NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE12_LEIMA

TriTrypDb:

LmjF.18.0300 , LMJLV39_180008400 , LMJSD75_180008300

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0005930	axoneme	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	5
GO:1990904	ribonucleoprotein complex	2	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	3
GO:0043229	intracellular organelle	3	3

Expansion

Sequence features

Q4QE12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.538
CLV_NRD_NRD_1	293	295	PF00675	0.622
CLV_NRD_NRD_1	349	351	PF00675	0.744
CLV_NRD_NRD_1	359	361	PF00675	0.634
CLV_PCSK_KEX2_1	291	293	PF00082	0.608
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.572
CLV_PCSK_SKI1_1	222	226	PF00082	0.688
CLV_PCSK_SKI1_1	362	366	PF00082	0.578
DEG_SPOP_SBC_1	245	249	PF00917	0.526
DEG_SPOP_SBC_1	263	267	PF00917	0.343
DEG_SPOP_SBC_1	78	82	PF00917	0.297
DOC_CKS1_1	35	40	PF01111	0.379
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.531
DOC_USP7_MATH_1	145	149	PF00917	0.659
DOC_USP7_MATH_1	230	234	PF00917	0.741
DOC_USP7_MATH_1	356	360	PF00917	0.639
DOC_USP7_MATH_1	79	83	PF00917	0.458
DOC_USP7_UBL2_3	218	222	PF12436	0.801
DOC_USP7_UBL2_3	240	244	PF12436	0.774
DOC_USP7_UBL2_3	361	365	PF12436	0.625
DOC_USP7_UBL2_3	86	90	PF12436	0.341
DOC_WW_Pin1_4	134	139	PF00397	0.565
DOC_WW_Pin1_4	228	233	PF00397	0.602
DOC_WW_Pin1_4	273	278	PF00397	0.510
DOC_WW_Pin1_4	34	39	PF00397	0.379
LIG_14-3-3_CanoR_1	4	10	PF00244	0.426
LIG_FHA_1	101	107	PF00498	0.300
LIG_FHA_1	113	119	PF00498	0.276
LIG_FHA_1	21	27	PF00498	0.324
LIG_FHA_2	22	28	PF00498	0.490
LIG_FHA_2	264	270	PF00498	0.408
LIG_LIR_Gen_1	124	132	PF02991	0.566
LIG_LIR_Gen_1	302	313	PF02991	0.418
LIG_LIR_Nem_3	124	128	PF02991	0.476
LIG_LIR_Nem_3	251	257	PF02991	0.431
LIG_LIR_Nem_3	302	308	PF02991	0.415
LIG_NRBOX	54	60	PF00104	0.341
LIG_PDZ_Class_2	361	366	PF00595	0.580
LIG_SH2_CRK	125	129	PF00017	0.539
LIG_SH2_CRK	22	26	PF00017	0.265
LIG_SH2_CRK	255	259	PF00017	0.361
LIG_SH2_NCK_1	125	129	PF00017	0.560
LIG_SH2_SRC	255	258	PF00017	0.423
LIG_SH2_STAP1	22	26	PF00017	0.265
LIG_SH2_STAP1	255	259	PF00017	0.361
LIG_SH2_STAT5	22	25	PF00017	0.292
LIG_SH2_STAT5	36	39	PF00017	0.365
LIG_SH3_2	142	147	PF14604	0.527
LIG_SH3_3	139	145	PF00018	0.519
LIG_SH3_3	23	29	PF00018	0.300
LIG_SH3_3	271	277	PF00018	0.459
LIG_SH3_4	240	247	PF00018	0.593
LIG_TRAF2_1	266	269	PF00917	0.461
LIG_TYR_ITIM	123	128	PF00017	0.499
LIG_TYR_ITIM	252	257	PF00017	0.392
MOD_CK1_1	233	239	PF00069	0.714
MOD_CK1_1	264	270	PF00069	0.355
MOD_CK1_1	57	63	PF00069	0.489
MOD_CK2_1	106	112	PF00069	0.281
MOD_CK2_1	182	188	PF00069	0.522
MOD_CK2_1	21	27	PF00069	0.452
MOD_CK2_1	262	268	PF00069	0.428
MOD_GlcNHglycan	125	128	PF01048	0.552
MOD_GlcNHglycan	147	150	PF01048	0.654
MOD_GlcNHglycan	232	235	PF01048	0.652
MOD_GlcNHglycan	345	348	PF01048	0.658
MOD_GlcNHglycan	38	41	PF01048	0.464
MOD_GlcNHglycan	81	84	PF01048	0.420
MOD_GlcNHglycan	94	97	PF01048	0.452
MOD_GSK3_1	112	119	PF00069	0.374
MOD_GSK3_1	244	251	PF00069	0.727
MOD_GSK3_1	297	304	PF00069	0.512
MOD_GSK3_1	30	37	PF00069	0.352
MOD_GSK3_1	53	60	PF00069	0.380
MOD_GSK3_1	92	99	PF00069	0.366
MOD_NEK2_1	123	128	PF00069	0.491
MOD_NEK2_1	201	206	PF00069	0.607
MOD_NEK2_1	58	63	PF00069	0.310
MOD_PIKK_1	96	102	PF00454	0.344
MOD_PKA_1	292	298	PF00069	0.523
MOD_PKA_2	206	212	PF00069	0.611
MOD_PKA_2	292	298	PF00069	0.616
MOD_PKA_2	3	9	PF00069	0.450
MOD_PKA_2	349	355	PF00069	0.596
MOD_Plk_1	53	59	PF00069	0.485
MOD_Plk_4	21	27	PF00069	0.320
MOD_Plk_4	248	254	PF00069	0.584
MOD_Plk_4	320	326	PF00069	0.429
MOD_Plk_4	5	11	PF00069	0.474
MOD_Plk_4	54	60	PF00069	0.433
MOD_ProDKin_1	134	140	PF00069	0.566
MOD_ProDKin_1	228	234	PF00069	0.603
MOD_ProDKin_1	273	279	PF00069	0.504
MOD_ProDKin_1	34	40	PF00069	0.379
MOD_SUMO_for_1	287	290	PF00179	0.550
MOD_SUMO_rev_2	264	271	PF00179	0.474
MOD_SUMO_rev_2	359	366	PF00179	0.553
TRG_DiLeu_BaEn_1	54	59	PF01217	0.393
TRG_ENDOCYTIC_2	125	128	PF00928	0.523
TRG_ENDOCYTIC_2	22	25	PF00928	0.245
TRG_ENDOCYTIC_2	254	257	PF00928	0.375
TRG_ER_diArg_1	292	294	PF00400	0.630
TRG_NLS_MonoExtN_4	222	229	PF00514	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH4	Leptomonas seymouri	51%	92%
A0A3S7WUR4	Leishmania donovani	85%	95%
A0A422NWQ6	Trypanosoma rangeli	28%	78%
A4H9D4	Leishmania braziliensis	67%	100%
A4HXQ6	Leishmania infantum	84%	95%
B6DTE9	Bodo saltans	25%	81%
D0A036	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	85%
E9ARG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	94%