CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania major

UniProt:

Q4QE29_LEIMA

TriTrypDb:

LmjF.18.0130 , LMJLV39_180006500 , LMJSD75_180006500

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 17, no: 15
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	14
GO:0016020	membrane	2	33
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	33

Expansion

Sequence features

Q4QE29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE29

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	33
GO:0042592	homeostatic process	3	33
GO:0048878	chemical homeostasis	4	33
GO:0050801	monoatomic ion homeostasis	5	33
GO:0055065	obsolete metal ion homeostasis	7	33
GO:0055080	monoatomic cation homeostasis	6	33
GO:0065007	biological regulation	1	33
GO:0065008	regulation of biological quality	2	33
GO:0072507	obsolete divalent inorganic cation homeostasis	7	33
GO:0098771	inorganic ion homeostasis	6	33

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.298
CLV_NRD_NRD_1	271	273	PF00675	0.474
CLV_NRD_NRD_1	362	364	PF00675	0.567
CLV_NRD_NRD_1	671	673	PF00675	0.759
CLV_NRD_NRD_1	95	97	PF00675	0.244
CLV_PCSK_KEX2_1	271	273	PF00082	0.503
CLV_PCSK_KEX2_1	361	363	PF00082	0.570
CLV_PCSK_KEX2_1	389	391	PF00082	0.737
CLV_PCSK_KEX2_1	683	685	PF00082	0.681
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.570
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.724
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.700
CLV_PCSK_PC7_1	679	685	PF00082	0.724
CLV_PCSK_SKI1_1	233	237	PF00082	0.598
CLV_PCSK_SKI1_1	323	327	PF00082	0.561
CLV_PCSK_SKI1_1	444	448	PF00082	0.734
CLV_PCSK_SKI1_1	48	52	PF00082	0.435
CLV_PCSK_SKI1_1	512	516	PF00082	0.498
CLV_PCSK_SKI1_1	646	650	PF00082	0.646
CLV_PCSK_SKI1_1	672	676	PF00082	0.768
CLV_PCSK_SKI1_1	96	100	PF00082	0.286
DEG_APCC_DBOX_1	206	214	PF00400	0.230
DEG_APCC_DBOX_1	232	240	PF00400	0.405
DEG_SPOP_SBC_1	11	15	PF00917	0.666
DOC_ANK_TNKS_1	287	294	PF00023	0.173
DOC_CDC14_PxL_1	602	610	PF14671	0.268
DOC_CKS1_1	395	400	PF01111	0.419
DOC_CKS1_1	649	654	PF01111	0.341
DOC_CYCLIN_RxL_1	640	654	PF00134	0.520
DOC_MAPK_gen_1	286	294	PF00069	0.298
DOC_MAPK_gen_1	396	406	PF00069	0.444
DOC_MAPK_MEF2A_6	170	179	PF00069	0.328
DOC_MAPK_MEF2A_6	96	103	PF00069	0.537
DOC_PP1_RVXF_1	465	471	PF00149	0.425
DOC_PP4_FxxP_1	350	353	PF00568	0.228
DOC_PP4_FxxP_1	649	652	PF00568	0.462
DOC_PP4_MxPP_1	3	6	PF00568	0.547
DOC_USP7_MATH_1	10	14	PF00917	0.690
DOC_USP7_MATH_1	33	37	PF00917	0.398
DOC_USP7_MATH_1	370	374	PF00917	0.527
DOC_USP7_MATH_1	613	617	PF00917	0.338
DOC_USP7_UBL2_3	220	224	PF12436	0.413
DOC_WW_Pin1_4	12	17	PF00397	0.632
DOC_WW_Pin1_4	248	253	PF00397	0.262
DOC_WW_Pin1_4	260	265	PF00397	0.333
DOC_WW_Pin1_4	374	379	PF00397	0.486
DOC_WW_Pin1_4	394	399	PF00397	0.412
DOC_WW_Pin1_4	535	540	PF00397	0.514
DOC_WW_Pin1_4	648	653	PF00397	0.545
LIG_14-3-3_CanoR_1	233	239	PF00244	0.420
LIG_14-3-3_CanoR_1	591	600	PF00244	0.282
LIG_14-3-3_CanoR_1	623	631	PF00244	0.341
LIG_APCC_ABBA_1	146	151	PF00400	0.309
LIG_APCC_ABBA_1	214	219	PF00400	0.249
LIG_BIR_III_2	375	379	PF00653	0.347
LIG_BRCT_BRCA1_1	565	569	PF00533	0.294
LIG_Clathr_ClatBox_1	348	352	PF01394	0.290
LIG_Clathr_ClatBox_1	419	423	PF01394	0.327
LIG_Clathr_ClatBox_1	72	76	PF01394	0.520
LIG_eIF4E_1	344	350	PF01652	0.365
LIG_FHA_1	109	115	PF00498	0.298
LIG_FHA_1	117	123	PF00498	0.296
LIG_FHA_1	141	147	PF00498	0.257
LIG_FHA_1	227	233	PF00498	0.280
LIG_FHA_1	239	245	PF00498	0.332
LIG_FHA_1	344	350	PF00498	0.315
LIG_FHA_1	503	509	PF00498	0.302
LIG_FHA_1	55	61	PF00498	0.322
LIG_FHA_1	566	572	PF00498	0.265
LIG_FHA_1	610	616	PF00498	0.300
LIG_FHA_1	67	73	PF00498	0.290
LIG_FHA_1	75	81	PF00498	0.429
LIG_FHA_2	261	267	PF00498	0.342
LIG_FHA_2	311	317	PF00498	0.311
LIG_FHA_2	419	425	PF00498	0.285
LIG_FHA_2	623	629	PF00498	0.350
LIG_GBD_Chelix_1	109	117	PF00786	0.313
LIG_GBD_Chelix_1	136	144	PF00786	0.437
LIG_KLC1_Yacidic_2	76	81	PF13176	0.535
LIG_LIR_Gen_1	497	508	PF02991	0.346
LIG_LIR_Gen_1	566	577	PF02991	0.268
LIG_LIR_Gen_1	592	601	PF02991	0.302
LIG_LIR_Gen_1	610	615	PF02991	0.273
LIG_LIR_Gen_1	76	86	PF02991	0.503
LIG_LIR_LC3C_4	143	146	PF02991	0.407
LIG_LIR_LC3C_4	324	328	PF02991	0.385
LIG_LIR_LC3C_4	520	523	PF02991	0.224
LIG_LIR_Nem_3	377	382	PF02991	0.538
LIG_LIR_Nem_3	414	419	PF02991	0.337
LIG_LIR_Nem_3	497	503	PF02991	0.324
LIG_LIR_Nem_3	566	572	PF02991	0.272
LIG_LIR_Nem_3	592	596	PF02991	0.305
LIG_LIR_Nem_3	610	614	PF02991	0.266
LIG_LIR_Nem_3	62	68	PF02991	0.338
LIG_LIR_Nem_3	76	82	PF02991	0.473
LIG_MAD2	557	565	PF02301	0.411
LIG_NRBOX	108	114	PF00104	0.309
LIG_Pex14_1	490	494	PF04695	0.318
LIG_SH2_CRK	611	615	PF00017	0.321
LIG_SH2_CRK	65	69	PF00017	0.439
LIG_SH2_SRC	79	82	PF00017	0.535
LIG_SH2_STAP1	611	615	PF00017	0.330
LIG_SH2_STAP1	94	98	PF00017	0.469
LIG_SH2_STAT3	205	208	PF00017	0.183
LIG_SH2_STAT3	344	347	PF00017	0.210
LIG_SH2_STAT5	296	299	PF00017	0.244
LIG_SH2_STAT5	305	308	PF00017	0.403
LIG_SH2_STAT5	339	342	PF00017	0.332
LIG_SH2_STAT5	440	443	PF00017	0.495
LIG_SH2_STAT5	495	498	PF00017	0.309
LIG_SH2_STAT5	500	503	PF00017	0.305
LIG_SH2_STAT5	611	614	PF00017	0.266
LIG_SH2_STAT5	65	68	PF00017	0.354
LIG_SH2_STAT5	79	82	PF00017	0.535
LIG_SH3_3	178	184	PF00018	0.320
LIG_SH3_3	603	609	PF00018	0.397
LIG_SH3_3	641	647	PF00018	0.356
LIG_SH3_3	659	665	PF00018	0.541
LIG_Sin3_3	110	117	PF02671	0.305
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.340
LIG_SUMO_SIM_par_1	118	124	PF11976	0.326
LIG_SUMO_SIM_par_1	234	241	PF11976	0.269
LIG_SUMO_SIM_par_1	418	424	PF11976	0.245
LIG_SUMO_SIM_par_1	520	527	PF11976	0.264
LIG_SUMO_SIM_par_1	566	574	PF11976	0.290
LIG_SUMO_SIM_par_1	57	62	PF11976	0.376
LIG_SUMO_SIM_par_1	628	633	PF11976	0.426
LIG_TRAF2_1	86	89	PF00917	0.507
LIG_TRFH_1	180	184	PF08558	0.328
LIG_TYR_ITSM	75	82	PF00017	0.535
LIG_UBA3_1	152	160	PF00899	0.305
LIG_UBA3_1	179	187	PF00899	0.272
LIG_UBA3_1	213	220	PF00899	0.335
LIG_WRC_WIRS_1	590	595	PF05994	0.377
LIG_WW_3	464	468	PF00397	0.446
MOD_CDK_SPK_2	394	399	PF00069	0.327
MOD_CDK_SPxxK_3	248	255	PF00069	0.312
MOD_CK1_1	222	228	PF00069	0.417
MOD_CK1_1	310	316	PF00069	0.418
MOD_CK1_1	377	383	PF00069	0.456
MOD_CK1_1	535	541	PF00069	0.531
MOD_CK1_1	567	573	PF00069	0.381
MOD_CK1_1	616	622	PF00069	0.296
MOD_CK2_1	264	270	PF00069	0.335
MOD_CK2_1	33	39	PF00069	0.437
MOD_CK2_1	453	459	PF00069	0.370
MOD_CK2_1	474	480	PF00069	0.435
MOD_CK2_1	527	533	PF00069	0.521
MOD_CMANNOS	46	49	PF00535	0.598
MOD_GlcNHglycan	223	227	PF01048	0.531
MOD_GlcNHglycan	379	382	PF01048	0.744
MOD_GlcNHglycan	39	43	PF01048	0.638
MOD_GlcNHglycan	573	576	PF01048	0.509
MOD_GlcNHglycan	602	605	PF01048	0.562
MOD_GlcNHglycan	61	64	PF01048	0.311
MOD_GlcNHglycan	653	656	PF01048	0.692
MOD_GSK3_1	116	123	PF00069	0.339
MOD_GSK3_1	222	229	PF00069	0.302
MOD_GSK3_1	234	241	PF00069	0.251
MOD_GSK3_1	260	267	PF00069	0.311
MOD_GSK3_1	351	358	PF00069	0.370
MOD_GSK3_1	366	373	PF00069	0.501
MOD_GSK3_1	425	432	PF00069	0.407
MOD_GSK3_1	55	62	PF00069	0.397
MOD_GSK3_1	563	570	PF00069	0.279
MOD_GSK3_1	585	592	PF00069	0.373
MOD_GSK3_1	6	13	PF00069	0.707
MOD_GSK3_1	609	616	PF00069	0.309
MOD_NEK2_1	108	113	PF00069	0.298
MOD_NEK2_1	120	125	PF00069	0.285
MOD_NEK2_1	175	180	PF00069	0.429
MOD_NEK2_1	234	239	PF00069	0.271
MOD_NEK2_1	259	264	PF00069	0.269
MOD_NEK2_1	453	458	PF00069	0.503
MOD_NEK2_1	496	501	PF00069	0.308
MOD_NEK2_1	54	59	PF00069	0.319
MOD_NEK2_1	571	576	PF00069	0.292
MOD_NEK2_2	74	79	PF00069	0.535
MOD_PIKK_1	121	127	PF00454	0.296
MOD_PIKK_1	343	349	PF00454	0.303
MOD_PKA_2	616	622	PF00069	0.292
MOD_Plk_1	301	307	PF00069	0.456
MOD_Plk_1	310	316	PF00069	0.393
MOD_Plk_1	453	459	PF00069	0.499
MOD_Plk_1	577	583	PF00069	0.363
MOD_Plk_1	609	615	PF00069	0.299
MOD_Plk_1	90	96	PF00069	0.439
MOD_Plk_2-3	454	460	PF00069	0.319
MOD_Plk_2-3	527	533	PF00069	0.499
MOD_Plk_2-3	589	595	PF00069	0.363
MOD_Plk_4	108	114	PF00069	0.295
MOD_Plk_4	116	122	PF00069	0.291
MOD_Plk_4	140	146	PF00069	0.316
MOD_Plk_4	175	181	PF00069	0.318
MOD_Plk_4	234	240	PF00069	0.418
MOD_Plk_4	301	307	PF00069	0.437
MOD_Plk_4	329	335	PF00069	0.320
MOD_Plk_4	412	418	PF00069	0.367
MOD_Plk_4	425	431	PF00069	0.293
MOD_Plk_4	55	61	PF00069	0.329
MOD_Plk_4	74	80	PF00069	0.409
MOD_ProDKin_1	12	18	PF00069	0.501
MOD_ProDKin_1	248	254	PF00069	0.262
MOD_ProDKin_1	260	266	PF00069	0.333
MOD_ProDKin_1	374	380	PF00069	0.487
MOD_ProDKin_1	394	400	PF00069	0.408
MOD_ProDKin_1	535	541	PF00069	0.514
MOD_ProDKin_1	648	654	PF00069	0.544
MOD_SUMO_rev_2	206	213	PF00179	0.263
MOD_SUMO_rev_2	437	447	PF00179	0.537
MOD_SUMO_rev_2	628	636	PF00179	0.420
MOD_SUMO_rev_2	676	685	PF00179	0.536
TRG_DiLeu_BaEn_1	209	214	PF01217	0.251
TRG_DiLeu_BaEn_2	134	140	PF01217	0.269
TRG_DiLeu_BaEn_2	411	417	PF01217	0.293
TRG_DiLeu_BaLyEn_6	617	622	PF01217	0.341
TRG_ENDOCYTIC_2	500	503	PF00928	0.302
TRG_ENDOCYTIC_2	611	614	PF00928	0.292
TRG_ENDOCYTIC_2	65	68	PF00928	0.372
TRG_ENDOCYTIC_2	79	82	PF00928	0.535
TRG_ER_diArg_1	271	273	PF00400	0.278
TRG_ER_diArg_1	362	365	PF00400	0.373
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.269
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B7P9G0	Drosophila melanogaster	26%	82%
A0A0N1I5K6	Leptomonas seymouri	61%	93%
A0A0N1IK76	Leptomonas seymouri	32%	91%
A0A0N1PDI6	Leptomonas seymouri	32%	100%
A0A0S4JDJ1	Bodo saltans	32%	73%
A0A0S4JGZ5	Bodo saltans	33%	83%
A0A0S4JSF9	Bodo saltans	31%	100%
A0A1X0P6Q5	Trypanosomatidae	34%	92%
A0A1X0P7K4	Trypanosomatidae	38%	99%
A0A1X0PAL3	Trypanosomatidae	31%	100%
A0A3Q8IL77	Leishmania donovani	31%	100%
A0A3R7M693	Trypanosoma rangeli	38%	100%
A0A3S7WUR9	Leishmania donovani	32%	92%
A0A3S7WUS2	Leishmania donovani	91%	98%
A0A422NS01	Trypanosoma rangeli	32%	100%
A0A422NWG4	Trypanosoma rangeli	33%	94%
A0JPA0	Xenopus tropicalis	26%	89%
A3QM97	Caenorhabditis elegans	25%	85%
A4H9B8	Leishmania braziliensis	75%	100%
A4H9B9	Leishmania braziliensis	32%	92%
A4HAY2	Leishmania braziliensis	32%	100%
A4HXN9	Leishmania infantum	91%	98%
A4HXP0	Leishmania infantum	32%	92%
A4IA41	Leishmania infantum	31%	100%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9ARF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	97%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	92%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
P0C588	Rattus norvegicus	26%	89%
Q32NY4	Mus musculus	26%	96%
Q3TWN3	Mus musculus	26%	79%
Q4Q2T0	Leishmania major	32%	100%
Q4QE28	Leishmania major	32%	100%
Q5U2P1	Rattus norvegicus	26%	79%
Q6P4Q7	Homo sapiens	25%	89%
Q8NE01	Homo sapiens	24%	97%
Q9GYL2	Caenorhabditis elegans	24%	90%
Q9H8M5	Homo sapiens	26%	79%
V5B9W6	Trypanosoma cruzi	32%	94%
V5BEH2	Trypanosoma cruzi	37%	100%
V5BKR5	Trypanosoma cruzi	33%	100%