Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QDW7_LEIMA

TriTrypDb:

LmjF.18.0750 , LMJLV39_180013000 , LMJSD75_180012900

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.421
CLV_NRD_NRD_1	141	143	PF00675	0.696
CLV_NRD_NRD_1	183	185	PF00675	0.659
CLV_NRD_NRD_1	230	232	PF00675	0.600
CLV_NRD_NRD_1	389	391	PF00675	0.581
CLV_NRD_NRD_1	440	442	PF00675	0.676
CLV_NRD_NRD_1	493	495	PF00675	0.608
CLV_NRD_NRD_1	559	561	PF00675	0.577
CLV_PCSK_KEX2_1	141	143	PF00082	0.717
CLV_PCSK_KEX2_1	183	185	PF00082	0.659
CLV_PCSK_KEX2_1	230	232	PF00082	0.600
CLV_PCSK_KEX2_1	389	391	PF00082	0.581
CLV_PCSK_KEX2_1	440	442	PF00082	0.676
CLV_PCSK_KEX2_1	493	495	PF00082	0.608
CLV_PCSK_KEX2_1	559	561	PF00082	0.577
CLV_PCSK_SKI1_1	262	266	PF00082	0.469
CLV_PCSK_SKI1_1	273	277	PF00082	0.502
CLV_PCSK_SKI1_1	494	498	PF00082	0.607
CLV_Separin_Metazoa	227	231	PF03568	0.569
DEG_SPOP_SBC_1	60	64	PF00917	0.556
DOC_CKS1_1	278	283	PF01111	0.424
DOC_CYCLIN_RxL_1	238	249	PF00134	0.557
DOC_MAPK_gen_1	141	149	PF00069	0.648
DOC_MAPK_gen_1	33	41	PF00069	0.504
DOC_MAPK_MEF2A_6	141	149	PF00069	0.624
DOC_PP2B_LxvP_1	288	291	PF13499	0.500
DOC_PP2B_LxvP_1	373	376	PF13499	0.487
DOC_PP4_FxxP_1	405	408	PF00568	0.629
DOC_PP4_FxxP_1	496	499	PF00568	0.622
DOC_PP4_FxxP_1	506	509	PF00568	0.537
DOC_PP4_FxxP_1	515	518	PF00568	0.509
DOC_PP4_FxxP_1	9	12	PF00568	0.576
DOC_USP7_MATH_1	12	16	PF00917	0.586
DOC_USP7_MATH_1	148	152	PF00917	0.568
DOC_USP7_MATH_1	264	268	PF00917	0.399
DOC_USP7_MATH_1	311	315	PF00917	0.550
DOC_USP7_MATH_1	408	412	PF00917	0.620
DOC_USP7_MATH_1	442	446	PF00917	0.600
DOC_USP7_MATH_1	524	528	PF00917	0.692
DOC_USP7_MATH_1	530	534	PF00917	0.614
DOC_USP7_MATH_1	72	76	PF00917	0.560
DOC_USP7_MATH_1	85	89	PF00917	0.816
DOC_WW_Pin1_4	111	116	PF00397	0.721
DOC_WW_Pin1_4	14	19	PF00397	0.524
DOC_WW_Pin1_4	141	146	PF00397	0.741
DOC_WW_Pin1_4	213	218	PF00397	0.628
DOC_WW_Pin1_4	277	282	PF00397	0.423
DOC_WW_Pin1_4	378	383	PF00397	0.588
DOC_WW_Pin1_4	433	438	PF00397	0.598
DOC_WW_Pin1_4	451	456	PF00397	0.615
DOC_WW_Pin1_4	522	527	PF00397	0.662
LIG_14-3-3_CanoR_1	105	113	PF00244	0.627
LIG_14-3-3_CanoR_1	141	145	PF00244	0.699
LIG_14-3-3_CanoR_1	162	168	PF00244	0.574
LIG_14-3-3_CanoR_1	266	272	PF00244	0.530
LIG_14-3-3_CanoR_1	279	285	PF00244	0.380
LIG_14-3-3_CanoR_1	431	438	PF00244	0.634
LIG_14-3-3_CanoR_1	441	449	PF00244	0.583
LIG_14-3-3_CanoR_1	493	499	PF00244	0.577
LIG_14-3-3_CanoR_1	559	565	PF00244	0.615
LIG_14-3-3_CanoR_1	71	77	PF00244	0.598
LIG_Actin_WH2_2	251	268	PF00022	0.419
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BIR_III_2	397	401	PF00653	0.536
LIG_BIR_III_4	318	322	PF00653	0.598
LIG_deltaCOP1_diTrp_1	358	366	PF00928	0.403
LIG_deltaCOP1_diTrp_1	480	490	PF00928	0.567
LIG_EH1_1	47	55	PF00400	0.557
LIG_FHA_1	127	133	PF00498	0.584
LIG_FHA_1	142	148	PF00498	0.649
LIG_FHA_1	23	29	PF00498	0.563
LIG_FHA_1	292	298	PF00498	0.608
LIG_FHA_1	303	309	PF00498	0.593
LIG_FHA_1	49	55	PF00498	0.467
LIG_FHA_1	546	552	PF00498	0.591
LIG_FHA_1	98	104	PF00498	0.529
LIG_FHA_2	162	168	PF00498	0.570
LIG_FHA_2	194	200	PF00498	0.555
LIG_FHA_2	207	213	PF00498	0.445
LIG_FHA_2	339	345	PF00498	0.436
LIG_FHA_2	498	504	PF00498	0.564
LIG_FHA_2	545	551	PF00498	0.518
LIG_FXI_DFP_1	487	491	PF00024	0.580
LIG_LIR_Apic_2	404	408	PF02991	0.629
LIG_LIR_Apic_2	503	509	PF02991	0.567
LIG_LIR_Apic_2	513	518	PF02991	0.579
LIG_LIR_Apic_2	8	12	PF02991	0.573
LIG_LIR_Gen_1	150	159	PF02991	0.686
LIG_LIR_Gen_1	165	174	PF02991	0.536
LIG_LIR_Gen_1	216	226	PF02991	0.559
LIG_LIR_Gen_1	337	346	PF02991	0.512
LIG_LIR_Gen_1	358	369	PF02991	0.485
LIG_LIR_Gen_1	500	509	PF02991	0.566
LIG_LIR_Nem_3	150	156	PF02991	0.730
LIG_LIR_Nem_3	165	171	PF02991	0.490
LIG_LIR_Nem_3	337	342	PF02991	0.508
LIG_LIR_Nem_3	358	364	PF02991	0.423
LIG_LIR_Nem_3	404	409	PF02991	0.629
LIG_LIR_Nem_3	500	505	PF02991	0.562
LIG_LIR_Nem_3	68	73	PF02991	0.702
LIG_NRBOX	203	209	PF00104	0.523
LIG_NRBOX	283	289	PF00104	0.485
LIG_PDZ_Class_1	560	565	PF00595	0.616
LIG_SH2_CRK	521	525	PF00017	0.770
LIG_SH2_CRK	554	558	PF00017	0.652
LIG_SH2_NCK_1	521	525	PF00017	0.642
LIG_SH2_STAP1	336	340	PF00017	0.488
LIG_SH2_STAP1	502	506	PF00017	0.563
LIG_SH2_STAT5	253	256	PF00017	0.355
LIG_SH2_STAT5	336	339	PF00017	0.505
LIG_SH2_STAT5	521	524	PF00017	0.640
LIG_SH2_STAT5	554	557	PF00017	0.654
LIG_SH2_STAT5	58	61	PF00017	0.679
LIG_SH3_1	142	148	PF00018	0.626
LIG_SH3_3	109	115	PF00018	0.515
LIG_SH3_3	142	148	PF00018	0.626
LIG_SH3_3	305	311	PF00018	0.651
LIG_SH3_3	513	519	PF00018	0.606
LIG_SH3_3	520	526	PF00018	0.558
LIG_SUMO_SIM_anti_2	198	206	PF11976	0.535
LIG_SUMO_SIM_par_1	19	25	PF11976	0.542
LIG_SUMO_SIM_par_1	280	286	PF11976	0.488
LIG_TRAF2_1	209	212	PF00917	0.588
LIG_TRAF2_1	235	238	PF00917	0.628
LIG_TRAF2_1	29	32	PF00917	0.497
LIG_TRAF2_1	541	544	PF00917	0.623
LIG_UBA3_1	254	260	PF00899	0.438
LIG_WRC_WIRS_1	149	154	PF05994	0.547
LIG_WRC_WIRS_1	6	11	PF05994	0.572
LIG_WW_1	518	521	PF00397	0.633
LIG_WW_3	374	378	PF00397	0.510
MOD_CDK_SPxxK_3	433	440	PF00069	0.625
MOD_CK1_1	126	132	PF00069	0.585
MOD_CK1_1	176	182	PF00069	0.637
MOD_CK1_1	193	199	PF00069	0.517
MOD_CK1_1	206	212	PF00069	0.660
MOD_CK1_1	236	242	PF00069	0.622
MOD_CK1_1	283	289	PF00069	0.544
MOD_CK1_1	320	326	PF00069	0.601
MOD_CK1_1	331	337	PF00069	0.391
MOD_CK2_1	105	111	PF00069	0.577
MOD_CK2_1	140	146	PF00069	0.647
MOD_CK2_1	161	167	PF00069	0.598
MOD_CK2_1	206	212	PF00069	0.494
MOD_CK2_1	442	448	PF00069	0.687
MOD_CK2_1	451	457	PF00069	0.526
MOD_CK2_1	544	550	PF00069	0.520
MOD_CK2_1	76	82	PF00069	0.623
MOD_Cter_Amidation	387	390	PF01082	0.582
MOD_GlcNHglycan	1	4	PF01048	0.584
MOD_GlcNHglycan	125	128	PF01048	0.640
MOD_GlcNHglycan	318	322	PF01048	0.644
MOD_GlcNHglycan	383	386	PF01048	0.634
MOD_GlcNHglycan	410	413	PF01048	0.628
MOD_GlcNHglycan	433	436	PF01048	0.671
MOD_GlcNHglycan	512	515	PF01048	0.577
MOD_GlcNHglycan	533	536	PF01048	0.647
MOD_GlcNHglycan	88	91	PF01048	0.636
MOD_GSK3_1	116	123	PF00069	0.595
MOD_GSK3_1	137	144	PF00069	0.662
MOD_GSK3_1	189	196	PF00069	0.587
MOD_GSK3_1	203	210	PF00069	0.430
MOD_GSK3_1	264	271	PF00069	0.501
MOD_GSK3_1	273	280	PF00069	0.468
MOD_GSK3_1	298	305	PF00069	0.484
MOD_GSK3_1	330	337	PF00069	0.452
MOD_GSK3_1	61	68	PF00069	0.635
MOD_GSK3_1	72	79	PF00069	0.561
MOD_N-GLC_1	137	142	PF02516	0.640
MOD_NEK2_1	120	125	PF00069	0.682
MOD_NEK2_1	203	208	PF00069	0.468
MOD_NEK2_1	265	270	PF00069	0.512
MOD_NEK2_1	329	334	PF00069	0.429
MOD_NEK2_1	338	343	PF00069	0.409
MOD_NEK2_1	54	59	PF00069	0.678
MOD_NEK2_1	61	66	PF00069	0.632
MOD_OFUCOSY	104	109	PF10250	0.595
MOD_PIKK_1	120	126	PF00454	0.600
MOD_PIKK_1	173	179	PF00454	0.625
MOD_PIKK_1	207	213	PF00454	0.530
MOD_PIKK_1	233	239	PF00454	0.638
MOD_PIKK_1	265	271	PF00454	0.513
MOD_PIKK_1	76	82	PF00454	0.623
MOD_PKA_2	120	126	PF00069	0.705
MOD_PKA_2	140	146	PF00069	0.595
MOD_PKA_2	161	167	PF00069	0.543
MOD_PKA_2	193	199	PF00069	0.577
MOD_PKA_2	233	239	PF00069	0.638
MOD_PKA_2	265	271	PF00069	0.513
MOD_PKA_2	388	394	PF00069	0.578
MOD_PKA_2	531	537	PF00069	0.631
MOD_Plk_1	166	172	PF00069	0.522
MOD_Plk_1	48	54	PF00069	0.556
MOD_Plk_2-3	161	167	PF00069	0.543
MOD_Plk_4	148	154	PF00069	0.621
MOD_Plk_4	203	209	PF00069	0.650
MOD_Plk_4	22	28	PF00069	0.502
MOD_Plk_4	253	259	PF00069	0.392
MOD_Plk_4	283	289	PF00069	0.485
MOD_Plk_4	331	337	PF00069	0.479
MOD_Plk_4	338	344	PF00069	0.462
MOD_Plk_4	401	407	PF00069	0.634
MOD_Plk_4	497	503	PF00069	0.566
MOD_Plk_4	5	11	PF00069	0.546
MOD_Plk_4	524	530	PF00069	0.580
MOD_ProDKin_1	111	117	PF00069	0.724
MOD_ProDKin_1	14	20	PF00069	0.521
MOD_ProDKin_1	141	147	PF00069	0.733
MOD_ProDKin_1	213	219	PF00069	0.630
MOD_ProDKin_1	277	283	PF00069	0.419
MOD_ProDKin_1	378	384	PF00069	0.592
MOD_ProDKin_1	433	439	PF00069	0.598
MOD_ProDKin_1	451	457	PF00069	0.609
MOD_ProDKin_1	522	528	PF00069	0.665
MOD_SUMO_for_1	541	544	PF00179	0.623
TRG_DiLeu_LyEn_5	293	298	PF01217	0.521
TRG_ENDOCYTIC_2	487	490	PF00928	0.581
TRG_ENDOCYTIC_2	502	505	PF00928	0.563
TRG_ENDOCYTIC_2	58	61	PF00928	0.567
TRG_ER_diArg_1	183	185	PF00400	0.659
TRG_ER_diArg_1	229	231	PF00400	0.605
TRG_ER_diArg_1	440	442	PF00400	0.663
TRG_ER_diArg_1	459	462	PF00400	0.748
TRG_ER_diArg_1	492	494	PF00400	0.662
TRG_ER_diArg_1	559	562	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	421	426	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2K4	Leptomonas seymouri	36%	100%
A0A3Q8IE86	Leishmania donovani	85%	100%
A4H9I6	Leishmania braziliensis	61%	100%
A4HXU9	Leishmania infantum	85%	100%
E9ARL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%