Dephospho-CoA kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dephospho-CoA kinase, putative

Species:

Leishmania major

UniProt:

Q4QE13_LEIMA

TriTrypDb:

LmjF.18.0290 , LMJLV39_180008300 , LMJSD75_180008200

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE13

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009152	purine ribonucleotide biosynthetic process	7	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0015936	coenzyme A metabolic process	6	11
GO:0015937	coenzyme A biosynthetic process	7	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033866	nucleoside bisphosphate biosynthetic process	6	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072522	purine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0016310	phosphorylation	5	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004140	dephospho-CoA kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.448
CLV_NRD_NRD_1	156	158	PF00675	0.412
CLV_NRD_NRD_1	279	281	PF00675	0.352
CLV_NRD_NRD_1	288	290	PF00675	0.357
CLV_NRD_NRD_1	328	330	PF00675	0.470
CLV_PCSK_KEX2_1	144	146	PF00082	0.489
CLV_PCSK_KEX2_1	156	158	PF00082	0.448
CLV_PCSK_KEX2_1	279	281	PF00082	0.322
CLV_PCSK_SKI1_1	144	148	PF00082	0.537
CLV_PCSK_SKI1_1	289	293	PF00082	0.360
DEG_APCC_DBOX_1	143	151	PF00400	0.466
DEG_MDM2_SWIB_1	324	332	PF02201	0.393
DEG_Nend_UBRbox_1	1	4	PF02207	0.559
DOC_CKS1_1	215	220	PF01111	0.579
DOC_MAPK_gen_1	144	152	PF00069	0.469
DOC_MAPK_gen_1	17	27	PF00069	0.390
DOC_MAPK_gen_1	279	287	PF00069	0.563
DOC_MAPK_gen_1	326	336	PF00069	0.477
DOC_MAPK_MEF2A_6	329	336	PF00069	0.525
DOC_PP1_RVXF_1	3	10	PF00149	0.531
DOC_PP2B_LxvP_1	103	106	PF13499	0.580
DOC_PP2B_LxvP_1	224	227	PF13499	0.574
DOC_PP4_MxPP_1	58	61	PF00568	0.526
DOC_USP7_MATH_1	213	217	PF00917	0.706
DOC_USP7_MATH_1	38	42	PF00917	0.743
DOC_USP7_MATH_1	62	66	PF00917	0.674
DOC_USP7_UBL2_3	22	26	PF12436	0.493
DOC_USP7_UBL2_3	39	43	PF12436	0.529
DOC_WW_Pin1_4	114	119	PF00397	0.777
DOC_WW_Pin1_4	201	206	PF00397	0.711
DOC_WW_Pin1_4	209	214	PF00397	0.669
DOC_WW_Pin1_4	255	260	PF00397	0.546
LIG_14-3-3_CanoR_1	128	135	PF00244	0.658
LIG_14-3-3_CanoR_1	279	287	PF00244	0.530
LIG_Clathr_ClatBox_1	231	235	PF01394	0.482
LIG_eIF4E_1	73	79	PF01652	0.513
LIG_FHA_1	117	123	PF00498	0.465
LIG_FHA_1	168	174	PF00498	0.528
LIG_FHA_1	241	247	PF00498	0.549
LIG_FHA_1	306	312	PF00498	0.470
LIG_FHA_1	45	51	PF00498	0.557
LIG_FHA_1	8	14	PF00498	0.404
LIG_FHA_1	98	104	PF00498	0.476
LIG_FHA_2	215	221	PF00498	0.690
LIG_FHA_2	259	265	PF00498	0.527
LIG_LIR_Apic_2	29	34	PF02991	0.391
LIG_LIR_Gen_1	175	184	PF02991	0.441
LIG_LIR_Nem_3	163	169	PF02991	0.499
LIG_LIR_Nem_3	175	180	PF02991	0.529
LIG_LIR_Nem_3	321	327	PF02991	0.374
LIG_LYPXL_yS_3	188	191	PF13949	0.605
LIG_PDZ_Class_2	331	336	PF00595	0.551
LIG_Pex14_2	324	328	PF04695	0.388
LIG_SH2_CRK	177	181	PF00017	0.525
LIG_SH2_CRK	92	96	PF00017	0.504
LIG_SH2_GRB2like	73	76	PF00017	0.497
LIG_SH2_NCK_1	177	181	PF00017	0.315
LIG_SH2_SRC	73	76	PF00017	0.476
LIG_SH2_SRC	84	87	PF00017	0.413
LIG_SH2_STAP1	177	181	PF00017	0.315
LIG_SH2_STAT5	168	171	PF00017	0.459
LIG_SH2_STAT5	73	76	PF00017	0.443
LIG_SH3_3	205	211	PF00018	0.754
LIG_SH3_3	212	218	PF00018	0.760
LIG_SH3_3	58	64	PF00018	0.707
LIG_SH3_3	83	89	PF00018	0.405
LIG_SUMO_SIM_par_1	230	235	PF11976	0.340
LIG_SUMO_SIM_par_1	243	251	PF11976	0.492
LIG_TRAF2_1	312	315	PF00917	0.478
MOD_CK1_1	15	21	PF00069	0.395
MOD_CK1_1	194	200	PF00069	0.750
MOD_CK1_1	209	215	PF00069	0.520
MOD_CK1_1	45	51	PF00069	0.724
MOD_CK1_1	54	60	PF00069	0.760
MOD_CK2_1	309	315	PF00069	0.473
MOD_GlcNHglycan	103	106	PF01048	0.573
MOD_GlcNHglycan	130	133	PF01048	0.667
MOD_GlcNHglycan	14	17	PF01048	0.401
MOD_GlcNHglycan	193	196	PF01048	0.715
MOD_GlcNHglycan	199	202	PF01048	0.742
MOD_GlcNHglycan	40	43	PF01048	0.752
MOD_GlcNHglycan	44	47	PF01048	0.729
MOD_GlcNHglycan	66	69	PF01048	0.629
MOD_GSK3_1	12	19	PF00069	0.386
MOD_GSK3_1	197	204	PF00069	0.769
MOD_GSK3_1	209	216	PF00069	0.750
MOD_GSK3_1	3	10	PF00069	0.412
MOD_GSK3_1	305	312	PF00069	0.431
MOD_GSK3_1	38	45	PF00069	0.617
MOD_GSK3_1	97	104	PF00069	0.458
MOD_NEK2_1	252	257	PF00069	0.519
MOD_NEK2_1	306	311	PF00069	0.522
MOD_NEK2_1	9	14	PF00069	0.426
MOD_PIKK_1	109	115	PF00454	0.761
MOD_PIKK_1	116	122	PF00454	0.675
MOD_PIKK_1	280	286	PF00454	0.502
MOD_PIKK_1	306	312	PF00454	0.537
MOD_Plk_1	306	312	PF00069	0.494
MOD_Plk_1	54	60	PF00069	0.662
MOD_ProDKin_1	114	120	PF00069	0.778
MOD_ProDKin_1	201	207	PF00069	0.713
MOD_ProDKin_1	209	215	PF00069	0.667
MOD_ProDKin_1	255	261	PF00069	0.546
MOD_SUMO_for_1	173	176	PF00179	0.540
MOD_SUMO_rev_2	283	292	PF00179	0.510
TRG_ENDOCYTIC_2	177	180	PF00928	0.522
TRG_ENDOCYTIC_2	181	184	PF00928	0.526
TRG_ENDOCYTIC_2	188	191	PF00928	0.524
TRG_ENDOCYTIC_2	91	94	PF00928	0.401
TRG_ER_diArg_1	144	146	PF00400	0.558
TRG_ER_diArg_1	156	158	PF00400	0.517
TRG_ER_diArg_1	279	281	PF00400	0.545
TRG_NLS_MonoExtN_4	326	333	PF00514	0.463
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I144	Leptomonas seymouri	52%	100%
A0A0S4JER7	Bodo saltans	32%	100%
A0A1X0P6Q6	Trypanosomatidae	32%	100%
A0A3R7MR11	Trypanosoma rangeli	32%	100%
A0A3S7WUR7	Leishmania donovani	93%	100%
A4H9D3	Leishmania braziliensis	75%	100%
A4HXQ5	Leishmania infantum	92%	100%
E9ARG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BRM4	Trypanosoma cruzi	29%	100%