Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE14_LEIMA

TriTrypDb:

LmjF.18.0280 , LMJLV39_180008200 , LMJSD75_180008100

Length:

683

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	445	449	PF00656	0.623
CLV_C14_Caspase3-7	476	480	PF00656	0.503
CLV_C14_Caspase3-7	515	519	PF00656	0.724
CLV_C14_Caspase3-7	600	604	PF00656	0.542
CLV_C14_Caspase3-7	663	667	PF00656	0.527
CLV_NRD_NRD_1	11	13	PF00675	0.635
CLV_NRD_NRD_1	157	159	PF00675	0.618
CLV_NRD_NRD_1	367	369	PF00675	0.621
CLV_NRD_NRD_1	563	565	PF00675	0.644
CLV_PCSK_KEX2_1	11	13	PF00082	0.635
CLV_PCSK_KEX2_1	367	369	PF00082	0.570
CLV_PCSK_KEX2_1	450	452	PF00082	0.641
CLV_PCSK_KEX2_1	562	564	PF00082	0.674
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.641
CLV_PCSK_SKI1_1	451	455	PF00082	0.555
CLV_PCSK_SKI1_1	458	462	PF00082	0.472
CLV_PCSK_SKI1_1	57	61	PF00082	0.613
CLV_PCSK_SKI1_1	668	672	PF00082	0.611
DEG_SPOP_SBC_1	315	319	PF00917	0.723
DOC_CDC14_PxL_1	189	197	PF14671	0.555
DOC_CKS1_1	361	366	PF01111	0.588
DOC_CKS1_1	433	438	PF01111	0.618
DOC_MAPK_DCC_7	562	571	PF00069	0.639
DOC_MAPK_gen_1	408	417	PF00069	0.605
DOC_MAPK_gen_1	450	456	PF00069	0.633
DOC_MAPK_gen_1	524	533	PF00069	0.506
DOC_MAPK_gen_1	562	571	PF00069	0.617
DOC_MAPK_HePTP_8	529	541	PF00069	0.563
DOC_MAPK_HePTP_8	559	571	PF00069	0.597
DOC_MAPK_HePTP_8	665	677	PF00069	0.540
DOC_MAPK_MEF2A_6	138	146	PF00069	0.552
DOC_MAPK_MEF2A_6	201	210	PF00069	0.548
DOC_MAPK_MEF2A_6	410	419	PF00069	0.587
DOC_MAPK_MEF2A_6	524	533	PF00069	0.471
DOC_MAPK_MEF2A_6	562	571	PF00069	0.652
DOC_MAPK_MEF2A_6	651	660	PF00069	0.514
DOC_MAPK_MEF2A_6	668	677	PF00069	0.597
DOC_MAPK_NFAT4_5	524	532	PF00069	0.543
DOC_PP2B_LxvP_1	470	473	PF13499	0.564
DOC_PP4_FxxP_1	464	467	PF00568	0.524
DOC_PP4_FxxP_1	520	523	PF00568	0.658
DOC_USP7_MATH_1	315	319	PF00917	0.727
DOC_USP7_MATH_1	501	505	PF00917	0.582
DOC_USP7_MATH_1	98	102	PF00917	0.711
DOC_USP7_UBL2_3	446	450	PF12436	0.678
DOC_WW_Pin1_4	116	121	PF00397	0.563
DOC_WW_Pin1_4	175	180	PF00397	0.632
DOC_WW_Pin1_4	360	365	PF00397	0.599
DOC_WW_Pin1_4	432	437	PF00397	0.596
DOC_WW_Pin1_4	438	443	PF00397	0.710
DOC_WW_Pin1_4	519	524	PF00397	0.541
LIG_14-3-3_CanoR_1	230	237	PF00244	0.473
LIG_14-3-3_CanoR_1	272	278	PF00244	0.703
LIG_14-3-3_CanoR_1	489	495	PF00244	0.507
LIG_14-3-3_CanoR_1	500	509	PF00244	0.533
LIG_14-3-3_CanoR_1	513	521	PF00244	0.513
LIG_14-3-3_CanoR_1	52	58	PF00244	0.653
LIG_14-3-3_CanoR_1	636	646	PF00244	0.579
LIG_Actin_WH2_2	257	274	PF00022	0.570
LIG_Actin_WH2_2	42	59	PF00022	0.612
LIG_APCC_ABBA_1	531	536	PF00400	0.487
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_4	371	375	PF00653	0.618
LIG_Clathr_ClatBox_1	325	329	PF01394	0.585
LIG_CSL_BTD_1	176	179	PF09270	0.631
LIG_FAT_LD_1	589	597	PF03623	0.374
LIG_FHA_1	102	108	PF00498	0.661
LIG_FHA_1	137	143	PF00498	0.465
LIG_FHA_1	229	235	PF00498	0.525
LIG_FHA_1	255	261	PF00498	0.489
LIG_FHA_1	272	278	PF00498	0.536
LIG_FHA_1	329	335	PF00498	0.510
LIG_FHA_1	433	439	PF00498	0.621
LIG_FHA_1	45	51	PF00498	0.610
LIG_FHA_1	467	473	PF00498	0.681
LIG_FHA_1	482	488	PF00498	0.481
LIG_FHA_1	490	496	PF00498	0.404
LIG_FHA_1	547	553	PF00498	0.528
LIG_FHA_1	669	675	PF00498	0.536
LIG_FHA_2	265	271	PF00498	0.556
LIG_FHA_2	322	328	PF00498	0.556
LIG_FHA_2	425	431	PF00498	0.490
LIG_FHA_2	491	497	PF00498	0.501
LIG_FHA_2	513	519	PF00498	0.726
LIG_FHA_2	643	649	PF00498	0.536
LIG_FHA_2	661	667	PF00498	0.407
LIG_GBD_Chelix_1	365	373	PF00786	0.593
LIG_Integrin_RGD_1	474	476	PF01839	0.569
LIG_LIR_Apic_2	518	523	PF02991	0.668
LIG_LIR_Gen_1	32	40	PF02991	0.659
LIG_LIR_Gen_1	413	424	PF02991	0.585
LIG_LIR_Gen_1	44	53	PF02991	0.482
LIG_LIR_Gen_1	492	502	PF02991	0.489
LIG_LIR_LC3C_4	469	472	PF02991	0.668
LIG_LIR_LC3C_4	536	539	PF02991	0.584
LIG_LIR_Nem_3	32	38	PF02991	0.642
LIG_LIR_Nem_3	413	419	PF02991	0.555
LIG_LIR_Nem_3	44	49	PF02991	0.644
LIG_LIR_Nem_3	492	497	PF02991	0.493
LIG_NRBOX	125	131	PF00104	0.437
LIG_PTB_Apo_2	197	204	PF02174	0.627
LIG_PTB_Apo_2	496	503	PF02174	0.506
LIG_PTB_Phospho_1	197	203	PF10480	0.628
LIG_SH2_SRC	676	679	PF00017	0.588
LIG_SH2_STAP1	89	93	PF00017	0.569
LIG_SH2_STAT3	356	359	PF00017	0.565
LIG_SH2_STAT3	588	591	PF00017	0.609
LIG_SH2_STAT5	356	359	PF00017	0.607
LIG_SH2_STAT5	382	385	PF00017	0.514
LIG_SH2_STAT5	416	419	PF00017	0.552
LIG_SH2_STAT5	551	554	PF00017	0.379
LIG_SH2_STAT5	588	591	PF00017	0.582
LIG_SH2_STAT5	676	679	PF00017	0.526
LIG_SH3_1	564	570	PF00018	0.570
LIG_SH3_2	120	125	PF14604	0.609
LIG_SH3_3	117	123	PF00018	0.582
LIG_SH3_3	141	147	PF00018	0.579
LIG_SH3_3	274	280	PF00018	0.623
LIG_SH3_3	329	335	PF00018	0.523
LIG_SH3_3	358	364	PF00018	0.573
LIG_SH3_3	430	436	PF00018	0.578
LIG_SH3_3	538	544	PF00018	0.452
LIG_SH3_3	564	570	PF00018	0.567
LIG_SH3_3	653	659	PF00018	0.466
LIG_SH3_4	446	453	PF00018	0.448
LIG_SUMO_SIM_anti_2	139	146	PF11976	0.550
LIG_SUMO_SIM_anti_2	492	499	PF11976	0.535
LIG_SUMO_SIM_par_1	273	278	PF11976	0.463
LIG_SUMO_SIM_par_1	324	331	PF11976	0.523
LIG_SUMO_SIM_par_1	573	580	PF11976	0.536
LIG_TYR_ITIM	674	679	PF00017	0.493
MOD_CDK_SPK_2	519	524	PF00069	0.545
MOD_CDK_SPxK_1	175	181	PF00069	0.663
MOD_CDK_SPxxK_3	360	367	PF00069	0.545
MOD_CDK_SPxxK_3	519	526	PF00069	0.531
MOD_CK1_1	101	107	PF00069	0.655
MOD_CK1_1	132	138	PF00069	0.577
MOD_CK1_1	163	169	PF00069	0.599
MOD_CK1_1	184	190	PF00069	0.641
MOD_CK1_1	239	245	PF00069	0.592
MOD_CK1_1	254	260	PF00069	0.452
MOD_CK1_1	289	295	PF00069	0.580
MOD_CK1_1	512	518	PF00069	0.619
MOD_CK1_1	522	528	PF00069	0.500
MOD_CK1_1	637	643	PF00069	0.531
MOD_CK1_1	647	653	PF00069	0.511
MOD_CK2_1	264	270	PF00069	0.551
MOD_CK2_1	321	327	PF00069	0.589
MOD_CK2_1	424	430	PF00069	0.410
MOD_CK2_1	438	444	PF00069	0.708
MOD_CK2_1	490	496	PF00069	0.512
MOD_CK2_1	642	648	PF00069	0.606
MOD_Cter_Amidation	560	563	PF01082	0.492
MOD_GlcNHglycan	1	4	PF01048	0.702
MOD_GlcNHglycan	126	129	PF01048	0.576
MOD_GlcNHglycan	132	135	PF01048	0.599
MOD_GlcNHglycan	238	241	PF01048	0.551
MOD_GlcNHglycan	248	251	PF01048	0.615
MOD_GlcNHglycan	277	280	PF01048	0.719
MOD_GlcNHglycan	290	294	PF01048	0.556
MOD_GlcNHglycan	338	341	PF01048	0.649
MOD_GlcNHglycan	80	83	PF01048	0.619
MOD_GSK3_1	124	131	PF00069	0.566
MOD_GSK3_1	132	139	PF00069	0.368
MOD_GSK3_1	159	166	PF00069	0.592
MOD_GSK3_1	251	258	PF00069	0.505
MOD_GSK3_1	271	278	PF00069	0.611
MOD_GSK3_1	315	322	PF00069	0.664
MOD_GSK3_1	402	409	PF00069	0.587
MOD_GSK3_1	438	445	PF00069	0.648
MOD_GSK3_1	44	51	PF00069	0.637
MOD_GSK3_1	481	488	PF00069	0.539
MOD_GSK3_1	508	515	PF00069	0.634
MOD_GSK3_1	622	629	PF00069	0.623
MOD_GSK3_1	69	76	PF00069	0.697
MOD_GSK3_1	98	105	PF00069	0.599
MOD_N-GLC_1	481	486	PF02516	0.607
MOD_NEK2_1	129	134	PF00069	0.642
MOD_NEK2_1	229	234	PF00069	0.489
MOD_NEK2_1	246	251	PF00069	0.499
MOD_NEK2_1	256	261	PF00069	0.510
MOD_NEK2_1	264	269	PF00069	0.441
MOD_NEK2_1	271	276	PF00069	0.538
MOD_NEK2_1	336	341	PF00069	0.544
MOD_NEK2_1	626	631	PF00069	0.609
MOD_NEK2_1	87	92	PF00069	0.553
MOD_PIKK_1	251	257	PF00454	0.411
MOD_PIKK_1	634	640	PF00454	0.406
MOD_PIKK_1	69	75	PF00454	0.665
MOD_PKA_2	124	130	PF00069	0.681
MOD_PKA_2	137	143	PF00069	0.449
MOD_PKA_2	229	235	PF00069	0.456
MOD_PKA_2	271	277	PF00069	0.587
MOD_PKA_2	51	57	PF00069	0.605
MOD_PKA_2	512	518	PF00069	0.670
MOD_Plk_1	212	218	PF00069	0.626
MOD_Plk_1	328	334	PF00069	0.522
MOD_Plk_1	481	487	PF00069	0.569
MOD_Plk_1	98	104	PF00069	0.649
MOD_Plk_4	102	108	PF00069	0.552
MOD_Plk_4	321	327	PF00069	0.567
MOD_Plk_4	466	472	PF00069	0.501
MOD_Plk_4	490	496	PF00069	0.469
MOD_ProDKin_1	116	122	PF00069	0.567
MOD_ProDKin_1	175	181	PF00069	0.637
MOD_ProDKin_1	360	366	PF00069	0.595
MOD_ProDKin_1	432	438	PF00069	0.606
MOD_ProDKin_1	519	525	PF00069	0.536
MOD_SUMO_for_1	59	62	PF00179	0.611
MOD_SUMO_for_1	93	96	PF00179	0.587
MOD_SUMO_rev_2	404	409	PF00179	0.509
MOD_SUMO_rev_2	441	447	PF00179	0.738
MOD_SUMO_rev_2	608	618	PF00179	0.712
TRG_DiLeu_BaEn_1	413	418	PF01217	0.517
TRG_DiLeu_BaEn_2	613	619	PF01217	0.630
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.600
TRG_DiLeu_BaLyEn_6	670	675	PF01217	0.573
TRG_ENDOCYTIC_2	203	206	PF00928	0.582
TRG_ENDOCYTIC_2	416	419	PF00928	0.517
TRG_ENDOCYTIC_2	676	679	PF00928	0.476
TRG_ER_diArg_1	10	12	PF00400	0.663
TRG_ER_diArg_1	367	369	PF00400	0.546
TRG_ER_diArg_1	562	564	PF00400	0.615
TRG_NES_CRM1_1	290	303	PF08389	0.567
TRG_NES_CRM1_1	48	62	PF08389	0.574
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	458	463	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	535	540	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ9	Leptomonas seymouri	54%	97%
A0A0S4JE75	Bodo saltans	25%	84%
A0A1X0P6Q4	Trypanosomatidae	31%	97%
A0A3Q8IJM4	Leishmania donovani	90%	97%
A0A3R7NYR2	Trypanosoma rangeli	34%	100%
A4H9D2	Leishmania braziliensis	73%	100%
A4HXQ4	Leishmania infantum	90%	97%
D0A034	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	97%
V5DMZ5	Trypanosoma cruzi	31%	100%