Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 29, putative

Species:

Leishmania major

UniProt:

Q4QE20_LEIMA

TriTrypDb:

LmjF.18.0220 , LMJLV39_180007600 , LMJSD75_180007500

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	2
GO:0005849	mRNA cleavage factor complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QE20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE20

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006379	mRNA cleavage	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0090501	RNA phosphodiester bond hydrolysis	6	2
GO:0098787	mRNA cleavage involved in mRNA processing	8	2
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	366	368	PF00675	0.511
CLV_NRD_NRD_1	75	77	PF00675	0.272
CLV_PCSK_KEX2_1	401	403	PF00082	0.761
CLV_PCSK_PC1ET2_1	401	403	PF00082	0.681
CLV_PCSK_SKI1_1	134	138	PF00082	0.463
CLV_PCSK_SKI1_1	19	23	PF00082	0.269
CLV_PCSK_SKI1_1	27	31	PF00082	0.269
CLV_PCSK_SKI1_1	398	402	PF00082	0.593
CLV_PCSK_SKI1_1	64	68	PF00082	0.269
CLV_PCSK_SKI1_1	76	80	PF00082	0.269
CLV_Separin_Metazoa	356	360	PF03568	0.467
DEG_APCC_DBOX_1	133	141	PF00400	0.460
DEG_SCF_FBW7_1	1	8	PF00400	0.575
DEG_SPOP_SBC_1	171	175	PF00917	0.566
DOC_MAPK_gen_1	76	82	PF00069	0.469
DOC_PP2B_LxvP_1	203	206	PF13499	0.656
DOC_PP4_FxxP_1	334	337	PF00568	0.650
DOC_PP4_MxPP_1	265	268	PF00568	0.661
DOC_PP4_MxPP_1	286	289	PF00568	0.644
DOC_USP7_MATH_1	170	174	PF00917	0.566
DOC_USP7_MATH_1	382	386	PF00917	0.635
DOC_USP7_MATH_1	400	404	PF00917	0.597
DOC_USP7_UBL2_3	345	349	PF12436	0.604
DOC_USP7_UBL2_3	364	368	PF12436	0.443
DOC_USP7_UBL2_3	397	401	PF12436	0.656
DOC_USP7_UBL2_3	405	409	PF12436	0.627
DOC_WW_Pin1_4	1	6	PF00397	0.595
DOC_WW_Pin1_4	123	128	PF00397	0.557
DOC_WW_Pin1_4	148	153	PF00397	0.498
DOC_WW_Pin1_4	179	184	PF00397	0.700
DOC_WW_Pin1_4	198	203	PF00397	0.600
DOC_WW_Pin1_4	221	226	PF00397	0.527
LIG_Actin_WH2_2	14	29	PF00022	0.469
LIG_BIR_II_1	1	5	PF00653	0.537
LIG_eIF4E_1	68	74	PF01652	0.469
LIG_FHA_1	341	347	PF00498	0.561
LIG_FHA_2	33	39	PF00498	0.469
LIG_FHA_2	56	62	PF00498	0.469
LIG_Integrin_isoDGR_2	42	44	PF01839	0.269
LIG_LIR_Gen_1	352	362	PF02991	0.474
LIG_LIR_Nem_3	352	358	PF02991	0.478
LIG_LIR_Nem_3	8	13	PF02991	0.385
LIG_SH2_STAP1	365	369	PF00017	0.493
LIG_SH2_STAT5	13	16	PF00017	0.469
LIG_SH3_1	297	303	PF00018	0.612
LIG_SH3_3	265	271	PF00018	0.625
LIG_SH3_3	297	303	PF00018	0.592
LIG_SH3_3	84	90	PF00018	0.496
LIG_TRAF2_2	273	278	PF00917	0.652
LIG_UBA3_1	136	144	PF00899	0.475
LIG_WW_3	266	270	PF00397	0.622
MOD_CK1_1	175	181	PF00069	0.661
MOD_CK1_1	385	391	PF00069	0.637
MOD_CK2_1	400	406	PF00069	0.594
MOD_Cter_Amidation	74	77	PF01082	0.269
MOD_GlcNHglycan	1	4	PF01048	0.566
MOD_GlcNHglycan	174	177	PF01048	0.617
MOD_GlcNHglycan	184	187	PF01048	0.750
MOD_GlcNHglycan	196	199	PF01048	0.790
MOD_GlcNHglycan	210	213	PF01048	0.534
MOD_GlcNHglycan	321	324	PF01048	0.651
MOD_GlcNHglycan	375	378	PF01048	0.559
MOD_GlcNHglycan	383	387	PF01048	0.640
MOD_GlcNHglycan	388	391	PF01048	0.663
MOD_GSK3_1	1	8	PF00069	0.575
MOD_GSK3_1	171	178	PF00069	0.667
MOD_GSK3_1	194	201	PF00069	0.679
MOD_GSK3_1	204	211	PF00069	0.565
MOD_GSK3_1	382	389	PF00069	0.677
MOD_GSK3_1	400	407	PF00069	0.633
MOD_N-GLC_1	165	170	PF02516	0.574
MOD_N-GLC_1	171	176	PF02516	0.631
MOD_NEK2_1	118	123	PF00069	0.564
MOD_NEK2_1	157	162	PF00069	0.464
MOD_NEK2_1	194	199	PF00069	0.757
MOD_NEK2_1	208	213	PF00069	0.564
MOD_NEK2_2	340	345	PF00069	0.552
MOD_Plk_1	17	23	PF00069	0.469
MOD_Plk_1	277	283	PF00069	0.550
MOD_Plk_1	37	43	PF00069	0.383
MOD_Plk_2-3	55	61	PF00069	0.469
MOD_Plk_4	210	216	PF00069	0.530
MOD_Plk_4	251	257	PF00069	0.649
MOD_Plk_4	32	38	PF00069	0.469
MOD_ProDKin_1	1	7	PF00069	0.586
MOD_ProDKin_1	123	129	PF00069	0.551
MOD_ProDKin_1	148	154	PF00069	0.493
MOD_ProDKin_1	179	185	PF00069	0.701
MOD_ProDKin_1	198	204	PF00069	0.597
MOD_ProDKin_1	221	227	PF00069	0.527
MOD_SUMO_rev_2	361	369	PF00179	0.480
MOD_SUMO_rev_2	389	399	PF00179	0.609
TRG_DiLeu_BaEn_1	132	137	PF01217	0.453
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.455
TRG_ENDOCYTIC_2	263	266	PF00928	0.628
TRG_ENDOCYTIC_2	68	71	PF00928	0.469
TRG_NLS_MonoExtC_3	400	405	PF00514	0.621
TRG_NLS_MonoExtN_4	398	405	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P353	Leptomonas seymouri	53%	100%
A0A3Q8IE55	Leishmania donovani	95%	100%
A4HXP8	Leishmania infantum	95%	100%
E9AI57	Leishmania braziliensis	84%	100%
E9ARF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%