Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDY7_LEIMA

TriTrypDb:

LmjF.18.0550 , LMJLV39_180010900 , LMJSD75_180010800

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 4, no: 6
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	299	301	PF00675	0.514
CLV_NRD_NRD_1	304	306	PF00675	0.476
CLV_NRD_NRD_1	308	310	PF00675	0.473
CLV_NRD_NRD_1	338	340	PF00675	0.576
CLV_NRD_NRD_1	42	44	PF00675	0.499
CLV_NRD_NRD_1	48	50	PF00675	0.447
CLV_PCSK_FUR_1	300	304	PF00082	0.538
CLV_PCSK_KEX2_1	233	235	PF00082	0.724
CLV_PCSK_KEX2_1	279	281	PF00082	0.529
CLV_PCSK_KEX2_1	299	301	PF00082	0.418
CLV_PCSK_KEX2_1	302	304	PF00082	0.496
CLV_PCSK_KEX2_1	338	340	PF00082	0.576
CLV_PCSK_KEX2_1	42	44	PF00082	0.510
CLV_PCSK_KEX2_1	48	50	PF00082	0.481
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.724
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.531
CLV_PCSK_PC7_1	299	305	PF00082	0.492
CLV_PCSK_SKI1_1	233	237	PF00082	0.586
CLV_PCSK_SKI1_1	322	326	PF00082	0.549
CLV_PCSK_SKI1_1	349	353	PF00082	0.495
CLV_PCSK_SKI1_1	4	8	PF00082	0.402
CLV_PCSK_SKI1_1	49	53	PF00082	0.587
DEG_APCC_DBOX_1	250	258	PF00400	0.670
DEG_APCC_DBOX_1	290	298	PF00400	0.366
DEG_Nend_UBRbox_4	1	3	PF02207	0.531
DEG_SCF_FBW7_1	161	167	PF00400	0.578
DOC_CDC14_PxL_1	108	116	PF14671	0.408
DOC_CKS1_1	161	166	PF01111	0.600
DOC_CYCLIN_RxL_1	231	241	PF00134	0.546
DOC_MAPK_gen_1	232	238	PF00069	0.732
DOC_MAPK_gen_1	286	294	PF00069	0.367
DOC_MAPK_gen_1	309	316	PF00069	0.592
DOC_MAPK_gen_1	338	347	PF00069	0.542
DOC_PP1_RVXF_1	347	354	PF00149	0.521
DOC_PP1_RVXF_1	91	98	PF00149	0.419
DOC_USP7_MATH_1	209	213	PF00917	0.800
DOC_USP7_MATH_1	227	231	PF00917	0.699
DOC_USP7_MATH_1	30	34	PF00917	0.405
DOC_USP7_UBL2_3	275	279	PF12436	0.606
DOC_USP7_UBL2_3	326	330	PF12436	0.492
DOC_WW_Pin1_4	160	165	PF00397	0.603
DOC_WW_Pin1_4	212	217	PF00397	0.591
LIG_14-3-3_CanoR_1	128	133	PF00244	0.517
LIG_14-3-3_CanoR_1	151	159	PF00244	0.605
LIG_14-3-3_CanoR_1	251	255	PF00244	0.570
LIG_BRCT_BRCA1_1	166	170	PF00533	0.602
LIG_BRCT_BRCA1_1	30	34	PF00533	0.507
LIG_Clathr_ClatBox_1	254	258	PF01394	0.669
LIG_FHA_1	238	244	PF00498	0.717
LIG_FHA_1	56	62	PF00498	0.475
LIG_FHA_2	313	319	PF00498	0.566
LIG_FHA_2	83	89	PF00498	0.430
LIG_Integrin_isoDGR_2	196	198	PF01839	0.556
LIG_LIR_Gen_1	139	149	PF02991	0.597
LIG_LIR_Gen_1	218	227	PF02991	0.625
LIG_LIR_Gen_1	26	36	PF02991	0.512
LIG_LIR_Gen_1	343	352	PF02991	0.411
LIG_LIR_Gen_1	76	86	PF02991	0.450
LIG_LIR_Nem_3	139	144	PF02991	0.619
LIG_LIR_Nem_3	218	223	PF02991	0.679
LIG_LIR_Nem_3	26	32	PF02991	0.514
LIG_LIR_Nem_3	343	347	PF02991	0.521
LIG_LIR_Nem_3	35	41	PF02991	0.590
LIG_LIR_Nem_3	350	356	PF02991	0.614
LIG_LIR_Nem_3	76	82	PF02991	0.465
LIG_PDZ_Class_1	351	356	PF00595	0.605
LIG_REV1ctd_RIR_1	325	334	PF16727	0.502
LIG_SH2_CRK	105	109	PF00017	0.442
LIG_SH2_CRK	141	145	PF00017	0.485
LIG_SH2_CRK	29	33	PF00017	0.439
LIG_SH2_CRK	38	42	PF00017	0.473
LIG_SH2_GRB2like	65	68	PF00017	0.487
LIG_SH2_NCK_1	105	109	PF00017	0.392
LIG_SH2_NCK_1	141	145	PF00017	0.535
LIG_SH2_NCK_1	29	33	PF00017	0.413
LIG_SH2_PTP2	79	82	PF00017	0.451
LIG_SH2_STAT5	141	144	PF00017	0.476
LIG_SH2_STAT5	191	194	PF00017	0.677
LIG_SH2_STAT5	344	347	PF00017	0.343
LIG_SH2_STAT5	65	68	PF00017	0.589
LIG_SH2_STAT5	79	82	PF00017	0.251
LIG_SH3_1	203	209	PF00018	0.642
LIG_SH3_1	213	219	PF00018	0.546
LIG_SH3_3	158	164	PF00018	0.584
LIG_SH3_3	16	22	PF00018	0.558
LIG_SH3_3	203	209	PF00018	0.808
LIG_SH3_3	213	219	PF00018	0.619
LIG_SUMO_SIM_par_1	128	135	PF11976	0.422
LIG_SUMO_SIM_par_1	234	241	PF11976	0.634
LIG_TRAF2_1	260	263	PF00917	0.626
LIG_TYR_ITIM	27	32	PF00017	0.542
LIG_TYR_ITIM	36	41	PF00017	0.571
LIG_WRC_WIRS_1	133	138	PF05994	0.598
MOD_CK1_1	131	137	PF00069	0.459
MOD_CK1_1	139	145	PF00069	0.424
MOD_CK1_1	181	187	PF00069	0.578
MOD_CK1_1	212	218	PF00069	0.713
MOD_CK1_1	253	259	PF00069	0.698
MOD_CK2_1	257	263	PF00069	0.606
MOD_CK2_1	312	318	PF00069	0.577
MOD_CK2_1	82	88	PF00069	0.464
MOD_GlcNHglycan	145	148	PF01048	0.465
MOD_GlcNHglycan	153	156	PF01048	0.515
MOD_GlcNHglycan	171	174	PF01048	0.533
MOD_GlcNHglycan	258	262	PF01048	0.592
MOD_GSK3_1	128	135	PF00069	0.444
MOD_GSK3_1	136	143	PF00069	0.445
MOD_GSK3_1	160	167	PF00069	0.559
MOD_GSK3_1	178	185	PF00069	0.530
MOD_GSK3_1	221	228	PF00069	0.577
MOD_GSK3_1	253	260	PF00069	0.675
MOD_GSK3_1	55	62	PF00069	0.446
MOD_N-GLC_1	159	164	PF02516	0.584
MOD_N-GLC_1	181	186	PF02516	0.562
MOD_NEK2_1	136	141	PF00069	0.528
MOD_NEK2_1	159	164	PF00069	0.573
MOD_NEK2_1	169	174	PF00069	0.633
MOD_NEK2_1	221	226	PF00069	0.543
MOD_NEK2_1	81	86	PF00069	0.520
MOD_NEK2_2	197	202	PF00069	0.476
MOD_PIKK_1	59	65	PF00454	0.331
MOD_PK_1	128	134	PF00069	0.473
MOD_PKA_2	197	203	PF00069	0.663
MOD_PKA_2	245	251	PF00069	0.588
MOD_Plk_4	128	134	PF00069	0.493
MOD_Plk_4	136	142	PF00069	0.530
MOD_Plk_4	164	170	PF00069	0.583
MOD_Plk_4	250	256	PF00069	0.579
MOD_ProDKin_1	160	166	PF00069	0.605
MOD_ProDKin_1	212	218	PF00069	0.584
MOD_SUMO_for_1	201	204	PF00179	0.588
MOD_SUMO_for_1	287	290	PF00179	0.589
MOD_SUMO_rev_2	228	235	PF00179	0.595
MOD_SUMO_rev_2	306	311	PF00179	0.603
MOD_SUMO_rev_2	88	95	PF00179	0.546
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.545
TRG_ENDOCYTIC_2	105	108	PF00928	0.447
TRG_ENDOCYTIC_2	141	144	PF00928	0.481
TRG_ENDOCYTIC_2	29	32	PF00928	0.603
TRG_ENDOCYTIC_2	344	347	PF00928	0.582
TRG_ENDOCYTIC_2	38	41	PF00928	0.687
TRG_ENDOCYTIC_2	79	82	PF00928	0.451
TRG_ER_diArg_1	298	300	PF00400	0.605
TRG_ER_diArg_1	302	305	PF00400	0.561
TRG_ER_diArg_1	337	339	PF00400	0.599
TRG_ER_diArg_1	41	43	PF00400	0.487
TRG_ER_diArg_1	48	50	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.543
TRG_PTS2	1	12	PF00400	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN8	Leptomonas seymouri	47%	81%
A0A0S4J078	Bodo saltans	25%	76%
A0A1X0P6U2	Trypanosomatidae	30%	81%
A0A3S7WUV0	Leishmania donovani	91%	100%
A0A422NJ54	Trypanosoma rangeli	26%	79%
A4H9G3	Leishmania braziliensis	71%	100%
A4HXT0	Leishmania infantum	91%	100%
D0A062	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
E9ARJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%