Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDZ0_LEIMA

TriTrypDb:

LmjF.18.0520 , LMJLV39_180010600 , LMJSD75_180010500

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDZ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.811
CLV_C14_Caspase3-7	249	253	PF00656	0.773
CLV_C14_Caspase3-7	7	11	PF00656	0.763
CLV_NRD_NRD_1	118	120	PF00675	0.809
CLV_NRD_NRD_1	26	28	PF00675	0.647
CLV_NRD_NRD_1	371	373	PF00675	0.657
CLV_NRD_NRD_1	374	376	PF00675	0.615
CLV_NRD_NRD_1	44	46	PF00675	0.744
CLV_NRD_NRD_1	483	485	PF00675	0.552
CLV_NRD_NRD_1	508	510	PF00675	0.665
CLV_NRD_NRD_1	554	556	PF00675	0.605
CLV_NRD_NRD_1	602	604	PF00675	0.521
CLV_PCSK_FUR_1	170	174	PF00082	0.640
CLV_PCSK_FUR_1	372	376	PF00082	0.666
CLV_PCSK_KEX2_1	172	174	PF00082	0.810
CLV_PCSK_KEX2_1	26	28	PF00082	0.647
CLV_PCSK_KEX2_1	373	375	PF00082	0.663
CLV_PCSK_KEX2_1	44	46	PF00082	0.744
CLV_PCSK_KEX2_1	483	485	PF00082	0.552
CLV_PCSK_KEX2_1	508	510	PF00082	0.665
CLV_PCSK_KEX2_1	601	603	PF00082	0.525
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.798
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.663
CLV_PCSK_SKI1_1	228	232	PF00082	0.869
CLV_PCSK_SKI1_1	39	43	PF00082	0.772
CLV_PCSK_SKI1_1	390	394	PF00082	0.671
CLV_PCSK_SKI1_1	484	488	PF00082	0.533
CLV_PCSK_SKI1_1	555	559	PF00082	0.523
CLV_Separin_Metazoa	492	496	PF03568	0.662
DEG_APCC_DBOX_1	483	491	PF00400	0.691
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DEG_SPOP_SBC_1	165	169	PF00917	0.800
DEG_SPOP_SBC_1	205	209	PF00917	0.794
DEG_SPOP_SBC_1	296	300	PF00917	0.756
DEG_SPOP_SBC_1	407	411	PF00917	0.597
DEG_SPOP_SBC_1	542	546	PF00917	0.667
DOC_CKS1_1	415	420	PF01111	0.615
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.751
DOC_CYCLIN_yCln2_LP_2	536	542	PF00134	0.817
DOC_MAPK_gen_1	513	521	PF00069	0.599
DOC_MAPK_gen_1	601	610	PF00069	0.518
DOC_PP2B_LxvP_1	536	539	PF13499	0.820
DOC_USP7_MATH_1	11	15	PF00917	0.782
DOC_USP7_MATH_1	153	157	PF00917	0.731
DOC_USP7_MATH_1	165	169	PF00917	0.797
DOC_USP7_MATH_1	206	210	PF00917	0.768
DOC_USP7_MATH_1	213	217	PF00917	0.656
DOC_USP7_MATH_1	226	230	PF00917	0.547
DOC_USP7_MATH_1	278	282	PF00917	0.801
DOC_USP7_MATH_1	295	299	PF00917	0.566
DOC_USP7_MATH_1	34	38	PF00917	0.789
DOC_USP7_MATH_1	432	436	PF00917	0.706
DOC_USP7_MATH_1	443	447	PF00917	0.536
DOC_USP7_MATH_1	80	84	PF00917	0.765
DOC_USP7_MATH_2	547	553	PF00917	0.642
DOC_USP7_UBL2_3	172	176	PF12436	0.804
DOC_WW_Pin1_4	179	184	PF00397	0.793
DOC_WW_Pin1_4	187	192	PF00397	0.739
DOC_WW_Pin1_4	194	199	PF00397	0.635
DOC_WW_Pin1_4	201	206	PF00397	0.626
DOC_WW_Pin1_4	219	224	PF00397	0.571
DOC_WW_Pin1_4	240	245	PF00397	0.849
DOC_WW_Pin1_4	297	302	PF00397	0.756
DOC_WW_Pin1_4	414	419	PF00397	0.664
DOC_WW_Pin1_4	543	548	PF00397	0.744
DOC_WW_Pin1_4	60	65	PF00397	0.812
DOC_WW_Pin1_4	72	77	PF00397	0.608
LIG_14-3-3_CanoR_1	110	116	PF00244	0.803
LIG_14-3-3_CanoR_1	199	205	PF00244	0.770
LIG_14-3-3_CanoR_1	346	353	PF00244	0.641
LIG_14-3-3_CanoR_1	44	49	PF00244	0.789
LIG_14-3-3_CanoR_1	464	472	PF00244	0.687
LIG_14-3-3_CanoR_1	601	611	PF00244	0.518
LIG_Actin_WH2_2	450	468	PF00022	0.670
LIG_Actin_WH2_2	490	507	PF00022	0.596
LIG_APCC_ABBA_1	263	268	PF00400	0.795
LIG_CaM_IQ_9	497	512	PF13499	0.653
LIG_eIF4E_1	250	256	PF01652	0.757
LIG_FHA_1	246	252	PF00498	0.682
LIG_FHA_1	391	397	PF00498	0.680
LIG_FHA_1	410	416	PF00498	0.516
LIG_FHA_1	449	455	PF00498	0.628
LIG_FHA_1	531	537	PF00498	0.708
LIG_FHA_1	603	609	PF00498	0.675
LIG_FHA_1	97	103	PF00498	0.582
LIG_FHA_2	45	51	PF00498	0.758
LIG_LIR_Apic_2	91	96	PF02991	0.765
LIG_LIR_Nem_3	312	318	PF02991	0.575
LIG_SH2_CRK	93	97	PF00017	0.832
LIG_SH2_SRC	250	253	PF00017	0.768
LIG_SH2_STAP1	586	590	PF00017	0.633
LIG_SH2_STAT3	611	614	PF00017	0.664
LIG_SH2_STAT5	250	253	PF00017	0.830
LIG_SH2_STAT5	506	509	PF00017	0.521
LIG_SH3_2	223	228	PF14604	0.840
LIG_SH3_3	195	201	PF00018	0.783
LIG_SH3_3	217	223	PF00018	0.684
LIG_SH3_3	536	542	PF00018	0.817
LIG_TRAF2_1	286	289	PF00917	0.831
LIG_TRAF2_1	547	550	PF00917	0.711
LIG_UBA3_1	232	236	PF00899	0.805
MOD_CDK_SPK_2	179	184	PF00069	0.811
MOD_CDK_SPK_2	194	199	PF00069	0.665
MOD_CDK_SPK_2	60	65	PF00069	0.756
MOD_CDK_SPxxK_3	179	186	PF00069	0.836
MOD_CDK_SPxxK_3	187	194	PF00069	0.750
MOD_CK1_1	111	117	PF00069	0.868
MOD_CK1_1	129	135	PF00069	0.560
MOD_CK1_1	144	150	PF00069	0.682
MOD_CK1_1	190	196	PF00069	0.858
MOD_CK1_1	197	203	PF00069	0.747
MOD_CK1_1	204	210	PF00069	0.626
MOD_CK1_1	211	217	PF00069	0.629
MOD_CK1_1	29	35	PF00069	0.752
MOD_CK1_1	299	305	PF00069	0.771
MOD_CK1_1	409	415	PF00069	0.779
MOD_CK1_1	477	483	PF00069	0.706
MOD_CK1_1	529	535	PF00069	0.585
MOD_CK1_1	83	89	PF00069	0.765
MOD_CK2_1	443	449	PF00069	0.599
MOD_CK2_1	543	549	PF00069	0.616
MOD_CK2_1	571	577	PF00069	0.660
MOD_CK2_1	610	616	PF00069	0.541
MOD_Cter_Amidation	117	120	PF01082	0.772
MOD_GlcNHglycan	128	131	PF01048	0.835
MOD_GlcNHglycan	151	154	PF01048	0.766
MOD_GlcNHglycan	211	214	PF01048	0.842
MOD_GlcNHglycan	434	437	PF01048	0.626
MOD_GlcNHglycan	440	443	PF01048	0.768
MOD_GlcNHglycan	628	631	PF01048	0.765
MOD_GlcNHglycan	76	79	PF01048	0.798
MOD_GlcNHglycan	85	88	PF01048	0.705
MOD_GlcNHglycan	90	93	PF01048	0.616
MOD_GSK3_1	104	111	PF00069	0.852
MOD_GSK3_1	126	133	PF00069	0.808
MOD_GSK3_1	141	148	PF00069	0.652
MOD_GSK3_1	149	156	PF00069	0.722
MOD_GSK3_1	159	166	PF00069	0.562
MOD_GSK3_1	190	197	PF00069	0.788
MOD_GSK3_1	200	207	PF00069	0.694
MOD_GSK3_1	208	215	PF00069	0.563
MOD_GSK3_1	240	247	PF00069	0.851
MOD_GSK3_1	295	302	PF00069	0.666
MOD_GSK3_1	432	439	PF00069	0.736
MOD_GSK3_1	526	533	PF00069	0.646
MOD_GSK3_1	610	617	PF00069	0.520
MOD_LATS_1	161	167	PF00433	0.833
MOD_LATS_1	335	341	PF00433	0.566
MOD_N-GLC_1	153	158	PF02516	0.795
MOD_N-GLC_1	83	88	PF02516	0.605
MOD_NEK2_1	16	21	PF00069	0.602
MOD_NEK2_1	303	308	PF00069	0.622
MOD_NEK2_1	438	443	PF00069	0.809
MOD_NEK2_1	504	509	PF00069	0.498
MOD_NEK2_1	610	615	PF00069	0.667
MOD_NEK2_2	226	231	PF00069	0.862
MOD_PIKK_1	108	114	PF00454	0.862
MOD_PIKK_1	34	40	PF00454	0.791
MOD_PIKK_1	443	449	PF00454	0.682
MOD_PIKK_1	477	483	PF00454	0.644
MOD_PIKK_1	610	616	PF00454	0.670
MOD_PKA_1	26	32	PF00069	0.642
MOD_PKA_1	44	50	PF00069	0.730
MOD_PKA_1	601	607	PF00069	0.678
MOD_PKA_2	26	32	PF00069	0.655
MOD_PKA_2	345	351	PF00069	0.615
MOD_PKA_2	44	50	PF00069	0.730
MOD_PKA_2	477	483	PF00069	0.706
MOD_PKA_2	504	510	PF00069	0.656
MOD_PKA_2	601	607	PF00069	0.678
MOD_PKB_1	462	470	PF00069	0.676
MOD_Plk_1	549	555	PF00069	0.631
MOD_Plk_1	577	583	PF00069	0.665
MOD_Plk_4	130	136	PF00069	0.672
MOD_ProDKin_1	179	185	PF00069	0.794
MOD_ProDKin_1	187	193	PF00069	0.739
MOD_ProDKin_1	194	200	PF00069	0.635
MOD_ProDKin_1	201	207	PF00069	0.628
MOD_ProDKin_1	219	225	PF00069	0.569
MOD_ProDKin_1	240	246	PF00069	0.850
MOD_ProDKin_1	297	303	PF00069	0.757
MOD_ProDKin_1	414	420	PF00069	0.664
MOD_ProDKin_1	543	549	PF00069	0.739
MOD_ProDKin_1	60	66	PF00069	0.807
MOD_ProDKin_1	72	78	PF00069	0.609
MOD_SUMO_for_1	138	141	PF00179	0.754
MOD_SUMO_for_1	394	397	PF00179	0.688
MOD_SUMO_rev_2	168	178	PF00179	0.791
TRG_DiLeu_BaEn_4	288	294	PF01217	0.596
TRG_DiLeu_BaEn_4	387	393	PF01217	0.667
TRG_DiLeu_BaEn_4	516	522	PF01217	0.663
TRG_DiLeu_BaEn_4	549	555	PF01217	0.693
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.606
TRG_ER_diArg_1	13	16	PF00400	0.736
TRG_ER_diArg_1	183	186	PF00400	0.757
TRG_ER_diArg_1	25	27	PF00400	0.610
TRG_ER_diArg_1	372	375	PF00400	0.665
TRG_ER_diArg_1	44	46	PF00400	0.739
TRG_ER_diArg_1	581	584	PF00400	0.668
TRG_ER_diArg_1	601	603	PF00400	0.355
TRG_NLS_MonoExtN_4	372	377	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	595	600	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IAX8	Leishmania donovani	89%	85%
A4H9G0	Leishmania braziliensis	68%	100%
A4HXS7	Leishmania infantum	89%	85%
E9ARI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	85%