Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDX4_LEIMA

TriTrypDb:

LmjF.18.0690 , LMJLV39_180012300 , LMJSD75_180012200

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	480	484	PF00656	0.696
CLV_C14_Caspase3-7	562	566	PF00656	0.633
CLV_C14_Caspase3-7	575	579	PF00656	0.643
CLV_C14_Caspase3-7	792	796	PF00656	0.481
CLV_NRD_NRD_1	12	14	PF00675	0.644
CLV_NRD_NRD_1	2	4	PF00675	0.650
CLV_NRD_NRD_1	210	212	PF00675	0.540
CLV_NRD_NRD_1	332	334	PF00675	0.563
CLV_NRD_NRD_1	529	531	PF00675	0.639
CLV_NRD_NRD_1	555	557	PF00675	0.684
CLV_NRD_NRD_1	635	637	PF00675	0.699
CLV_NRD_NRD_1	682	684	PF00675	0.590
CLV_NRD_NRD_1	805	807	PF00675	0.538
CLV_NRD_NRD_1	93	95	PF00675	0.664
CLV_PCSK_FUR_1	802	806	PF00082	0.438
CLV_PCSK_KEX2_1	12	14	PF00082	0.644
CLV_PCSK_KEX2_1	2	4	PF00082	0.659
CLV_PCSK_KEX2_1	529	531	PF00082	0.639
CLV_PCSK_KEX2_1	555	557	PF00082	0.684
CLV_PCSK_KEX2_1	572	574	PF00082	0.635
CLV_PCSK_KEX2_1	635	637	PF00082	0.699
CLV_PCSK_KEX2_1	682	684	PF00082	0.574
CLV_PCSK_KEX2_1	804	806	PF00082	0.459
CLV_PCSK_KEX2_1	93	95	PF00082	0.664
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.635
CLV_PCSK_PC7_1	631	637	PF00082	0.698
CLV_PCSK_PC7_1	8	14	PF00082	0.641
CLV_PCSK_SKI1_1	693	697	PF00082	0.504
CLV_PCSK_SKI1_1	750	754	PF00082	0.445
CLV_PCSK_SKI1_1	88	92	PF00082	0.641
DEG_APCC_DBOX_1	12	20	PF00400	0.661
DEG_APCC_DBOX_1	214	222	PF00400	0.593
DEG_APCC_DBOX_1	332	340	PF00400	0.543
DEG_APCC_DBOX_1	630	638	PF00400	0.645
DEG_Nend_UBRbox_1	1	4	PF02207	0.641
DEG_SPOP_SBC_1	450	454	PF00917	0.547
DEG_SPOP_SBC_1	47	51	PF00917	0.631
DOC_CDC14_PxL_1	213	221	PF14671	0.479
DOC_CKS1_1	289	294	PF01111	0.712
DOC_CKS1_1	730	735	PF01111	0.468
DOC_CKS1_1	783	788	PF01111	0.551
DOC_MAPK_DCC_7	211	221	PF00069	0.489
DOC_MAPK_FxFP_2	435	438	PF00069	0.453
DOC_MAPK_gen_1	165	173	PF00069	0.540
DOC_MAPK_gen_1	211	221	PF00069	0.497
DOC_MAPK_MEF2A_6	212	221	PF00069	0.483
DOC_MAPK_MEF2A_6	359	368	PF00069	0.561
DOC_PP2B_LxvP_1	581	584	PF13499	0.600
DOC_PP2B_LxvP_1	705	708	PF13499	0.506
DOC_PP2B_LxvP_1	739	742	PF13499	0.552
DOC_PP2B_LxvP_1	95	98	PF13499	0.560
DOC_PP4_FxxP_1	435	438	PF00568	0.453
DOC_PP4_FxxP_1	44	47	PF00568	0.668
DOC_PP4_MxPP_1	460	463	PF00568	0.555
DOC_USP7_MATH_1	107	111	PF00917	0.627
DOC_USP7_MATH_1	23	27	PF00917	0.734
DOC_USP7_MATH_1	257	261	PF00917	0.592
DOC_USP7_MATH_1	268	272	PF00917	0.677
DOC_USP7_MATH_1	300	304	PF00917	0.563
DOC_USP7_MATH_1	477	481	PF00917	0.672
DOC_USP7_MATH_1	48	52	PF00917	0.663
DOC_USP7_MATH_1	490	494	PF00917	0.628
DOC_USP7_MATH_1	498	502	PF00917	0.574
DOC_USP7_MATH_1	626	630	PF00917	0.704
DOC_USP7_MATH_1	724	728	PF00917	0.621
DOC_USP7_MATH_1	742	746	PF00917	0.570
DOC_WW_Pin1_4	153	158	PF00397	0.638
DOC_WW_Pin1_4	270	275	PF00397	0.637
DOC_WW_Pin1_4	288	293	PF00397	0.576
DOC_WW_Pin1_4	37	42	PF00397	0.643
DOC_WW_Pin1_4	410	415	PF00397	0.614
DOC_WW_Pin1_4	493	498	PF00397	0.676
DOC_WW_Pin1_4	515	520	PF00397	0.693
DOC_WW_Pin1_4	554	559	PF00397	0.648
DOC_WW_Pin1_4	611	616	PF00397	0.646
DOC_WW_Pin1_4	729	734	PF00397	0.460
DOC_WW_Pin1_4	782	787	PF00397	0.566
LIG_14-3-3_CanoR_1	108	116	PF00244	0.675
LIG_14-3-3_CanoR_1	165	174	PF00244	0.524
LIG_14-3-3_CanoR_1	301	307	PF00244	0.573
LIG_14-3-3_CanoR_1	333	341	PF00244	0.545
LIG_14-3-3_CanoR_1	355	359	PF00244	0.615
LIG_14-3-3_CanoR_1	476	482	PF00244	0.657
LIG_14-3-3_CanoR_1	573	577	PF00244	0.672
LIG_14-3-3_CanoR_1	58	66	PF00244	0.599
LIG_14-3-3_CanoR_1	597	605	PF00244	0.651
LIG_14-3-3_CanoR_1	608	618	PF00244	0.637
LIG_14-3-3_CanoR_1	631	635	PF00244	0.699
LIG_14-3-3_CanoR_1	93	98	PF00244	0.673
LIG_Actin_WH2_2	344	361	PF00022	0.721
LIG_Actin_WH2_2	669	684	PF00022	0.524
LIG_BRCT_BRCA1_1	108	112	PF00533	0.635
LIG_CtBP_PxDLS_1	151	155	PF00389	0.584
LIG_EVH1_1	16	20	PF00568	0.647
LIG_FHA_1	227	233	PF00498	0.560
LIG_FHA_1	411	417	PF00498	0.507
LIG_FHA_1	476	482	PF00498	0.657
LIG_FHA_1	783	789	PF00498	0.474
LIG_FHA_2	400	406	PF00498	0.655
LIG_FHA_2	560	566	PF00498	0.698
LIG_FHA_2	573	579	PF00498	0.648
LIG_FHA_2	751	757	PF00498	0.440
LIG_FHA_2	790	796	PF00498	0.484
LIG_Integrin_RGD_1	71	73	PF01839	0.592
LIG_LIR_Apic_2	357	363	PF02991	0.584
LIG_LIR_Apic_2	434	438	PF02991	0.460
LIG_LIR_Gen_1	319	330	PF02991	0.580
LIG_LIR_Gen_1	345	356	PF02991	0.574
LIG_LIR_Gen_1	431	438	PF02991	0.481
LIG_LIR_Gen_1	756	766	PF02991	0.456
LIG_LIR_Gen_1	774	783	PF02991	0.326
LIG_LIR_LC3C_4	738	741	PF02991	0.467
LIG_LIR_Nem_3	193	198	PF02991	0.599
LIG_LIR_Nem_3	319	325	PF02991	0.586
LIG_LIR_Nem_3	345	351	PF02991	0.587
LIG_LIR_Nem_3	423	428	PF02991	0.480
LIG_LIR_Nem_3	431	435	PF02991	0.470
LIG_LIR_Nem_3	661	665	PF02991	0.611
LIG_LIR_Nem_3	672	676	PF02991	0.552
LIG_LIR_Nem_3	756	762	PF02991	0.440
LIG_LIR_Nem_3	774	780	PF02991	0.304
LIG_PCNA_yPIPBox_3	690	699	PF02747	0.502
LIG_SH2_CRK	759	763	PF00017	0.461
LIG_SH2_SRC	428	431	PF00017	0.462
LIG_SH2_SRC	781	784	PF00017	0.524
LIG_SH2_SRC	811	814	PF00017	0.453
LIG_SH2_STAT5	244	247	PF00017	0.577
LIG_SH2_STAT5	428	431	PF00017	0.462
LIG_SH2_STAT5	610	613	PF00017	0.636
LIG_SH2_STAT5	700	703	PF00017	0.726
LIG_SH2_STAT5	811	814	PF00017	0.453
LIG_SH3_1	35	41	PF00018	0.595
LIG_SH3_3	14	20	PF00018	0.808
LIG_SH3_3	145	151	PF00018	0.828
LIG_SH3_3	214	220	PF00018	0.609
LIG_SH3_3	271	277	PF00018	0.698
LIG_SH3_3	35	41	PF00018	0.598
LIG_SH3_3	456	462	PF00018	0.629
LIG_SH3_3	507	513	PF00018	0.633
LIG_SH3_3	548	554	PF00018	0.621
LIG_SH3_3	601	607	PF00018	0.655
LIG_SH3_3	612	618	PF00018	0.620
LIG_SH3_3	705	711	PF00018	0.690
LIG_SH3_3	727	733	PF00018	0.448
LIG_SH3_3	780	786	PF00018	0.496
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.478
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.469
LIG_SUMO_SIM_anti_2	726	732	PF11976	0.449
LIG_SUMO_SIM_par_1	219	226	PF11976	0.449
LIG_SUMO_SIM_par_1	228	235	PF11976	0.480
LIG_SUMO_SIM_par_1	477	483	PF11976	0.658
LIG_SUMO_SIM_par_1	726	732	PF11976	0.419
LIG_SUMO_SIM_par_1	750	756	PF11976	0.461
LIG_TRAF2_1	501	504	PF00917	0.573
LIG_TYR_ITIM	757	762	PF00017	0.438
LIG_WRC_WIRS_1	429	434	PF05994	0.529
LIG_WRC_WIRS_1	543	548	PF05994	0.664
LIG_WW_2	17	20	PF00397	0.598
LIG_WW_3	552	556	PF00397	0.676
MOD_CDK_SPxxK_3	493	500	PF00069	0.670
MOD_CDK_SPxxK_3	729	736	PF00069	0.426
MOD_CK1_1	153	159	PF00069	0.779
MOD_CK1_1	235	241	PF00069	0.420
MOD_CK1_1	260	266	PF00069	0.665
MOD_CK1_1	399	405	PF00069	0.551
MOD_CK1_1	475	481	PF00069	0.781
MOD_CK1_1	493	499	PF00069	0.541
MOD_CK1_1	505	511	PF00069	0.643
MOD_CK1_1	518	524	PF00069	0.629
MOD_CK1_1	557	563	PF00069	0.654
MOD_CK1_1	619	625	PF00069	0.649
MOD_CK2_1	153	159	PF00069	0.646
MOD_CK2_1	399	405	PF00069	0.667
MOD_CK2_1	4	10	PF00069	0.686
MOD_CK2_1	428	434	PF00069	0.455
MOD_CK2_1	498	504	PF00069	0.678
MOD_CK2_1	636	642	PF00069	0.678
MOD_Cter_Amidation	331	334	PF01082	0.544
MOD_GlcNHglycan	188	191	PF01048	0.544
MOD_GlcNHglycan	204	207	PF01048	0.628
MOD_GlcNHglycan	254	257	PF01048	0.580
MOD_GlcNHglycan	259	262	PF01048	0.559
MOD_GlcNHglycan	266	269	PF01048	0.537
MOD_GlcNHglycan	310	313	PF01048	0.645
MOD_GlcNHglycan	314	317	PF01048	0.619
MOD_GlcNHglycan	369	372	PF01048	0.541
MOD_GlcNHglycan	453	456	PF01048	0.612
MOD_GlcNHglycan	50	53	PF01048	0.677
MOD_GlcNHglycan	500	503	PF01048	0.696
MOD_GlcNHglycan	520	523	PF01048	0.636
MOD_GlcNHglycan	54	57	PF01048	0.635
MOD_GlcNHglycan	599	602	PF01048	0.668
MOD_GlcNHglycan	701	704	PF01048	0.553
MOD_GlcNHglycan	763	766	PF01048	0.644
MOD_GlcNHglycan	95	98	PF01048	0.635
MOD_GSK3_1	182	189	PF00069	0.543
MOD_GSK3_1	196	203	PF00069	0.643
MOD_GSK3_1	222	229	PF00069	0.545
MOD_GSK3_1	252	259	PF00069	0.636
MOD_GSK3_1	260	267	PF00069	0.634
MOD_GSK3_1	296	303	PF00069	0.655
MOD_GSK3_1	308	315	PF00069	0.572
MOD_GSK3_1	48	55	PF00069	0.632
MOD_GSK3_1	498	505	PF00069	0.676
MOD_GSK3_1	538	545	PF00069	0.733
MOD_GSK3_1	567	574	PF00069	0.755
MOD_GSK3_1	626	633	PF00069	0.640
MOD_GSK3_1	757	764	PF00069	0.501
MOD_GSK3_1	89	96	PF00069	0.667
MOD_N-GLC_1	100	105	PF02516	0.650
MOD_N-GLC_1	181	186	PF02516	0.442
MOD_N-GLC_1	235	240	PF02516	0.486
MOD_NEK2_1	183	188	PF00069	0.595
MOD_NEK2_1	232	237	PF00069	0.396
MOD_NEK2_1	251	256	PF00069	0.455
MOD_NEK2_1	506	511	PF00069	0.748
MOD_NEK2_1	542	547	PF00069	0.593
MOD_NEK2_1	630	635	PF00069	0.621
MOD_NEK2_1	681	686	PF00069	0.587
MOD_NEK2_1	761	766	PF00069	0.467
MOD_NEK2_1	82	87	PF00069	0.690
MOD_NEK2_1	99	104	PF00069	0.538
MOD_NEK2_2	567	572	PF00069	0.662
MOD_PIKK_1	320	326	PF00454	0.648
MOD_PIKK_1	465	471	PF00454	0.635
MOD_PIKK_1	616	622	PF00454	0.654
MOD_PIKK_1	681	687	PF00454	0.593
MOD_PIKK_1	706	712	PF00454	0.737
MOD_PKA_1	572	578	PF00069	0.675
MOD_PKA_1	805	811	PF00069	0.527
MOD_PKA_1	93	99	PF00069	0.592
MOD_PKA_2	107	113	PF00069	0.637
MOD_PKA_2	166	172	PF00069	0.515
MOD_PKA_2	300	306	PF00069	0.544
MOD_PKA_2	332	338	PF00069	0.609
MOD_PKA_2	354	360	PF00069	0.608
MOD_PKA_2	475	481	PF00069	0.664
MOD_PKA_2	490	496	PF00069	0.567
MOD_PKA_2	572	578	PF00069	0.626
MOD_PKA_2	630	636	PF00069	0.698
MOD_PKA_2	681	687	PF00069	0.582
MOD_PKA_2	805	811	PF00069	0.527
MOD_PKA_2	82	88	PF00069	0.688
MOD_PKA_2	93	99	PF00069	0.593
MOD_Plk_1	190	196	PF00069	0.511
MOD_Plk_2-3	638	644	PF00069	0.614
MOD_Plk_4	191	197	PF00069	0.690
MOD_Plk_4	226	232	PF00069	0.559
MOD_Plk_4	335	341	PF00069	0.544
MOD_Plk_4	396	402	PF00069	0.530
MOD_Plk_4	428	434	PF00069	0.455
MOD_Plk_4	502	508	PF00069	0.561
MOD_Plk_4	538	544	PF00069	0.684
MOD_Plk_4	724	730	PF00069	0.454
MOD_Plk_4	757	763	PF00069	0.503
MOD_Plk_4	789	795	PF00069	0.484
MOD_ProDKin_1	153	159	PF00069	0.636
MOD_ProDKin_1	270	276	PF00069	0.632
MOD_ProDKin_1	288	294	PF00069	0.572
MOD_ProDKin_1	37	43	PF00069	0.648
MOD_ProDKin_1	410	416	PF00069	0.608
MOD_ProDKin_1	493	499	PF00069	0.676
MOD_ProDKin_1	515	521	PF00069	0.693
MOD_ProDKin_1	554	560	PF00069	0.648
MOD_ProDKin_1	611	617	PF00069	0.640
MOD_ProDKin_1	729	735	PF00069	0.464
MOD_ProDKin_1	782	788	PF00069	0.553
TRG_DiLeu_BaEn_1	362	367	PF01217	0.469
TRG_DiLeu_BaEn_2	774	780	PF01217	0.353
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.482
TRG_DiLeu_BaLyEn_6	510	515	PF01217	0.677
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.676
TRG_ENDOCYTIC_2	759	762	PF00928	0.445
TRG_ER_diArg_1	1	3	PF00400	0.675
TRG_ER_diArg_1	11	13	PF00400	0.658
TRG_ER_diArg_1	380	383	PF00400	0.607
TRG_ER_diArg_1	554	556	PF00400	0.685
TRG_ER_diArg_1	634	636	PF00400	0.699
TRG_ER_diArg_1	681	683	PF00400	0.585
TRG_ER_diArg_1	801	804	PF00400	0.418
TRG_ER_diArg_1	93	95	PF00400	0.664
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	674	678	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G3	Leptomonas seymouri	30%	100%
A0A3S7WUV1	Leishmania donovani	83%	99%
A4H9H7	Leishmania braziliensis	60%	92%
A4HXU3	Leishmania infantum	83%	99%
E9ARK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	96%