ATP12 chaperone family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP12 chaperone protein, putative

Species:

Leishmania major

UniProt:

Q4QE07_LEIMA

TriTrypDb:

LmjF.18.0350 , LMJLV39_180008900 , LMJSD75_180008800

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QE07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE07

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly	8	2
GO:0043461	proton-transporting ATP synthase complex assembly	7	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070071	proton-transporting two-sector ATPase complex assembly	6	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.410
CLV_NRD_NRD_1	13	15	PF00675	0.569
CLV_NRD_NRD_1	73	75	PF00675	0.304
CLV_PCSK_SKI1_1	195	199	PF00082	0.401
CLV_PCSK_SKI1_1	278	282	PF00082	0.506
CLV_PCSK_SKI1_1	74	78	PF00082	0.303
CLV_Separin_Metazoa	11	15	PF03568	0.561
CLV_Separin_Metazoa	290	294	PF03568	0.481
DEG_APCC_DBOX_1	194	202	PF00400	0.381
DEG_SCF_FBW7_1	184	191	PF00400	0.538
DOC_ANK_TNKS_1	176	183	PF00023	0.411
DOC_CKS1_1	128	133	PF01111	0.412
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.323
DOC_MAPK_gen_1	40	49	PF00069	0.488
DOC_MAPK_gen_1	77	87	PF00069	0.450
DOC_PP1_RVXF_1	46	52	PF00149	0.303
DOC_PP2B_LxvP_1	110	113	PF13499	0.303
DOC_PP2B_LxvP_1	221	224	PF13499	0.331
DOC_PP2B_LxvP_1	289	292	PF13499	0.543
DOC_PP2B_LxvP_1	85	88	PF13499	0.303
DOC_USP7_MATH_1	41	45	PF00917	0.626
DOC_USP7_MATH_1	78	82	PF00917	0.303
DOC_USP7_MATH_1	86	90	PF00917	0.303
DOC_WW_Pin1_4	127	132	PF00397	0.380
DOC_WW_Pin1_4	184	189	PF00397	0.505
LIG_14-3-3_CanoR_1	25	33	PF00244	0.573
LIG_14-3-3_CanoR_1	42	50	PF00244	0.531
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_FHA_1	102	108	PF00498	0.450
LIG_FHA_1	128	134	PF00498	0.412
LIG_FHA_1	216	222	PF00498	0.337
LIG_FHA_1	274	280	PF00498	0.349
LIG_IBAR_NPY_1	204	206	PF08397	0.326
LIG_PDZ_Class_3	299	304	PF00595	0.613
LIG_SH2_CRK	206	210	PF00017	0.329
LIG_SH2_STAP1	171	175	PF00017	0.492
LIG_SH2_STAT3	100	103	PF00017	0.319
LIG_SH2_STAT5	135	138	PF00017	0.298
LIG_SH2_STAT5	146	149	PF00017	0.300
LIG_SH3_3	229	235	PF00018	0.373
LIG_SH3_5	131	135	PF00018	0.303
LIG_SUMO_SIM_anti_2	53	58	PF11976	0.371
LIG_SUMO_SIM_par_1	223	229	PF11976	0.407
LIG_SUMO_SIM_par_1	230	236	PF11976	0.319
LIG_SUMO_SIM_par_1	55	61	PF11976	0.396
LIG_SUMO_SIM_par_1	81	90	PF11976	0.410
LIG_TRAF2_1	297	300	PF00917	0.680
LIG_WRC_WIRS_1	136	141	PF05994	0.290
MOD_CDK_SPK_2	127	132	PF00069	0.412
MOD_CK1_1	28	34	PF00069	0.593
MOD_CK2_1	245	251	PF00069	0.448
MOD_CK2_1	293	299	PF00069	0.659
MOD_Cter_Amidation	72	75	PF01082	0.303
MOD_GlcNHglycan	118	121	PF01048	0.330
MOD_GlcNHglycan	228	231	PF01048	0.515
MOD_GlcNHglycan	295	298	PF01048	0.650
MOD_GSK3_1	112	119	PF00069	0.298
MOD_GSK3_1	184	191	PF00069	0.538
MOD_GSK3_1	21	28	PF00069	0.555
MOD_GSK3_1	211	218	PF00069	0.452
MOD_N-GLC_1	20	25	PF02516	0.600
MOD_NEK2_1	211	216	PF00069	0.354
MOD_NEK2_1	217	222	PF00069	0.306
MOD_NEK2_1	35	40	PF00069	0.528
MOD_NEK2_1	79	84	PF00069	0.360
MOD_NEK2_2	135	140	PF00069	0.303
MOD_PIKK_1	79	85	PF00454	0.390
MOD_PKA_2	41	47	PF00069	0.546
MOD_Plk_1	21	27	PF00069	0.483
MOD_Plk_1	28	34	PF00069	0.499
MOD_Plk_1	35	41	PF00069	0.538
MOD_Plk_2-3	245	251	PF00069	0.545
MOD_Plk_4	135	141	PF00069	0.293
MOD_Plk_4	217	223	PF00069	0.331
MOD_Plk_4	28	34	PF00069	0.496
MOD_ProDKin_1	127	133	PF00069	0.380
MOD_ProDKin_1	184	190	PF00069	0.497
MOD_SUMO_rev_2	2	9	PF00179	0.388
TRG_ENDOCYTIC_2	206	209	PF00928	0.330
TRG_ENDOCYTIC_2	258	261	PF00928	0.395
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4E1	Leptomonas seymouri	87%	78%
A0A1X0P7M1	Trypanosomatidae	66%	78%
A0A3R7KUB6	Trypanosoma rangeli	65%	78%
A0A3S7WUT0	Leishmania donovani	97%	100%
A4H9D9	Leishmania braziliensis	92%	80%
A4HXR0	Leishmania infantum	97%	100%
B6DTF4	Bodo saltans	64%	80%
D0A042	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	80%
E9ARH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q1LZ96	Bos taurus	25%	100%
Q8N5M1	Homo sapiens	25%	100%
Q91YY4	Mus musculus	26%	100%
V5BRM9	Trypanosoma cruzi	64%	78%