Putative phosphatidic acid phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidic acid phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QDZ8_LEIMA

TriTrypDb:

LmjF.18.0440 , LMJLV39_180009800 , LMJSD75_180009700

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QDZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDZ8

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0006644	phospholipid metabolic process	4	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0019637	organophosphate metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044255	cellular lipid metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008195	phosphatidate phosphatase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	334	336	PF00675	0.277
CLV_NRD_NRD_1	91	93	PF00675	0.361
CLV_PCSK_KEX2_1	105	107	PF00082	0.459
CLV_PCSK_KEX2_1	334	336	PF00082	0.277
CLV_PCSK_KEX2_1	90	92	PF00082	0.365
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.417
CLV_PCSK_SKI1_1	241	245	PF00082	0.381
CLV_PCSK_SKI1_1	342	346	PF00082	0.245
DOC_CKS1_1	192	197	PF01111	0.700
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.390
DOC_MAPK_DCC_7	342	352	PF00069	0.390
DOC_MAPK_gen_1	331	340	PF00069	0.473
DOC_MAPK_MEF2A_6	241	250	PF00069	0.457
DOC_PP1_RVXF_1	302	308	PF00149	0.286
DOC_PP2B_LxvP_1	350	353	PF13499	0.390
DOC_PP2B_PxIxI_1	66	72	PF00149	0.281
DOC_SPAK_OSR1_1	11	15	PF12202	0.548
DOC_USP7_MATH_1	132	136	PF00917	0.661
DOC_USP7_MATH_1	157	161	PF00917	0.626
DOC_USP7_MATH_1	178	182	PF00917	0.683
DOC_USP7_MATH_1	215	219	PF00917	0.732
DOC_USP7_MATH_1	220	224	PF00917	0.682
DOC_USP7_MATH_1	56	60	PF00917	0.299
DOC_WW_Pin1_4	174	179	PF00397	0.724
DOC_WW_Pin1_4	191	196	PF00397	0.745
DOC_WW_Pin1_4	285	290	PF00397	0.297
LIG_14-3-3_CanoR_1	219	225	PF00244	0.726
LIG_14-3-3_CanoR_1	304	308	PF00244	0.277
LIG_14-3-3_CanoR_1	335	341	PF00244	0.532
LIG_14-3-3_CanoR_1	42	47	PF00244	0.325
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BIR_III_2	214	218	PF00653	0.686
LIG_BRCT_BRCA1_1	12	16	PF00533	0.428
LIG_BRCT_BRCA1_1	134	138	PF00533	0.619
LIG_BRCT_BRCA1_1	255	259	PF00533	0.390
LIG_BRCT_BRCA1_1	312	316	PF00533	0.332
LIG_BRCT_BRCA1_1	49	53	PF00533	0.382
LIG_FHA_1	230	236	PF00498	0.633
LIG_FHA_1	343	349	PF00498	0.470
LIG_FHA_1	394	400	PF00498	0.529
LIG_FHA_1	63	69	PF00498	0.336
LIG_FHA_2	197	203	PF00498	0.703
LIG_FHA_2	290	296	PF00498	0.297
LIG_LIR_Apic_2	45	49	PF02991	0.358
LIG_LIR_Apic_2	63	67	PF02991	0.318
LIG_LIR_Gen_1	232	238	PF02991	0.548
LIG_LIR_Gen_1	252	263	PF02991	0.315
LIG_LIR_Gen_1	295	300	PF02991	0.285
LIG_LIR_Gen_1	313	324	PF02991	0.260
LIG_LIR_Nem_3	13	18	PF02991	0.428
LIG_LIR_Nem_3	232	236	PF02991	0.563
LIG_LIR_Nem_3	252	258	PF02991	0.326
LIG_LIR_Nem_3	295	299	PF02991	0.256
LIG_LIR_Nem_3	313	319	PF02991	0.447
LIG_LIR_Nem_3	339	344	PF02991	0.573
LIG_MLH1_MIPbox_1	12	16	PF16413	0.428
LIG_OCRL_FandH_1	14	26	PF00620	0.294
LIG_Pex14_2	12	16	PF04695	0.532
LIG_Pex14_2	255	259	PF04695	0.340
LIG_PTB_Apo_2	281	288	PF02174	0.314
LIG_PTB_Phospho_1	281	287	PF10480	0.280
LIG_REV1ctd_RIR_1	13	21	PF16727	0.469
LIG_SH2_CRK	233	237	PF00017	0.541
LIG_SH2_STAT3	287	290	PF00017	0.280
LIG_SH2_STAT5	21	24	PF00017	0.314
LIG_SH2_STAT5	325	328	PF00017	0.314
LIG_SH2_STAT5	367	370	PF00017	0.297
LIG_SH2_STAT5	77	80	PF00017	0.354
LIG_SH3_3	172	178	PF00018	0.653
LIG_SH3_3	302	308	PF00018	0.262
MOD_CK1_1	139	145	PF00069	0.668
MOD_CK1_1	191	197	PF00069	0.667
MOD_CK1_1	206	212	PF00069	0.568
MOD_CK1_1	218	224	PF00069	0.700
MOD_CK1_1	288	294	PF00069	0.285
MOD_CK1_1	306	312	PF00069	0.434
MOD_CK1_1	336	342	PF00069	0.390
MOD_CK2_1	163	169	PF00069	0.526
MOD_CK2_1	196	202	PF00069	0.634
MOD_Cter_Amidation	88	91	PF01082	0.438
MOD_GlcNHglycan	208	211	PF01048	0.568
MOD_GlcNHglycan	222	225	PF01048	0.606
MOD_GlcNHglycan	264	267	PF01048	0.249
MOD_GlcNHglycan	308	311	PF01048	0.322
MOD_GlcNHglycan	316	319	PF01048	0.348
MOD_GlcNHglycan	335	338	PF01048	0.248
MOD_GlcNHglycan	374	377	PF01048	0.322
MOD_GlcNHglycan	380	383	PF01048	0.269
MOD_GlcNHglycan	408	411	PF01048	0.561
MOD_GSK3_1	132	139	PF00069	0.614
MOD_GSK3_1	163	170	PF00069	0.580
MOD_GSK3_1	174	181	PF00069	0.544
MOD_GSK3_1	249	256	PF00069	0.378
MOD_GSK3_1	285	292	PF00069	0.342
MOD_GSK3_1	306	313	PF00069	0.390
MOD_GSK3_1	56	63	PF00069	0.371
MOD_LATS_1	40	46	PF00433	0.362
MOD_NEK2_1	196	201	PF00069	0.605
MOD_NEK2_1	262	267	PF00069	0.324
MOD_NEK2_1	333	338	PF00069	0.338
MOD_NEK2_2	10	15	PF00069	0.344
MOD_PIKK_1	249	255	PF00454	0.293
MOD_PKA_2	10	16	PF00069	0.344
MOD_PKA_2	206	212	PF00069	0.629
MOD_PKA_2	218	224	PF00069	0.711
MOD_PKA_2	303	309	PF00069	0.314
MOD_PKA_2	333	339	PF00069	0.314
MOD_PKA_2	405	411	PF00069	0.482
MOD_Plk_1	56	62	PF00069	0.307
MOD_Plk_4	336	342	PF00069	0.511
MOD_Plk_4	386	392	PF00069	0.355
MOD_Plk_4	5	11	PF00069	0.417
MOD_ProDKin_1	174	180	PF00069	0.662
MOD_ProDKin_1	191	197	PF00069	0.690
MOD_ProDKin_1	285	291	PF00069	0.342
MOD_SUMO_rev_2	99	107	PF00179	0.524
TRG_DiLeu_BaEn_1	144	149	PF01217	0.536
TRG_DiLeu_BaEn_1	154	159	PF01217	0.660
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.532
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.318
TRG_ENDOCYTIC_2	233	236	PF00928	0.433
TRG_ER_diArg_1	273	276	PF00400	0.314
TRG_ER_diArg_1	333	335	PF00400	0.314
TRG_ER_diArg_1	90	92	PF00400	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I046	Leptomonas seymouri	46%	91%
A0A3S7WUU8	Leishmania donovani	79%	100%
A4H9E7	Leishmania braziliensis	53%	100%
A4H9F0	Leishmania braziliensis	53%	100%
A4HXR9	Leishmania infantum	79%	100%
E9ARI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%