DUF4379 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379), putative

Species:

Leishmania major

UniProt:

Q4QE10_LEIMA

TriTrypDb:

LmjF.18.0320 , LMJLV39_180008600 , LMJSD75_180008500

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE10

PDB structure(s): 7ane_at

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.199
CLV_NRD_NRD_1	229	231	PF00675	0.199
CLV_NRD_NRD_1	242	244	PF00675	0.199
CLV_NRD_NRD_1	361	363	PF00675	0.330
CLV_NRD_NRD_1	392	394	PF00675	0.365
CLV_NRD_NRD_1	94	96	PF00675	0.456
CLV_PCSK_FUR_1	92	96	PF00082	0.454
CLV_PCSK_KEX2_1	210	212	PF00082	0.295
CLV_PCSK_KEX2_1	229	231	PF00082	0.199
CLV_PCSK_KEX2_1	387	389	PF00082	0.378
CLV_PCSK_KEX2_1	391	393	PF00082	0.369
CLV_PCSK_KEX2_1	94	96	PF00082	0.456
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.295
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.378
CLV_PCSK_PC7_1	388	394	PF00082	0.367
CLV_PCSK_SKI1_1	94	98	PF00082	0.456
CLV_Separin_Metazoa	266	270	PF03568	0.324
DEG_APCC_DBOX_1	50	58	PF00400	0.442
DEG_SCF_FBW7_1	127	133	PF00400	0.467
DOC_CKS1_1	127	132	PF01111	0.469
DOC_MAPK_DCC_7	51	59	PF00069	0.441
DOC_MAPK_gen_1	210	218	PF00069	0.199
DOC_MAPK_MEF2A_6	112	120	PF00069	0.470
DOC_MAPK_MEF2A_6	211	220	PF00069	0.199
DOC_MAPK_MEF2A_6	269	277	PF00069	0.324
DOC_PP1_RVXF_1	179	186	PF00149	0.321
DOC_PP1_RVXF_1	227	234	PF00149	0.199
DOC_PP2B_LxvP_1	118	121	PF13499	0.468
DOC_PP2B_LxvP_1	86	89	PF13499	0.450
DOC_USP7_MATH_1	74	78	PF00917	0.455
DOC_WW_Pin1_4	126	131	PF00397	0.468
DOC_WW_Pin1_4	269	274	PF00397	0.341
DOC_WW_Pin1_4	45	50	PF00397	0.451
DOC_WW_Pin1_4	52	57	PF00397	0.437
LIG_14-3-3_CanoR_1	155	160	PF00244	0.313
LIG_14-3-3_CanoR_1	199	204	PF00244	0.284
LIG_14-3-3_CanoR_1	243	249	PF00244	0.199
LIG_14-3-3_CanoR_1	326	332	PF00244	0.199
LIG_14-3-3_CanoR_1	51	55	PF00244	0.446
LIG_14-3-3_CanoR_1	78	88	PF00244	0.455
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_BRCT_BRCA1_1	54	58	PF00533	0.437
LIG_FHA_1	1	7	PF00498	0.449
LIG_FHA_1	105	111	PF00498	0.483
LIG_FHA_1	140	146	PF00498	0.339
LIG_FHA_1	270	276	PF00498	0.332
LIG_FHA_1	38	44	PF00498	0.453
LIG_FHA_2	131	137	PF00498	0.451
LIG_HP1_1	273	277	PF01393	0.318
LIG_LIR_Gen_1	154	163	PF02991	0.307
LIG_LIR_Gen_1	55	66	PF02991	0.439
LIG_LIR_Nem_3	154	159	PF02991	0.315
LIG_LIR_Nem_3	167	172	PF02991	0.295
LIG_LIR_Nem_3	283	288	PF02991	0.199
LIG_LIR_Nem_3	367	373	PF02991	0.337
LIG_LIR_Nem_3	42	47	PF02991	0.456
LIG_LIR_Nem_3	55	61	PF02991	0.435
LIG_LIR_Nem_3	64	69	PF02991	0.443
LIG_PDZ_Class_2	392	397	PF00595	0.380
LIG_Pex14_1	233	237	PF04695	0.199
LIG_Pex14_2	306	310	PF04695	0.199
LIG_SH2_CRK	200	204	PF00017	0.274
LIG_SH2_GRB2like	169	172	PF00017	0.289
LIG_SH2_STAP1	16	20	PF00017	0.437
LIG_SH2_STAP1	200	204	PF00017	0.274
LIG_SH2_STAP1	263	267	PF00017	0.279
LIG_SH2_STAT5	16	19	PF00017	0.436
LIG_SH2_STAT5	169	172	PF00017	0.289
LIG_SH2_STAT5	370	373	PF00017	0.331
LIG_SH3_3	333	339	PF00018	0.199
LIG_SH3_3	64	70	PF00018	0.442
LIG_SUMO_SIM_par_1	2	9	PF11976	0.444
LIG_SUMO_SIM_par_1	272	279	PF11976	0.320
LIG_TRAF2_1	364	367	PF00917	0.339
LIG_TRAF2_1	5	8	PF00917	0.442
LIG_UBA3_1	284	293	PF00899	0.199
MOD_CDC14_SPxK_1	48	51	PF00782	0.446
MOD_CDK_SPK_2	126	131	PF00069	0.468
MOD_CDK_SPxK_1	45	51	PF00069	0.452
MOD_CK1_1	154	160	PF00069	0.312
MOD_CK1_1	247	253	PF00069	0.199
MOD_CK1_1	301	307	PF00069	0.199
MOD_CK1_1	82	88	PF00069	0.453
MOD_CK2_1	130	136	PF00069	0.459
MOD_CK2_1	199	205	PF00069	0.289
MOD_CK2_1	373	379	PF00069	0.331
MOD_Cter_Amidation	360	363	PF01082	0.318
MOD_Cter_Amidation	385	388	PF01082	0.404
MOD_GlcNHglycan	343	347	PF01048	0.199
MOD_GlcNHglycan	81	84	PF01048	0.454
MOD_GSK3_1	110	117	PF00069	0.471
MOD_GSK3_1	122	129	PF00069	0.468
MOD_GSK3_1	151	158	PF00069	0.324
MOD_GSK3_1	187	194	PF00069	0.288
MOD_GSK3_1	233	240	PF00069	0.199
MOD_GSK3_1	296	303	PF00069	0.199
MOD_GSK3_1	33	40	PF00069	0.449
MOD_GSK3_1	57	64	PF00069	0.443
MOD_GSK3_1	74	81	PF00069	0.456
MOD_N-GLC_1	110	115	PF02516	0.477
MOD_N-GLC_1	170	175	PF02516	0.289
MOD_N-GLC_1	244	249	PF02516	0.199
MOD_N-GLC_1	355	360	PF02516	0.298
MOD_N-GLC_2	126	128	PF02516	0.465
MOD_N-GLC_2	257	259	PF02516	0.199
MOD_NEK2_1	14	19	PF00069	0.436
MOD_NEK2_1	170	175	PF00069	0.289
MOD_NEK2_1	237	242	PF00069	0.199
MOD_NEK2_1	300	305	PF00069	0.199
MOD_NEK2_1	373	378	PF00069	0.328
MOD_NEK2_1	43	48	PF00069	0.458
MOD_NEK2_1	50	55	PF00069	0.448
MOD_NEK2_1	57	62	PF00069	0.443
MOD_NEK2_1	84	89	PF00069	0.451
MOD_NEK2_2	319	324	PF00069	0.199
MOD_PK_1	155	161	PF00069	0.309
MOD_PK_1	199	205	PF00069	0.289
MOD_PK_1	244	250	PF00069	0.199
MOD_PKA_2	130	136	PF00069	0.459
MOD_PKA_2	139	145	PF00069	0.353
MOD_PKA_2	154	160	PF00069	0.312
MOD_PKA_2	187	193	PF00069	0.287
MOD_PKA_2	198	204	PF00069	0.292
MOD_PKA_2	319	325	PF00069	0.199
MOD_PKA_2	339	345	PF00069	0.199
MOD_PKA_2	50	56	PF00069	0.440
MOD_Plk_1	110	116	PF00069	0.472
MOD_Plk_1	170	176	PF00069	0.288
MOD_Plk_1	244	250	PF00069	0.199
MOD_Plk_1	355	361	PF00069	0.300
MOD_Plk_1	373	379	PF00069	0.331
MOD_Plk_4	114	120	PF00069	0.468
MOD_Plk_4	130	136	PF00069	0.459
MOD_Plk_4	155	161	PF00069	0.309
MOD_Plk_4	164	170	PF00069	0.308
MOD_Plk_4	199	205	PF00069	0.289
MOD_Plk_4	61	67	PF00069	0.443
MOD_ProDKin_1	126	132	PF00069	0.468
MOD_ProDKin_1	269	275	PF00069	0.339
MOD_ProDKin_1	45	51	PF00069	0.452
MOD_ProDKin_1	52	58	PF00069	0.438
TRG_DiLeu_BaEn_4	366	372	PF01217	0.340
TRG_ENDOCYTIC_2	165	168	PF00928	0.320
TRG_ENDOCYTIC_2	200	203	PF00928	0.276
TRG_ENDOCYTIC_2	370	373	PF00928	0.331
TRG_ER_diArg_1	229	231	PF00400	0.199
TRG_ER_diArg_1	323	326	PF00400	0.199
TRG_ER_diArg_1	390	393	PF00400	0.368
TRG_ER_diArg_1	92	95	PF00400	0.455
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.199
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.457