Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paralyzed flagella protein 20

Species:

Leishmania major

UniProt:

Q4QDZ5_LEIMA

TriTrypDb:

LmjF.18.0470 , LMJLV39_180010100 , LMJSD75_180010000

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005840	ribosome	5	11
GO:0005930	axoneme	2	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

Q4QDZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDZ5

Function

Biological processes
Term	Name	Level	Count
GO:0001539	cilium or flagellum-dependent cell motility	3	2
GO:0003341	cilium movement	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2
GO:0048870	cell motility	2	2
GO:0060285	cilium-dependent cell motility	4	2
GO:0060294	cilium movement involved in cell motility	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	212	214	PF00675	0.573
CLV_NRD_NRD_1	268	270	PF00675	0.709
CLV_NRD_NRD_1	41	43	PF00675	0.625
CLV_NRD_NRD_1	539	541	PF00675	0.441
CLV_PCSK_KEX2_1	268	270	PF00082	0.739
CLV_PCSK_KEX2_1	41	43	PF00082	0.668
CLV_PCSK_KEX2_1	539	541	PF00082	0.441
CLV_PCSK_SKI1_1	172	176	PF00082	0.486
CLV_PCSK_SKI1_1	202	206	PF00082	0.441
CLV_PCSK_SKI1_1	404	408	PF00082	0.259
CLV_PCSK_SKI1_1	72	76	PF00082	0.530
DOC_CYCLIN_RxL_1	199	208	PF00134	0.484
DOC_MAPK_gen_1	200	207	PF00069	0.458
DOC_MAPK_gen_1	539	547	PF00069	0.415
DOC_PP2B_LxvP_1	50	53	PF13499	0.621
DOC_PP2B_LxvP_1	61	64	PF13499	0.584
DOC_PP4_FxxP_1	18	21	PF00568	0.649
DOC_PP4_FxxP_1	290	293	PF00568	0.579
DOC_USP7_MATH_1	251	255	PF00917	0.661
DOC_USP7_MATH_1	305	309	PF00917	0.714
DOC_USP7_MATH_1	342	346	PF00917	0.492
DOC_USP7_MATH_1	356	360	PF00917	0.414
DOC_USP7_MATH_1	374	378	PF00917	0.357
DOC_USP7_MATH_1	398	402	PF00917	0.459
DOC_USP7_MATH_1	518	522	PF00917	0.459
DOC_USP7_MATH_1	567	571	PF00917	0.423
DOC_USP7_MATH_1	594	598	PF00917	0.554
DOC_USP7_MATH_1	86	90	PF00917	0.554
DOC_WW_Pin1_4	17	22	PF00397	0.679
DOC_WW_Pin1_4	271	276	PF00397	0.787
DOC_WW_Pin1_4	322	327	PF00397	0.733
LIG_14-3-3_CanoR_1	157	164	PF00244	0.575
LIG_14-3-3_CanoR_1	269	275	PF00244	0.790
LIG_14-3-3_CanoR_1	3	10	PF00244	0.646
LIG_14-3-3_CanoR_1	365	370	PF00244	0.585
LIG_14-3-3_CanoR_1	41	45	PF00244	0.672
LIG_14-3-3_CanoR_1	415	421	PF00244	0.493
LIG_14-3-3_CanoR_1	459	463	PF00244	0.489
LIG_BIR_II_1	1	5	PF00653	0.658
LIG_BRCT_BRCA1_1	5	9	PF00533	0.649
LIG_BRCT_BRCA1_1	520	524	PF00533	0.494
LIG_BRCT_BRCA1_1	596	600	PF00533	0.529
LIG_BRCT_BRCA1_1	603	607	PF00533	0.488
LIG_Clathr_ClatBox_1	204	208	PF01394	0.465
LIG_Clathr_ClatBox_1	544	548	PF01394	0.522
LIG_deltaCOP1_diTrp_1	329	336	PF00928	0.561
LIG_deltaCOP1_diTrp_1	425	432	PF00928	0.442
LIG_FHA_1	116	122	PF00498	0.368
LIG_FHA_1	278	284	PF00498	0.690
LIG_FHA_1	338	344	PF00498	0.489
LIG_FHA_1	403	409	PF00498	0.459
LIG_FHA_1	422	428	PF00498	0.447
LIG_FHA_1	433	439	PF00498	0.416
LIG_FHA_1	445	451	PF00498	0.438
LIG_FHA_1	476	482	PF00498	0.447
LIG_FHA_1	5	11	PF00498	0.741
LIG_FHA_1	55	61	PF00498	0.688
LIG_FHA_1	572	578	PF00498	0.386
LIG_FHA_1	584	590	PF00498	0.289
LIG_FHA_1	597	603	PF00498	0.532
LIG_FHA_1	79	85	PF00498	0.536
LIG_FHA_1	97	103	PF00498	0.545
LIG_FHA_2	185	191	PF00498	0.461
LIG_FHA_2	3	9	PF00498	0.718
LIG_FHA_2	532	538	PF00498	0.455
LIG_LIR_Apic_2	288	293	PF02991	0.595
LIG_NRBOX	169	175	PF00104	0.531
LIG_PCNA_yPIPBox_3	162	174	PF02747	0.569
LIG_PDZ_Class_2	616	621	PF00595	0.489
LIG_PDZ_Wminus1_1	619	621	PF00595	0.489
LIG_Pex14_1	428	432	PF04695	0.459
LIG_Pex14_2	70	74	PF04695	0.490
LIG_Pex14_2	87	91	PF04695	0.492
LIG_RPA_C_Fungi	534	546	PF08784	0.504
LIG_SH3_1	297	303	PF00018	0.535
LIG_SH3_3	103	109	PF00018	0.738
LIG_SH3_3	239	245	PF00018	0.753
LIG_SH3_3	295	301	PF00018	0.622
LIG_SH3_3	347	353	PF00018	0.355
LIG_SH3_3	49	55	PF00018	0.586
LIG_SUMO_SIM_par_1	203	208	PF11976	0.463
LIG_SUMO_SIM_par_1	576	582	PF11976	0.406
LIG_UBA3_1	204	211	PF00899	0.448
MOD_CK1_1	2	8	PF00069	0.759
MOD_CK1_1	203	209	PF00069	0.550
MOD_CK1_1	260	266	PF00069	0.732
MOD_CK1_1	273	279	PF00069	0.597
MOD_CK1_1	421	427	PF00069	0.438
MOD_CK1_1	526	532	PF00069	0.466
MOD_CK1_1	570	576	PF00069	0.336
MOD_CK1_1	610	616	PF00069	0.331
MOD_CK2_1	184	190	PF00069	0.470
MOD_GlcNHglycan	259	262	PF01048	0.724
MOD_GlcNHglycan	309	312	PF01048	0.731
MOD_GlcNHglycan	356	359	PF01048	0.373
MOD_GlcNHglycan	376	379	PF01048	0.239
MOD_GlcNHglycan	400	403	PF01048	0.312
MOD_GlcNHglycan	420	423	PF01048	0.126
MOD_GlcNHglycan	440	443	PF01048	0.126
MOD_GlcNHglycan	484	487	PF01048	0.312
MOD_GlcNHglycan	609	612	PF01048	0.355
MOD_GlcNHglycan	94	97	PF01048	0.458
MOD_GSK3_1	140	147	PF00069	0.477
MOD_GSK3_1	17	24	PF00069	0.694
MOD_GSK3_1	184	191	PF00069	0.573
MOD_GSK3_1	253	260	PF00069	0.719
MOD_GSK3_1	273	280	PF00069	0.711
MOD_GSK3_1	301	308	PF00069	0.698
MOD_GSK3_1	316	323	PF00069	0.737
MOD_GSK3_1	337	344	PF00069	0.362
MOD_GSK3_1	356	363	PF00069	0.296
MOD_GSK3_1	36	43	PF00069	0.470
MOD_GSK3_1	364	371	PF00069	0.414
MOD_GSK3_1	379	386	PF00069	0.293
MOD_GSK3_1	392	399	PF00069	0.261
MOD_GSK3_1	4	11	PF00069	0.703
MOD_GSK3_1	496	503	PF00069	0.560
MOD_GSK3_1	519	526	PF00069	0.498
MOD_GSK3_1	567	574	PF00069	0.381
MOD_GSK3_1	609	616	PF00069	0.438
MOD_GSK3_1	92	99	PF00069	0.580
MOD_NEK2_1	1	6	PF00069	0.695
MOD_NEK2_1	188	193	PF00069	0.569
MOD_NEK2_1	257	262	PF00069	0.550
MOD_NEK2_1	341	346	PF00069	0.385
MOD_NEK2_1	396	401	PF00069	0.312
MOD_NEK2_1	40	45	PF00069	0.570
MOD_NEK2_1	411	416	PF00069	0.432
MOD_NEK2_1	432	437	PF00069	0.307
MOD_NEK2_1	438	443	PF00069	0.286
MOD_NEK2_1	444	449	PF00069	0.274
MOD_NEK2_1	480	485	PF00069	0.359
MOD_NEK2_1	607	612	PF00069	0.318
MOD_NEK2_1	80	85	PF00069	0.591
MOD_NEK2_2	402	407	PF00069	0.312
MOD_NEK2_2	458	463	PF00069	0.331
MOD_PIKK_1	140	146	PF00454	0.572
MOD_PIKK_1	245	251	PF00454	0.808
MOD_PIKK_1	526	532	PF00454	0.478
MOD_PKA_2	115	121	PF00069	0.586
MOD_PKA_2	140	146	PF00069	0.555
MOD_PKA_2	156	162	PF00069	0.471
MOD_PKA_2	168	174	PF00069	0.438
MOD_PKA_2	2	8	PF00069	0.642
MOD_PKA_2	364	370	PF00069	0.430
MOD_PKA_2	392	398	PF00069	0.424
MOD_PKA_2	40	46	PF00069	0.685
MOD_PKA_2	458	464	PF00069	0.355
MOD_Plk_1	331	337	PF00069	0.457
MOD_Plk_1	402	408	PF00069	0.312
MOD_Plk_1	570	576	PF00069	0.329
MOD_Plk_1	613	619	PF00069	0.385
MOD_Plk_4	200	206	PF00069	0.480
MOD_Plk_4	331	337	PF00069	0.348
MOD_Plk_4	392	398	PF00069	0.317
MOD_Plk_4	470	476	PF00069	0.457
MOD_Plk_4	519	525	PF00069	0.471
MOD_Plk_4	531	537	PF00069	0.455
MOD_ProDKin_1	17	23	PF00069	0.682
MOD_ProDKin_1	271	277	PF00069	0.786
MOD_ProDKin_1	322	328	PF00069	0.722
TRG_DiLeu_BaEn_2	285	291	PF01217	0.738
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.568
TRG_ER_diArg_1	40	42	PF00400	0.595
TRG_ER_diArg_1	539	541	PF00400	0.441
TRG_NES_CRM1_1	36	49	PF08389	0.680
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN2	Leptomonas seymouri	70%	97%
A0A0S4JA64	Bodo saltans	45%	100%
A0A1X0P716	Trypanosomatidae	52%	100%
A0A3R7NP23	Trypanosoma rangeli	51%	100%
A0A3S7WR72	Leishmania donovani	31%	100%
A0A3S7WUV4	Leishmania donovani	94%	100%
A4H666	Leishmania braziliensis	29%	100%
A4H9F5	Leishmania braziliensis	83%	100%
A4HL42	Leishmania braziliensis	23%	100%
A4HUJ0	Leishmania infantum	31%	100%
A4HXS2	Leishmania infantum	95%	100%
B6Q4Z5	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	25%	94%
B8NGT5	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	24%	88%
D0A054	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ARI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P93107	Chlamydomonas reinhardtii	33%	100%
Q2UFN8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	88%
Q4QHD6	Leishmania major	30%	100%
Q8K450	Mus musculus	32%	97%
Q8N0X2	Homo sapiens	33%	98%
Q9P7I3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	95%