Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDX8_LEIMA

TriTrypDb:

LmjF.18.0630 , LMJLV39_180011900 , LMJSD75_180011800

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDX8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.607
CLV_C14_Caspase3-7	43	47	PF00656	0.729
CLV_NRD_NRD_1	10	12	PF00675	0.768
CLV_NRD_NRD_1	172	174	PF00675	0.835
CLV_NRD_NRD_1	186	188	PF00675	0.616
CLV_NRD_NRD_1	310	312	PF00675	0.608
CLV_NRD_NRD_1	329	331	PF00675	0.656
CLV_NRD_NRD_1	37	39	PF00675	0.754
CLV_NRD_NRD_1	381	383	PF00675	0.797
CLV_NRD_NRD_1	450	452	PF00675	0.573
CLV_NRD_NRD_1	495	497	PF00675	0.624
CLV_NRD_NRD_1	535	537	PF00675	0.641
CLV_PCSK_KEX2_1	172	174	PF00082	0.835
CLV_PCSK_KEX2_1	310	312	PF00082	0.608
CLV_PCSK_KEX2_1	329	331	PF00082	0.707
CLV_PCSK_KEX2_1	36	38	PF00082	0.744
CLV_PCSK_KEX2_1	381	383	PF00082	0.793
CLV_PCSK_KEX2_1	450	452	PF00082	0.573
CLV_PCSK_KEX2_1	495	497	PF00082	0.624
CLV_PCSK_KEX2_1	535	537	PF00082	0.641
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.744
CLV_PCSK_PC7_1	325	331	PF00082	0.716
CLV_PCSK_SKI1_1	24	28	PF00082	0.738
CLV_PCSK_SKI1_1	495	499	PF00082	0.702
CLV_PCSK_SKI1_1	535	539	PF00082	0.731
CLV_Separin_Metazoa	264	268	PF03568	0.778
CLV_Separin_Metazoa	307	311	PF03568	0.711
DEG_APCC_DBOX_1	358	366	PF00400	0.808
DEG_Nend_UBRbox_1	1	4	PF02207	0.660
DEG_SCF_FBW7_1	94	101	PF00400	0.839
DEG_SPOP_SBC_1	247	251	PF00917	0.784
DOC_MAPK_gen_1	21	30	PF00069	0.741
DOC_PP2B_LxvP_1	74	77	PF13499	0.704
DOC_PP4_MxPP_1	263	266	PF00568	0.776
DOC_USP7_MATH_1	22	26	PF00917	0.670
DOC_USP7_MATH_1	247	251	PF00917	0.792
DOC_USP7_MATH_1	269	273	PF00917	0.699
DOC_USP7_MATH_1	274	278	PF00917	0.705
DOC_USP7_MATH_1	407	411	PF00917	0.795
DOC_USP7_MATH_1	45	49	PF00917	0.739
DOC_USP7_MATH_1	457	461	PF00917	0.774
DOC_USP7_MATH_1	471	475	PF00917	0.694
DOC_USP7_MATH_1	99	103	PF00917	0.826
DOC_USP7_UBL2_3	12	16	PF12436	0.711
DOC_USP7_UBL2_3	65	69	PF12436	0.854
DOC_WW_Pin1_4	105	110	PF00397	0.590
DOC_WW_Pin1_4	121	126	PF00397	0.598
DOC_WW_Pin1_4	203	208	PF00397	0.833
DOC_WW_Pin1_4	213	218	PF00397	0.671
DOC_WW_Pin1_4	233	238	PF00397	0.599
DOC_WW_Pin1_4	251	256	PF00397	0.544
DOC_WW_Pin1_4	295	300	PF00397	0.624
DOC_WW_Pin1_4	352	357	PF00397	0.789
DOC_WW_Pin1_4	461	466	PF00397	0.765
DOC_WW_Pin1_4	475	480	PF00397	0.559
DOC_WW_Pin1_4	512	517	PF00397	0.681
DOC_WW_Pin1_4	68	73	PF00397	0.700
DOC_WW_Pin1_4	82	87	PF00397	0.738
DOC_WW_Pin1_4	94	99	PF00397	0.635
LIG_14-3-3_CanoR_1	209	218	PF00244	0.835
LIG_14-3-3_CanoR_1	21	30	PF00244	0.663
LIG_14-3-3_CanoR_1	245	255	PF00244	0.752
LIG_14-3-3_CanoR_1	270	278	PF00244	0.845
LIG_14-3-3_CanoR_1	385	390	PF00244	0.635
LIG_BRCT_BRCA1_1	362	366	PF00533	0.778
LIG_BRCT_BRCA1_1	367	371	PF00533	0.725
LIG_CSL_BTD_1	109	112	PF09270	0.826
LIG_CSL_BTD_1	214	217	PF09270	0.723
LIG_deltaCOP1_diTrp_1	107	114	PF00928	0.755
LIG_FHA_1	396	402	PF00498	0.579
LIG_FHA_1	476	482	PF00498	0.692
LIG_FHA_1	485	491	PF00498	0.583
LIG_FHA_1	69	75	PF00498	0.642
LIG_FHA_2	280	286	PF00498	0.646
LIG_FHA_2	339	345	PF00498	0.715
LIG_LIR_Apic_2	216	221	PF02991	0.710
LIG_LIR_Gen_1	384	393	PF02991	0.605
LIG_LIR_Nem_3	107	113	PF02991	0.730
LIG_LIR_Nem_3	146	152	PF02991	0.697
LIG_LIR_Nem_3	384	389	PF02991	0.607
LIG_MLH1_MIPbox_1	367	371	PF16413	0.792
LIG_MYND_1	72	76	PF01753	0.711
LIG_Pex14_1	110	114	PF04695	0.833
LIG_Pex14_2	238	242	PF04695	0.695
LIG_Pex14_2	366	370	PF04695	0.791
LIG_REV1ctd_RIR_1	368	374	PF16727	0.789
LIG_SH2_CRK	386	390	PF00017	0.600
LIG_SH2_NCK_1	386	390	PF00017	0.716
LIG_SH2_SRC	4	7	PF00017	0.723
LIG_SH2_STAP1	333	337	PF00017	0.747
LIG_SH2_STAP1	386	390	PF00017	0.716
LIG_SH2_STAT5	190	193	PF00017	0.609
LIG_SH2_STAT5	4	7	PF00017	0.723
LIG_SH2_STAT5	547	550	PF00017	0.730
LIG_SH3_3	106	112	PF00018	0.833
LIG_SH3_3	214	220	PF00018	0.794
LIG_SH3_3	263	269	PF00018	0.779
LIG_SH3_3	293	299	PF00018	0.690
LIG_SH3_3	312	318	PF00018	0.548
LIG_SH3_3	350	356	PF00018	0.797
LIG_SH3_3	74	80	PF00018	0.796
LIG_SH3_4	12	19	PF00018	0.716
LIG_SH3_5	423	427	PF00018	0.733
LIG_SH3_CIN85_PxpxPR_1	55	60	PF14604	0.685
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.645
LIG_SUMO_SIM_par_1	25	31	PF11976	0.645
LIG_TRAF2_1	135	138	PF00917	0.786
LIG_WW_3	264	268	PF00397	0.778
LIG_WW_3	307	311	PF00397	0.754
LIG_WW_3	76	80	PF00397	0.829
MOD_CDC14_SPxK_1	206	209	PF00782	0.828
MOD_CDK_SPK_2	121	126	PF00069	0.785
MOD_CDK_SPxK_1	203	209	PF00069	0.833
MOD_CDK_SPxK_1	512	518	PF00069	0.682
MOD_CDK_SPxxK_3	352	359	PF00069	0.792
MOD_CK1_1	201	207	PF00069	0.732
MOD_CK1_1	213	219	PF00069	0.633
MOD_CK1_1	248	254	PF00069	0.771
MOD_CK1_1	277	283	PF00069	0.691
MOD_CK1_1	332	338	PF00069	0.746
MOD_CK1_1	361	367	PF00069	0.746
MOD_CK1_1	406	412	PF00069	0.807
MOD_CK1_1	458	464	PF00069	0.805
MOD_CK1_1	474	480	PF00069	0.639
MOD_CK1_1	48	54	PF00069	0.643
MOD_CK2_1	133	139	PF00069	0.788
MOD_CK2_1	192	198	PF00069	0.834
MOD_CK2_1	258	264	PF00069	0.871
MOD_CK2_1	98	104	PF00069	0.761
MOD_CMANNOS	215	218	PF00535	0.839
MOD_DYRK1A_RPxSP_1	352	356	PF00069	0.793
MOD_DYRK1A_RPxSP_1	84	88	PF00069	0.831
MOD_GlcNHglycan	115	118	PF01048	0.777
MOD_GlcNHglycan	194	197	PF01048	0.832
MOD_GlcNHglycan	212	215	PF01048	0.541
MOD_GlcNHglycan	24	27	PF01048	0.663
MOD_GlcNHglycan	272	275	PF01048	0.824
MOD_GlcNHglycan	315	318	PF01048	0.765
MOD_GlcNHglycan	335	338	PF01048	0.748
MOD_GlcNHglycan	367	370	PF01048	0.790
MOD_GlcNHglycan	405	408	PF01048	0.821
MOD_GlcNHglycan	505	508	PF01048	0.740
MOD_GSK3_1	133	140	PF00069	0.780
MOD_GSK3_1	148	155	PF00069	0.603
MOD_GSK3_1	198	205	PF00069	0.636
MOD_GSK3_1	229	236	PF00069	0.821
MOD_GSK3_1	246	253	PF00069	0.547
MOD_GSK3_1	270	277	PF00069	0.748
MOD_GSK3_1	279	286	PF00069	0.774
MOD_GSK3_1	329	336	PF00069	0.745
MOD_GSK3_1	360	367	PF00069	0.740
MOD_GSK3_1	403	410	PF00069	0.805
MOD_GSK3_1	412	419	PF00069	0.686
MOD_GSK3_1	455	462	PF00069	0.700
MOD_GSK3_1	471	478	PF00069	0.608
MOD_GSK3_1	94	101	PF00069	0.763
MOD_LATS_1	327	333	PF00433	0.749
MOD_N-GLC_1	433	438	PF02516	0.684
MOD_N-GLC_2	433	435	PF02516	0.673
MOD_NEK2_1	113	118	PF00069	0.722
MOD_NEK2_1	192	197	PF00069	0.719
MOD_NEK2_1	28	33	PF00069	0.717
MOD_NEK2_1	365	370	PF00069	0.748
MOD_NEK2_1	40	45	PF00069	0.583
MOD_NEK2_1	400	405	PF00069	0.672
MOD_NEK2_1	484	489	PF00069	0.454
MOD_NEK2_1	503	508	PF00069	0.597
MOD_NEK2_2	207	212	PF00069	0.598
MOD_PIKK_1	115	121	PF00454	0.773
MOD_PIKK_1	346	352	PF00454	0.767
MOD_PIKK_1	40	46	PF00454	0.708
MOD_PIKK_1	412	418	PF00454	0.764
MOD_PK_1	160	166	PF00069	0.596
MOD_PKA_1	329	335	PF00069	0.707
MOD_PKA_2	133	139	PF00069	0.851
MOD_PKA_2	198	204	PF00069	0.607
MOD_PKA_2	20	26	PF00069	0.761
MOD_PKA_2	269	275	PF00069	0.849
MOD_PKA_2	329	335	PF00069	0.590
MOD_PKA_2	358	364	PF00069	0.678
MOD_PKA_2	384	390	PF00069	0.799
MOD_PKA_2	491	497	PF00069	0.574
MOD_PKB_1	243	251	PF00069	0.746
MOD_Plk_1	160	166	PF00069	0.596
MOD_Plk_1	433	439	PF00069	0.680
MOD_Plk_1	484	490	PF00069	0.603
MOD_Plk_4	361	367	PF00069	0.753
MOD_ProDKin_1	105	111	PF00069	0.590
MOD_ProDKin_1	121	127	PF00069	0.598
MOD_ProDKin_1	203	209	PF00069	0.833
MOD_ProDKin_1	213	219	PF00069	0.670
MOD_ProDKin_1	233	239	PF00069	0.600
MOD_ProDKin_1	251	257	PF00069	0.542
MOD_ProDKin_1	295	301	PF00069	0.630
MOD_ProDKin_1	352	358	PF00069	0.791
MOD_ProDKin_1	461	467	PF00069	0.764
MOD_ProDKin_1	475	481	PF00069	0.558
MOD_ProDKin_1	512	518	PF00069	0.682
MOD_ProDKin_1	68	74	PF00069	0.698
MOD_ProDKin_1	82	88	PF00069	0.733
MOD_ProDKin_1	94	100	PF00069	0.635
MOD_SUMO_rev_2	461	471	PF00179	0.770
TRG_DiLeu_BaEn_4	525	531	PF01217	0.518
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.563
TRG_ENDOCYTIC_2	386	389	PF00928	0.603
TRG_ER_diArg_1	172	174	PF00400	0.835
TRG_ER_diArg_1	242	245	PF00400	0.744
TRG_ER_diArg_1	309	311	PF00400	0.602
TRG_ER_diArg_1	427	430	PF00400	0.752
TRG_ER_diArg_1	450	452	PF00400	0.579
TRG_ER_diArg_1	534	536	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.680
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	496	500	PF00026	0.629
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WV31	Leishmania donovani	88%	100%
A4H9H3	Leishmania braziliensis	61%	100%
A4HXT9	Leishmania infantum	88%	100%
E9ARK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%