RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4475), putative

Species:

Leishmania major

UniProt:

Q4QE08_LEIMA

TriTrypDb:

LmjF.18.0340 , LMJLV39_180008800 , LMJSD75_180008700

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QE08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.484
CLV_NRD_NRD_1	246	248	PF00675	0.242
CLV_NRD_NRD_1	45	47	PF00675	0.615
CLV_PCSK_KEX2_1	183	185	PF00082	0.483
CLV_PCSK_KEX2_1	246	248	PF00082	0.388
CLV_PCSK_KEX2_1	367	369	PF00082	0.633
CLV_PCSK_KEX2_1	45	47	PF00082	0.615
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.624
CLV_PCSK_SKI1_1	384	388	PF00082	0.572
CLV_PCSK_SKI1_1	45	49	PF00082	0.505
DEG_APCC_KENBOX_2	49	53	PF00400	0.512
DEG_SPOP_SBC_1	302	306	PF00917	0.559
DOC_ANK_TNKS_1	245	252	PF00023	0.242
DOC_CKS1_1	170	175	PF01111	0.506
DOC_PP1_RVXF_1	54	60	PF00149	0.490
DOC_USP7_MATH_1	107	111	PF00917	0.650
DOC_WW_Pin1_4	100	105	PF00397	0.509
DOC_WW_Pin1_4	139	144	PF00397	0.441
DOC_WW_Pin1_4	169	174	PF00397	0.497
DOC_WW_Pin1_4	344	349	PF00397	0.636
LIG_14-3-3_CanoR_1	360	366	PF00244	0.571
LIG_deltaCOP1_diTrp_1	178	187	PF00928	0.445
LIG_deltaCOP1_diTrp_1	231	241	PF00928	0.449
LIG_FHA_2	170	176	PF00498	0.507
LIG_FHA_2	237	243	PF00498	0.314
LIG_FHA_2	24	30	PF00498	0.614
LIG_LIR_Apic_2	364	369	PF02991	0.559
LIG_LIR_Gen_1	222	233	PF02991	0.385
LIG_LIR_Gen_1	355	366	PF02991	0.595
LIG_LIR_Nem_3	222	228	PF02991	0.363
LIG_LIR_Nem_3	256	261	PF02991	0.315
LIG_LIR_Nem_3	285	291	PF02991	0.645
LIG_LIR_Nem_3	355	361	PF02991	0.614
LIG_NRP_CendR_1	387	389	PF00754	0.736
LIG_Pex14_2	221	225	PF04695	0.344
LIG_SH2_CRK	166	170	PF00017	0.500
LIG_SH2_CRK	258	262	PF00017	0.449
LIG_SH2_SRC	88	91	PF00017	0.403
LIG_SH2_STAT5	168	171	PF00017	0.356
LIG_SH2_STAT5	288	291	PF00017	0.638
LIG_SH2_STAT5	358	361	PF00017	0.517
LIG_SH2_STAT5	64	67	PF00017	0.367
LIG_SH3_1	167	173	PF00018	0.514
LIG_SH3_2	382	387	PF14604	0.627
LIG_SH3_3	167	173	PF00018	0.363
LIG_SH3_3	201	207	PF00018	0.465
LIG_SH3_3	379	385	PF00018	0.620
LIG_SUMO_SIM_par_1	172	178	PF11976	0.530
LIG_SUMO_SIM_par_1	351	357	PF11976	0.569
LIG_TYR_ITIM	86	91	PF00017	0.483
MOD_CDK_SPxK_1	100	106	PF00069	0.585
MOD_CK1_1	110	116	PF00069	0.665
MOD_CK1_1	136	142	PF00069	0.632
MOD_CK1_1	190	196	PF00069	0.385
MOD_CK1_1	219	225	PF00069	0.393
MOD_CK1_1	41	47	PF00069	0.475
MOD_CK2_1	169	175	PF00069	0.500
MOD_CK2_1	23	29	PF00069	0.625
MOD_CK2_1	236	242	PF00069	0.314
MOD_Cter_Amidation	244	247	PF01082	0.242
MOD_GlcNHglycan	110	113	PF01048	0.733
MOD_GlcNHglycan	191	195	PF01048	0.399
MOD_GlcNHglycan	218	221	PF01048	0.413
MOD_GlcNHglycan	222	225	PF01048	0.413
MOD_GlcNHglycan	283	287	PF01048	0.660
MOD_GlcNHglycan	295	298	PF01048	0.618
MOD_GlcNHglycan	312	315	PF01048	0.672
MOD_GlcNHglycan	336	339	PF01048	0.723
MOD_GlcNHglycan	75	78	PF01048	0.448
MOD_GSK3_1	138	145	PF00069	0.614
MOD_GSK3_1	216	223	PF00069	0.415
MOD_GSK3_1	236	243	PF00069	0.145
MOD_GSK3_1	303	310	PF00069	0.653
MOD_GSK3_1	8	15	PF00069	0.572
MOD_N-GLC_1	108	113	PF02516	0.708
MOD_NEK2_1	301	306	PF00069	0.744
MOD_NEK2_1	309	314	PF00069	0.782
MOD_NEK2_1	361	366	PF00069	0.570
MOD_OFUCOSY	156	163	PF10250	0.467
MOD_PIKK_1	8	14	PF00454	0.612
MOD_PKA_2	293	299	PF00069	0.638
MOD_PKA_2	321	327	PF00069	0.751
MOD_PKA_2	73	79	PF00069	0.559
MOD_Plk_1	274	280	PF00069	0.625
MOD_Plk_4	12	18	PF00069	0.605
MOD_Plk_4	236	242	PF00069	0.325
MOD_Plk_4	284	290	PF00069	0.640
MOD_Plk_4	361	367	PF00069	0.532
MOD_ProDKin_1	100	106	PF00069	0.523
MOD_ProDKin_1	139	145	PF00069	0.432
MOD_ProDKin_1	169	175	PF00069	0.500
MOD_ProDKin_1	344	350	PF00069	0.635
TRG_ENDOCYTIC_2	166	169	PF00928	0.474
TRG_ENDOCYTIC_2	258	261	PF00928	0.344
TRG_ENDOCYTIC_2	288	291	PF00928	0.638
TRG_ENDOCYTIC_2	358	361	PF00928	0.607
TRG_ENDOCYTIC_2	88	91	PF00928	0.493
TRG_ER_diArg_1	246	248	PF00400	0.242
TRG_ER_diArg_1	45	47	PF00400	0.620
TRG_ER_diArg_1	67	70	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P400	Leptomonas seymouri	60%	92%
A0A1X0P6R6	Trypanosomatidae	46%	100%
A0A3Q8IAW5	Leishmania donovani	96%	100%
A0A422NWL4	Trypanosoma rangeli	42%	100%
A4H9D8	Leishmania braziliensis	79%	86%
A4HXQ9	Leishmania infantum	96%	100%
B6DTF3	Bodo saltans	30%	100%
D0A041	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ARH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DN00	Trypanosoma cruzi	41%	100%