RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4QE24_LEIMA

TriTrypDb:

LmjF.18.0180 , LMJLV39_180007000 , LMJSD75_180007000

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QE24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE24

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003727	single-stranded RNA binding	5	2
GO:0003729	mRNA binding	5	2
GO:0003730	mRNA 3'-UTR binding	6	2
GO:0005488	binding	1	8
GO:0008143	poly(A) binding	7	2
GO:0008187	poly-pyrimidine tract binding	6	2
GO:0008266	poly(U) RNA binding	7	2
GO:0070717	poly-purine tract binding	6	2
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.263
CLV_NRD_NRD_1	215	217	PF00675	0.571
CLV_NRD_NRD_1	269	271	PF00675	0.644
CLV_PCSK_KEX2_1	156	158	PF00082	0.322
CLV_PCSK_KEX2_1	215	217	PF00082	0.595
CLV_PCSK_KEX2_1	269	271	PF00082	0.589
CLV_PCSK_KEX2_1	345	347	PF00082	0.614
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.614
CLV_PCSK_SKI1_1	113	117	PF00082	0.368
CLV_PCSK_SKI1_1	139	143	PF00082	0.436
CLV_PCSK_SKI1_1	158	162	PF00082	0.211
CLV_PCSK_SKI1_1	230	234	PF00082	0.708
CLV_PCSK_SKI1_1	342	346	PF00082	0.632
CLV_PCSK_SKI1_1	36	40	PF00082	0.319
DEG_SCF_TRCP1_1	328	334	PF00400	0.648
DOC_CKS1_1	265	270	PF01111	0.696
DOC_MAPK_gen_1	108	116	PF00069	0.454
DOC_MAPK_gen_1	156	164	PF00069	0.523
DOC_MAPK_gen_1	269	275	PF00069	0.557
DOC_MAPK_gen_1	75	85	PF00069	0.630
DOC_MAPK_MEF2A_6	156	164	PF00069	0.630
DOC_PP1_RVXF_1	155	162	PF00149	0.520
DOC_PP4_FxxP_1	318	321	PF00568	0.590
DOC_USP7_MATH_1	134	138	PF00917	0.522
DOC_USP7_MATH_1	231	235	PF00917	0.756
DOC_USP7_MATH_1	274	278	PF00917	0.675
DOC_USP7_MATH_1	326	330	PF00917	0.700
DOC_WW_Pin1_4	12	17	PF00397	0.575
DOC_WW_Pin1_4	130	135	PF00397	0.592
DOC_WW_Pin1_4	202	207	PF00397	0.642
DOC_WW_Pin1_4	220	225	PF00397	0.718
DOC_WW_Pin1_4	264	269	PF00397	0.738
DOC_WW_Pin1_4	99	104	PF00397	0.527
LIG_14-3-3_CanoR_1	204	213	PF00244	0.566
LIG_14-3-3_CanoR_1	278	288	PF00244	0.602
LIG_14-3-3_CanoR_1	312	319	PF00244	0.677
LIG_14-3-3_CterR_2	346	348	PF00244	0.615
LIG_Actin_WH2_2	23	38	PF00022	0.630
LIG_APCC_ABBA_1	141	146	PF00400	0.520
LIG_APCC_ABBAyCdc20_2	140	146	PF00400	0.630
LIG_BIR_III_4	79	83	PF00653	0.630
LIG_BRCT_BRCA1_1	10	14	PF00533	0.618
LIG_BRCT_BRCA1_1	340	344	PF00533	0.688
LIG_FHA_1	145	151	PF00498	0.592
LIG_FHA_1	259	265	PF00498	0.666
LIG_FHA_1	289	295	PF00498	0.656
LIG_FHA_1	330	336	PF00498	0.650
LIG_FHA_1	60	66	PF00498	0.630
LIG_FHA_1	87	93	PF00498	0.630
LIG_FHA_2	161	167	PF00498	0.630
LIG_LIR_Apic_2	316	321	PF02991	0.592
LIG_LIR_Gen_1	37	45	PF02991	0.592
LIG_LIR_Nem_3	133	138	PF02991	0.628
LIG_LIR_Nem_3	19	25	PF02991	0.523
LIG_LIR_Nem_3	37	42	PF02991	0.423
LIG_LIR_Nem_3	62	67	PF02991	0.530
LIG_SH2_CRK	135	139	PF00017	0.630
LIG_SH2_SRC	67	70	PF00017	0.592
LIG_SH2_STAP1	199	203	PF00017	0.568
LIG_SH2_STAP1	213	217	PF00017	0.525
LIG_SH2_STAT3	55	58	PF00017	0.630
LIG_SH2_STAT5	199	202	PF00017	0.629
LIG_SH2_STAT5	25	28	PF00017	0.503
LIG_SH3_3	236	242	PF00018	0.675
LIG_SH3_3	262	268	PF00018	0.609
LIG_SUMO_SIM_par_1	119	127	PF11976	0.551
LIG_TRAF2_1	104	107	PF00917	0.677
LIG_WRC_WIRS_1	161	166	PF05994	0.630
MOD_CDK_SPK_2	202	207	PF00069	0.575
MOD_CDK_SPK_2	264	269	PF00069	0.618
MOD_CDK_SPxK_1	264	270	PF00069	0.589
MOD_CK1_1	12	18	PF00069	0.481
MOD_CK1_1	220	226	PF00069	0.664
MOD_CK1_1	277	283	PF00069	0.757
MOD_CK1_1	329	335	PF00069	0.682
MOD_CK1_1	340	346	PF00069	0.658
MOD_CK1_1	59	65	PF00069	0.607
MOD_CK2_1	160	166	PF00069	0.630
MOD_CK2_1	215	221	PF00069	0.570
MOD_CK2_1	231	237	PF00069	0.576
MOD_GlcNHglycan	217	220	PF01048	0.623
MOD_GlcNHglycan	224	227	PF01048	0.639
MOD_GlcNHglycan	248	251	PF01048	0.617
MOD_GlcNHglycan	328	331	PF01048	0.657
MOD_GlcNHglycan	39	42	PF01048	0.430
MOD_GSK3_1	130	137	PF00069	0.592
MOD_GSK3_1	193	200	PF00069	0.576
MOD_GSK3_1	211	218	PF00069	0.712
MOD_GSK3_1	220	227	PF00069	0.686
MOD_GSK3_1	8	15	PF00069	0.735
MOD_N-GLC_1	144	149	PF02516	0.430
MOD_N-GLC_2	179	181	PF02516	0.319
MOD_NEK2_1	1	6	PF00069	0.697
MOD_NEK2_1	276	281	PF00069	0.536
MOD_NEK2_1	288	293	PF00069	0.606
MOD_NEK2_1	294	299	PF00069	0.604
MOD_NEK2_1	86	91	PF00069	0.630
MOD_NEK2_2	134	139	PF00069	0.526
MOD_PIKK_1	197	203	PF00454	0.557
MOD_PIKK_1	2	8	PF00454	0.722
MOD_PIKK_1	258	264	PF00454	0.744
MOD_PIKK_1	279	285	PF00454	0.674
MOD_PIKK_1	294	300	PF00454	0.574
MOD_PK_1	88	94	PF00069	0.698
MOD_PKA_1	139	145	PF00069	0.630
MOD_PKA_1	215	221	PF00069	0.556
MOD_PKA_2	215	221	PF00069	0.571
MOD_PKA_2	277	283	PF00069	0.587
MOD_PKA_2	311	317	PF00069	0.605
MOD_PKA_2	337	343	PF00069	0.664
MOD_PKB_1	336	344	PF00069	0.618
MOD_Plk_4	45	51	PF00069	0.520
MOD_ProDKin_1	12	18	PF00069	0.568
MOD_ProDKin_1	130	136	PF00069	0.592
MOD_ProDKin_1	202	208	PF00069	0.643
MOD_ProDKin_1	220	226	PF00069	0.720
MOD_ProDKin_1	264	270	PF00069	0.741
MOD_ProDKin_1	99	105	PF00069	0.526
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.592
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.630
TRG_ENDOCYTIC_2	135	138	PF00928	0.630
TRG_ER_diArg_1	156	158	PF00400	0.523
TRG_ER_diArg_1	215	217	PF00400	0.601
TRG_ER_diArg_1	268	270	PF00400	0.583
TRG_ER_diArg_1	335	338	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAX1	Leishmania donovani	76%	100%
A0A3S7WUT6	Leishmania donovani	90%	100%
A4H9C3	Leishmania braziliensis	68%	100%
A4HXP3	Leishmania infantum	76%	100%
A4HXP4	Leishmania infantum	89%	100%
E9ARF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%