Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania major

UniProt:

Q4QE26_LEIMA

TriTrypDb:

LmjF.18.0160 , LMJLV39_180006800 , LMJSD75_180006800

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QE26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE26

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	2
GO:0016042	lipid catabolic process	4	2
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0005488	binding	1	1
GO:0008901	ferredoxin hydrogenase activity	5	1
GO:0016151	nickel cation binding	6	1
GO:0016491	oxidoreductase activity	2	1
GO:0016695	oxidoreductase activity, acting on hydrogen as donor	3	1
GO:0016699	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor	4	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.363
CLV_NRD_NRD_1	237	239	PF00675	0.252
CLV_NRD_NRD_1	562	564	PF00675	0.631
CLV_NRD_NRD_1	93	95	PF00675	0.283
CLV_PCSK_FUR_1	235	239	PF00082	0.306
CLV_PCSK_KEX2_1	167	169	PF00082	0.387
CLV_PCSK_KEX2_1	237	239	PF00082	0.244
CLV_PCSK_KEX2_1	562	564	PF00082	0.631
CLV_PCSK_KEX2_1	653	655	PF00082	0.455
CLV_PCSK_KEX2_1	93	95	PF00082	0.255
CLV_PCSK_PC1ET2_1	653	655	PF00082	0.498
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.255
CLV_PCSK_SKI1_1	137	141	PF00082	0.427
CLV_PCSK_SKI1_1	237	241	PF00082	0.295
CLV_PCSK_SKI1_1	571	575	PF00082	0.559
CLV_PCSK_SKI1_1	638	642	PF00082	0.583
CLV_PCSK_SKI1_1	650	654	PF00082	0.457
DEG_APCC_DBOX_1	236	244	PF00400	0.560
DEG_APCC_DBOX_1	470	478	PF00400	0.227
DOC_CDC14_PxL_1	505	513	PF14671	0.307
DOC_CYCLIN_RxL_1	234	241	PF00134	0.512
DOC_MAPK_DCC_7	397	405	PF00069	0.423
DOC_MAPK_gen_1	650	658	PF00069	0.195
DOC_MAPK_gen_1	93	101	PF00069	0.437
DOC_MAPK_HePTP_8	91	103	PF00069	0.458
DOC_MAPK_MEF2A_6	141	148	PF00069	0.297
DOC_MAPK_MEF2A_6	365	374	PF00069	0.471
DOC_MAPK_MEF2A_6	397	405	PF00069	0.423
DOC_MAPK_MEF2A_6	60	67	PF00069	0.264
DOC_MAPK_MEF2A_6	94	103	PF00069	0.456
DOC_MAPK_NFAT4_5	60	68	PF00069	0.297
DOC_SPAK_OSR1_1	283	287	PF12202	0.461
DOC_SPAK_OSR1_1	666	670	PF12202	0.309
DOC_USP7_MATH_1	19	23	PF00917	0.313
DOC_USP7_MATH_1	528	532	PF00917	0.274
DOC_USP7_MATH_1	553	557	PF00917	0.399
DOC_WW_Pin1_4	265	270	PF00397	0.553
DOC_WW_Pin1_4	396	401	PF00397	0.437
DOC_WW_Pin1_4	577	582	PF00397	0.382
DOC_WW_Pin1_4	633	638	PF00397	0.292
DOC_WW_Pin1_4	687	692	PF00397	0.466
LIG_14-3-3_CanoR_1	133	140	PF00244	0.286
LIG_14-3-3_CanoR_1	256	263	PF00244	0.475
LIG_14-3-3_CanoR_1	365	372	PF00244	0.479
LIG_14-3-3_CanoR_1	39	48	PF00244	0.324
LIG_14-3-3_CanoR_1	543	551	PF00244	0.318
LIG_14-3-3_CanoR_1	562	570	PF00244	0.372
LIG_14-3-3_CanoR_1	638	645	PF00244	0.340
LIG_Actin_WH2_2	383	399	PF00022	0.447
LIG_Actin_WH2_2	529	545	PF00022	0.366
LIG_BRCT_BRCA1_1	14	18	PF00533	0.440
LIG_BRCT_BRCA1_1	281	285	PF00533	0.460
LIG_BRCT_BRCA1_1	555	559	PF00533	0.430
LIG_FHA_1	103	109	PF00498	0.315
LIG_FHA_1	391	397	PF00498	0.440
LIG_FHA_1	40	46	PF00498	0.326
LIG_FHA_1	542	548	PF00498	0.377
LIG_FHA_1	583	589	PF00498	0.334
LIG_FHA_1	605	611	PF00498	0.455
LIG_FHA_1	694	700	PF00498	0.437
LIG_FHA_2	346	352	PF00498	0.505
LIG_FHA_2	397	403	PF00498	0.448
LIG_GBD_Chelix_1	331	339	PF00786	0.245
LIG_GBD_Chelix_1	370	378	PF00786	0.215
LIG_GBD_Chelix_1	455	463	PF00786	0.271
LIG_KLC1_Yacidic_2	665	670	PF13176	0.350
LIG_LIR_Apic_2	605	611	PF02991	0.363
LIG_LIR_Gen_1	17	28	PF02991	0.437
LIG_LIR_Gen_1	198	209	PF02991	0.500
LIG_LIR_Gen_1	295	304	PF02991	0.527
LIG_LIR_Gen_1	385	394	PF02991	0.399
LIG_LIR_Gen_1	515	524	PF02991	0.295
LIG_LIR_Gen_1	572	581	PF02991	0.247
LIG_LIR_Nem_3	17	23	PF02991	0.394
LIG_LIR_Nem_3	198	204	PF02991	0.488
LIG_LIR_Nem_3	295	299	PF02991	0.523
LIG_LIR_Nem_3	385	390	PF02991	0.399
LIG_LIR_Nem_3	515	519	PF02991	0.300
LIG_LIR_Nem_3	521	527	PF02991	0.284
LIG_LIR_Nem_3	55	61	PF02991	0.207
LIG_LIR_Nem_3	572	576	PF02991	0.242
LIG_LIR_Nem_3	617	623	PF02991	0.279
LIG_LIR_Nem_3	626	630	PF02991	0.320
LIG_MLH1_MIPbox_1	281	285	PF16413	0.460
LIG_NRBOX	430	436	PF00104	0.431
LIG_Pex14_1	180	184	PF04695	0.564
LIG_Pex14_2	208	212	PF04695	0.494
LIG_Pex14_2	7	11	PF04695	0.479
LIG_SH2_CRK	215	219	PF00017	0.463
LIG_SH2_CRK	479	483	PF00017	0.197
LIG_SH2_CRK	505	509	PF00017	0.307
LIG_SH2_GRB2like	102	105	PF00017	0.265
LIG_SH2_GRB2like	176	179	PF00017	0.476
LIG_SH2_NCK_1	215	219	PF00017	0.463
LIG_SH2_NCK_1	479	483	PF00017	0.203
LIG_SH2_NCK_1	505	509	PF00017	0.307
LIG_SH2_NCK_1	616	620	PF00017	0.212
LIG_SH2_PTP2	154	157	PF00017	0.425
LIG_SH2_PTP2	201	204	PF00017	0.473
LIG_SH2_PTP2	597	600	PF00017	0.258
LIG_SH2_PTP2	620	623	PF00017	0.261
LIG_SH2_SRC	176	179	PF00017	0.562
LIG_SH2_SRC	215	218	PF00017	0.522
LIG_SH2_SRC	409	412	PF00017	0.427
LIG_SH2_SRC	479	482	PF00017	0.227
LIG_SH2_SRC	616	619	PF00017	0.273
LIG_SH2_SRC	620	623	PF00017	0.247
LIG_SH2_SRC	686	689	PF00017	0.500
LIG_SH2_STAP1	176	180	PF00017	0.466
LIG_SH2_STAP1	281	285	PF00017	0.427
LIG_SH2_STAP1	616	620	PF00017	0.300
LIG_SH2_STAT3	583	586	PF00017	0.307
LIG_SH2_STAT5	130	133	PF00017	0.366
LIG_SH2_STAT5	154	157	PF00017	0.317
LIG_SH2_STAT5	201	204	PF00017	0.573
LIG_SH2_STAT5	360	363	PF00017	0.464
LIG_SH2_STAT5	420	423	PF00017	0.427
LIG_SH2_STAT5	47	50	PF00017	0.309
LIG_SH2_STAT5	597	600	PF00017	0.254
LIG_SH2_STAT5	620	623	PF00017	0.314
LIG_SH2_STAT5	668	671	PF00017	0.342
LIG_SH2_STAT5	686	689	PF00017	0.377
LIG_SH3_3	351	357	PF00018	0.481
LIG_SH3_3	398	404	PF00018	0.495
LIG_SH3_3	616	622	PF00018	0.253
LIG_SUMO_SIM_par_1	390	395	PF11976	0.450
LIG_SUMO_SIM_par_1	599	605	PF11976	0.272
LIG_TYR_ITIM	152	157	PF00017	0.265
LIG_TYR_ITIM	595	600	PF00017	0.313
LIG_UBA3_1	113	120	PF00899	0.265
LIG_UBA3_1	648	653	PF00899	0.312
LIG_WRC_WIRS_1	516	521	PF05994	0.441
LIG_WRC_WIRS_1	576	581	PF05994	0.310
MOD_CDK_SPK_2	633	638	PF00069	0.476
MOD_CDK_SPxxK_3	265	272	PF00069	0.484
MOD_CK1_1	129	135	PF00069	0.453
MOD_CK1_1	465	471	PF00069	0.393
MOD_CK1_1	564	570	PF00069	0.367
MOD_CK1_1	689	695	PF00069	0.580
MOD_CK1_1	698	704	PF00069	0.636
MOD_CK2_1	169	175	PF00069	0.299
MOD_CK2_1	345	351	PF00069	0.311
MOD_CK2_1	515	521	PF00069	0.422
MOD_CK2_1	566	572	PF00069	0.454
MOD_Cter_Amidation	165	168	PF01082	0.416
MOD_Cter_Amidation	440	443	PF01082	0.265
MOD_GlcNHglycan	163	167	PF01048	0.447
MOD_GlcNHglycan	300	303	PF01048	0.401
MOD_GlcNHglycan	31	34	PF01048	0.260
MOD_GlcNHglycan	459	462	PF01048	0.406
MOD_GlcNHglycan	54	57	PF01048	0.347
MOD_GlcNHglycan	555	558	PF01048	0.489
MOD_GlcNHglycan	563	566	PF01048	0.512
MOD_GSK3_1	129	136	PF00069	0.413
MOD_GSK3_1	392	399	PF00069	0.299
MOD_GSK3_1	543	550	PF00069	0.413
MOD_GSK3_1	575	582	PF00069	0.419
MOD_GSK3_1	686	693	PF00069	0.576
MOD_GSK3_1	76	83	PF00069	0.243
MOD_LATS_1	254	260	PF00433	0.538
MOD_N-GLC_1	589	594	PF02516	0.442
MOD_N-GLC_2	424	426	PF02516	0.242
MOD_NEK2_1	112	117	PF00069	0.294
MOD_NEK2_1	18	23	PF00069	0.232
MOD_NEK2_1	29	34	PF00069	0.237
MOD_NEK2_1	335	340	PF00069	0.274
MOD_NEK2_1	435	440	PF00069	0.323
MOD_NEK2_1	447	452	PF00069	0.252
MOD_NEK2_1	457	462	PF00069	0.278
MOD_NEK2_1	527	532	PF00069	0.348
MOD_NEK2_1	542	547	PF00069	0.424
MOD_NEK2_1	574	579	PF00069	0.413
MOD_NEK2_1	76	81	PF00069	0.272
MOD_NEK2_1	89	94	PF00069	0.253
MOD_NEK2_2	80	85	PF00069	0.424
MOD_PIKK_1	256	262	PF00454	0.399
MOD_PIKK_1	582	588	PF00454	0.377
MOD_PKA_2	132	138	PF00069	0.376
MOD_PKA_2	255	261	PF00069	0.351
MOD_PKA_2	364	370	PF00069	0.331
MOD_PKA_2	374	380	PF00069	0.184
MOD_PKA_2	435	441	PF00069	0.356
MOD_PKA_2	542	548	PF00069	0.438
MOD_PKA_2	561	567	PF00069	0.515
MOD_Plk_1	126	132	PF00069	0.443
MOD_Plk_1	465	471	PF00069	0.372
MOD_Plk_1	589	595	PF00069	0.419
MOD_Plk_2-3	566	572	PF00069	0.441
MOD_Plk_4	19	25	PF00069	0.278
MOD_Plk_4	335	341	PF00069	0.415
MOD_Plk_4	465	471	PF00069	0.279
MOD_Plk_4	589	595	PF00069	0.277
MOD_Plk_4	695	701	PF00069	0.533
MOD_ProDKin_1	265	271	PF00069	0.442
MOD_ProDKin_1	396	402	PF00069	0.285
MOD_ProDKin_1	577	583	PF00069	0.494
MOD_ProDKin_1	633	639	PF00069	0.359
MOD_ProDKin_1	687	693	PF00069	0.609
TRG_DiLeu_BaEn_1	342	347	PF01217	0.338
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.422
TRG_ENDOCYTIC_2	154	157	PF00928	0.329
TRG_ENDOCYTIC_2	201	204	PF00928	0.381
TRG_ENDOCYTIC_2	215	218	PF00928	0.244
TRG_ENDOCYTIC_2	281	284	PF00928	0.278
TRG_ENDOCYTIC_2	289	292	PF00928	0.275
TRG_ENDOCYTIC_2	419	422	PF00928	0.299
TRG_ENDOCYTIC_2	505	508	PF00928	0.383
TRG_ENDOCYTIC_2	597	600	PF00928	0.376
TRG_ENDOCYTIC_2	616	619	PF00928	0.335
TRG_ENDOCYTIC_2	620	623	PF00928	0.298
TRG_ER_diArg_1	167	169	PF00400	0.511
TRG_ER_diArg_1	235	238	PF00400	0.295
TRG_ER_diArg_1	470	473	PF00400	0.273
TRG_NES_CRM1_1	147	163	PF08389	0.299
TRG_NES_CRM1_1	646	660	PF08389	0.316
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	638	642	PF00026	0.337

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJR2	Leptomonas seymouri	59%	100%
A0A0S4JEE8	Bodo saltans	35%	90%
A0A1X0P6P4	Trypanosomatidae	42%	100%
A0A3R7KUA8	Trypanosoma rangeli	42%	100%
A0A3S7WUY2	Leishmania donovani	94%	100%
A4H9C1	Leishmania braziliensis	74%	100%
A4HXP2	Leishmania infantum	94%	100%
D0A020	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ARF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
P0C1S9	Rattus norvegicus	27%	100%
Q5YLM1	Rattus norvegicus	27%	68%
Q6WQJ1	Mus musculus	27%	68%
Q8NCG7	Homo sapiens	27%	100%
Q91WC9	Mus musculus	27%	100%
Q9Y4D2	Homo sapiens	28%	68%
V5APZ1	Trypanosoma cruzi	42%	100%