CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania major

UniProt:

Q4QE28_LEIMA

TriTrypDb:

LmjF.18.0140 , LMJLV39_180006600 , LMJSD75_180006600

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 13, no: 11
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	25
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	25
GO:0005886	plasma membrane	3	8

Expansion

Sequence features

Q4QE28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE28

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	25
GO:0042592	homeostatic process	3	25
GO:0048878	chemical homeostasis	4	25
GO:0050801	monoatomic ion homeostasis	5	25
GO:0055065	obsolete metal ion homeostasis	7	25
GO:0055080	monoatomic cation homeostasis	6	25
GO:0065007	biological regulation	1	25
GO:0065008	regulation of biological quality	2	25
GO:0072507	obsolete divalent inorganic cation homeostasis	7	25
GO:0098771	inorganic ion homeostasis	6	25

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	717	721	PF00656	0.557
CLV_NRD_NRD_1	117	119	PF00675	0.251
CLV_NRD_NRD_1	244	246	PF00675	0.453
CLV_NRD_NRD_1	278	280	PF00675	0.531
CLV_NRD_NRD_1	54	56	PF00675	0.608
CLV_NRD_NRD_1	735	737	PF00675	0.693
CLV_PCSK_KEX2_1	59	61	PF00082	0.613
CLV_PCSK_KEX2_1	735	737	PF00082	0.775
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.636
CLV_PCSK_PC7_1	55	61	PF00082	0.524
CLV_PCSK_SKI1_1	172	176	PF00082	0.187
CLV_PCSK_SKI1_1	268	272	PF00082	0.614
CLV_PCSK_SKI1_1	373	377	PF00082	0.556
CLV_PCSK_SKI1_1	528	532	PF00082	0.509
CLV_PCSK_SKI1_1	614	618	PF00082	0.525
CLV_PCSK_SKI1_1	671	675	PF00082	0.598
DEG_COP1_1	648	656	PF00400	0.406
DOC_CKS1_1	284	289	PF01111	0.331
DOC_CKS1_1	299	304	PF01111	0.380
DOC_CKS1_1	479	484	PF01111	0.356
DOC_CKS1_1	647	652	PF01111	0.298
DOC_CYCLIN_RxL_1	525	533	PF00134	0.279
DOC_CYCLIN_RxL_1	665	675	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.307
DOC_CYCLIN_yCln2_LP_2	647	653	PF00134	0.417
DOC_MAPK_DCC_7	665	674	PF00069	0.234
DOC_MAPK_gen_1	12	20	PF00069	0.532
DOC_MAPK_gen_1	193	200	PF00069	0.432
DOC_MAPK_gen_1	241	249	PF00069	0.351
DOC_MAPK_gen_1	310	318	PF00069	0.369
DOC_MAPK_gen_1	454	463	PF00069	0.478
DOC_MAPK_gen_1	608	618	PF00069	0.367
DOC_MAPK_gen_1	685	693	PF00069	0.487
DOC_MAPK_MEF2A_6	12	20	PF00069	0.530
DOC_MAPK_MEF2A_6	264	271	PF00069	0.391
DOC_MAPK_MEF2A_6	611	619	PF00069	0.391
DOC_MAPK_MEF2A_6	665	674	PF00069	0.377
DOC_MAPK_NFAT4_5	264	272	PF00069	0.302
DOC_PP1_RVXF_1	482	488	PF00149	0.441
DOC_PP1_RVXF_1	669	675	PF00149	0.327
DOC_PP2B_LxvP_1	473	476	PF13499	0.419
DOC_PP4_FxxP_1	491	494	PF00568	0.496
DOC_PP4_FxxP_1	651	654	PF00568	0.397
DOC_USP7_MATH_1	10	14	PF00917	0.712
DOC_USP7_MATH_1	202	206	PF00917	0.335
DOC_USP7_MATH_1	317	321	PF00917	0.404
DOC_USP7_MATH_1	364	368	PF00917	0.325
DOC_USP7_MATH_1	494	498	PF00917	0.386
DOC_USP7_MATH_1	631	635	PF00917	0.448
DOC_USP7_UBL2_3	119	123	PF12436	0.534
DOC_USP7_UBL2_3	242	246	PF12436	0.348
DOC_USP7_UBL2_3	264	268	PF12436	0.408
DOC_WW_Pin1_4	102	107	PF00397	0.416
DOC_WW_Pin1_4	283	288	PF00397	0.350
DOC_WW_Pin1_4	298	303	PF00397	0.394
DOC_WW_Pin1_4	341	346	PF00397	0.423
DOC_WW_Pin1_4	478	483	PF00397	0.492
DOC_WW_Pin1_4	547	552	PF00397	0.525
DOC_WW_Pin1_4	555	560	PF00397	0.533
DOC_WW_Pin1_4	578	583	PF00397	0.438
DOC_WW_Pin1_4	646	651	PF00397	0.423
DOC_WW_Pin1_4	692	697	PF00397	0.532
LIG_14-3-3_CanoR_1	156	163	PF00244	0.187
LIG_14-3-3_CanoR_1	193	199	PF00244	0.541
LIG_14-3-3_CanoR_1	60	65	PF00244	0.365
LIG_14-3-3_CanoR_1	608	618	PF00244	0.344
LIG_14-3-3_CanoR_1	685	694	PF00244	0.476
LIG_14-3-3_CanoR_1	7	14	PF00244	0.684
LIG_14-3-3_CanoR_1	703	707	PF00244	0.544
LIG_Actin_WH2_2	184	201	PF00022	0.307
LIG_AP2alpha_1	143	147	PF02296	0.347
LIG_APCC_ABBA_1	180	185	PF00400	0.309
LIG_APCC_ABBA_1	248	253	PF00400	0.270
LIG_BRCT_BRCA1_1	339	343	PF00533	0.441
LIG_BRCT_BRCA1_1	582	586	PF00533	0.529
LIG_BRCT_BRCA1_1	628	632	PF00533	0.383
LIG_BRCT_BRCA1_1	77	81	PF00533	0.279
LIG_BRCT_BRCA1_2	582	588	PF00533	0.388
LIG_FHA_1	125	131	PF00498	0.331
LIG_FHA_1	158	164	PF00498	0.314
LIG_FHA_1	175	181	PF00498	0.266
LIG_FHA_1	213	219	PF00498	0.435
LIG_FHA_1	233	239	PF00498	0.353
LIG_FHA_1	295	301	PF00498	0.321
LIG_FHA_1	363	369	PF00498	0.319
LIG_FHA_1	470	476	PF00498	0.474
LIG_FHA_1	493	499	PF00498	0.437
LIG_FHA_1	56	62	PF00498	0.474
LIG_FHA_1	571	577	PF00498	0.564
LIG_FHA_1	83	89	PF00498	0.321
LIG_FHA_1	91	97	PF00498	0.460
LIG_FHA_2	284	290	PF00498	0.377
LIG_FHA_2	337	343	PF00498	0.428
LIG_FHA_2	400	406	PF00498	0.435
LIG_FHA_2	427	433	PF00498	0.312
LIG_FHA_2	44	50	PF00498	0.491
LIG_FHA_2	555	561	PF00498	0.560
LIG_FHA_2	713	719	PF00498	0.452
LIG_LIR_Apic_2	489	494	PF02991	0.456
LIG_LIR_Apic_2	521	525	PF02991	0.343
LIG_LIR_Apic_2	648	654	PF02991	0.370
LIG_LIR_Gen_1	142	150	PF02991	0.331
LIG_LIR_Gen_1	205	214	PF02991	0.432
LIG_LIR_Gen_1	301	308	PF02991	0.298
LIG_LIR_Gen_1	356	366	PF02991	0.300
LIG_LIR_Gen_1	455	464	PF02991	0.467
LIG_LIR_Gen_1	638	647	PF02991	0.327
LIG_LIR_LC3C_4	326	331	PF02991	0.399
LIG_LIR_Nem_3	142	146	PF02991	0.319
LIG_LIR_Nem_3	168	174	PF02991	0.307
LIG_LIR_Nem_3	205	210	PF02991	0.407
LIG_LIR_Nem_3	340	346	PF02991	0.423
LIG_LIR_Nem_3	356	362	PF02991	0.286
LIG_LIR_Nem_3	440	446	PF02991	0.372
LIG_LIR_Nem_3	447	452	PF02991	0.415
LIG_LIR_Nem_3	455	461	PF02991	0.397
LIG_LIR_Nem_3	638	642	PF02991	0.333
LIG_LIR_Nem_3	675	680	PF02991	0.365
LIG_LIR_Nem_3	78	84	PF02991	0.346
LIG_MLH1_MIPbox_1	582	586	PF16413	0.394
LIG_NRBOX	266	272	PF00104	0.376
LIG_Pex14_1	506	510	PF04695	0.324
LIG_Pex14_1	522	526	PF04695	0.329
LIG_Pex14_2	143	147	PF04695	0.353
LIG_Pex14_2	487	491	PF04695	0.340
LIG_REV1ctd_RIR_1	583	592	PF16727	0.356
LIG_RPA_C_Fungi	721	733	PF08784	0.541
LIG_SH2_CRK	667	671	PF00017	0.371
LIG_SH2_CRK	74	78	PF00017	0.342
LIG_SH2_GRB2like	511	514	PF00017	0.323
LIG_SH2_NCK_1	449	453	PF00017	0.631
LIG_SH2_NCK_1	458	462	PF00017	0.579
LIG_SH2_PTP2	526	529	PF00017	0.463
LIG_SH2_SRC	449	452	PF00017	0.661
LIG_SH2_STAP1	110	114	PF00017	0.370
LIG_SH2_STAP1	196	200	PF00017	0.268
LIG_SH2_STAP1	656	660	PF00017	0.389
LIG_SH2_STAT3	520	523	PF00017	0.486
LIG_SH2_STAT5	490	493	PF00017	0.375
LIG_SH2_STAT5	511	514	PF00017	0.383
LIG_SH2_STAT5	526	529	PF00017	0.330
LIG_SH2_STAT5	641	644	PF00017	0.496
LIG_SH3_2	479	484	PF14604	0.565
LIG_SH3_3	458	464	PF00018	0.624
LIG_SH3_3	473	479	PF00018	0.494
LIG_SH3_3	595	601	PF00018	0.315
LIG_SH3_3	693	699	PF00018	0.728
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.350
LIG_SUMO_SIM_anti_2	326	333	PF11976	0.396
LIG_SUMO_SIM_anti_2	612	619	PF11976	0.539
LIG_SUMO_SIM_anti_2	95	102	PF11976	0.284
LIG_SUMO_SIM_par_1	136	142	PF11976	0.340
LIG_SUMO_SIM_par_1	326	333	PF11976	0.357
LIG_SUMO_SIM_par_1	344	349	PF11976	0.328
LIG_TRAF2_2	559	564	PF00917	0.557
LIG_UBA3_1	114	119	PF00899	0.429
LIG_UBA3_1	284	290	PF00899	0.469
LIG_WRC_WIRS_1	636	641	PF05994	0.475
LIG_WW_3	481	485	PF00397	0.594
MOD_CDK_SPxK_1	478	484	PF00069	0.639
MOD_CDK_SPxxK_3	102	109	PF00069	0.241
MOD_CDK_SPxxK_3	283	290	PF00069	0.517
MOD_CK1_1	102	108	PF00069	0.263
MOD_CK1_1	194	200	PF00069	0.322
MOD_CK1_1	232	238	PF00069	0.432
MOD_CK1_1	311	317	PF00069	0.414
MOD_CK1_1	344	350	PF00069	0.559
MOD_CK1_1	367	373	PF00069	0.399
MOD_CK1_1	43	49	PF00069	0.568
MOD_CK1_1	489	495	PF00069	0.554
MOD_CK1_1	565	571	PF00069	0.685
MOD_CK1_1	6	12	PF00069	0.568
MOD_CK2_1	283	289	PF00069	0.521
MOD_CK2_1	336	342	PF00069	0.519
MOD_CK2_1	399	405	PF00069	0.552
MOD_CK2_1	43	49	PF00069	0.564
MOD_CK2_1	474	480	PF00069	0.622
MOD_CK2_1	712	718	PF00069	0.563
MOD_GlcNHglycan	101	104	PF01048	0.312
MOD_GlcNHglycan	167	170	PF01048	0.330
MOD_GlcNHglycan	218	221	PF01048	0.384
MOD_GlcNHglycan	310	313	PF01048	0.432
MOD_GlcNHglycan	319	322	PF01048	0.407
MOD_GlcNHglycan	410	414	PF01048	0.518
MOD_GlcNHglycan	655	659	PF01048	0.482
MOD_GlcNHglycan	704	707	PF01048	0.650
MOD_GlcNHglycan	728	731	PF01048	0.692
MOD_GlcNHglycan	77	80	PF01048	0.322
MOD_GlcNHglycan	8	11	PF01048	0.584
MOD_GSK3_1	152	159	PF00069	0.434
MOD_GSK3_1	187	194	PF00069	0.365
MOD_GSK3_1	212	219	PF00069	0.432
MOD_GSK3_1	294	301	PF00069	0.477
MOD_GSK3_1	333	340	PF00069	0.443
MOD_GSK3_1	474	481	PF00069	0.611
MOD_GSK3_1	494	501	PF00069	0.604
MOD_GSK3_1	562	569	PF00069	0.660
MOD_GSK3_1	6	13	PF00069	0.656
MOD_GSK3_1	631	638	PF00069	0.462
MOD_GSK3_1	697	704	PF00069	0.648
MOD_GSK3_1	710	717	PF00069	0.699
MOD_GSK3_1	739	746	PF00069	0.691
MOD_N-GLC_1	337	342	PF02516	0.517
MOD_N-GLC_1	512	517	PF02516	0.454
MOD_N-GLC_1	547	552	PF02516	0.522
MOD_N-GLC_2	466	468	PF02516	0.386
MOD_NEK2_1	173	178	PF00069	0.299
MOD_NEK2_1	212	217	PF00069	0.460
MOD_NEK2_1	218	223	PF00069	0.458
MOD_NEK2_1	27	32	PF00069	0.406
MOD_NEK2_1	308	313	PF00069	0.427
MOD_NEK2_1	409	414	PF00069	0.522
MOD_NEK2_1	417	422	PF00069	0.665
MOD_NEK2_1	500	505	PF00069	0.464
MOD_NEK2_1	512	517	PF00069	0.428
MOD_NEK2_1	553	558	PF00069	0.714
MOD_NEK2_1	562	567	PF00069	0.657
MOD_NEK2_1	65	70	PF00069	0.480
MOD_NEK2_1	701	706	PF00069	0.670
MOD_NEK2_2	10	15	PF00069	0.410
MOD_NEK2_2	202	207	PF00069	0.387
MOD_PIKK_1	40	46	PF00454	0.712
MOD_PIKK_1	500	506	PF00454	0.467
MOD_PIKK_1	542	548	PF00454	0.709
MOD_PIKK_1	568	574	PF00454	0.793
MOD_PIKK_1	580	586	PF00454	0.634
MOD_PK_1	665	671	PF00069	0.464
MOD_PKA_1	55	61	PF00069	0.567
MOD_PKA_2	155	161	PF00069	0.432
MOD_PKA_2	294	300	PF00069	0.515
MOD_PKA_2	6	12	PF00069	0.589
MOD_PKA_2	686	692	PF00069	0.581
MOD_PKA_2	702	708	PF00069	0.708
MOD_PKA_2	718	724	PF00069	0.732
MOD_PKB_1	154	162	PF00069	0.201
MOD_Plk_1	337	343	PF00069	0.650
MOD_Plk_1	512	518	PF00069	0.511
MOD_Plk_1	65	71	PF00069	0.516
MOD_Plk_2-3	445	451	PF00069	0.597
MOD_Plk_4	110	116	PF00069	0.349
MOD_Plk_4	124	130	PF00069	0.312
MOD_Plk_4	174	180	PF00069	0.355
MOD_Plk_4	202	208	PF00069	0.340
MOD_Plk_4	324	330	PF00069	0.505
MOD_Plk_4	367	373	PF00069	0.388
MOD_Plk_4	486	492	PF00069	0.425
MOD_Plk_4	60	66	PF00069	0.460
MOD_Plk_4	697	703	PF00069	0.687
MOD_Plk_4	718	724	PF00069	0.773
MOD_ProDKin_1	102	108	PF00069	0.241
MOD_ProDKin_1	283	289	PF00069	0.437
MOD_ProDKin_1	298	304	PF00069	0.485
MOD_ProDKin_1	341	347	PF00069	0.517
MOD_ProDKin_1	478	484	PF00069	0.629
MOD_ProDKin_1	547	553	PF00069	0.676
MOD_ProDKin_1	555	561	PF00069	0.685
MOD_ProDKin_1	578	584	PF00069	0.548
MOD_ProDKin_1	646	652	PF00069	0.525
MOD_ProDKin_1	692	698	PF00069	0.686
MOD_SUMO_for_1	263	266	PF00179	0.557
MOD_SUMO_rev_2	101	111	PF00179	0.268
MOD_SUMO_rev_2	159	168	PF00179	0.187
MOD_SUMO_rev_2	234	244	PF00179	0.390
MOD_SUMO_rev_2	265	270	PF00179	0.398
MOD_SUMO_rev_2	275	281	PF00179	0.338
MOD_SUMO_rev_2	532	537	PF00179	0.544
TRG_DiLeu_BaEn_1	243	248	PF01217	0.339
TRG_DiLeu_BaEn_1	266	271	PF01217	0.366
TRG_DiLeu_BaEn_1	718	723	PF01217	0.702
TRG_DiLeu_BaEn_3	387	393	PF01217	0.412
TRG_DiLeu_BaEn_4	233	239	PF01217	0.432
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.522
TRG_ENDOCYTIC_2	23	26	PF00928	0.350
TRG_ENDOCYTIC_2	449	452	PF00928	0.617
TRG_ENDOCYTIC_2	458	461	PF00928	0.530
TRG_ENDOCYTIC_2	488	491	PF00928	0.536
TRG_ENDOCYTIC_2	526	529	PF00928	0.342
TRG_ENDOCYTIC_2	62	65	PF00928	0.423
TRG_ENDOCYTIC_2	679	682	PF00928	0.389
TRG_ENDOCYTIC_2	74	77	PF00928	0.375
TRG_ER_diArg_1	153	156	PF00400	0.432
TRG_ER_diArg_1	313	316	PF00400	0.421
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK76	Leptomonas seymouri	65%	99%
A0A0S4JDJ1	Bodo saltans	39%	79%
A0A0S4JGZ5	Bodo saltans	32%	90%
A0A1X0P6Q5	Trypanosomatidae	40%	100%
A0A1X0P7K4	Trypanosomatidae	27%	100%
A0A3Q8IL77	Leishmania donovani	29%	100%
A0A3R7M693	Trypanosoma rangeli	27%	100%
A0A3S7WUR9	Leishmania donovani	94%	100%
A0A3S7WUS2	Leishmania donovani	32%	100%
A0A422NWG4	Trypanosoma rangeli	39%	100%
A4H9B8	Leishmania braziliensis	31%	100%
A4H9B9	Leishmania braziliensis	78%	100%
A4HXN9	Leishmania infantum	32%	100%
A4HXP0	Leishmania infantum	94%	100%
A4IA41	Leishmania infantum	29%	100%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ARF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2T0	Leishmania major	30%	100%
Q4QE29	Leishmania major	32%	100%
V5B9W6	Trypanosoma cruzi	42%	100%
V5BEH2	Trypanosoma cruzi	30%	100%