Putative dynein-light chain-protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light chain Tctex-type, putative

Species:

Leishmania major

UniProt:

Q4QDW9_LEIMA

TriTrypDb:

LmjF.18.0730 , LMJLV39_180012800 , LMJSD75_180012700

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4QDW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDW9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.647
CLV_C14_Caspase3-7	17	21	PF00656	0.691
CLV_NRD_NRD_1	207	209	PF00675	0.408
CLV_PCSK_SKI1_1	196	200	PF00082	0.430
CLV_PCSK_SKI1_1	42	46	PF00082	0.790
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.452
DOC_MAPK_gen_1	208	216	PF00069	0.376
DOC_USP7_MATH_1	2	6	PF00917	0.772
DOC_USP7_MATH_1	71	75	PF00917	0.735
DOC_WW_Pin1_4	122	127	PF00397	0.499
LIG_14-3-3_CanoR_1	110	120	PF00244	0.593
LIG_APCC_ABBA_1	124	129	PF00400	0.521
LIG_BIR_II_1	1	5	PF00653	0.804
LIG_BRCT_BRCA1_1	124	128	PF00533	0.509
LIG_EH1_1	199	207	PF00400	0.376
LIG_LIR_Apic_2	218	224	PF02991	0.502
LIG_LIR_Gen_1	177	187	PF02991	0.502
LIG_LIR_Gen_1	244	250	PF02991	0.429
LIG_LIR_Nem_3	177	182	PF02991	0.502
LIG_LIR_Nem_3	244	250	PF02991	0.429
LIG_MLH1_MIPbox_1	124	128	PF16413	0.509
LIG_PTAP_UEV_1	152	157	PF05743	0.576
LIG_SH2_PTP2	240	243	PF00017	0.263
LIG_SH2_STAT5	127	130	PF00017	0.519
LIG_SH2_STAT5	240	243	PF00017	0.263
LIG_SH3_3	120	126	PF00018	0.452
LIG_SH3_3	150	156	PF00018	0.755
LIG_SUMO_SIM_anti_2	177	185	PF11976	0.502
LIG_TRAF2_1	157	160	PF00917	0.684
LIG_UBA3_1	187	196	PF00899	0.395
MOD_CK1_1	146	152	PF00069	0.688
MOD_CK1_1	6	12	PF00069	0.785
MOD_GlcNHglycan	148	151	PF01048	0.702
MOD_GlcNHglycan	153	156	PF01048	0.701
MOD_GlcNHglycan	234	238	PF01048	0.342
MOD_GlcNHglycan	34	37	PF01048	0.695
MOD_GlcNHglycan	46	49	PF01048	0.749
MOD_GlcNHglycan	73	76	PF01048	0.777
MOD_GSK3_1	2	9	PF00069	0.754
MOD_GSK3_1	27	34	PF00069	0.797
MOD_GSK3_1	38	45	PF00069	0.825
MOD_GSK3_1	76	83	PF00069	0.760
MOD_N-GLC_1	42	47	PF02516	0.742
MOD_N-GLC_1	7	12	PF02516	0.810
MOD_N-GLC_1	85	90	PF02516	0.684
MOD_NEK2_1	19	24	PF00069	0.816
MOD_NEK2_1	31	36	PF00069	0.613
MOD_PIKK_1	87	93	PF00454	0.706
MOD_Plk_4	241	247	PF00069	0.376
MOD_ProDKin_1	122	128	PF00069	0.499
MOD_SUMO_for_1	174	177	PF00179	0.452
MOD_SUMO_rev_2	109	119	PF00179	0.509
TRG_DiLeu_BaEn_1	178	183	PF01217	0.502
TRG_ENDOCYTIC_2	171	174	PF00928	0.376
TRG_ENDOCYTIC_2	222	225	PF00928	0.502
TRG_ENDOCYTIC_2	240	243	PF00928	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7KQL0	Trypanosoma rangeli	45%	100%
A0A3S7WUW6	Leishmania donovani	94%	100%
A4H9I4	Leishmania braziliensis	70%	98%
A4HXU8	Leishmania infantum	94%	100%
E9ARL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
V5DN82	Trypanosoma cruzi	42%	100%