Putative tubulin-specific chaperone

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-specific chaperone, putative

Species:

Leishmania major

UniProt:

Q4QDZ6_LEIMA

TriTrypDb:

LmjF.18.0460 , LMJLV39_180010000 , LMJSD75_180009900

Length:

232

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QDZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	111	113	PF00082	0.471
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.457
CLV_PCSK_SKI1_1	176	180	PF00082	0.283
DOC_CYCLIN_RxL_1	117	130	PF00134	0.493
DOC_MAPK_gen_1	117	126	PF00069	0.490
DOC_MAPK_MEF2A_6	181	190	PF00069	0.280
DOC_PP1_RVXF_1	64	71	PF00149	0.537
DOC_PP4_FxxP_1	190	193	PF00568	0.297
DOC_PP4_FxxP_1	39	42	PF00568	0.443
DOC_SPAK_OSR1_1	38	42	PF12202	0.531
LIG_14-3-3_CanoR_1	176	181	PF00244	0.286
LIG_BIR_II_1	1	5	PF00653	0.339
LIG_FHA_2	103	109	PF00498	0.498
LIG_FHA_2	138	144	PF00498	0.586
LIG_FHA_2	147	153	PF00498	0.534
LIG_LIR_Apic_2	189	193	PF02991	0.293
LIG_LIR_Apic_2	37	42	PF02991	0.443
LIG_LIR_Gen_1	205	213	PF02991	0.355
LIG_LIR_Gen_1	33	43	PF02991	0.488
LIG_LIR_Gen_1	91	99	PF02991	0.519
LIG_LIR_Nem_3	33	39	PF02991	0.488
LIG_LIR_Nem_3	91	96	PF02991	0.489
LIG_PCNA_yPIPBox_3	57	71	PF02747	0.394
LIG_SH2_CRK	213	217	PF00017	0.412
LIG_SH2_NCK_1	93	97	PF00017	0.628
LIG_SH2_SRC	93	96	PF00017	0.573
LIG_SH2_STAT5	173	176	PF00017	0.324
LIG_SH3_3	136	142	PF00018	0.658
LIG_SH3_3	213	219	PF00018	0.412
LIG_TRAF2_1	105	108	PF00917	0.557
LIG_TRAF2_1	228	231	PF00917	0.502
MOD_CK1_1	146	152	PF00069	0.545
MOD_CK1_1	197	203	PF00069	0.404
MOD_CK2_1	102	108	PF00069	0.446
MOD_CK2_1	202	208	PF00069	0.356
MOD_CK2_1	27	33	PF00069	0.505
MOD_CK2_1	94	100	PF00069	0.469
MOD_GlcNHglycan	10	13	PF01048	0.294
MOD_GSK3_1	6	13	PF00069	0.450
MOD_N-GLC_1	197	202	PF02516	0.404
MOD_NEK2_1	24	29	PF00069	0.512
MOD_PIKK_1	10	16	PF00454	0.506
MOD_Plk_1	143	149	PF00069	0.475
MOD_Plk_4	202	208	PF00069	0.356
MOD_SUMO_for_1	62	65	PF00179	0.509
MOD_SUMO_rev_2	49	58	PF00179	0.486
TRG_ENDOCYTIC_2	213	216	PF00928	0.280
TRG_ENDOCYTIC_2	36	39	PF00928	0.515
TRG_ENDOCYTIC_2	93	96	PF00928	0.562
TRG_ER_diArg_1	153	156	PF00400	0.343
TRG_NES_CRM1_1	29	44	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN4	Leptomonas seymouri	83%	100%
A0A0S4JE98	Bodo saltans	56%	100%
A0A1X0P6T3	Trypanosomatidae	59%	100%
A0A3Q8IJN5	Leishmania donovani	95%	100%
A0A422NJ66	Trypanosoma rangeli	56%	100%
A4H9F4	Leishmania braziliensis	88%	100%
A4HXS1	Leishmania infantum	95%	100%
D0A053	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ARI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q10235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	99%
Q20728	Caenorhabditis elegans	38%	100%
Q54Z01	Dictyostelium discoideum	32%	86%
Q5E951	Bos taurus	37%	95%
Q67Z52	Arabidopsis thaliana	34%	95%
Q99426	Homo sapiens	36%	95%
Q9D1E6	Mus musculus	36%	95%