J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QE09_LEIMA

TriTrypDb:

LmjF.18.0330 , LMJLV39_180008700 , LMJSD75_180008600

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 15
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15
GO:0031207	Sec62/Sec63 complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1

Expansion

Sequence features

Q4QE09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE09

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006613	cotranslational protein targeting to membrane	6	1
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	1
GO:0006620	post-translational protein targeting to endoplasmic reticulum membrane	6	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0045047	protein targeting to ER	6	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0070972	protein localization to endoplasmic reticulum	6	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0008320	protein transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022884	macromolecule transmembrane transporter activity	3	1
GO:0140318	protein transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.737
CLV_NRD_NRD_1	172	174	PF00675	0.636
CLV_NRD_NRD_1	216	218	PF00675	0.471
CLV_NRD_NRD_1	226	228	PF00675	0.463
CLV_NRD_NRD_1	73	75	PF00675	0.451
CLV_PCSK_KEX2_1	172	174	PF00082	0.636
CLV_PCSK_SKI1_1	12	16	PF00082	0.684
CLV_PCSK_SKI1_1	201	205	PF00082	0.332
DEG_APCC_DBOX_1	200	208	PF00400	0.372
DEG_APCC_DBOX_1	7	15	PF00400	0.654
DEG_MDM2_SWIB_1	189	196	PF02201	0.306
DEG_Nend_UBRbox_1	1	4	PF02207	0.547
DOC_MAPK_DCC_7	227	237	PF00069	0.633
DOC_MAPK_MEF2A_6	201	208	PF00069	0.297
DOC_MAPK_NFAT4_5	201	209	PF00069	0.298
DOC_PP1_RVXF_1	199	206	PF00149	0.364
DOC_PP4_MxPP_1	207	210	PF00568	0.467
DOC_SPAK_OSR1_1	188	192	PF12202	0.323
DOC_USP7_MATH_1	31	35	PF00917	0.600
DOC_USP7_MATH_1	81	85	PF00917	0.261
DOC_USP7_UBL2_3	214	218	PF12436	0.718
DOC_USP7_UBL2_3	62	66	PF12436	0.277
LIG_14-3-3_CanoR_1	12	21	PF00244	0.616
LIG_14-3-3_CanoR_1	236	243	PF00244	0.620
LIG_14-3-3_CanoR_1	43	51	PF00244	0.438
LIG_Actin_WH2_1	188	203	PF00022	0.413
LIG_Actin_WH2_2	174	190	PF00022	0.475
LIG_AP2alpha_2	155	157	PF02296	0.496
LIG_BIR_III_4	79	83	PF00653	0.246
LIG_EH_1	173	177	PF12763	0.456
LIG_FHA_1	13	19	PF00498	0.557
LIG_FHA_1	147	153	PF00498	0.453
LIG_FHA_1	33	39	PF00498	0.570
LIG_IBAR_NPY_1	49	51	PF08397	0.237
LIG_IRF3_LxIS_1	231	238	PF10401	0.571
LIG_LIR_Gen_1	139	147	PF02991	0.423
LIG_LIR_Gen_1	93	102	PF02991	0.295
LIG_LIR_Nem_3	139	143	PF02991	0.424
LIG_LIR_Nem_3	85	91	PF02991	0.269
LIG_LIR_Nem_3	93	98	PF02991	0.287
LIG_MAD2	70	78	PF02301	0.246
LIG_PDZ_Class_2	239	244	PF00595	0.625
LIG_Pex14_1	193	197	PF04695	0.266
LIG_Pex14_2	189	193	PF04695	0.344
LIG_Pex14_2	208	212	PF04695	0.655
LIG_SH2_CRK	51	55	PF00017	0.277
LIG_SH2_CRK	69	73	PF00017	0.277
LIG_SH2_NCK_1	21	25	PF00017	0.447
LIG_SH2_STAP1	140	144	PF00017	0.425
LIG_SH2_STAP1	21	25	PF00017	0.447
LIG_SH2_STAT5	128	131	PF00017	0.523
LIG_SH2_STAT5	51	54	PF00017	0.235
LIG_SH3_1	228	234	PF00018	0.655
LIG_SH3_1	75	81	PF00018	0.259
LIG_SH3_2	231	236	PF14604	0.678
LIG_SH3_3	226	232	PF00018	0.692
LIG_SH3_3	75	81	PF00018	0.259
LIG_SH3_4	214	221	PF00018	0.734
LIG_UBA3_1	204	211	PF00899	0.614
LIG_WW_3	219	223	PF00397	0.793
MOD_CK1_1	136	142	PF00069	0.440
MOD_Cter_Amidation	225	228	PF01082	0.499
MOD_GlcNHglycan	123	126	PF01048	0.748
MOD_GlcNHglycan	99	102	PF01048	0.644
MOD_GSK3_1	129	136	PF00069	0.531
MOD_NEK2_1	1	6	PF00069	0.550
MOD_NEK2_1	126	131	PF00069	0.444
MOD_NEK2_1	25	30	PF00069	0.608
MOD_PIKK_1	37	43	PF00454	0.522
MOD_PKA_2	1	7	PF00069	0.640
MOD_PKA_2	121	127	PF00069	0.452
MOD_PKA_2	235	241	PF00069	0.622
MOD_Plk_4	49	55	PF00069	0.238
MOD_SUMO_for_1	210	213	PF00179	0.639
MOD_SUMO_rev_2	61	68	PF00179	0.309
TRG_ENDOCYTIC_2	123	126	PF00928	0.448
TRG_ENDOCYTIC_2	140	143	PF00928	0.438
TRG_ENDOCYTIC_2	144	147	PF00928	0.434
TRG_ENDOCYTIC_2	51	54	PF00928	0.277
TRG_ENDOCYTIC_2	69	72	PF00928	0.293
TRG_ENDOCYTIC_2	95	98	PF00928	0.278
TRG_ER_diArg_1	171	173	PF00400	0.446
TRG_ER_diArg_1	224	227	PF00400	0.765

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA62	Leptomonas seymouri	75%	100%
A0A1X0NIB0	Trypanosomatidae	29%	100%
A0A1X0P719	Trypanosomatidae	63%	100%
A0A3Q8IAY4	Leishmania donovani	97%	100%
A0A3R7M6A3	Trypanosoma rangeli	61%	100%
A0A3S7X515	Leishmania donovani	28%	100%
A4H9D7	Leishmania braziliensis	85%	100%
A4HJV4	Leishmania braziliensis	28%	100%
A4HXQ8	Leishmania infantum	97%	100%
A4I7B6	Leishmania infantum	28%	100%
B6DTF2	Bodo saltans	62%	100%
D0A039	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9ARH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B2A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q5U7	Leishmania major	29%	100%