Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE32_LEIMA

TriTrypDb:

LmjF.18.0100 , LMJLV39_180006200 , LMJSD75_180006200

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.659
CLV_MEL_PAP_1	175	181	PF00089	0.419
CLV_NRD_NRD_1	177	179	PF00675	0.602
CLV_NRD_NRD_1	237	239	PF00675	0.433
CLV_NRD_NRD_1	276	278	PF00675	0.456
CLV_NRD_NRD_1	287	289	PF00675	0.647
CLV_NRD_NRD_1	447	449	PF00675	0.616
CLV_PCSK_KEX2_1	138	140	PF00082	0.666
CLV_PCSK_KEX2_1	177	179	PF00082	0.588
CLV_PCSK_KEX2_1	237	239	PF00082	0.442
CLV_PCSK_KEX2_1	276	278	PF00082	0.414
CLV_PCSK_KEX2_1	287	289	PF00082	0.604
CLV_PCSK_KEX2_1	447	449	PF00082	0.640
CLV_PCSK_KEX2_1	66	68	PF00082	0.479
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.693
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.579
CLV_PCSK_SKI1_1	237	241	PF00082	0.483
CLV_PCSK_SKI1_1	245	249	PF00082	0.566
CLV_PCSK_SKI1_1	31	35	PF00082	0.529
CLV_PCSK_SKI1_1	326	330	PF00082	0.353
DEG_APCC_DBOX_1	236	244	PF00400	0.498
DOC_CDC14_PxL_1	330	338	PF14671	0.394
DOC_CKS1_1	48	53	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.466
DOC_MAPK_gen_1	109	118	PF00069	0.439
DOC_MAPK_gen_1	66	73	PF00069	0.531
DOC_MAPK_HePTP_8	63	75	PF00069	0.484
DOC_MAPK_MEF2A_6	208	216	PF00069	0.511
DOC_MAPK_MEF2A_6	356	364	PF00069	0.538
DOC_MAPK_MEF2A_6	379	388	PF00069	0.556
DOC_MAPK_MEF2A_6	66	75	PF00069	0.533
DOC_MAPK_NFAT4_5	379	387	PF00069	0.563
DOC_PP1_RVXF_1	261	268	PF00149	0.508
DOC_PP1_RVXF_1	324	331	PF00149	0.488
DOC_PP2B_LxvP_1	26	29	PF13499	0.480
DOC_PP2B_LxvP_1	386	389	PF13499	0.528
DOC_PP4_FxxP_1	216	219	PF00568	0.579
DOC_USP7_MATH_1	33	37	PF00917	0.547
DOC_WW_Pin1_4	188	193	PF00397	0.630
DOC_WW_Pin1_4	297	302	PF00397	0.734
DOC_WW_Pin1_4	47	52	PF00397	0.481
LIG_14-3-3_CanoR_1	112	117	PF00244	0.564
LIG_14-3-3_CanoR_1	164	168	PF00244	0.606
LIG_14-3-3_CanoR_1	177	186	PF00244	0.564
LIG_14-3-3_CanoR_1	206	212	PF00244	0.607
LIG_14-3-3_CanoR_1	341	345	PF00244	0.516
LIG_APCC_ABBA_1	116	121	PF00400	0.510
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_BRCT_BRCA1_1	240	244	PF00533	0.476
LIG_CSL_BTD_1	26	29	PF09270	0.395
LIG_EVH1_2	212	216	PF00568	0.517
LIG_FHA_1	113	119	PF00498	0.581
LIG_FHA_1	170	176	PF00498	0.598
LIG_FHA_1	193	199	PF00498	0.631
LIG_FHA_1	23	29	PF00498	0.523
LIG_FHA_1	361	367	PF00498	0.400
LIG_FHA_1	389	395	PF00498	0.458
LIG_FHA_1	401	407	PF00498	0.454
LIG_FHA_1	409	415	PF00498	0.437
LIG_FHA_1	57	63	PF00498	0.467
LIG_FHA_1	82	88	PF00498	0.547
LIG_FHA_2	221	227	PF00498	0.581
LIG_FHA_2	246	252	PF00498	0.581
LIG_FHA_2	298	304	PF00498	0.705
LIG_FHA_2	317	323	PF00498	0.228
LIG_FHA_2	437	443	PF00498	0.496
LIG_FHA_2	55	61	PF00498	0.596
LIG_LIR_Nem_3	241	247	PF02991	0.446
LIG_LIR_Nem_3	25	30	PF02991	0.403
LIG_LIR_Nem_3	331	336	PF02991	0.413
LIG_LYPXL_yS_3	333	336	PF13949	0.405
LIG_MAD2	326	334	PF02301	0.375
LIG_PCNA_PIPBox_1	390	399	PF02747	0.505
LIG_Rb_LxCxE_1	1	16	PF01857	0.561
LIG_SH2_STAT5	268	271	PF00017	0.436
LIG_SH2_STAT5	342	345	PF00017	0.581
LIG_SH2_STAT5	440	443	PF00017	0.447
LIG_SH3_3	45	51	PF00018	0.531
LIG_SH3_3	84	90	PF00018	0.597
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.702
LIG_SUMO_SIM_anti_2	303	309	PF11976	0.416
LIG_SUMO_SIM_anti_2	363	369	PF11976	0.367
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.229
LIG_SUMO_SIM_anti_2	50	57	PF11976	0.438
LIG_SUMO_SIM_par_1	363	369	PF11976	0.367
LIG_SUMO_SIM_par_1	50	57	PF11976	0.435
LIG_SUMO_SIM_par_1	59	65	PF11976	0.504
LIG_SUMO_SIM_par_1	82	89	PF11976	0.526
LIG_TRAF2_1	301	304	PF00917	0.612
LIG_WRC_WIRS_1	317	322	PF05994	0.473
LIG_WRC_WIRS_1	393	398	PF05994	0.449
MOD_CDK_SPK_2	188	193	PF00069	0.630
MOD_CK1_1	129	135	PF00069	0.612
MOD_CK1_1	163	169	PF00069	0.702
MOD_CK1_1	191	197	PF00069	0.603
MOD_CK1_1	220	226	PF00069	0.518
MOD_CK1_1	246	252	PF00069	0.556
MOD_CK1_1	253	259	PF00069	0.535
MOD_CK1_1	340	346	PF00069	0.555
MOD_CK1_1	369	375	PF00069	0.406
MOD_CK2_1	220	226	PF00069	0.518
MOD_CK2_1	245	251	PF00069	0.533
MOD_CK2_1	297	303	PF00069	0.750
MOD_CK2_1	316	322	PF00069	0.219
MOD_CK2_1	8	14	PF00069	0.487
MOD_Cter_Amidation	107	110	PF01082	0.626
MOD_GlcNHglycan	128	131	PF01048	0.657
MOD_GlcNHglycan	134	137	PF01048	0.629
MOD_GlcNHglycan	179	182	PF01048	0.571
MOD_GlcNHglycan	248	251	PF01048	0.612
MOD_GlcNHglycan	368	371	PF01048	0.375
MOD_GSK3_1	145	152	PF00069	0.663
MOD_GSK3_1	188	195	PF00069	0.594
MOD_GSK3_1	197	204	PF00069	0.552
MOD_GSK3_1	246	253	PF00069	0.454
MOD_GSK3_1	293	300	PF00069	0.733
MOD_GSK3_1	340	347	PF00069	0.505
MOD_GSK3_1	362	369	PF00069	0.387
MOD_GSK3_1	388	395	PF00069	0.475
MOD_GSK3_1	396	403	PF00069	0.432
MOD_GSK3_1	4	11	PF00069	0.525
MOD_GSK3_1	415	422	PF00069	0.589
MOD_GSK3_1	54	61	PF00069	0.565
MOD_N-GLC_1	123	128	PF02516	0.750
MOD_N-GLC_1	144	149	PF02516	0.760
MOD_N-GLC_1	401	406	PF02516	0.538
MOD_N-GLC_1	434	439	PF02516	0.538
MOD_NEK2_1	137	142	PF00069	0.718
MOD_NEK2_1	154	159	PF00069	0.634
MOD_NEK2_1	198	203	PF00069	0.553
MOD_NEK2_1	354	359	PF00069	0.500
MOD_NEK2_1	362	367	PF00069	0.442
MOD_NEK2_1	382	387	PF00069	0.247
MOD_NEK2_1	401	406	PF00069	0.278
MOD_NEK2_1	54	59	PF00069	0.503
MOD_NEK2_2	392	397	PF00069	0.448
MOD_PIKK_1	13	19	PF00454	0.503
MOD_PIKK_1	192	198	PF00454	0.641
MOD_PIKK_1	207	213	PF00454	0.555
MOD_PKA_1	177	183	PF00069	0.585
MOD_PKA_2	101	107	PF00069	0.544
MOD_PKA_2	163	169	PF00069	0.667
MOD_PKA_2	177	183	PF00069	0.612
MOD_PKA_2	192	198	PF00069	0.586
MOD_PKA_2	207	213	PF00069	0.549
MOD_PKA_2	275	281	PF00069	0.563
MOD_PKA_2	340	346	PF00069	0.555
MOD_PKA_2	419	425	PF00069	0.596
MOD_Plk_1	144	150	PF00069	0.699
MOD_Plk_1	220	226	PF00069	0.572
MOD_Plk_1	344	350	PF00069	0.501
MOD_Plk_1	382	388	PF00069	0.539
MOD_Plk_1	401	407	PF00069	0.533
MOD_Plk_1	434	440	PF00069	0.509
MOD_Plk_1	8	14	PF00069	0.498
MOD_Plk_1	81	87	PF00069	0.538
MOD_Plk_2-3	316	322	PF00069	0.539
MOD_Plk_2-3	8	14	PF00069	0.492
MOD_Plk_4	112	118	PF00069	0.528
MOD_Plk_4	163	169	PF00069	0.624
MOD_Plk_4	22	28	PF00069	0.568
MOD_Plk_4	220	226	PF00069	0.557
MOD_Plk_4	362	368	PF00069	0.368
MOD_Plk_4	382	388	PF00069	0.242
MOD_Plk_4	392	398	PF00069	0.436
MOD_Plk_4	401	407	PF00069	0.269
MOD_Plk_4	436	442	PF00069	0.480
MOD_Plk_4	58	64	PF00069	0.570
MOD_Plk_4	82	88	PF00069	0.555
MOD_ProDKin_1	188	194	PF00069	0.627
MOD_ProDKin_1	297	303	PF00069	0.726
MOD_ProDKin_1	47	53	PF00069	0.473
MOD_SUMO_for_1	309	312	PF00179	0.606
MOD_SUMO_rev_2	291	296	PF00179	0.783
MOD_SUMO_rev_2	404	412	PF00179	0.540
MOD_SUMO_rev_2	437	446	PF00179	0.543
TRG_DiLeu_BaEn_1	303	308	PF01217	0.532
TRG_ENDOCYTIC_2	333	336	PF00928	0.447
TRG_ER_diArg_1	139	142	PF00400	0.744
TRG_ER_diArg_1	177	179	PF00400	0.617
TRG_ER_diArg_1	237	239	PF00400	0.427
TRG_ER_diArg_1	275	277	PF00400	0.430
TRG_ER_diArg_1	446	448	PF00400	0.609
TRG_NLS_MonoExtC_3	137	143	PF00514	0.699
TRG_NLS_MonoExtN_4	106	113	PF00514	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P518	Leptomonas seymouri	59%	99%
A0A1X0P854	Trypanosomatidae	28%	100%
A0A3Q8IJL1	Leishmania donovani	91%	99%
A0A3R7KLI0	Trypanosoma rangeli	29%	100%
A4H9B5	Leishmania braziliensis	78%	100%
A4HXN6	Leishmania infantum	92%	100%
D0A013	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	99%
E9ARE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5APZ6	Trypanosoma cruzi	28%	100%