Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QE01_LEIMA

TriTrypDb:

LmjF.18.0410 , LMJLV39_180009500 , LMJSD75_180009400

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QE01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QE01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.626
CLV_NRD_NRD_1	3	5	PF00675	0.597
CLV_PCSK_KEX2_1	140	142	PF00082	0.648
CLV_PCSK_KEX2_1	145	147	PF00082	0.691
CLV_PCSK_KEX2_1	3	5	PF00082	0.597
CLV_PCSK_KEX2_1	86	88	PF00082	0.614
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.648
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.691
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.629
CLV_PCSK_PC7_1	141	147	PF00082	0.599
CLV_PCSK_SKI1_1	101	105	PF00082	0.529
CLV_PCSK_SKI1_1	4	8	PF00082	0.646
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DEG_SCF_FBW7_1	187	194	PF00400	0.617
DOC_CKS1_1	188	193	PF01111	0.616
DOC_CKS1_1	48	53	PF01111	0.520
DOC_CYCLIN_RxL_1	1	10	PF00134	0.566
DOC_PP4_FxxP_1	48	51	PF00568	0.531
DOC_USP7_UBL2_3	145	149	PF12436	0.581
DOC_WW_Pin1_4	111	116	PF00397	0.636
DOC_WW_Pin1_4	187	192	PF00397	0.622
DOC_WW_Pin1_4	23	28	PF00397	0.534
DOC_WW_Pin1_4	47	52	PF00397	0.567
LIG_BRCT_BRCA1_1	157	161	PF00533	0.630
LIG_FHA_1	62	68	PF00498	0.582
LIG_FHA_2	47	53	PF00498	0.609
LIG_GSK3_LRP6_1	191	196	PF00069	0.506
LIG_LIR_Apic_2	47	51	PF02991	0.538
LIG_LIR_Gen_1	55	62	PF02991	0.559
LIG_LIR_Nem_3	55	60	PF02991	0.560
LIG_SH2_STAT5	162	165	PF00017	0.585
LIG_SH2_STAT5	181	184	PF00017	0.468
LIG_SH3_1	33	39	PF00018	0.482
LIG_SH3_2	195	200	PF14604	0.608
LIG_SH3_2	36	41	PF14604	0.541
LIG_SH3_3	189	195	PF00018	0.555
LIG_SH3_3	33	39	PF00018	0.502
LIG_SH3_5	152	156	PF00018	0.582
MOD_CDK_SPxxK_3	111	118	PF00069	0.622
MOD_CK1_1	89	95	PF00069	0.685
MOD_CK2_1	46	52	PF00069	0.597
MOD_CK2_1	73	79	PF00069	0.677
MOD_GlcNHglycan	76	79	PF01048	0.580
MOD_GlcNHglycan	88	91	PF01048	0.598
MOD_GlcNHglycan	9	12	PF01048	0.663
MOD_GSK3_1	187	194	PF00069	0.630
MOD_GSK3_1	69	76	PF00069	0.557
MOD_GSK3_1	82	89	PF00069	0.441
MOD_N-GLC_1	111	116	PF02516	0.602
MOD_NEK2_1	7	12	PF00069	0.642
MOD_PIKK_1	156	162	PF00454	0.629
MOD_PKA_1	86	92	PF00069	0.579
MOD_PKA_2	86	92	PF00069	0.518
MOD_ProDKin_1	111	117	PF00069	0.626
MOD_ProDKin_1	187	193	PF00069	0.624
MOD_ProDKin_1	23	29	PF00069	0.535
MOD_ProDKin_1	47	53	PF00069	0.574
TRG_ENDOCYTIC_2	45	48	PF00928	0.485
TRG_ER_diArg_1	2	4	PF00400	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC40	Leptomonas seymouri	64%	100%
A0A0S4JE60	Bodo saltans	31%	100%
A0A1X0P7T6	Trypanosomatidae	38%	100%
A0A3Q8I9X5	Leishmania donovani	94%	100%
A4H9E5	Leishmania braziliensis	83%	100%
A4HXR6	Leishmania infantum	93%	100%
D0A048	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	70%
E9ARH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%