Armadillo-type protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HEAT repeats, putative

Species:

Leishmania major

UniProt:

Q4QDX5_LEIMA

TriTrypDb:

LmjF.18.0700 , LMJLV39_180012200 , LMJSD75_180012100

Length:

711

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDX5

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	2
GO:0019888	protein phosphatase regulator activity	4	2
GO:0030234	enzyme regulator activity	2	2
GO:0098772	molecular function regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.408
CLV_C14_Caspase3-7	603	607	PF00656	0.695
CLV_C14_Caspase3-7	9	13	PF00656	0.688
CLV_NRD_NRD_1	210	212	PF00675	0.450
CLV_NRD_NRD_1	367	369	PF00675	0.371
CLV_PCSK_KEX2_1	210	212	PF00082	0.576
CLV_PCSK_KEX2_1	406	408	PF00082	0.514
CLV_PCSK_KEX2_1	450	452	PF00082	0.538
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.514
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.538
CLV_PCSK_SKI1_1	231	235	PF00082	0.492
CLV_PCSK_SKI1_1	313	317	PF00082	0.503
CLV_PCSK_SKI1_1	46	50	PF00082	0.391
CLV_PCSK_SKI1_1	516	520	PF00082	0.467
CLV_PCSK_SKI1_1	526	530	PF00082	0.373
CLV_PCSK_SKI1_1	574	578	PF00082	0.468
CLV_PCSK_SKI1_1	85	89	PF00082	0.370
CLV_Separin_Metazoa	310	314	PF03568	0.542
DEG_APCC_DBOX_1	424	432	PF00400	0.397
DEG_SPOP_SBC_1	484	488	PF00917	0.432
DOC_CKS1_1	419	424	PF01111	0.545
DOC_CYCLIN_RxL_1	412	421	PF00134	0.531
DOC_MAPK_gen_1	450	457	PF00069	0.523
DOC_MAPK_MEF2A_6	231	240	PF00069	0.462
DOC_MAPK_MEF2A_6	450	459	PF00069	0.405
DOC_MAPK_NFAT4_5	231	239	PF00069	0.539
DOC_PP1_RVXF_1	266	272	PF00149	0.544
DOC_PP1_RVXF_1	359	366	PF00149	0.399
DOC_PP4_FxxP_1	271	274	PF00568	0.535
DOC_USP7_MATH_1	291	295	PF00917	0.439
DOC_USP7_MATH_1	319	323	PF00917	0.433
DOC_USP7_MATH_1	436	440	PF00917	0.463
DOC_USP7_MATH_1	471	475	PF00917	0.470
DOC_USP7_MATH_1	686	690	PF00917	0.708
DOC_WW_Pin1_4	305	310	PF00397	0.445
DOC_WW_Pin1_4	324	329	PF00397	0.580
DOC_WW_Pin1_4	418	423	PF00397	0.586
DOC_WW_Pin1_4	457	462	PF00397	0.513
DOC_WW_Pin1_4	648	653	PF00397	0.827
LIG_14-3-3_CanoR_1	210	214	PF00244	0.446
LIG_14-3-3_CanoR_1	231	237	PF00244	0.534
LIG_14-3-3_CanoR_1	297	303	PF00244	0.481
LIG_14-3-3_CanoR_1	313	320	PF00244	0.536
LIG_14-3-3_CanoR_1	368	372	PF00244	0.408
LIG_14-3-3_CanoR_1	485	490	PF00244	0.415
LIG_APCC_ABBA_1	312	317	PF00400	0.405
LIG_BIR_III_2	79	83	PF00653	0.508
LIG_BRCT_BRCA1_1	462	466	PF00533	0.542
LIG_CtBP_PxDLS_1	264	268	PF00389	0.418
LIG_EH1_1	375	383	PF00400	0.438
LIG_FHA_1	1	7	PF00498	0.772
LIG_FHA_1	189	195	PF00498	0.485
LIG_FHA_1	531	537	PF00498	0.448
LIG_FHA_1	562	568	PF00498	0.569
LIG_FHA_1	617	623	PF00498	0.713
LIG_FHA_1	703	709	PF00498	0.654
LIG_FHA_2	116	122	PF00498	0.536
LIG_FHA_2	223	229	PF00498	0.513
LIG_FHA_2	383	389	PF00498	0.366
LIG_FHA_2	666	672	PF00498	0.682
LIG_GBD_Chelix_1	173	181	PF00786	0.369
LIG_LIR_Gen_1	105	116	PF02991	0.380
LIG_LIR_Gen_1	118	128	PF02991	0.524
LIG_LIR_Gen_1	235	245	PF02991	0.537
LIG_LIR_Gen_1	289	299	PF02991	0.446
LIG_LIR_Gen_1	347	357	PF02991	0.432
LIG_LIR_Gen_1	414	423	PF02991	0.498
LIG_LIR_LC3C_4	564	568	PF02991	0.548
LIG_LIR_Nem_3	105	111	PF02991	0.388
LIG_LIR_Nem_3	118	123	PF02991	0.402
LIG_LIR_Nem_3	16	22	PF02991	0.525
LIG_LIR_Nem_3	168	173	PF02991	0.418
LIG_LIR_Nem_3	235	240	PF02991	0.532
LIG_LIR_Nem_3	289	295	PF02991	0.449
LIG_LIR_Nem_3	330	335	PF02991	0.430
LIG_LIR_Nem_3	347	352	PF02991	0.416
LIG_LIR_Nem_3	414	419	PF02991	0.405
LIG_LIR_Nem_3	463	469	PF02991	0.535
LIG_LIR_Nem_3	486	492	PF02991	0.522
LIG_LIR_Nem_3	504	510	PF02991	0.452
LIG_LIR_Nem_3	56	62	PF02991	0.394
LIG_NRBOX	294	300	PF00104	0.521
LIG_PCNA_PIPBox_1	109	118	PF02747	0.469
LIG_PCNA_PIPBox_1	230	239	PF02747	0.443
LIG_PCNA_PIPBox_1	86	95	PF02747	0.520
LIG_PCNA_yPIPBox_3	85	93	PF02747	0.522
LIG_Pex14_2	185	189	PF04695	0.543
LIG_SH2_CRK	108	112	PF00017	0.465
LIG_SH2_CRK	170	174	PF00017	0.391
LIG_SH2_CRK	335	339	PF00017	0.516
LIG_SH2_GRB2like	507	510	PF00017	0.548
LIG_SH2_NCK_1	489	493	PF00017	0.520
LIG_SH2_PTP2	237	240	PF00017	0.433
LIG_SH2_SRC	489	492	PF00017	0.523
LIG_SH2_SRC	62	65	PF00017	0.543
LIG_SH2_STAP1	356	360	PF00017	0.396
LIG_SH2_STAP1	62	66	PF00017	0.543
LIG_SH2_STAT5	237	240	PF00017	0.438
LIG_SH2_STAT5	332	335	PF00017	0.470
LIG_SH2_STAT5	510	513	PF00017	0.486
LIG_SH2_STAT5	531	534	PF00017	0.401
LIG_SH3_3	322	328	PF00018	0.596
LIG_SH3_3	340	346	PF00018	0.523
LIG_SH3_3	458	464	PF00018	0.501
LIG_Sin3_3	416	423	PF02671	0.542
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.401
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.446
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.522
LIG_SUMO_SIM_anti_2	590	596	PF11976	0.592
LIG_SUMO_SIM_par_1	131	136	PF11976	0.534
LIG_SUMO_SIM_par_1	190	197	PF11976	0.536
LIG_SUMO_SIM_par_1	46	52	PF11976	0.478
LIG_SUMO_SIM_par_1	468	474	PF11976	0.536
LIG_TRAF2_1	13	16	PF00917	0.683
LIG_TRAF2_1	225	228	PF00917	0.585
LIG_TRAF2_1	600	603	PF00917	0.662
LIG_UBA3_1	398	406	PF00899	0.534
LIG_UBA3_1	549	555	PF00899	0.502
LIG_WRC_WIRS_1	73	78	PF05994	0.551
MOD_CDK_SPxxK_3	418	425	PF00069	0.576
MOD_CK1_1	187	193	PF00069	0.548
MOD_CK1_1	202	208	PF00069	0.363
MOD_CK1_1	327	333	PF00069	0.527
MOD_CK1_1	40	46	PF00069	0.404
MOD_CK1_1	460	466	PF00069	0.499
MOD_CK1_1	65	71	PF00069	0.465
MOD_CK1_1	693	699	PF00069	0.801
MOD_CK2_1	115	121	PF00069	0.541
MOD_CK2_1	222	228	PF00069	0.527
MOD_CK2_1	371	377	PF00069	0.370
MOD_CK2_1	382	388	PF00069	0.391
MOD_CK2_1	477	483	PF00069	0.430
MOD_CK2_1	484	490	PF00069	0.397
MOD_CK2_1	598	604	PF00069	0.586
MOD_CK2_1	665	671	PF00069	0.682
MOD_GlcNHglycan	260	263	PF01048	0.580
MOD_GlcNHglycan	546	549	PF01048	0.617
MOD_GlcNHglycan	64	67	PF01048	0.471
MOD_GlcNHglycan	693	696	PF01048	0.716
MOD_GSK3_1	184	191	PF00069	0.545
MOD_GSK3_1	199	206	PF00069	0.452
MOD_GSK3_1	232	239	PF00069	0.513
MOD_GSK3_1	301	308	PF00069	0.443
MOD_GSK3_1	367	374	PF00069	0.387
MOD_GSK3_1	686	693	PF00069	0.779
MOD_GSK3_1	694	701	PF00069	0.671
MOD_N-GLC_1	202	207	PF02516	0.425
MOD_NEK2_1	189	194	PF00069	0.512
MOD_NEK2_1	236	241	PF00069	0.428
MOD_NEK2_1	298	303	PF00069	0.441
MOD_NEK2_1	371	376	PF00069	0.363
MOD_NEK2_1	381	386	PF00069	0.513
MOD_NEK2_1	477	482	PF00069	0.429
MOD_NEK2_1	53	58	PF00069	0.443
MOD_NEK2_1	6	11	PF00069	0.621
MOD_NEK2_1	702	707	PF00069	0.810
MOD_NEK2_1	72	77	PF00069	0.540
MOD_PIKK_1	598	604	PF00454	0.663
MOD_PIKK_1	616	622	PF00454	0.720
MOD_PIKK_1	7	13	PF00454	0.604
MOD_PIKK_1	74	80	PF00454	0.558
MOD_PKA_2	209	215	PF00069	0.442
MOD_PKA_2	367	373	PF00069	0.425
MOD_PKA_2	484	490	PF00069	0.411
MOD_Plk_1	202	208	PF00069	0.433
MOD_Plk_1	24	30	PF00069	0.431
MOD_Plk_1	281	287	PF00069	0.464
MOD_Plk_1	40	46	PF00069	0.289
MOD_Plk_1	477	483	PF00069	0.441
MOD_Plk_2-3	631	637	PF00069	0.697
MOD_Plk_4	189	195	PF00069	0.475
MOD_Plk_4	232	238	PF00069	0.491
MOD_Plk_4	355	361	PF00069	0.388
MOD_Plk_4	465	471	PF00069	0.425
MOD_Plk_4	477	483	PF00069	0.446
MOD_Plk_4	510	516	PF00069	0.484
MOD_Plk_4	695	701	PF00069	0.676
MOD_ProDKin_1	305	311	PF00069	0.439
MOD_ProDKin_1	324	330	PF00069	0.569
MOD_ProDKin_1	418	424	PF00069	0.579
MOD_ProDKin_1	457	463	PF00069	0.507
MOD_ProDKin_1	648	654	PF00069	0.828
TRG_DiLeu_BaEn_1	377	382	PF01217	0.537
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.515
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.415
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.406
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.393
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.419
TRG_ENDOCYTIC_2	108	111	PF00928	0.376
TRG_ENDOCYTIC_2	170	173	PF00928	0.405
TRG_ENDOCYTIC_2	237	240	PF00928	0.438
TRG_ENDOCYTIC_2	292	295	PF00928	0.420
TRG_ENDOCYTIC_2	356	359	PF00928	0.399
TRG_ENDOCYTIC_2	489	492	PF00928	0.525
TRG_ER_diArg_1	209	211	PF00400	0.573
TRG_ER_diArg_1	287	290	PF00400	0.562
TRG_ER_diArg_1	442	445	PF00400	0.463
TRG_ER_diArg_1	523	526	PF00400	0.492
TRG_NES_CRM1_1	26	39	PF08389	0.555
TRG_NES_CRM1_1	426	440	PF08389	0.429
TRG_NES_CRM1_1	90	102	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHR7	Leptomonas seymouri	88%	97%
A0A0S4J1S0	Bodo saltans	55%	100%
A0A1X0P6U3	Trypanosomatidae	58%	100%
A0A3R7KDP1	Trypanosoma rangeli	56%	100%
A0A3S7WUV3	Leishmania donovani	97%	100%
A4H9H6	Leishmania braziliensis	93%	100%
A4HXU2	Leishmania infantum	97%	100%
C9ZZW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AIC2	Leishmania braziliensis	24%	100%
E9ARK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P30153	Homo sapiens	21%	100%
P30154	Homo sapiens	21%	100%
P36179	Drosophila melanogaster	22%	100%
P54612	Sus scrofa	21%	100%
P54613	Sus scrofa	21%	100%
Q32PI5	Bos taurus	21%	100%
Q38950	Arabidopsis thaliana	21%	100%
Q38951	Arabidopsis thaliana	21%	100%
Q4QCX5	Leishmania major	23%	100%
Q4QQT4	Rattus norvegicus	21%	100%
Q54QR9	Dictyostelium discoideum	23%	100%
Q76MZ3	Mus musculus	21%	100%
Q8C0Y0	Mus musculus	20%	81%
V5DN32	Trypanosoma cruzi	55%	100%