Tubulin--tyrosine ligase-like protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin tyrosine ligase protein, putative

Species:

Leishmania major

UniProt:

Q4QE05_LEIMA

TriTrypDb:

LmjF.18.0370 , LMJLV39_180009100 , LMJSD75_180009000

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QE05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE05

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0018095	protein polyglutamylation	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018200	peptidyl-glutamic acid modification	6	2
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	2
GO:0005524	ATP binding	5	11
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2
GO:0016874	ligase activity	2	11
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0070739	protein-glutamic acid ligase activity	3	2
GO:0070740	tubulin-glutamic acid ligase activity	4	2
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.520
CLV_C14_Caspase3-7	421	425	PF00656	0.600
CLV_NRD_NRD_1	124	126	PF00675	0.243
CLV_NRD_NRD_1	157	159	PF00675	0.248
CLV_NRD_NRD_1	398	400	PF00675	0.406
CLV_NRD_NRD_1	4	6	PF00675	0.526
CLV_NRD_NRD_1	74	76	PF00675	0.229
CLV_PCSK_KEX2_1	124	126	PF00082	0.229
CLV_PCSK_KEX2_1	157	159	PF00082	0.287
CLV_PCSK_KEX2_1	398	400	PF00082	0.408
CLV_PCSK_KEX2_1	4	6	PF00082	0.526
CLV_PCSK_KEX2_1	84	86	PF00082	0.216
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.216
CLV_PCSK_SKI1_1	14	18	PF00082	0.359
CLV_PCSK_SKI1_1	142	146	PF00082	0.235
CLV_PCSK_SKI1_1	158	162	PF00082	0.279
CLV_PCSK_SKI1_1	304	308	PF00082	0.302
CLV_PCSK_SKI1_1	329	333	PF00082	0.329
CLV_PCSK_SKI1_1	336	340	PF00082	0.334
CLV_PCSK_SKI1_1	387	391	PF00082	0.261
CLV_PCSK_SKI1_1	427	431	PF00082	0.461
CLV_PCSK_SKI1_1	81	85	PF00082	0.229
DEG_APCC_DBOX_1	264	272	PF00400	0.443
DEG_Nend_UBRbox_2	1	3	PF02207	0.689
DOC_CYCLIN_RxL_1	326	333	PF00134	0.461
DOC_CYCLIN_yClb5_NLxxxL_5	298	307	PF00134	0.527
DOC_MAPK_gen_1	124	132	PF00069	0.429
DOC_MAPK_gen_1	233	241	PF00069	0.429
DOC_MAPK_gen_1	4	13	PF00069	0.434
DOC_MAPK_MEF2A_6	233	241	PF00069	0.445
DOC_PP2B_LxvP_1	440	443	PF13499	0.532
DOC_PP2B_LxvP_1	447	450	PF13499	0.504
DOC_PP4_FxxP_1	110	113	PF00568	0.443
DOC_PP4_MxPP_1	133	136	PF00568	0.429
DOC_USP7_MATH_1	367	371	PF00917	0.429
DOC_USP7_MATH_1	418	422	PF00917	0.521
DOC_USP7_MATH_1	44	48	PF00917	0.453
DOC_USP7_UBL2_3	134	138	PF12436	0.443
DOC_USP7_UBL2_3	285	289	PF12436	0.429
DOC_USP7_UBL2_3	84	88	PF12436	0.429
DOC_WW_Pin1_4	365	370	PF00397	0.429
DOC_WW_Pin1_4	372	377	PF00397	0.429
LIG_14-3-3_CanoR_1	265	269	PF00244	0.429
LIG_14-3-3_CanoR_1	329	335	PF00244	0.461
LIG_deltaCOP1_diTrp_1	155	160	PF00928	0.520
LIG_deltaCOP1_diTrp_1	36	43	PF00928	0.320
LIG_EH1_1	331	339	PF00400	0.485
LIG_FHA_1	107	113	PF00498	0.433
LIG_FHA_1	127	133	PF00498	0.528
LIG_FHA_1	248	254	PF00498	0.468
LIG_FHA_1	6	12	PF00498	0.531
LIG_FHA_2	18	24	PF00498	0.302
LIG_FHA_2	31	37	PF00498	0.353
LIG_FHA_2	373	379	PF00498	0.429
LIG_FHA_2	72	78	PF00498	0.429
LIG_LIR_Apic_2	109	113	PF02991	0.442
LIG_LIR_Apic_2	207	212	PF02991	0.461
LIG_LIR_Gen_1	256	266	PF02991	0.443
LIG_LIR_Gen_1	272	283	PF02991	0.455
LIG_LIR_Gen_1	388	395	PF02991	0.429
LIG_LIR_Gen_1	40	49	PF02991	0.322
LIG_LIR_Nem_3	104	108	PF02991	0.432
LIG_LIR_Nem_3	115	119	PF02991	0.440
LIG_LIR_Nem_3	245	249	PF02991	0.433
LIG_LIR_Nem_3	256	261	PF02991	0.482
LIG_LIR_Nem_3	272	278	PF02991	0.455
LIG_LIR_Nem_3	286	290	PF02991	0.429
LIG_LIR_Nem_3	36	42	PF02991	0.323
LIG_LIR_Nem_3	388	393	PF02991	0.429
LIG_LIR_Nem_3	51	56	PF02991	0.367
LIG_OCRL_FandH_1	159	171	PF00620	0.502
LIG_PCNA_PIPBox_1	325	334	PF02747	0.502
LIG_PCNA_yPIPBox_3	325	336	PF02747	0.502
LIG_Pex14_1	156	160	PF04695	0.429
LIG_Pex14_2	106	110	PF04695	0.443
LIG_Pex14_2	119	123	PF04695	0.443
LIG_Pex14_2	409	413	PF04695	0.338
LIG_Rb_pABgroove_1	384	392	PF01858	0.508
LIG_SH2_CRK	246	250	PF00017	0.429
LIG_SH2_CRK	53	57	PF00017	0.503
LIG_SH2_NCK_1	290	294	PF00017	0.485
LIG_SH2_PTP2	240	243	PF00017	0.429
LIG_SH2_PTP2	275	278	PF00017	0.520
LIG_SH2_SRC	275	278	PF00017	0.520
LIG_SH2_STAP1	235	239	PF00017	0.443
LIG_SH2_STAP1	350	354	PF00017	0.429
LIG_SH2_STAT3	218	221	PF00017	0.429
LIG_SH2_STAT5	166	169	PF00017	0.520
LIG_SH2_STAT5	218	221	PF00017	0.429
LIG_SH2_STAT5	223	226	PF00017	0.429
LIG_SH2_STAT5	240	243	PF00017	0.429
LIG_SH2_STAT5	275	278	PF00017	0.520
LIG_SH2_STAT5	290	293	PF00017	0.443
LIG_SH2_STAT5	433	436	PF00017	0.437
LIG_SH3_3	208	214	PF00018	0.479
LIG_SH3_4	134	141	PF00018	0.443
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.301
LIG_TRAF2_1	400	403	PF00917	0.540
LIG_UBA3_1	327	336	PF00899	0.434
LIG_WW_3	449	453	PF00397	0.426
MOD_CK1_1	148	154	PF00069	0.443
MOD_CK1_1	198	204	PF00069	0.550
MOD_CK2_1	30	36	PF00069	0.386
MOD_CK2_1	397	403	PF00069	0.426
MOD_CK2_1	454	460	PF00069	0.520
MOD_Cter_Amidation	231	234	PF01082	0.229
MOD_Cter_Amidation	396	399	PF01082	0.523
MOD_GlcNHglycan	169	172	PF01048	0.293
MOD_GlcNHglycan	188	191	PF01048	0.372
MOD_GlcNHglycan	200	203	PF01048	0.312
MOD_GlcNHglycan	293	296	PF01048	0.232
MOD_GlcNHglycan	312	315	PF01048	0.219
MOD_GlcNHglycan	399	402	PF01048	0.544
MOD_GSK3_1	30	37	PF00069	0.447
MOD_GSK3_1	365	372	PF00069	0.429
MOD_GSK3_1	425	432	PF00069	0.572
MOD_GSK3_1	452	459	PF00069	0.411
MOD_GSK3_1	71	78	PF00069	0.502
MOD_LATS_1	3	9	PF00433	0.607
MOD_N-GLC_1	365	370	PF02516	0.229
MOD_NEK2_1	145	150	PF00069	0.429
MOD_NEK2_1	167	172	PF00069	0.502
MOD_NEK2_1	17	22	PF00069	0.315
MOD_NEK2_1	242	247	PF00069	0.439
MOD_NEK2_1	253	258	PF00069	0.402
MOD_NEK2_1	307	312	PF00069	0.485
MOD_NEK2_1	362	367	PF00069	0.438
MOD_NEK2_1	429	434	PF00069	0.530
MOD_NEK2_2	204	209	PF00069	0.461
MOD_PIKK_1	148	154	PF00454	0.429
MOD_PIKK_1	442	448	PF00454	0.526
MOD_PKA_1	75	81	PF00069	0.502
MOD_PKA_2	17	23	PF00069	0.254
MOD_PKA_2	264	270	PF00069	0.429
MOD_PKA_2	3	9	PF00069	0.538
MOD_PKA_2	397	403	PF00069	0.426
MOD_Plk_1	271	277	PF00069	0.429
MOD_Plk_1	354	360	PF00069	0.502
MOD_Plk_1	44	50	PF00069	0.454
MOD_Plk_2-3	32	38	PF00069	0.435
MOD_Plk_4	126	132	PF00069	0.520
MOD_Plk_4	17	23	PF00069	0.325
MOD_Plk_4	204	210	PF00069	0.461
MOD_Plk_4	247	253	PF00069	0.485
MOD_Plk_4	271	277	PF00069	0.429
MOD_Plk_4	429	435	PF00069	0.388
MOD_Plk_4	44	50	PF00069	0.456
MOD_Plk_4	75	81	PF00069	0.502
MOD_ProDKin_1	365	371	PF00069	0.429
MOD_ProDKin_1	372	378	PF00069	0.429
MOD_SUMO_rev_2	155	162	PF00179	0.510
TRG_ENDOCYTIC_2	116	119	PF00928	0.429
TRG_ENDOCYTIC_2	240	243	PF00928	0.429
TRG_ENDOCYTIC_2	246	249	PF00928	0.429
TRG_ENDOCYTIC_2	275	278	PF00928	0.504
TRG_ENDOCYTIC_2	350	353	PF00928	0.429
TRG_ENDOCYTIC_2	53	56	PF00928	0.386
TRG_ER_diArg_1	123	125	PF00400	0.443
TRG_ER_diArg_1	156	158	PF00400	0.488
TRG_ER_diArg_1	25	28	PF00400	0.338
TRG_ER_diArg_1	4	7	PF00400	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P402	Leptomonas seymouri	84%	100%
A0A0N1I1A1	Leptomonas seymouri	23%	100%
A0A0N1IH77	Leptomonas seymouri	23%	83%
A0A0S4JEF0	Bodo saltans	39%	100%
A0A0S4KQK8	Bodo saltans	25%	71%
A0A1X0NFL2	Trypanosomatidae	21%	100%
A0A1X0NFU6	Trypanosomatidae	36%	88%
A0A1X0NZP1	Trypanosomatidae	36%	89%
A0A1X0P6A0	Trypanosomatidae	24%	70%
A0A1X0P705	Trypanosomatidae	65%	100%
A0A3R7MY56	Trypanosoma rangeli	66%	100%
A0A3S5IS28	Trypanosoma rangeli	25%	72%
A0A3S7WUU3	Leishmania donovani	93%	99%
A0A422N932	Trypanosoma rangeli	34%	100%
A0A422NPL9	Trypanosoma rangeli	25%	75%
A0A422P136	Trypanosoma rangeli	24%	71%
A2APC3	Mus musculus	47%	100%
A4H9E1	Leishmania braziliensis	90%	100%
A4HG29	Leishmania braziliensis	21%	91%
A4HH59	Leishmania braziliensis	22%	100%
A4HXR2	Leishmania infantum	98%	100%
A4Q9E4	Mus musculus	25%	86%
B6DTF7	Bodo saltans	64%	100%
C9ZI96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	68%
C9ZJM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZPR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	89%
C9ZR25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	73%
C9ZYH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	71%
D0A044	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9ARH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AZF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	97%
O95922	Homo sapiens	40%	100%
P38160	Sus scrofa	25%	100%
P38584	Bos taurus	25%	100%
P38585	Mus musculus	24%	100%
Q0VC71	Bos taurus	40%	100%
Q23SI8	Tetrahymena thermophila (strain SB210)	39%	100%
Q3SXZ7	Homo sapiens	43%	100%
Q3SZH6	Bos taurus	46%	100%
Q564U4	Caenorhabditis elegans	42%	100%
Q5PPI9	Rattus norvegicus	40%	100%
Q641W7	Rattus norvegicus	46%	100%
Q6ZVT0	Homo sapiens	24%	69%
Q8NG68	Homo sapiens	24%	100%
Q91V51	Mus musculus	40%	100%
Q9QXJ0	Rattus norvegicus	25%	100%
V5ARK1	Trypanosoma cruzi	24%	99%
V5BVF5	Trypanosoma cruzi	23%	72%
V5D711	Trypanosoma cruzi	23%	100%