Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE18_LEIMA

TriTrypDb:

LmjF.18.0240 , LMJLV39_180007800 , LMJSD75_180007700

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QE18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.661
CLV_C14_Caspase3-7	266	270	PF00656	0.649
CLV_C14_Caspase3-7	324	328	PF00656	0.761
CLV_C14_Caspase3-7	54	58	PF00656	0.716
CLV_C14_Caspase3-7	83	87	PF00656	0.744
CLV_NRD_NRD_1	184	186	PF00675	0.489
CLV_NRD_NRD_1	252	254	PF00675	0.515
CLV_NRD_NRD_1	308	310	PF00675	0.502
CLV_NRD_NRD_1	50	52	PF00675	0.566
CLV_PCSK_KEX2_1	184	186	PF00082	0.489
CLV_PCSK_KEX2_1	254	256	PF00082	0.579
CLV_PCSK_KEX2_1	307	309	PF00082	0.500
CLV_PCSK_KEX2_1	50	52	PF00082	0.566
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.556
CLV_PCSK_SKI1_1	171	175	PF00082	0.594
CLV_PCSK_SKI1_1	184	188	PF00082	0.473
CLV_PCSK_SKI1_1	255	259	PF00082	0.451
DEG_SPOP_SBC_1	320	324	PF00917	0.666
DOC_MAPK_MEF2A_6	229	236	PF00069	0.795
DOC_PP2B_LxvP_1	174	177	PF13499	0.780
DOC_PP2B_LxvP_1	204	207	PF13499	0.752
DOC_PP4_FxxP_1	301	304	PF00568	0.659
DOC_USP7_MATH_1	179	183	PF00917	0.705
DOC_USP7_MATH_1	218	222	PF00917	0.774
DOC_USP7_MATH_1	288	292	PF00917	0.646
DOC_USP7_MATH_1	294	298	PF00917	0.671
DOC_USP7_MATH_1	321	325	PF00917	0.711
DOC_USP7_MATH_1	56	60	PF00917	0.795
DOC_USP7_MATH_1	62	66	PF00917	0.755
DOC_WW_Pin1_4	363	368	PF00397	0.692
LIG_14-3-3_CanoR_1	132	139	PF00244	0.744
LIG_14-3-3_CanoR_1	191	197	PF00244	0.737
LIG_14-3-3_CanoR_1	200	205	PF00244	0.725
LIG_14-3-3_CanoR_1	314	321	PF00244	0.700
LIG_14-3-3_CanoR_1	81	89	PF00244	0.744
LIG_Actin_WH2_2	68	83	PF00022	0.791
LIG_BRCT_BRCA1_1	63	67	PF00533	0.664
LIG_FHA_1	14	20	PF00498	0.435
LIG_FHA_1	36	42	PF00498	0.710
LIG_FHA_1	43	49	PF00498	0.721
LIG_FHA_1	66	72	PF00498	0.764
LIG_FHA_2	118	124	PF00498	0.610
LIG_FHA_2	165	171	PF00498	0.819
LIG_FHA_2	370	376	PF00498	0.676
LIG_FHA_2	81	87	PF00498	0.740
LIG_HP1_1	346	350	PF01393	0.603
LIG_LIR_Apic_2	299	304	PF02991	0.662
LIG_LIR_Apic_2	342	346	PF02991	0.749
LIG_LIR_Gen_1	123	130	PF02991	0.744
LIG_LIR_Gen_1	152	162	PF02991	0.800
LIG_LIR_Gen_1	21	30	PF02991	0.300
LIG_LIR_Gen_1	230	240	PF02991	0.782
LIG_LIR_Gen_1	269	275	PF02991	0.712
LIG_LIR_Nem_3	113	118	PF02991	0.748
LIG_LIR_Nem_3	123	127	PF02991	0.651
LIG_LIR_Nem_3	152	158	PF02991	0.673
LIG_LIR_Nem_3	21	27	PF02991	0.495
LIG_LIR_Nem_3	230	236	PF02991	0.789
LIG_LIR_Nem_3	269	274	PF02991	0.657
LIG_LIR_Nem_3	46	52	PF02991	0.732
LIG_MAD2	197	205	PF02301	0.827
LIG_MLH1_MIPbox_1	63	67	PF16413	0.664
LIG_Pex14_1	115	119	PF04695	0.760
LIG_SH2_CRK	343	347	PF00017	0.729
LIG_SH2_PTP2	26	29	PF00017	0.530
LIG_SH2_PTP2	347	350	PF00017	0.693
LIG_SH2_STAT5	10	13	PF00017	0.569
LIG_SH2_STAT5	118	121	PF00017	0.769
LIG_SH2_STAT5	26	29	PF00017	0.265
LIG_SH2_STAT5	331	334	PF00017	0.757
LIG_SH2_STAT5	347	350	PF00017	0.577
LIG_SH3_2	303	308	PF14604	0.650
LIG_SH3_3	300	306	PF00018	0.751
LIG_SUMO_SIM_anti_2	372	381	PF11976	0.709
LIG_SUMO_SIM_anti_2	387	394	PF11976	0.753
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.781
LIG_SUMO_SIM_par_1	107	113	PF11976	0.737
LIG_SUMO_SIM_par_1	172	178	PF11976	0.757
LIG_TRAF2_1	270	273	PF00917	0.791
MOD_CK1_1	110	116	PF00069	0.595
MOD_CK1_1	128	134	PF00069	0.443
MOD_CK1_1	164	170	PF00069	0.730
MOD_CK1_1	263	269	PF00069	0.762
MOD_CK1_1	352	358	PF00069	0.739
MOD_CK1_1	61	67	PF00069	0.638
MOD_CK2_1	369	375	PF00069	0.683
MOD_CK2_1	97	103	PF00069	0.763
MOD_GlcNHglycan	127	130	PF01048	0.685
MOD_GlcNHglycan	135	138	PF01048	0.606
MOD_GlcNHglycan	177	180	PF01048	0.622
MOD_GlcNHglycan	244	247	PF01048	0.672
MOD_GlcNHglycan	262	265	PF01048	0.561
MOD_GlcNHglycan	290	293	PF01048	0.594
MOD_GlcNHglycan	355	358	PF01048	0.623
MOD_GlcNHglycan	367	370	PF01048	0.693
MOD_GlcNHglycan	60	63	PF01048	0.786
MOD_GSK3_1	145	152	PF00069	0.604
MOD_GSK3_1	175	182	PF00069	0.699
MOD_GSK3_1	234	241	PF00069	0.603
MOD_GSK3_1	274	281	PF00069	0.638
MOD_GSK3_1	315	322	PF00069	0.648
MOD_GSK3_1	349	356	PF00069	0.717
MOD_GSK3_1	365	372	PF00069	0.565
MOD_GSK3_1	52	59	PF00069	0.741
MOD_GSK3_1	61	68	PF00069	0.683
MOD_N-GLC_1	238	243	PF02516	0.610
MOD_N-GLC_1	362	367	PF02516	0.723
MOD_NEK2_1	133	138	PF00069	0.637
MOD_NEK2_1	274	279	PF00069	0.766
MOD_NEK2_1	339	344	PF00069	0.642
MOD_NEK2_1	66	71	PF00069	0.751
MOD_NEK2_2	62	67	PF00069	0.568
MOD_PIKK_1	278	284	PF00454	0.522
MOD_PKA_2	13	19	PF00069	0.530
MOD_PKA_2	131	137	PF00069	0.692
MOD_PKA_2	80	86	PF00069	0.747
MOD_PKB_1	253	261	PF00069	0.550
MOD_Plk_1	122	128	PF00069	0.707
MOD_Plk_4	145	151	PF00069	0.719
MOD_Plk_4	321	327	PF00069	0.562
MOD_Plk_4	62	68	PF00069	0.786
MOD_ProDKin_1	363	369	PF00069	0.607
MOD_SUMO_rev_2	249	256	PF00179	0.684
TRG_DiLeu_BaEn_1	373	378	PF01217	0.797
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.696
TRG_ENDOCYTIC_2	118	121	PF00928	0.717
TRG_ENDOCYTIC_2	26	29	PF00928	0.530
TRG_ENDOCYTIC_2	347	350	PF00928	0.650
TRG_ER_diArg_1	253	256	PF00400	0.580
TRG_ER_diArg_1	306	309	PF00400	0.616
TRG_ER_diArg_1	49	51	PF00400	0.715
TRG_Pf-PMV_PEXEL_1	185	190	PF00026	0.778
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.802

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WUS7	Leishmania donovani	86%	100%
A4H9C8	Leishmania braziliensis	62%	100%
A4HXQ0	Leishmania infantum	87%	100%
E9ARG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%