Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QDY3_LEIMA

TriTrypDb:

LmjF.18.0590 , LMJLV39_180011300 , LMJSD75_180011200

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QDY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDY3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.682
CLV_PCSK_SKI1_1	199	203	PF00082	0.303
CLV_PCSK_SKI1_1	237	241	PF00082	0.314
CLV_PCSK_SKI1_1	3	7	PF00082	0.638
DEG_Nend_UBRbox_2	1	3	PF02207	0.711
DEG_SPOP_SBC_1	305	309	PF00917	0.513
DEG_SPOP_SBC_1	53	57	PF00917	0.617
DOC_CKS1_1	113	118	PF01111	0.682
DOC_CKS1_1	150	155	PF01111	0.695
DOC_CKS1_1	156	161	PF01111	0.632
DOC_CKS1_1	298	303	PF01111	0.684
DOC_CKS1_1	393	398	PF01111	0.674
DOC_PP1_RVXF_1	254	260	PF00149	0.448
DOC_PP4_FxxP_1	259	262	PF00568	0.486
DOC_USP7_MATH_1	104	108	PF00917	0.656
DOC_USP7_MATH_1	129	133	PF00917	0.620
DOC_USP7_MATH_1	260	264	PF00917	0.603
DOC_USP7_MATH_1	273	277	PF00917	0.463
DOC_USP7_MATH_1	334	338	PF00917	0.621
DOC_USP7_MATH_1	5	9	PF00917	0.640
DOC_USP7_MATH_1	69	73	PF00917	0.709
DOC_WW_Pin1_4	112	117	PF00397	0.753
DOC_WW_Pin1_4	144	149	PF00397	0.634
DOC_WW_Pin1_4	155	160	PF00397	0.637
DOC_WW_Pin1_4	297	302	PF00397	0.784
DOC_WW_Pin1_4	316	321	PF00397	0.581
DOC_WW_Pin1_4	325	330	PF00397	0.714
DOC_WW_Pin1_4	34	39	PF00397	0.700
DOC_WW_Pin1_4	356	361	PF00397	0.660
DOC_WW_Pin1_4	371	376	PF00397	0.658
DOC_WW_Pin1_4	392	397	PF00397	0.678
DOC_WW_Pin1_4	62	67	PF00397	0.658
LIG_14-3-3_CanoR_1	140	148	PF00244	0.710
LIG_14-3-3_CanoR_1	3	12	PF00244	0.646
LIG_BRCT_BRCA1_1	108	112	PF00533	0.681
LIG_BRCT_BRCA1_1	181	185	PF00533	0.497
LIG_BRCT_BRCA1_1	92	96	PF00533	0.700
LIG_FHA_1	152	158	PF00498	0.636
LIG_FHA_1	250	256	PF00498	0.478
LIG_FHA_1	262	268	PF00498	0.548
LIG_FHA_2	205	211	PF00498	0.508
LIG_FHA_2	359	365	PF00498	0.682
LIG_Integrin_isoDGR_2	218	220	PF01839	0.282
LIG_LIR_Apic_2	297	301	PF02991	0.685
LIG_LIR_Apic_2	61	66	PF02991	0.646
LIG_LIR_Nem_3	224	229	PF02991	0.497
LIG_LIR_Nem_3	93	99	PF02991	0.606
LIG_MLH1_MIPbox_1	108	112	PF16413	0.682
LIG_SH2_CRK	113	117	PF00017	0.593
LIG_SH2_CRK	298	302	PF00017	0.687
LIG_SH2_CRK	63	67	PF00017	0.646
LIG_SH2_GRB2like	12	15	PF00017	0.662
LIG_SH2_NCK_1	113	117	PF00017	0.683
LIG_SH2_NCK_1	12	16	PF00017	0.713
LIG_SH2_NCK_1	292	296	PF00017	0.639
LIG_SH2_NCK_1	298	302	PF00017	0.572
LIG_SH2_NCK_1	355	359	PF00017	0.646
LIG_SH2_NCK_1	63	67	PF00017	0.587
LIG_SH2_STAP1	292	296	PF00017	0.614
LIG_SH2_STAT5	32	35	PF00017	0.689
LIG_SH2_STAT5	344	347	PF00017	0.605
LIG_SH2_STAT5	382	385	PF00017	0.608
LIG_SH2_STAT5	394	397	PF00017	0.585
LIG_SH3_3	145	151	PF00018	0.712
LIG_SH3_3	244	250	PF00018	0.605
LIG_SH3_3	280	286	PF00018	0.682
LIG_SH3_3	406	412	PF00018	0.699
LIG_UBA3_1	208	212	PF00899	0.482
MOD_CK1_1	10	16	PF00069	0.664
MOD_CK1_1	114	120	PF00069	0.617
MOD_CK1_1	221	227	PF00069	0.482
MOD_CK1_1	31	37	PF00069	0.675
MOD_CK1_1	356	362	PF00069	0.598
MOD_CK1_1	55	61	PF00069	0.628
MOD_CK1_1	90	96	PF00069	0.704
MOD_CK2_1	204	210	PF00069	0.585
MOD_GlcNHglycan	104	107	PF01048	0.558
MOD_GlcNHglycan	108	111	PF01048	0.577
MOD_GlcNHglycan	116	119	PF01048	0.463
MOD_GlcNHglycan	127	130	PF01048	0.694
MOD_GlcNHglycan	131	134	PF01048	0.552
MOD_GlcNHglycan	223	226	PF01048	0.282
MOD_GlcNHglycan	232	236	PF01048	0.282
MOD_GlcNHglycan	271	274	PF01048	0.595
MOD_GlcNHglycan	280	283	PF01048	0.518
MOD_GlcNHglycan	336	339	PF01048	0.595
MOD_GlcNHglycan	47	50	PF01048	0.576
MOD_GSK3_1	102	109	PF00069	0.495
MOD_GSK3_1	125	132	PF00069	0.663
MOD_GSK3_1	140	147	PF00069	0.531
MOD_GSK3_1	151	158	PF00069	0.613
MOD_GSK3_1	17	24	PF00069	0.558
MOD_GSK3_1	269	276	PF00069	0.553
MOD_GSK3_1	27	34	PF00069	0.682
MOD_GSK3_1	3	10	PF00069	0.637
MOD_GSK3_1	349	356	PF00069	0.606
MOD_GSK3_1	54	61	PF00069	0.610
MOD_GSK3_1	85	92	PF00069	0.707
MOD_N-GLC_1	17	22	PF02516	0.770
MOD_N-GLC_1	34	39	PF02516	0.487
MOD_N-GLC_1	85	90	PF02516	0.707
MOD_NEK2_1	111	116	PF00069	0.781
MOD_NEK2_1	231	236	PF00069	0.508
MOD_NEK2_1	353	358	PF00069	0.607
MOD_NEK2_1	399	404	PF00069	0.777
MOD_NEK2_1	87	92	PF00069	0.711
MOD_NEK2_2	122	127	PF00069	0.531
MOD_PIKK_1	151	157	PF00454	0.652
MOD_PIKK_1	3	9	PF00454	0.609
MOD_PIKK_1	64	70	PF00454	0.647
MOD_PIKK_1	85	91	PF00454	0.639
MOD_Plk_4	122	128	PF00069	0.531
MOD_Plk_4	204	210	PF00069	0.573
MOD_Plk_4	273	279	PF00069	0.665
MOD_Plk_4	28	34	PF00069	0.635
MOD_Plk_4	349	355	PF00069	0.529
MOD_Plk_4	58	64	PF00069	0.615
MOD_Plk_4	7	13	PF00069	0.706
MOD_ProDKin_1	112	118	PF00069	0.751
MOD_ProDKin_1	144	150	PF00069	0.636
MOD_ProDKin_1	155	161	PF00069	0.634
MOD_ProDKin_1	297	303	PF00069	0.782
MOD_ProDKin_1	316	322	PF00069	0.584
MOD_ProDKin_1	325	331	PF00069	0.713
MOD_ProDKin_1	34	40	PF00069	0.702
MOD_ProDKin_1	356	362	PF00069	0.658
MOD_ProDKin_1	371	377	PF00069	0.661
MOD_ProDKin_1	392	398	PF00069	0.675
MOD_ProDKin_1	62	68	PF00069	0.660
TRG_Pf-PMV_PEXEL_1	199	204	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z4	Leptomonas seymouri	47%	85%
A0A3S7WUU6	Leishmania donovani	95%	99%
A4H9G7	Leishmania braziliensis	79%	98%
A4HXT4	Leishmania infantum	95%	99%
E9ARJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%