LeishMANIAdb
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Putative peroxisomal enoyl-coa hydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative peroxisomal enoyl-coa hydratase
Gene product:
peroxisomal enoyl-coa hydratase, putative
Species:
Leishmania major
UniProt:
Q4QDY4_LEIMA
TriTrypDb:
LmjF.18.0580 , LMJLV39_180011200 , LMJSD75_180011100
Length:
323

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 7
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4QDY4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDY4

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 9
GO:0006629 lipid metabolic process 3 9
GO:0006631 fatty acid metabolic process 4 9
GO:0006635 fatty acid beta-oxidation 6 9
GO:0008152 metabolic process 1 9
GO:0009056 catabolic process 2 9
GO:0009062 fatty acid catabolic process 5 9
GO:0009987 cellular process 1 9
GO:0016042 lipid catabolic process 4 9
GO:0016054 organic acid catabolic process 4 9
GO:0019395 fatty acid oxidation 5 9
GO:0019752 carboxylic acid metabolic process 5 9
GO:0030258 lipid modification 4 9
GO:0032787 monocarboxylic acid metabolic process 6 9
GO:0034440 lipid oxidation 5 9
GO:0043436 oxoacid metabolic process 4 9
GO:0044237 cellular metabolic process 2 9
GO:0044238 primary metabolic process 2 9
GO:0044242 cellular lipid catabolic process 4 9
GO:0044248 cellular catabolic process 3 9
GO:0044255 cellular lipid metabolic process 3 9
GO:0044281 small molecule metabolic process 2 9
GO:0044282 small molecule catabolic process 3 9
GO:0046395 carboxylic acid catabolic process 5 9
GO:0071704 organic substance metabolic process 2 9
GO:0072329 monocarboxylic acid catabolic process 6 9
GO:1901575 organic substance catabolic process 3 9
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0004300 enoyl-CoA hydratase activity 5 6
GO:0016829 lyase activity 2 6
GO:0016835 carbon-oxygen lyase activity 3 6
GO:0016836 hydro-lyase activity 4 6
GO:0016853 isomerase activity 2 2
GO:0016860 intramolecular oxidoreductase activity 3 2
GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds 4 2
GO:0051750 delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity 5 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 133 137 PF00656 0.264
CLV_NRD_NRD_1 18 20 PF00675 0.399
CLV_NRD_NRD_1 241 243 PF00675 0.290
CLV_NRD_NRD_1 301 303 PF00675 0.204
CLV_PCSK_KEX2_1 18 20 PF00082 0.359
CLV_PCSK_KEX2_1 243 245 PF00082 0.350
CLV_PCSK_KEX2_1 301 303 PF00082 0.368
CLV_PCSK_PC1ET2_1 243 245 PF00082 0.308
CLV_PCSK_SKI1_1 260 264 PF00082 0.357
DEG_Nend_UBRbox_1 1 4 PF02207 0.594
DOC_CYCLIN_RxL_1 204 215 PF00134 0.309
DOC_MAPK_gen_1 46 53 PF00069 0.537
DOC_PP1_RVXF_1 205 212 PF00149 0.309
DOC_PP4_MxPP_1 99 102 PF00568 0.481
DOC_USP7_MATH_1 102 106 PF00917 0.607
DOC_USP7_MATH_1 111 115 PF00917 0.627
DOC_USP7_MATH_1 271 275 PF00917 0.349
DOC_WW_Pin1_4 249 254 PF00397 0.274
LIG_14-3-3_CanoR_1 129 135 PF00244 0.278
LIG_14-3-3_CanoR_1 170 178 PF00244 0.274
LIG_14-3-3_CanoR_1 269 277 PF00244 0.397
LIG_14-3-3_CterR_2 321 323 PF00244 0.587
LIG_APCC_ABBAyCdc20_2 302 308 PF00400 0.359
LIG_CaM_IQ_9 121 137 PF13499 0.368
LIG_FHA_1 175 181 PF00498 0.448
LIG_FHA_1 204 210 PF00498 0.375
LIG_FHA_1 257 263 PF00498 0.422
LIG_FHA_1 29 35 PF00498 0.451
LIG_FHA_2 131 137 PF00498 0.204
LIG_FHA_2 210 216 PF00498 0.368
LIG_FHA_2 271 277 PF00498 0.394
LIG_LIR_Nem_3 215 219 PF02991 0.386
LIG_LIR_Nem_3 233 237 PF02991 0.211
LIG_LIR_Nem_3 303 309 PF02991 0.215
LIG_LYPXL_SIV_4 54 62 PF13949 0.323
LIG_LYPXL_yS_3 234 237 PF13949 0.308
LIG_NRBOX 61 67 PF00104 0.403
LIG_RPA_C_Fungi 237 249 PF08784 0.309
LIG_SH2_STAP1 55 59 PF00017 0.333
LIG_SH2_STAT5 171 174 PF00017 0.456
LIG_SH3_2 41 46 PF14604 0.480
LIG_SH3_3 114 120 PF00018 0.410
LIG_SH3_3 38 44 PF00018 0.465
LIG_SUMO_SIM_par_1 31 38 PF11976 0.436
LIG_WRC_WIRS_1 131 136 PF05994 0.415
MOD_CK1_1 162 168 PF00069 0.284
MOD_CK2_1 176 182 PF00069 0.309
MOD_CK2_1 214 220 PF00069 0.350
MOD_CK2_1 270 276 PF00069 0.359
MOD_CK2_1 6 12 PF00069 0.474
MOD_GlcNHglycan 102 105 PF01048 0.527
MOD_GlcNHglycan 114 117 PF01048 0.580
MOD_GlcNHglycan 215 219 PF01048 0.393
MOD_GlcNHglycan 37 40 PF01048 0.430
MOD_GlcNHglycan 8 11 PF01048 0.481
MOD_GlcNHglycan 87 90 PF01048 0.307
MOD_GlcNHglycan 95 99 PF01048 0.408
MOD_GSK3_1 107 114 PF00069 0.750
MOD_GSK3_1 158 165 PF00069 0.340
MOD_GSK3_1 170 177 PF00069 0.349
MOD_GSK3_1 282 289 PF00069 0.355
MOD_GSK3_1 60 67 PF00069 0.457
MOD_NEK2_1 209 214 PF00069 0.274
MOD_NEK2_2 176 181 PF00069 0.368
MOD_PKA_2 169 175 PF00069 0.359
MOD_Plk_2-3 64 70 PF00069 0.369
MOD_Plk_4 12 18 PF00069 0.460
MOD_ProDKin_1 249 255 PF00069 0.274
MOD_SUMO_rev_2 215 224 PF00179 0.277
MOD_SUMO_rev_2 86 96 PF00179 0.331
TRG_DiLeu_BaEn_1 12 17 PF01217 0.437
TRG_DiLeu_BaEn_1 61 66 PF01217 0.404
TRG_DiLeu_BaLyEn_6 3 8 PF01217 0.565
TRG_ENDOCYTIC_2 234 237 PF00928 0.334
TRG_ER_diArg_1 143 146 PF00400 0.309
TRG_ER_diArg_1 17 19 PF00400 0.408

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVP1 Leptomonas seymouri 72% 100%
A0A0S4J4R9 Bodo saltans 42% 97%
A0A0S4JWH0 Bodo saltans 28% 100%
A0A1X0NJ83 Trypanosomatidae 26% 100%
A0A3Q8IIZ5 Leishmania donovani 30% 100%
A0A3R7KI60 Trypanosoma rangeli 25% 100%
A0A3S7WUX8 Leishmania donovani 95% 100%
A0PJR5 Danio rerio 27% 100%
A0R4Q3 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 29% 100%
A4H9G6 Leishmania braziliensis 86% 100%
A4HHN0 Leishmania braziliensis 31% 100%
A4HXT3 Leishmania infantum 95% 100%
A4I4U5 Leishmania infantum 30% 100%
A4YI89 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 29% 100%
A8ALR7 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 29% 100%
A9MR28 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 29% 100%
A9MYJ5 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 28% 100%
B1IRE0 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 28% 100%
B1LFW9 Escherichia coli (strain SMS-3-5 / SECEC) 28% 100%
B4T6J5 Salmonella newport (strain SL254) 28% 100%
B4TIG9 Salmonella heidelberg (strain SL476) 28% 100%
B4TWR3 Salmonella schwarzengrund (strain CVM19633) 28% 100%
B5BL54 Salmonella paratyphi A (strain AKU_12601) 28% 100%
B5F749 Salmonella agona (strain SL483) 28% 100%
B5FHG4 Salmonella dublin (strain CT_02021853) 28% 100%
B5R1Q9 Salmonella enteritidis PT4 (strain P125109) 29% 100%
B5RGA4 Salmonella gallinarum (strain 287/91 / NCTC 13346) 29% 100%
C0Q4L2 Salmonella paratyphi C (strain RKS4594) 28% 100%
D0A2C1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AE93 Leishmania major 32% 100%
E9ALJ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9ARJ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
F1LU71 Rattus norvegicus 30% 100%
F4JML5 Arabidopsis thaliana 27% 100%
F9XMX6 Zymoseptoria tritici (strain CBS 115943 / IPO323) 24% 100%
G4V4T7 Amycolatopsis orientalis 26% 100%
I6Y3U6 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 25% 100%
O34893 Bacillus subtilis (strain 168) 29% 100%
O35459 Mus musculus 35% 99%
O53561 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 32% 100%
O85078 Arthrobacter sp. 30% 100%
P30084 Homo sapiens 26% 100%
P31551 Escherichia coli (strain K12) 28% 100%
P34559 Caenorhabditis elegans 28% 100%
P52045 Escherichia coli (strain K12) 25% 100%
P52046 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) 27% 100%
P59395 Shigella flexneri 28% 100%
P94549 Bacillus subtilis (strain 168) 27% 100%
Q0S7P8 Rhodococcus jostii (strain RHA1) 24% 100%
Q0TLV3 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 28% 100%
Q13011 Homo sapiens 33% 98%
Q13825 Homo sapiens 28% 95%
Q1ZXF1 Dictyostelium discoideum 26% 100%
Q2TBT3 Bos taurus 29% 100%
Q3MIE0 Rattus norvegicus 23% 100%
Q3TLP5 Mus musculus 28% 100%
Q4PEN0 Ustilago maydis (strain 521 / FGSC 9021) 28% 100%
Q4WF54 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 30% 100%
Q52995 Rhizobium meliloti (strain 1021) 26% 100%
Q57TJ1 Salmonella choleraesuis (strain SC-B67) 28% 100%
Q5PIL1 Salmonella paratyphi A (strain ATCC 9150 / SARB42) 28% 100%
Q5R646 Pongo abelii 26% 100%
Q5RFG0 Pongo abelii 33% 98%
Q62651 Rattus norvegicus 34% 99%
Q6NL24 Arabidopsis thaliana 29% 100%
Q869N6 Dictyostelium discoideum 25% 100%
Q86YB7 Homo sapiens 29% 100%
Q8FLA6 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 28% 100%
Q8XA35 Escherichia coli O157:H7 28% 100%
Q8Z9L5 Salmonella typhi 28% 100%
Q8ZRX5 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 28% 100%
Q9FHR8 Arabidopsis thaliana 34% 100%
Q9JLZ3 Mus musculus 28% 100%
Q9LCU3 Arthrobacter sp. 30% 100%
V5BNA5 Trypanosoma cruzi 26% 100%
V5BWB9 Trypanosoma cruzi 46% 88%
V5DTT7 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS