LeishMANIAdb
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DUF3849 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF3849 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QE17_LEIMA
TriTrypDb:
LmjF.18.0250 * , LMJLV39_180007900 * , LMJSD75_180007800 *
Length:
142

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE17
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 131 133 PF00675 0.588
CLV_NRD_NRD_1 15 17 PF00675 0.558
CLV_NRD_NRD_1 51 53 PF00675 0.564
CLV_PCSK_KEX2_1 131 133 PF00082 0.585
CLV_PCSK_KEX2_1 15 17 PF00082 0.558
CLV_PCSK_KEX2_1 51 53 PF00082 0.576
CLV_PCSK_KEX2_1 61 63 PF00082 0.646
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.649
CLV_PCSK_SKI1_1 103 107 PF00082 0.726
DOC_CYCLIN_yCln2_LP_2 82 88 PF00134 0.613
DOC_PP4_FxxP_1 110 113 PF00568 0.640
DOC_WW_Pin1_4 104 109 PF00397 0.660
DOC_WW_Pin1_4 65 70 PF00397 0.608
DOC_WW_Pin1_4 81 86 PF00397 0.491
LIG_Actin_WH2_2 35 53 PF00022 0.565
LIG_BRCT_BRCA1_1 106 110 PF00533 0.601
LIG_FHA_2 118 124 PF00498 0.710
LIG_LIR_Apic_2 107 113 PF02991 0.633
LIG_SH2_STAP1 126 130 PF00017 0.659
LIG_SH3_3 82 88 PF00018 0.571
LIG_TRAF2_1 113 116 PF00917 0.671
MOD_GlcNHglycan 42 45 PF01048 0.549
MOD_GSK3_1 40 47 PF00069 0.574
MOD_GSK3_1 76 83 PF00069 0.585
MOD_NEK2_1 76 81 PF00069 0.644
MOD_ProDKin_1 104 110 PF00069 0.656
MOD_ProDKin_1 65 71 PF00069 0.612
MOD_ProDKin_1 81 87 PF00069 0.485
TRG_DiLeu_BaEn_1 13 18 PF01217 0.537
TRG_ER_diArg_1 130 132 PF00400 0.570
TRG_ER_diArg_1 15 17 PF00400 0.562
TRG_ER_diArg_1 50 52 PF00400 0.566

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P7L2 Trypanosomatidae 47% 67%
A0A3Q8I9W5 Leishmania donovani 94% 100%
A0A3S5IS43 Trypanosoma rangeli 50% 98%
A4H9C9 Leishmania braziliensis 80% 100%
A4HXQ1 Leishmania infantum 94% 100%
E9ARG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS