ARF-like 2-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor-like protein 2-binding protein, putative

Species:

Leishmania major

UniProt:

Q4QE30_LEIMA

TriTrypDb:

LmjF.18.0120 , LMJLV39_180006400 , LMJSD75_180006400

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	125	127	PF00082	0.542
CLV_PCSK_KEX2_1	95	97	PF00082	0.479
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.542
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.508
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DOC_WW_Pin1_4	13	18	PF00397	0.527
LIG_deltaCOP1_diTrp_1	102	107	PF00928	0.398
LIG_FHA_1	60	66	PF00498	0.392
LIG_FHA_1	99	105	PF00498	0.551
LIG_GBD_Chelix_1	25	33	PF00786	0.394
LIG_LIR_Gen_1	102	113	PF02991	0.386
LIG_LIR_Gen_1	114	119	PF02991	0.372
LIG_LIR_Gen_1	19	29	PF02991	0.377
LIG_LIR_Gen_1	39	48	PF02991	0.259
LIG_LIR_Gen_1	59	68	PF02991	0.392
LIG_LIR_Nem_3	102	108	PF02991	0.377
LIG_LIR_Nem_3	114	118	PF02991	0.359
LIG_LIR_Nem_3	19	25	PF02991	0.396
LIG_LIR_Nem_3	39	45	PF02991	0.465
LIG_LIR_Nem_3	59	64	PF02991	0.443
LIG_LIR_Nem_3	82	86	PF02991	0.405
LIG_Pex14_2	118	122	PF04695	0.337
LIG_Pex14_2	32	36	PF04695	0.353
LIG_SH2_STAP1	115	119	PF00017	0.402
LIG_SH2_STAP1	61	65	PF00017	0.389
LIG_SH2_STAT5	61	64	PF00017	0.477
LIG_WRC_WIRS_1	104	109	PF05994	0.346
LIG_WRC_WIRS_1	33	38	PF05994	0.449
LIG_WRC_WIRS_1	61	66	PF05994	0.442
MOD_CK1_1	106	112	PF00069	0.297
MOD_CK2_1	60	66	PF00069	0.512
MOD_CK2_1	76	82	PF00069	0.421
MOD_GlcNHglycan	51	54	PF01048	0.522
MOD_GSK3_1	56	63	PF00069	0.542
MOD_Plk_2-3	82	88	PF00069	0.381
MOD_Plk_2-3	98	104	PF00069	0.464
MOD_Plk_4	56	62	PF00069	0.451
MOD_Plk_4	88	94	PF00069	0.493
MOD_ProDKin_1	13	19	PF00069	0.515
MOD_SUMO_rev_2	79	86	PF00179	0.299
TRG_DiLeu_BaEn_2	3	9	PF01217	0.559
TRG_DiLeu_BaEn_3	102	108	PF01217	0.421
TRG_DiLeu_BaEn_3	4	10	PF01217	0.653
TRG_ENDOCYTIC_2	115	118	PF00928	0.348
TRG_ENDOCYTIC_2	61	64	PF00928	0.440
TRG_ENDOCYTIC_2	83	86	PF00928	0.494
TRG_ER_diLys_1	123	127	PF00400	0.488
TRG_NLS_MonoCore_2	122	127	PF00514	0.312
TRG_NLS_MonoExtC_3	122	127	PF00514	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I435	Leptomonas seymouri	68%	100%
A0A0S4JEB2	Bodo saltans	41%	74%
A0A1X0P6P8	Trypanosomatidae	47%	88%
A0A3Q8IB11	Leishmania donovani	94%	100%
A0A422NWK1	Trypanosoma rangeli	48%	100%
A4H9B7	Leishmania braziliensis	82%	100%
A4HXN8	Leishmania infantum	95%	100%
D0A014	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ARE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D5T3	Trypanosoma cruzi	47%	100%