BTB_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QDZ3_LEIMA

TriTrypDb:

LmjF.18.0490 , LMJLV39_180010300 , LMJSD75_180010200

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDZ3

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043933	protein-containing complex organization	4	7
GO:0051259	protein complex oligomerization	6	7
GO:0051260	protein homooligomerization	7	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.609
CLV_NRD_NRD_1	242	244	PF00675	0.501
CLV_NRD_NRD_1	36	38	PF00675	0.315
CLV_PCSK_KEX2_1	126	128	PF00082	0.457
CLV_PCSK_KEX2_1	242	244	PF00082	0.501
CLV_PCSK_KEX2_1	36	38	PF00082	0.315
CLV_PCSK_SKI1_1	184	188	PF00082	0.689
CLV_PCSK_SKI1_1	243	247	PF00082	0.483
CLV_PCSK_SKI1_1	279	283	PF00082	0.390
CLV_PCSK_SKI1_1	41	45	PF00082	0.395
DEG_APCC_DBOX_1	36	44	PF00400	0.315
DOC_CYCLIN_RxL_1	276	283	PF00134	0.408
DOC_MAPK_DCC_7	226	236	PF00069	0.429
DOC_MAPK_gen_1	277	284	PF00069	0.477
DOC_MAPK_MEF2A_6	277	284	PF00069	0.477
DOC_PP1_RVXF_1	240	247	PF00149	0.520
DOC_PP2B_LxvP_1	282	285	PF13499	0.400
DOC_PP2B_LxvP_1	86	89	PF13499	0.315
DOC_PP4_FxxP_1	169	172	PF00568	0.535
DOC_USP7_MATH_1	139	143	PF00917	0.483
DOC_USP7_MATH_1	206	210	PF00917	0.682
DOC_USP7_MATH_1	213	217	PF00917	0.589
DOC_USP7_MATH_1	221	225	PF00917	0.464
LIG_14-3-3_CanoR_1	208	215	PF00244	0.652
LIG_14-3-3_CanoR_1	279	285	PF00244	0.399
LIG_14-3-3_CanoR_1	36	41	PF00244	0.395
LIG_14-3-3_CanoR_1	85	89	PF00244	0.345
LIG_APCC_ABBAyCdc20_2	242	248	PF00400	0.525
LIG_BIR_II_1	1	5	PF00653	0.460
LIG_CSL_BTD_1	135	138	PF09270	0.378
LIG_FHA_1	189	195	PF00498	0.682
LIG_FHA_1	247	253	PF00498	0.500
LIG_FHA_1	258	264	PF00498	0.331
LIG_FHA_2	37	43	PF00498	0.395
LIG_LIR_Apic_2	167	172	PF02991	0.510
LIG_LIR_Gen_1	94	102	PF02991	0.502
LIG_LIR_Nem_3	101	107	PF02991	0.356
LIG_LIR_Nem_3	72	77	PF02991	0.319
LIG_LIR_Nem_3	94	98	PF02991	0.354
LIG_SH2_NCK_1	105	109	PF00017	0.395
LIG_SH2_SRC	76	79	PF00017	0.383
LIG_SH2_STAT5	134	137	PF00017	0.405
LIG_SH2_STAT5	33	36	PF00017	0.315
LIG_SH2_STAT5	38	41	PF00017	0.315
LIG_SH2_STAT5	76	79	PF00017	0.315
LIG_SH2_STAT5	80	83	PF00017	0.315
LIG_SH3_1	226	232	PF00018	0.430
LIG_SH3_3	132	138	PF00018	0.382
LIG_SH3_3	158	164	PF00018	0.683
LIG_SH3_3	226	232	PF00018	0.614
LIG_SUMO_SIM_par_1	259	264	PF11976	0.513
LIG_TYR_ITIM	102	107	PF00017	0.395
LIG_WW_2	229	232	PF00397	0.549
MOD_CK1_1	216	222	PF00069	0.586
MOD_CK2_1	139	145	PF00069	0.502
MOD_CK2_1	36	42	PF00069	0.395
MOD_CK2_1	84	90	PF00069	0.247
MOD_Cter_Amidation	240	243	PF01082	0.516
MOD_GlcNHglycan	1	4	PF01048	0.495
MOD_GlcNHglycan	175	178	PF01048	0.546
MOD_GlcNHglycan	209	212	PF01048	0.756
MOD_GlcNHglycan	219	222	PF01048	0.658
MOD_GlcNHglycan	239	242	PF01048	0.352
MOD_GSK3_1	171	178	PF00069	0.645
MOD_GSK3_1	184	191	PF00069	0.545
MOD_GSK3_1	213	220	PF00069	0.693
MOD_GSK3_1	232	239	PF00069	0.408
MOD_GSK3_1	257	264	PF00069	0.490
MOD_GSK3_1	28	35	PF00069	0.415
MOD_NEK2_1	110	115	PF00069	0.461
MOD_NEK2_1	120	125	PF00069	0.380
MOD_NEK2_1	246	251	PF00069	0.447
MOD_NEK2_1	32	37	PF00069	0.315
MOD_NEK2_1	8	13	PF00069	0.461
MOD_NEK2_2	221	226	PF00069	0.397
MOD_PIKK_1	139	145	PF00454	0.440
MOD_PIKK_1	246	252	PF00454	0.435
MOD_PKA_1	36	42	PF00069	0.395
MOD_PKA_2	207	213	PF00069	0.637
MOD_PKA_2	246	252	PF00069	0.435
MOD_PKA_2	36	42	PF00069	0.395
MOD_PKA_2	84	90	PF00069	0.345
MOD_Plk_1	110	116	PF00069	0.467
MOD_Plk_4	110	116	PF00069	0.467
MOD_Plk_4	120	126	PF00069	0.380
MOD_Plk_4	164	170	PF00069	0.584
MOD_Plk_4	257	263	PF00069	0.374
MOD_Plk_4	28	34	PF00069	0.428
MOD_Plk_4	3	9	PF00069	0.450
MOD_Plk_4	61	67	PF00069	0.315
MOD_Plk_4	69	75	PF00069	0.315
TRG_DiLeu_BaEn_1	94	99	PF01217	0.350
TRG_DiLeu_BaEn_2	60	66	PF01217	0.315
TRG_ENDOCYTIC_2	104	107	PF00928	0.395
TRG_ER_diArg_1	125	127	PF00400	0.526
TRG_ER_diArg_1	242	244	PF00400	0.501
TRG_ER_diArg_1	277	280	PF00400	0.594
TRG_ER_diArg_1	36	38	PF00400	0.395
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.345

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z1	Leptomonas seymouri	56%	100%
A0A3S5H729	Leishmania donovani	92%	100%
A4H9F7	Leishmania braziliensis	78%	98%
A4HXS4	Leishmania infantum	92%	100%
E9ARI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%