Aha1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Activator of Hsp90 ATPase, N-terminal/Activator of Hsp90 ATPase homolog 1-like protein, putative

Species:

Leishmania major

UniProt:

Q4QE21_LEIMA

TriTrypDb:

LmjF.18.0210 , LMJLV39_180007500 , LMJSD75_180007400

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QE21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE21

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2
GO:0032781	positive regulation of ATP-dependent activity	4	2
GO:0043462	regulation of ATP-dependent activity	3	2
GO:0044093	positive regulation of molecular function	3	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0031072	heat shock protein binding	3	12
GO:0051087	protein-folding chaperone binding	3	12
GO:0051879	Hsp90 protein binding	4	12
GO:0098772	molecular function regulator activity	1	12
GO:0140677	molecular function activator activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.483
CLV_C14_Caspase3-7	15	19	PF00656	0.579
CLV_NRD_NRD_1	78	80	PF00675	0.286
CLV_PCSK_SKI1_1	171	175	PF00082	0.536
CLV_PCSK_SKI1_1	341	345	PF00082	0.286
CLV_PCSK_SKI1_1	41	45	PF00082	0.326
DOC_PP2B_LxvP_1	179	182	PF13499	0.605
DOC_USP7_MATH_1	188	192	PF00917	0.791
DOC_USP7_UBL2_3	90	94	PF12436	0.480
DOC_WW_Pin1_4	190	195	PF00397	0.699
DOC_WW_Pin1_4	247	252	PF00397	0.572
LIG_14-3-3_CanoR_1	149	153	PF00244	0.572
LIG_14-3-3_CanoR_1	249	255	PF00244	0.509
LIG_BIR_II_1	1	5	PF00653	0.585
LIG_deltaCOP1_diTrp_1	330	337	PF00928	0.486
LIG_EVH1_1	179	183	PF00568	0.653
LIG_FHA_1	251	257	PF00498	0.576
LIG_FHA_2	127	133	PF00498	0.565
LIG_FHA_2	309	315	PF00498	0.507
LIG_LIR_Gen_1	233	241	PF02991	0.489
LIG_LIR_Gen_1	270	281	PF02991	0.496
LIG_LIR_Gen_1	58	67	PF02991	0.556
LIG_LIR_LC3C_4	297	300	PF02991	0.507
LIG_LIR_Nem_3	161	167	PF02991	0.501
LIG_LIR_Nem_3	233	238	PF02991	0.472
LIG_LIR_Nem_3	270	276	PF02991	0.496
LIG_LIR_Nem_3	58	64	PF02991	0.556
LIG_Pex14_1	332	336	PF04695	0.486
LIG_Pex14_2	160	164	PF04695	0.486
LIG_SH2_CRK	235	239	PF00017	0.563
LIG_SH2_PTP2	273	276	PF00017	0.546
LIG_SH2_SRC	124	127	PF00017	0.546
LIG_SH2_SRC	167	170	PF00017	0.465
LIG_SH2_SRC	273	276	PF00017	0.546
LIG_SH2_STAP1	124	128	PF00017	0.497
LIG_SH2_STAP1	346	350	PF00017	0.407
LIG_SH2_STAT5	247	250	PF00017	0.477
LIG_SH2_STAT5	273	276	PF00017	0.524
LIG_SH2_STAT5	61	64	PF00017	0.567
LIG_SH2_STAT5	86	89	PF00017	0.484
LIG_SH3_3	177	183	PF00018	0.630
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.557
LIG_TRAF2_1	327	330	PF00917	0.546
LIG_TYR_ITIM	59	64	PF00017	0.572
MOD_CK1_1	14	20	PF00069	0.694
MOD_CK1_1	186	192	PF00069	0.792
MOD_CK1_1	193	199	PF00069	0.743
MOD_CK1_1	209	215	PF00069	0.561
MOD_CK1_1	242	248	PF00069	0.507
MOD_CK1_1	250	256	PF00069	0.483
MOD_CK1_1	33	39	PF00069	0.572
MOD_CK1_1	68	74	PF00069	0.491
MOD_CK2_1	211	217	PF00069	0.739
MOD_CK2_1	308	314	PF00069	0.494
MOD_CK2_1	324	330	PF00069	0.497
MOD_GlcNHglycan	174	177	PF01048	0.671
MOD_GlcNHglycan	186	189	PF01048	0.656
MOD_GlcNHglycan	269	272	PF01048	0.334
MOD_GlcNHglycan	317	320	PF01048	0.361
MOD_GlcNHglycan	69	73	PF01048	0.286
MOD_GSK3_1	184	191	PF00069	0.744
MOD_GSK3_1	202	209	PF00069	0.706
MOD_GSK3_1	212	219	PF00069	0.554
MOD_GSK3_1	309	316	PF00069	0.595
MOD_GSK3_1	35	42	PF00069	0.535
MOD_GSK3_1	68	75	PF00069	0.489
MOD_LATS_1	37	43	PF00433	0.591
MOD_N-GLC_1	217	222	PF02516	0.570
MOD_NEK2_1	313	318	PF00069	0.575
MOD_NEK2_1	89	94	PF00069	0.488
MOD_NEK2_2	148	153	PF00069	0.572
MOD_PIKK_1	134	140	PF00454	0.494
MOD_PIKK_1	30	36	PF00454	0.572
MOD_PIKK_1	313	319	PF00454	0.591
MOD_PK_1	39	45	PF00069	0.591
MOD_PKA_1	203	209	PF00069	0.789
MOD_PKA_2	148	154	PF00069	0.572
MOD_Plk_1	216	222	PF00069	0.546
MOD_Plk_1	72	78	PF00069	0.479
MOD_Plk_2-3	324	330	PF00069	0.563
MOD_Plk_4	139	145	PF00069	0.572
MOD_Plk_4	242	248	PF00069	0.510
MOD_Plk_4	277	283	PF00069	0.542
MOD_Plk_4	294	300	PF00069	0.390
MOD_Plk_4	39	45	PF00069	0.581
MOD_ProDKin_1	190	196	PF00069	0.697
MOD_ProDKin_1	247	253	PF00069	0.572
MOD_SUMO_for_1	304	307	PF00179	0.512
MOD_SUMO_for_1	62	65	PF00179	0.572
MOD_SUMO_rev_2	196	206	PF00179	0.794
MOD_SUMO_rev_2	250	258	PF00179	0.572
TRG_ENDOCYTIC_2	235	238	PF00928	0.572
TRG_ENDOCYTIC_2	273	276	PF00928	0.546
TRG_ENDOCYTIC_2	61	64	PF00928	0.570
TRG_ENDOCYTIC_2	86	89	PF00928	0.481
TRG_NES_CRM1_1	54	66	PF08389	0.550
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2A4	Leptomonas seymouri	70%	99%
A0A0S4JAT2	Bodo saltans	50%	100%
A0A1X0P6W4	Trypanosomatidae	58%	100%
A0A3R7MY48	Trypanosoma rangeli	54%	100%
A0A3S7WUS5	Leishmania donovani	96%	100%
A4H9C6	Leishmania braziliensis	84%	100%
A4HXP7	Leishmania infantum	96%	100%
A6QQC0	Bos taurus	27%	100%
D0A023	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ARF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O95433	Homo sapiens	30%	100%
Q12449	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q8BK64	Mus musculus	29%	100%
Q8N9S3	Mus musculus	28%	100%
Q9P782	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
V5B6E4	Trypanosoma cruzi	56%	100%