1	100	110	PF00244	0.240
LIG_14-3-3_CanoR_1	2	10	PF00244	0.528
LIG_14-3-3_CanoR_1	318	324	PF00244	0.345
LIG_14-3-3_CanoR_1	676	686	PF00244	0.333
LIG_14-3-3_CanoR_1	723	728	PF00244	0.284
LIG_AP2alpha_2	687	689	PF02296	0.282
LIG_BIR_III_4	349	353	PF00653	0.327
LIG_BIR_III_4	36	40	PF00653	0.209
LIG_BRCT_BRCA1_1	173	177	PF00533	0.263
LIG_BRCT_BRCA1_1	378	382	PF00533	0.327
LIG_deltaCOP1_diTrp_1	376	382	PF00928	0.203
LIG_deltaCOP1_diTrp_1	549	553	PF00928	0.266
LIG_deltaCOP1_diTrp_1	636	643	PF00928	0.394
LIG_deltaCOP1_diTrp_1	804	809	PF00928	0.383
LIG_FHA_1	166	172	PF00498	0.362
LIG_FHA_1	184	190	PF00498	0.145
LIG_FHA_1	308	314	PF00498	0.375
LIG_FHA_1	628	634	PF00498	0.302
LIG_FHA_1	651	657	PF00498	0.295
LIG_FHA_1	688	694	PF00498	0.264
LIG_FHA_1	741	747	PF00498	0.531
LIG_FHA_1	775	781	PF00498	0.485
LIG_FHA_1	789	795	PF00498	0.319
LIG_FHA_2	300	306	PF00498	0.345
LIG_FHA_2	320	326	PF00498	0.241
LIG_FHA_2	394	400	PF00498	0.285
LIG_FHA_2	709	715	PF00498	0.388
LIG_FHA_2	770	776	PF00498	0.439
LIG_FHA_2	779	785	PF00498	0.368
LIG_FXI_DFP_1	737	741	PF00024	0.344
LIG_GBD_Chelix_1	563	571	PF00786	0.241
LIG_IRF3_LxIS_1	497	503	PF10401	0.315
LIG_KLC1_Yacidic_2	704	708	PF13176	0.437
LIG_LIR_Apic_2	124	130	PF02991	0.355
LIG_LIR_Apic_2	220	225	PF02991	0.266
LIG_LIR_Apic_2	299	304	PF02991	0.351
LIG_LIR_Apic_2	78	84	PF02991	0.346
LIG_LIR_Gen_1	281	291	PF02991	0.251
LIG_LIR_Gen_1	376	382	PF02991	0.289
LIG_LIR_Gen_1	396	405	PF02991	0.316
LIG_LIR_Gen_1	472	482	PF02991	0.285
LIG_LIR_Gen_1	687	697	PF02991	0.286
LIG_LIR_Gen_1	784	793	PF02991	0.417
LIG_LIR_Nem_3	151	156	PF02991	0.182
LIG_LIR_Nem_3	169	175	PF02991	0.379
LIG_LIR_Nem_3	281	287	PF02991	0.251
LIG_LIR_Nem_3	297	301	PF02991	0.251
LIG_LIR_Nem_3	363	369	PF02991	0.253
LIG_LIR_Nem_3	376	381	PF02991	0.247
LIG_LIR_Nem_3	437	441	PF02991	0.303
LIG_LIR_Nem_3	636	642	PF02991	0.261
LIG_LIR_Nem_3	687	692	PF02991	0.268
LIG_LIR_Nem_3	701	705	PF02991	0.290
LIG_LIR_Nem_3	735	740	PF02991	0.522
LIG_LIR_Nem_3	784	788	PF02991	0.430
LIG_MLH1_MIPbox_1	378	382	PF16413	0.279
LIG_NRBOX	12	18	PF00104	0.525
LIG_Pex14_1	377	381	PF04695	0.306
LIG_Pex14_1	639	643	PF04695	0.345
LIG_Pex14_1	805	809	PF04695	0.421
LIG_PTB_Apo_2	501	508	PF02174	0.251
LIG_PTB_Apo_2	731	738	PF02174	0.353
LIG_PTB_Phospho_1	731	737	PF10480	0.338
LIG_SH2_CRK	172	176	PF00017	0.251
LIG_SH2_CRK	569	573	PF00017	0.251
LIG_SH2_CRK	759	763	PF00017	0.310
LIG_SH2_GRB2like	260	263	PF00017	0.279
LIG_SH2_GRB2like	727	730	PF00017	0.488
LIG_SH2_NCK_1	747	751	PF00017	0.348
LIG_SH2_STAP1	280	284	PF00017	0.251
LIG_SH2_STAP1	378	382	PF00017	0.251
LIG_SH2_STAP1	439	443	PF00017	0.394
LIG_SH2_STAP1	475	479	PF00017	0.251
LIG_SH2_STAP1	576	580	PF00017	0.277
LIG_SH2_STAP1	727	731	PF00017	0.493
LIG_SH2_STAT3	181	184	PF00017	0.255
LIG_SH2_STAT3	439	442	PF00017	0.377
LIG_SH2_STAT3	727	730	PF00017	0.495
LIG_SH2_STAT5	248	251	PF00017	0.259
LIG_SH2_STAT5	260	263	PF00017	0.259
LIG_SH2_STAT5	295	298	PF00017	0.251
LIG_SH2_STAT5	301	304	PF00017	0.251
LIG_SH2_STAT5	335	338	PF00017	0.259
LIG_SH2_STAT5	346	349	PF00017	0.247
LIG_SH2_STAT5	355	358	PF00017	0.251
LIG_SH2_STAT5	574	577	PF00017	0.282
LIG_SH2_STAT5	610	613	PF00017	0.292
LIG_SH2_STAT5	642	645	PF00017	0.394
LIG_SH2_STAT5	706	709	PF00017	0.379
LIG_SH2_STAT5	715	718	PF00017	0.324
LIG_SH2_STAT5	761	764	PF00017	0.472
LIG_SH3_3	241	247	PF00018	0.394
LIG_SH3_3	320	326	PF00018	0.345
LIG_SH3_3	455	461	PF00018	0.251
LIG_SH3_3	529	535	PF00018	0.300
LIG_SH3_3	618	624	PF00018	0.330
LIG_SH3_3	626	632	PF00018	0.242
LIG_SH3_3	735	741	PF00018	0.522
LIG_SH3_3	776	782	PF00018	0.532
LIG_SH3_3	791	797	PF00018	0.225
LIG_SH3_4	50	57	PF00018	0.468
LIG_SUMO_SIM_anti_2	22	30	PF11976	0.417
LIG_SUMO_SIM_par_1	13	19	PF11976	0.575
LIG_SUMO_SIM_par_1	319	325	PF11976	0.251
LIG_SUMO_SIM_par_1	496	501	PF11976	0.251
LIG_SUMO_SIM_par_1	87	93	PF11976	0.375
LIG_TRAF2_1	519	522	PF00917	0.266
LIG_TRFH_1	569	573	PF08558	0.217
LIG_TYR_ITIM	567	572	PF00017	0.251
LIG_TYR_ITIM	757	762	PF00017	0.357
LIG_WRC_WIRS_1	576	581	PF05994	0.345
LIG_WRC_WIRS_1	806	811	PF05994	0.368
MOD_CDK_SPxK_1	225	231	PF00069	0.323
MOD_CK1_1	164	170	PF00069	0.456
MOD_CK1_1	19	25	PF00069	0.443
MOD_CK1_1	4	10	PF00069	0.671
MOD_CK1_1	437	443	PF00069	0.326
MOD_CK1_1	467	473	PF00069	0.231
MOD_CK2_1	106	112	PF00069	0.453
MOD_CK2_1	148	154	PF00069	0.300
MOD_CK2_1	265	271	PF00069	0.395
MOD_CK2_1	490	496	PF00069	0.266
MOD_CK2_1	778	784	PF00069	0.505
MOD_Cter_Amidation	316	319	PF01082	0.251
MOD_GlcNHglycan	204	207	PF01048	0.478
MOD_GlcNHglycan	349	353	PF01048	0.321
MOD_GlcNHglycan	469	472	PF01048	0.247
MOD_GlcNHglycan	643	646	PF01048	0.309
MOD_GlcNHglycan	734	737	PF01048	0.492
MOD_GSK3_1	157	164	PF00069	0.279
MOD_GSK3_1	16	23	PF00069	0.579
MOD_GSK3_1	202	209	PF00069	0.480
MOD_GSK3_1	496	503	PF00069	0.266
MOD_GSK3_1	552	559	PF00069	0.320
MOD_GSK3_1	581	588	PF00069	0.358
MOD_GSK3_1	709	716	PF00069	0.466
MOD_GSK3_1	774	781	PF00069	0.481
MOD_N-GLC_1	125	130	PF02516	0.383
MOD_N-GLC_1	165	170	PF02516	0.362
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NEK2_1	101	106	PF00069	0.334
MOD_NEK2_1	16	21	PF00069	0.394
MOD_NEK2_1	161	166	PF00069	0.366
MOD_NEK2_1	171	176	PF00069	0.216
MOD_NEK2_1	369	374	PF00069	0.387
MOD_NEK2_1	462	467	PF00069	0.299
MOD_NEK2_1	469	474	PF00069	0.316
MOD_NEK2_1	490	495	PF00069	0.253
MOD_NEK2_1	498	503	PF00069	0.251
MOD_NEK2_1	575	580	PF00069	0.241
MOD_NEK2_1	677	682	PF00069	0.367
MOD_NEK2_1	70	75	PF00069	0.412
MOD_NEK2_1	725	730	PF00069	0.343
MOD_NEK2_1	732	737	PF00069	0.310
MOD_NEK2_1	788	793	PF00069	0.455
MOD_NEK2_1	90	95	PF00069	0.411
MOD_NEK2_2	131	136	PF00069	0.306
MOD_PIKK_1	376	382	PF00454	0.357
MOD_PIKK_1	469	475	PF00454	0.313
MOD_PK_1	148	154	PF00069	0.300
MOD_PK_1	795	801	PF00069	0.315
MOD_PKA_1	678	684	PF00069	0.302
MOD_PKA_1	795	801	PF00069	0.315
MOD_PKA_2	1	7	PF00069	0.502
MOD_PKA_2	409	415	PF00069	0.279
MOD_PKA_2	45	51	PF00069	0.378
MOD_PKA_2	677	683	PF00069	0.310
MOD_PKB_1	676	684	PF00069	0.307
MOD_Plk_1	111	117	PF00069	0.426
MOD_Plk_1	125	131	PF00069	0.275
MOD_Plk_1	490	496	PF00069	0.345
MOD_Plk_1	627	633	PF00069	0.317
MOD_Plk_2-3	265	271	PF00069	0.345
MOD_Plk_2-3	299	305	PF00069	0.308
MOD_Plk_2-3	393	399	PF00069	0.266
MOD_Plk_2-3	709	715	PF00069	0.375
MOD_Plk_4	106	112	PF00069	0.367
MOD_Plk_4	131	137	PF00069	0.427
MOD_Plk_4	148	154	PF00069	0.178
MOD_Plk_4	22	28	PF00069	0.450
MOD_Plk_4	240	246	PF00069	0.278
MOD_Plk_4	393	399	PF00069	0.354
MOD_Plk_4	401	407	PF00069	0.230
MOD_Plk_4	434	440	PF00069	0.275
MOD_Plk_4	556	562	PF00069	0.304
MOD_Plk_4	575	581	PF00069	0.141
MOD_Plk_4	585	591	PF00069	0.345
MOD_Plk_4	606	612	PF00069	0.250
MOD_Plk_4	788	794	PF00069	0.386
MOD_Plk_4	795	801	PF00069	0.360
MOD_ProDKin_1	225	231	PF00069	0.266
MOD_ProDKin_1	4	10	PF00069	0.436
MOD_ProDKin_1	778	784	PF00069	0.432
MOD_SUMO_rev_2	299	309	PF00179	0.249
TRG_DiLeu_BaEn_1	556	561	PF01217	0.394
TRG_DiLeu_BaEn_2	519	525	PF01217	0.394
TRG_ENDOCYTIC_2	172	175	PF00928	0.251
TRG_ENDOCYTIC_2	248	251	PF00928	0.266
TRG_ENDOCYTIC_2	260	263	PF00928	0.266
TRG_ENDOCYTIC_2	280	283	PF00928	0.224
TRG_ENDOCYTIC_2	378	381	PF00928	0.289
TRG_ENDOCYTIC_2	475	478	PF00928	0.251
TRG_ENDOCYTIC_2	569	572	PF00928	0.251
TRG_ENDOCYTIC_2	576	579	PF00928	0.251
TRG_ENDOCYTIC_2	640	643	PF00928	0.345
TRG_ENDOCYTIC_2	702	705	PF00928	0.375
TRG_ENDOCYTIC_2	737	740	PF00928	0.355
TRG_ENDOCYTIC_2	759	762	PF00928	0.302
TRG_ER_diArg_1	1	3	PF00400	0.557
TRG_ER_diArg_1	675	678	PF00400	0.327
TRG_Pf-PMV_PEXEL_1	591	596	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F9	Leptomonas seymouri	69%	99%
A0A0S4ITP0	Bodo saltans	40%	94%
A0A0S4JEB6	Bodo saltans	47%	97%
A0A0S4JFD6	Bodo saltans	29%	85%
A0A0S4JJL0	Bodo saltans	27%	100%
A0A1X0P3Y3	Trypanosomatidae	31%	67%
A0A1X0P7R2	Trypanosomatidae	52%	99%
A0A3R7MQZ9	Trypanosoma rangeli	52%	99%
A0A3S5H722	Leishmania donovani	93%	100%
A0A422NT82	Trypanosoma rangeli	32%	77%
A4H9B4	Leishmania braziliensis	82%	100%
A4HXN5	Leishmania infantum	93%	100%
A7LXT0	Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153)	28%	85%
B3PEE6	Cellvibrio japonicus (strain Ueda107)	26%	100%
B9F676	Oryza sativa subsp. japonica	44%	88%
D0A012	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A8P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	77%
D0KQM8	Saccharolobus solfataricus (strain 98/2)	32%	100%
E9ARE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4J6T7	Arabidopsis thaliana	32%	94%
O00906	Tetrahymena pyriformis	26%	88%
O04893	Spinacia oleracea	32%	90%
O04931	Beta vulgaris	33%	89%
P0CD66	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	32%	100%
P10253	Homo sapiens	32%	85%
P38138	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	85%
P70699	Mus musculus	33%	85%
P79403	Sus scrofa	44%	86%
Q14697	Homo sapiens	45%	86%
Q43763	Hordeum vulgare	33%	93%
Q4R4N7	Macaca fascicularis	45%	86%
Q5AW25	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	100%
Q5R7A9	Pongo abelii	32%	85%
Q653V7	Oryza sativa subsp. japonica	33%	92%
Q6P7A9	Rattus norvegicus	32%	85%
Q8BHN3	Mus musculus	45%	86%
Q8BVW0	Mus musculus	42%	90%
Q8TET4	Homo sapiens	42%	89%
Q92442	Mucor javanicus	27%	94%
Q94502	Dictyostelium discoideum	41%	86%
Q9BE70	Macaca fascicularis	43%	100%
Q9F234	Bacillus thermoamyloliquefaciens	33%	100%
Q9FN05	Arabidopsis thaliana	41%	88%
Q9MYM4	Bos taurus	33%	87%
Q9P999	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	100%
Q9S7Y7	Arabidopsis thaliana	31%	89%
Q9US55	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	88%
V5BS12	Trypanosoma cruzi	32%	77%
V5D5S5	Trypanosoma cruzi	53%	99%