Origin recognition complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDX0_LEIMA

TriTrypDb:

LmjF.18.0720 , LMJLV39_180012700 , LMJSD75_180012600

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.661
CLV_C14_Caspase3-7	364	368	PF00656	0.415
CLV_NRD_NRD_1	180	182	PF00675	0.685
CLV_NRD_NRD_1	200	202	PF00675	0.634
CLV_NRD_NRD_1	380	382	PF00675	0.366
CLV_NRD_NRD_1	438	440	PF00675	0.482
CLV_NRD_NRD_1	604	606	PF00675	0.499
CLV_NRD_NRD_1	663	665	PF00675	0.641
CLV_NRD_NRD_1	70	72	PF00675	0.440
CLV_PCSK_KEX2_1	180	182	PF00082	0.685
CLV_PCSK_KEX2_1	200	202	PF00082	0.681
CLV_PCSK_KEX2_1	333	335	PF00082	0.483
CLV_PCSK_KEX2_1	379	381	PF00082	0.364
CLV_PCSK_KEX2_1	438	440	PF00082	0.482
CLV_PCSK_KEX2_1	604	606	PF00082	0.499
CLV_PCSK_KEX2_1	663	665	PF00082	0.641
CLV_PCSK_KEX2_1	70	72	PF00082	0.440
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.483
CLV_PCSK_PC7_1	329	335	PF00082	0.484
CLV_PCSK_SKI1_1	354	358	PF00082	0.619
CLV_PCSK_SKI1_1	439	443	PF00082	0.466
CLV_PCSK_SKI1_1	604	608	PF00082	0.498
CLV_PCSK_SKI1_1	740	744	PF00082	0.461
CLV_PCSK_SKI1_1	783	787	PF00082	0.417
CLV_PCSK_SKI1_1	819	823	PF00082	0.392
CLV_PCSK_SKI1_1	83	87	PF00082	0.539
CLV_Separin_Metazoa	528	532	PF03568	0.533
CLV_Separin_Metazoa	843	847	PF03568	0.382
DEG_APCC_DBOX_1	437	445	PF00400	0.499
DEG_APCC_DBOX_1	604	612	PF00400	0.502
DEG_APCC_DBOX_1	739	747	PF00400	0.461
DEG_APCC_DBOX_1	794	802	PF00400	0.405
DEG_APCC_DBOX_1	818	826	PF00400	0.381
DEG_SPOP_SBC_1	244	248	PF00917	0.559
DOC_CDC14_PxL_1	710	718	PF14671	0.494
DOC_CKS1_1	658	663	PF01111	0.529
DOC_CYCLIN_RxL_1	435	446	PF00134	0.525
DOC_CYCLIN_RxL_1	54	68	PF00134	0.428
DOC_CYCLIN_yClb5_NLxxxL_5	718	727	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	161	164	PF00134	0.509
DOC_CYCLIN_yCln2_LP_2	479	485	PF00134	0.642
DOC_CYCLIN_yCln2_LP_2	718	721	PF00134	0.545
DOC_MAPK_DCC_7	475	485	PF00069	0.640
DOC_MAPK_DCC_7	637	647	PF00069	0.472
DOC_MAPK_DCC_7	708	718	PF00069	0.676
DOC_MAPK_gen_1	435	444	PF00069	0.455
DOC_MAPK_gen_1	673	682	PF00069	0.487
DOC_MAPK_gen_1	817	825	PF00069	0.492
DOC_MAPK_MEF2A_6	637	646	PF00069	0.475
DOC_MAPK_MEF2A_6	673	682	PF00069	0.487
DOC_MAPK_MEF2A_6	740	749	PF00069	0.355
DOC_PP2B_LxvP_1	161	164	PF13499	0.509
DOC_PP2B_LxvP_1	718	721	PF13499	0.582
DOC_USP7_MATH_1	154	158	PF00917	0.589
DOC_USP7_MATH_1	219	223	PF00917	0.724
DOC_USP7_MATH_1	4	8	PF00917	0.633
DOC_USP7_MATH_1	496	500	PF00917	0.725
DOC_USP7_MATH_1	513	517	PF00917	0.662
DOC_USP7_MATH_1	53	57	PF00917	0.448
DOC_USP7_MATH_1	631	635	PF00917	0.584
DOC_WW_Pin1_4	102	107	PF00397	0.410
DOC_WW_Pin1_4	186	191	PF00397	0.663
DOC_WW_Pin1_4	460	465	PF00397	0.635
DOC_WW_Pin1_4	478	483	PF00397	0.537
DOC_WW_Pin1_4	494	499	PF00397	0.601
DOC_WW_Pin1_4	657	662	PF00397	0.529
DOC_WW_Pin1_4	69	74	PF00397	0.533
LIG_14-3-3_CanoR_1	183	188	PF00244	0.749
LIG_14-3-3_CanoR_1	203	211	PF00244	0.560
LIG_14-3-3_CanoR_1	338	346	PF00244	0.447
LIG_14-3-3_CanoR_1	423	431	PF00244	0.482
LIG_14-3-3_CanoR_1	439	445	PF00244	0.464
LIG_14-3-3_CanoR_1	475	479	PF00244	0.727
LIG_14-3-3_CanoR_1	605	611	PF00244	0.531
LIG_14-3-3_CanoR_1	846	851	PF00244	0.501
LIG_Actin_WH2_2	786	802	PF00022	0.497
LIG_Actin_WH2_2	96	114	PF00022	0.415
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	496	500	PF00533	0.714
LIG_BRCT_BRCA1_1	684	688	PF00533	0.501
LIG_Clathr_ClatBox_1	128	132	PF01394	0.516
LIG_EH1_1	58	66	PF00400	0.420
LIG_eIF4E_1	295	301	PF01652	0.398
LIG_FHA_1	246	252	PF00498	0.558
LIG_FHA_1	341	347	PF00498	0.396
LIG_FHA_1	451	457	PF00498	0.673
LIG_FHA_1	503	509	PF00498	0.674
LIG_FHA_1	516	522	PF00498	0.435
LIG_FHA_2	229	235	PF00498	0.642
LIG_FHA_2	362	368	PF00498	0.420
LIG_FHA_2	428	434	PF00498	0.504
LIG_FHA_2	566	572	PF00498	0.635
LIG_FHA_2	759	765	PF00498	0.414
LIG_GBD_Chelix_1	562	570	PF00786	0.619
LIG_GBD_Chelix_1	95	103	PF00786	0.389
LIG_LIR_Apic_2	704	709	PF02991	0.672
LIG_LIR_Nem_3	122	128	PF02991	0.389
LIG_LIR_Nem_3	26	32	PF02991	0.434
LIG_LIR_Nem_3	342	348	PF02991	0.433
LIG_NRBOX	352	358	PF00104	0.515
LIG_NRBOX	440	446	PF00104	0.547
LIG_NRBOX	722	728	PF00104	0.582
LIG_NRBOX	742	748	PF00104	0.208
LIG_PDZ_Class_1	846	851	PF00595	0.501
LIG_Pex14_2	125	129	PF04695	0.398
LIG_SH2_CRK	29	33	PF00017	0.426
LIG_SH2_CRK	706	710	PF00017	0.673
LIG_SH2_GRB2like	468	471	PF00017	0.502
LIG_SH2_PTP2	345	348	PF00017	0.435
LIG_SH2_STAT5	116	119	PF00017	0.516
LIG_SH2_STAT5	250	253	PF00017	0.576
LIG_SH2_STAT5	295	298	PF00017	0.395
LIG_SH2_STAT5	345	348	PF00017	0.435
LIG_SH2_STAT5	507	510	PF00017	0.437
LIG_SH3_1	344	350	PF00018	0.437
LIG_SH3_1	616	622	PF00018	0.609
LIG_SH3_1	708	714	PF00018	0.621
LIG_SH3_3	184	190	PF00018	0.678
LIG_SH3_3	344	350	PF00018	0.437
LIG_SH3_3	616	622	PF00018	0.679
LIG_SH3_3	708	714	PF00018	0.621
LIG_SUMO_SIM_anti_2	574	585	PF11976	0.560
LIG_SUMO_SIM_anti_2	715	720	PF11976	0.432
LIG_SUMO_SIM_anti_2	741	747	PF11976	0.353
LIG_SUMO_SIM_par_1	265	271	PF11976	0.379
LIG_SUMO_SIM_par_1	440	449	PF11976	0.563
LIG_SUMO_SIM_par_1	820	827	PF11976	0.415
LIG_TYR_ITIM	746	751	PF00017	0.355
LIG_UBA3_1	266	270	PF00899	0.371
LIG_UBA3_1	822	829	PF00899	0.490
LIG_ULM_U2AF65_1	200	205	PF00076	0.751
LIG_WRC_WIRS_1	99	104	PF05994	0.496
MOD_CDK_SPxK_1	657	663	PF00069	0.525
MOD_CDK_SPxxK_3	186	193	PF00069	0.540
MOD_CDK_SPxxK_3	657	664	PF00069	0.527
MOD_CK1_1	105	111	PF00069	0.415
MOD_CK1_1	157	163	PF00069	0.527
MOD_CK1_1	176	182	PF00069	0.670
MOD_CK1_1	185	191	PF00069	0.621
MOD_CK1_1	246	252	PF00069	0.558
MOD_CK1_1	337	343	PF00069	0.475
MOD_CK1_1	390	396	PF00069	0.453
MOD_CK1_1	427	433	PF00069	0.468
MOD_CK1_1	460	466	PF00069	0.639
MOD_CK1_1	492	498	PF00069	0.628
MOD_CK1_1	499	505	PF00069	0.696
MOD_CK1_1	515	521	PF00069	0.430
MOD_CK1_1	574	580	PF00069	0.593
MOD_CK1_1	626	632	PF00069	0.630
MOD_CK1_1	772	778	PF00069	0.447
MOD_CK2_1	228	234	PF00069	0.676
MOD_CK2_1	427	433	PF00069	0.503
MOD_CK2_1	565	571	PF00069	0.628
MOD_CK2_1	699	705	PF00069	0.718
MOD_Cter_Amidation	377	380	PF01082	0.350
MOD_Cter_Amidation	602	605	PF01082	0.486
MOD_GlcNHglycan	1	4	PF01048	0.701
MOD_GlcNHglycan	107	110	PF01048	0.535
MOD_GlcNHglycan	156	159	PF01048	0.599
MOD_GlcNHglycan	175	178	PF01048	0.625
MOD_GlcNHglycan	220	224	PF01048	0.775
MOD_GlcNHglycan	239	242	PF01048	0.517
MOD_GlcNHglycan	256	259	PF01048	0.421
MOD_GlcNHglycan	297	300	PF01048	0.404
MOD_GlcNHglycan	322	325	PF01048	0.410
MOD_GlcNHglycan	389	392	PF01048	0.441
MOD_GlcNHglycan	400	404	PF01048	0.477
MOD_GlcNHglycan	459	462	PF01048	0.686
MOD_GlcNHglycan	471	474	PF01048	0.569
MOD_GlcNHglycan	491	494	PF01048	0.640
MOD_GlcNHglycan	55	58	PF01048	0.415
MOD_GlcNHglycan	553	556	PF01048	0.537
MOD_GlcNHglycan	592	595	PF01048	0.721
MOD_GlcNHglycan	6	9	PF01048	0.726
MOD_GlcNHglycan	601	604	PF01048	0.578
MOD_GlcNHglycan	628	631	PF01048	0.630
MOD_GlcNHglycan	754	757	PF01048	0.536
MOD_GlcNHglycan	813	816	PF01048	0.319
MOD_GSK3_1	182	189	PF00069	0.750
MOD_GSK3_1	242	249	PF00069	0.545
MOD_GSK3_1	268	275	PF00069	0.376
MOD_GSK3_1	28	35	PF00069	0.428
MOD_GSK3_1	333	340	PF00069	0.494
MOD_GSK3_1	357	364	PF00069	0.441
MOD_GSK3_1	440	447	PF00069	0.525
MOD_GSK3_1	469	476	PF00069	0.709
MOD_GSK3_1	488	495	PF00069	0.633
MOD_GSK3_1	498	505	PF00069	0.524
MOD_GSK3_1	561	568	PF00069	0.536
MOD_GSK3_1	571	578	PF00069	0.534
MOD_GSK3_1	606	613	PF00069	0.395
MOD_GSK3_1	622	629	PF00069	0.484
MOD_GSK3_1	652	659	PF00069	0.557
MOD_GSK3_1	693	700	PF00069	0.562
MOD_GSK3_1	768	775	PF00069	0.432
MOD_GSK3_1	98	105	PF00069	0.509
MOD_N-GLC_1	469	474	PF02516	0.498
MOD_N-GLC_1	572	577	PF02516	0.657
MOD_NEK2_1	117	122	PF00069	0.495
MOD_NEK2_1	214	219	PF00069	0.571
MOD_NEK2_1	243	248	PF00069	0.570
MOD_NEK2_1	268	273	PF00069	0.384
MOD_NEK2_1	32	37	PF00069	0.524
MOD_NEK2_1	357	362	PF00069	0.520
MOD_NEK2_1	384	389	PF00069	0.404
MOD_NEK2_1	413	418	PF00069	0.488
MOD_NEK2_1	452	457	PF00069	0.518
MOD_NEK2_1	512	517	PF00069	0.581
MOD_NEK2_1	572	577	PF00069	0.662
MOD_NEK2_1	599	604	PF00069	0.553
MOD_NEK2_1	656	661	PF00069	0.728
MOD_NEK2_1	821	826	PF00069	0.368
MOD_NEK2_2	28	33	PF00069	0.424
MOD_OFUCOSY	40	47	PF10250	0.425
MOD_PIKK_1	163	169	PF00454	0.623
MOD_PIKK_1	366	372	PF00454	0.429
MOD_PIKK_1	803	809	PF00454	0.437
MOD_PKA_1	333	339	PF00069	0.492
MOD_PKA_2	182	188	PF00069	0.819
MOD_PKA_2	204	210	PF00069	0.660
MOD_PKA_2	32	38	PF00069	0.426
MOD_PKA_2	333	339	PF00069	0.492
MOD_PKA_2	474	480	PF00069	0.702
MOD_PKA_2	53	59	PF00069	0.432
MOD_PKB_1	181	189	PF00069	0.758
MOD_PKB_1	201	209	PF00069	0.638
MOD_Plk_1	138	144	PF00069	0.460
MOD_Plk_1	427	433	PF00069	0.503
MOD_Plk_1	758	764	PF00069	0.525
MOD_Plk_2-3	228	234	PF00069	0.673
MOD_Plk_2-3	565	571	PF00069	0.628
MOD_Plk_4	157	163	PF00069	0.662
MOD_Plk_4	246	252	PF00069	0.535
MOD_Plk_4	272	278	PF00069	0.359
MOD_Plk_4	315	321	PF00069	0.395
MOD_Plk_4	440	446	PF00069	0.617
MOD_Plk_4	474	480	PF00069	0.543
MOD_Plk_4	507	513	PF00069	0.598
MOD_Plk_4	576	582	PF00069	0.530
MOD_Plk_4	606	612	PF00069	0.534
MOD_Plk_4	652	658	PF00069	0.560
MOD_Plk_4	714	720	PF00069	0.545
MOD_Plk_4	821	827	PF00069	0.376
MOD_Plk_4	98	104	PF00069	0.496
MOD_ProDKin_1	102	108	PF00069	0.404
MOD_ProDKin_1	186	192	PF00069	0.664
MOD_ProDKin_1	460	466	PF00069	0.636
MOD_ProDKin_1	478	484	PF00069	0.539
MOD_ProDKin_1	494	500	PF00069	0.601
MOD_ProDKin_1	657	663	PF00069	0.532
MOD_ProDKin_1	69	75	PF00069	0.526
TRG_DiLeu_BaEn_3	651	657	PF01217	0.447
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.433
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.434
TRG_DiLeu_BaLyEn_6	794	799	PF01217	0.405
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.269
TRG_ENDOCYTIC_2	29	32	PF00928	0.420
TRG_ENDOCYTIC_2	345	348	PF00928	0.435
TRG_ENDOCYTIC_2	748	751	PF00928	0.357
TRG_ER_diArg_1	180	183	PF00400	0.842
TRG_ER_diArg_1	200	203	PF00400	0.668
TRG_ER_diArg_1	379	381	PF00400	0.409
TRG_ER_diArg_1	604	606	PF00400	0.499
TRG_ER_diArg_1	611	614	PF00400	0.516
TRG_ER_diArg_1	69	71	PF00400	0.423
TRG_ER_FFAT_2	494	505	PF00635	0.708
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	63	68	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN4	Leptomonas seymouri	54%	76%
A0A3S5H733	Leishmania donovani	92%	100%
A4H9I3	Leishmania braziliensis	78%	100%
A4HXU7	Leishmania infantum	91%	100%
E9ARK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%