RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others/FYVE zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QDY1_LEIMA

TriTrypDb:

LmjF.18.0600 , LMJLV39_180011400 , LMJSD75_180011300

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	244	246	PF00675	0.470
CLV_NRD_NRD_1	255	257	PF00675	0.492
CLV_NRD_NRD_1	519	521	PF00675	0.348
CLV_NRD_NRD_1	581	583	PF00675	0.319
CLV_NRD_NRD_1	631	633	PF00675	0.591
CLV_PCSK_FUR_1	242	246	PF00082	0.467
CLV_PCSK_KEX2_1	244	246	PF00082	0.470
CLV_PCSK_KEX2_1	470	472	PF00082	0.602
CLV_PCSK_KEX2_1	529	531	PF00082	0.400
CLV_PCSK_KEX2_1	581	583	PF00082	0.319
CLV_PCSK_KEX2_1	631	633	PF00082	0.597
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.602
CLV_PCSK_PC1ET2_1	529	531	PF00082	0.391
DEG_APCC_DBOX_1	233	241	PF00400	0.470
DEG_APCC_DBOX_1	271	279	PF00400	0.312
DEG_COP1_1	349	357	PF00400	0.506
DEG_MDM2_SWIB_1	377	385	PF02201	0.451
DEG_Nend_UBRbox_3	1	3	PF02207	0.623
DEG_SCF_FBW7_1	372	379	PF00400	0.464
DEG_SPOP_SBC_1	123	127	PF00917	0.659
DOC_CYCLIN_RxL_1	239	252	PF00134	0.496
DOC_MAPK_gen_1	239	249	PF00069	0.494
DOC_PP4_FxxP_1	27	30	PF00568	0.620
DOC_PP4_FxxP_1	514	517	PF00568	0.312
DOC_PP4_MxPP_1	158	161	PF00568	0.557
DOC_USP7_MATH_1	123	127	PF00917	0.749
DOC_USP7_MATH_1	195	199	PF00917	0.680
DOC_USP7_MATH_1	223	227	PF00917	0.649
DOC_USP7_MATH_1	313	317	PF00917	0.694
DOC_USP7_MATH_1	346	350	PF00917	0.470
DOC_USP7_MATH_1	357	361	PF00917	0.672
DOC_USP7_MATH_1	415	419	PF00917	0.604
DOC_USP7_MATH_1	427	431	PF00917	0.644
DOC_USP7_MATH_1	457	461	PF00917	0.479
DOC_USP7_MATH_1	594	598	PF00917	0.312
DOC_USP7_MATH_1	68	72	PF00917	0.670
DOC_USP7_MATH_1	73	77	PF00917	0.696
DOC_USP7_UBL2_3	394	398	PF12436	0.507
DOC_USP7_UBL2_3	625	629	PF12436	0.480
DOC_WW_Pin1_4	110	115	PF00397	0.752
DOC_WW_Pin1_4	116	121	PF00397	0.662
DOC_WW_Pin1_4	128	133	PF00397	0.594
DOC_WW_Pin1_4	200	205	PF00397	0.600
DOC_WW_Pin1_4	311	316	PF00397	0.819
DOC_WW_Pin1_4	355	360	PF00397	0.617
DOC_WW_Pin1_4	372	377	PF00397	0.562
LIG_14-3-3_CanoR_1	287	293	PF00244	0.552
LIG_BIR_III_2	412	416	PF00653	0.610
LIG_EVH1_2	120	124	PF00568	0.601
LIG_FHA_1	409	415	PF00498	0.632
LIG_FHA_1	575	581	PF00498	0.388
LIG_IBAR_NPY_1	2	4	PF08397	0.614
LIG_LIR_Apic_2	101	105	PF02991	0.648
LIG_LIR_Apic_2	24	30	PF02991	0.619
LIG_LIR_Apic_2	263	267	PF02991	0.340
LIG_LIR_Apic_2	511	517	PF02991	0.312
LIG_LIR_Apic_2	597	602	PF02991	0.388
LIG_LIR_Gen_1	50	58	PF02991	0.711
LIG_LIR_Gen_1	574	580	PF02991	0.388
LIG_LIR_Nem_3	50	54	PF02991	0.629
LIG_LIR_Nem_3	574	579	PF02991	0.312
LIG_LYPXL_yS_3	150	153	PF13949	0.656
LIG_MYND_1	136	140	PF01753	0.681
LIG_Pex14_2	377	381	PF04695	0.455
LIG_PTB_Apo_2	371	378	PF02174	0.482
LIG_SH2_CRK	102	106	PF00017	0.640
LIG_SH2_CRK	290	294	PF00017	0.556
LIG_SH2_CRK	5	9	PF00017	0.595
LIG_SH2_CRK	51	55	PF00017	0.633
LIG_SH2_CRK	599	603	PF00017	0.388
LIG_SH2_NCK_1	290	294	PF00017	0.556
LIG_SH2_NCK_1	5	9	PF00017	0.595
LIG_SH2_NCK_1	58	62	PF00017	0.704
LIG_SH2_PTP2	173	176	PF00017	0.587
LIG_SH2_STAP1	534	538	PF00017	0.529
LIG_SH2_STAT5	173	176	PF00017	0.587
LIG_SH2_STAT5	290	293	PF00017	0.542
LIG_SH2_STAT5	590	593	PF00017	0.312
LIG_SH3_1	5	11	PF00018	0.606
LIG_SH3_3	134	140	PF00018	0.642
LIG_SH3_3	148	154	PF00018	0.657
LIG_SH3_3	157	163	PF00018	0.724
LIG_SH3_3	207	213	PF00018	0.637
LIG_SH3_3	386	392	PF00018	0.419
LIG_SH3_3	40	46	PF00018	0.681
LIG_SH3_3	411	417	PF00018	0.792
LIG_SH3_3	430	436	PF00018	0.499
LIG_SH3_3	5	11	PF00018	0.621
LIG_SxIP_EBH_1	348	358	PF03271	0.534
LIG_TRAF2_1	228	231	PF00917	0.697
LIG_TRAF2_1	547	550	PF00917	0.587
LIG_WRC_WIRS_1	268	273	PF05994	0.302
LIG_WRC_WIRS_1	443	448	PF05994	0.435
LIG_WW_1	48	51	PF00397	0.614
LIG_WW_2	433	436	PF00397	0.537
MOD_CK1_1	125	131	PF00069	0.706
MOD_CK1_1	17	23	PF00069	0.716
MOD_CK1_1	198	204	PF00069	0.623
MOD_CK1_1	225	231	PF00069	0.459
MOD_CK1_1	418	424	PF00069	0.685
MOD_CK1_1	442	448	PF00069	0.467
MOD_CK1_1	476	482	PF00069	0.771
MOD_CK1_1	484	490	PF00069	0.706
MOD_CK1_1	502	508	PF00069	0.322
MOD_CK1_1	597	603	PF00069	0.388
MOD_CK2_1	225	231	PF00069	0.640
MOD_CK2_1	562	568	PF00069	0.312
MOD_Cter_Amidation	518	521	PF01082	0.312
MOD_GlcNHglycan	110	113	PF01048	0.664
MOD_GlcNHglycan	155	158	PF01048	0.606
MOD_GlcNHglycan	204	207	PF01048	0.678
MOD_GlcNHglycan	220	223	PF01048	0.499
MOD_GlcNHglycan	227	230	PF01048	0.527
MOD_GlcNHglycan	349	352	PF01048	0.586
MOD_GlcNHglycan	359	362	PF01048	0.675
MOD_GlcNHglycan	400	403	PF01048	0.510
MOD_GlcNHglycan	420	423	PF01048	0.611
MOD_GlcNHglycan	429	432	PF01048	0.754
MOD_GlcNHglycan	450	453	PF01048	0.455
MOD_GlcNHglycan	459	462	PF01048	0.497
MOD_GlcNHglycan	474	478	PF01048	0.711
MOD_GlcNHglycan	486	489	PF01048	0.674
MOD_GlcNHglycan	59	62	PF01048	0.760
MOD_GlcNHglycan	81	84	PF01048	0.743
MOD_GSK3_1	122	129	PF00069	0.688
MOD_GSK3_1	196	203	PF00069	0.746
MOD_GSK3_1	218	225	PF00069	0.521
MOD_GSK3_1	288	295	PF00069	0.541
MOD_GSK3_1	353	360	PF00069	0.592
MOD_GSK3_1	372	379	PF00069	0.535
MOD_GSK3_1	442	449	PF00069	0.529
MOD_GSK3_1	498	505	PF00069	0.552
MOD_GSK3_1	597	604	PF00069	0.321
MOD_GSK3_1	79	86	PF00069	0.662
MOD_N-GLC_1	196	201	PF02516	0.578
MOD_N-GLC_1	405	410	PF02516	0.467
MOD_N-GLC_1	79	84	PF02516	0.704
MOD_N-GLC_2	570	572	PF02516	0.312
MOD_NEK2_1	124	129	PF00069	0.617
MOD_NEK2_1	282	287	PF00069	0.312
MOD_NEK2_1	446	451	PF00069	0.536
MOD_NEK2_2	267	272	PF00069	0.293
MOD_NEK2_2	83	88	PF00069	0.706
MOD_PIKK_1	313	319	PF00454	0.648
MOD_PIKK_1	502	508	PF00454	0.480
MOD_PKA_1	498	504	PF00069	0.580
MOD_PKA_2	17	23	PF00069	0.716
MOD_PKA_2	347	353	PF00069	0.487
MOD_PKA_2	484	490	PF00069	0.711
MOD_Plk_1	446	452	PF00069	0.493
MOD_Plk_1	562	568	PF00069	0.335
MOD_Plk_1	83	89	PF00069	0.707
MOD_Plk_2-3	562	568	PF00069	0.312
MOD_Plk_4	434	440	PF00069	0.608
MOD_Plk_4	510	516	PF00069	0.312
MOD_Plk_4	83	89	PF00069	0.707
MOD_ProDKin_1	110	116	PF00069	0.753
MOD_ProDKin_1	128	134	PF00069	0.597
MOD_ProDKin_1	200	206	PF00069	0.601
MOD_ProDKin_1	311	317	PF00069	0.816
MOD_ProDKin_1	355	361	PF00069	0.620
MOD_ProDKin_1	372	378	PF00069	0.559
MOD_SUMO_for_1	278	281	PF00179	0.312
MOD_SUMO_for_1	547	550	PF00179	0.587
MOD_SUMO_rev_2	491	501	PF00179	0.619
MOD_SUMO_rev_2	622	627	PF00179	0.445
TRG_DiLeu_BaEn_4	230	236	PF01217	0.558
TRG_ENDOCYTIC_2	150	153	PF00928	0.656
TRG_ENDOCYTIC_2	51	54	PF00928	0.630
TRG_ER_diArg_1	241	244	PF00400	0.466
TRG_ER_diArg_1	580	582	PF00400	0.388
TRG_ER_diArg_1	631	633	PF00400	0.591
TRG_NES_CRM1_1	238	252	PF08389	0.495
TRG_NLS_MonoExtC_3	627	632	PF00514	0.566
TRG_NLS_MonoExtN_4	625	632	PF00514	0.558
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D5	Leptomonas seymouri	56%	100%
A0A3Q8I9Y5	Leishmania donovani	92%	100%
A4H9G8	Leishmania braziliensis	80%	100%
A4HXT6	Leishmania infantum	92%	100%
E9ARJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%