RNA recognition motif family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4QE25_LEIMA

TriTrypDb:

LmjF.18.0170 , LMJLV39_180006900 , LMJSD75_180006900

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QE25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE25

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	13
GO:0003723	RNA binding	4	13
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	3
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	13
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.536
CLV_NRD_NRD_1	164	166	PF00675	0.258
CLV_NRD_NRD_1	255	257	PF00675	0.574
CLV_PCSK_KEX2_1	163	165	PF00082	0.283
CLV_PCSK_KEX2_1	210	212	PF00082	0.597
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.534
CLV_PCSK_SKI1_1	120	124	PF00082	0.423
CLV_PCSK_SKI1_1	146	150	PF00082	0.323
CLV_PCSK_SKI1_1	165	169	PF00082	0.304
CLV_PCSK_SKI1_1	43	47	PF00082	0.311
DEG_Nend_UBRbox_3	1	3	PF02207	0.547
DEG_SCF_FBW7_1	279	286	PF00400	0.550
DEG_SPOP_SBC_1	321	325	PF00917	0.540
DOC_CKS1_1	20	25	PF01111	0.529
DOC_MAPK_gen_1	10	20	PF00069	0.487
DOC_MAPK_gen_1	115	123	PF00069	0.414
DOC_MAPK_gen_1	163	171	PF00069	0.485
DOC_MAPK_gen_1	82	92	PF00069	0.492
DOC_MAPK_MEF2A_6	163	171	PF00069	0.517
DOC_PP1_RVXF_1	162	169	PF00149	0.480
DOC_PP4_FxxP_1	20	23	PF00568	0.555
DOC_USP7_MATH_1	141	145	PF00917	0.474
DOC_USP7_MATH_1	206	210	PF00917	0.574
DOC_USP7_MATH_1	216	220	PF00917	0.550
DOC_USP7_MATH_1	236	240	PF00917	0.653
DOC_USP7_MATH_1	283	287	PF00917	0.603
DOC_USP7_MATH_1	321	325	PF00917	0.732
DOC_WW_Pin1_4	1	6	PF00397	0.610
DOC_WW_Pin1_4	106	111	PF00397	0.503
DOC_WW_Pin1_4	137	142	PF00397	0.466
DOC_WW_Pin1_4	19	24	PF00397	0.516
DOC_WW_Pin1_4	227	232	PF00397	0.619
DOC_WW_Pin1_4	261	266	PF00397	0.671
DOC_WW_Pin1_4	279	284	PF00397	0.672
DOC_WW_Pin1_4	300	305	PF00397	0.634
LIG_14-3-3_CanoR_1	256	261	PF00244	0.542
LIG_14-3-3_CanoR_1	322	329	PF00244	0.633
LIG_Actin_WH2_2	30	45	PF00022	0.517
LIG_APCC_ABBA_1	148	153	PF00400	0.451
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.517
LIG_BIR_III_4	86	90	PF00653	0.485
LIG_BRCT_BRCA1_1	222	226	PF00533	0.503
LIG_BRCT_BRCA1_1	329	333	PF00533	0.611
LIG_FHA_1	152	158	PF00498	0.494
LIG_FHA_1	222	228	PF00498	0.509
LIG_FHA_1	67	73	PF00498	0.477
LIG_FHA_1	94	100	PF00498	0.531
LIG_FHA_2	168	174	PF00498	0.536
LIG_IBAR_NPY_1	336	338	PF08397	0.628
LIG_LIR_Gen_1	44	52	PF02991	0.466
LIG_LIR_Nem_3	140	145	PF02991	0.500
LIG_LIR_Nem_3	26	32	PF02991	0.380
LIG_LIR_Nem_3	44	49	PF02991	0.481
LIG_LIR_Nem_3	69	74	PF02991	0.493
LIG_PCNA_yPIPBox_3	285	298	PF02747	0.522
LIG_PDZ_Class_1	342	347	PF00595	0.492
LIG_SH2_CRK	142	146	PF00017	0.511
LIG_SH2_CRK	338	342	PF00017	0.626
LIG_SH2_SRC	74	77	PF00017	0.466
LIG_SH2_STAP1	329	333	PF00017	0.629
LIG_SH2_STAT3	62	65	PF00017	0.485
LIG_SH2_STAT5	21	24	PF00017	0.520
LIG_SH2_STAT5	32	35	PF00017	0.465
LIG_SH3_3	304	310	PF00018	0.521
LIG_SH3_CIN85_PxpxPR_1	304	309	PF14604	0.522
LIG_SUMO_SIM_anti_2	4	12	PF11976	0.474
LIG_SUMO_SIM_par_1	126	134	PF11976	0.478
LIG_TRAF2_1	111	114	PF00917	0.618
LIG_TRAF2_1	274	277	PF00917	0.533
LIG_WRC_WIRS_1	168	173	PF05994	0.517
LIG_WRC_WIRS_1	260	265	PF05994	0.550
MOD_CDK_SPxK_1	279	285	PF00069	0.550
MOD_CK1_1	221	227	PF00069	0.674
MOD_CK1_1	230	236	PF00069	0.717
MOD_CK1_1	259	265	PF00069	0.573
MOD_CK1_1	275	281	PF00069	0.627
MOD_CK1_1	300	306	PF00069	0.588
MOD_CK1_1	315	321	PF00069	0.557
MOD_CK1_1	325	331	PF00069	0.633
MOD_CK1_1	66	72	PF00069	0.473
MOD_CK2_1	167	173	PF00069	0.517
MOD_CK2_1	270	276	PF00069	0.560
MOD_GlcNHglycan	46	49	PF01048	0.342
MOD_GSK3_1	137	144	PF00069	0.490
MOD_GSK3_1	19	26	PF00069	0.512
MOD_GSK3_1	214	221	PF00069	0.676
MOD_GSK3_1	225	232	PF00069	0.784
MOD_GSK3_1	259	266	PF00069	0.774
MOD_GSK3_1	271	278	PF00069	0.672
MOD_GSK3_1	279	286	PF00069	0.632
MOD_GSK3_1	312	319	PF00069	0.614
MOD_GSK3_1	321	328	PF00069	0.576
MOD_GSK3_1	9	16	PF00069	0.634
MOD_N-GLC_1	151	156	PF02516	0.317
MOD_N-GLC_1	214	219	PF02516	0.608
MOD_N-GLC_2	186	188	PF02516	0.305
MOD_NEK2_1	214	219	PF00069	0.510
MOD_NEK2_1	9	14	PF00069	0.757
MOD_NEK2_1	93	98	PF00069	0.485
MOD_NEK2_2	141	146	PF00069	0.532
MOD_PIKK_1	13	19	PF00454	0.635
MOD_PIKK_1	263	269	PF00454	0.553
MOD_PK_1	218	224	PF00069	0.624
MOD_PK_1	95	101	PF00069	0.582
MOD_PKA_1	146	152	PF00069	0.517
MOD_PKA_1	256	262	PF00069	0.534
MOD_PKA_2	236	242	PF00069	0.556
MOD_PKA_2	321	327	PF00069	0.662
MOD_PKA_2	9	15	PF00069	0.569
MOD_Plk_1	275	281	PF00069	0.707
MOD_Plk_1	316	322	PF00069	0.714
MOD_Plk_1	325	331	PF00069	0.491
MOD_Plk_4	336	342	PF00069	0.724
MOD_Plk_4	52	58	PF00069	0.505
MOD_ProDKin_1	1	7	PF00069	0.609
MOD_ProDKin_1	106	112	PF00069	0.504
MOD_ProDKin_1	137	143	PF00069	0.466
MOD_ProDKin_1	19	25	PF00069	0.500
MOD_ProDKin_1	227	233	PF00069	0.620
MOD_ProDKin_1	261	267	PF00069	0.666
MOD_ProDKin_1	279	285	PF00069	0.674
MOD_ProDKin_1	300	306	PF00069	0.635
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.466
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.485
TRG_ENDOCYTIC_2	142	145	PF00928	0.516
TRG_ENDOCYTIC_2	338	341	PF00928	0.537
TRG_ER_diArg_1	163	165	PF00400	0.548
TRG_ER_diArg_1	211	214	PF00400	0.606
TRG_NLS_MonoExtN_4	208	214	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	31	36	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P516	Leptomonas seymouri	58%	93%
A0A0N1HUA1	Leptomonas seymouri	47%	99%
A0A3Q8IAV4	Leishmania donovani	48%	100%
A0A3Q8IAX1	Leishmania donovani	96%	100%
A0A3R7KE41	Trypanosoma rangeli	38%	73%
A4H9C2	Leishmania braziliensis	78%	100%
A4HXP3	Leishmania infantum	96%	100%
A4HXP5	Leishmania infantum	48%	100%
E9ARF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9ARF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
Q4Q774	Leishmania major	25%	70%