C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc-finger double-stranded RNA-binding, putative

Species:

Leishmania major

UniProt:

Q4QDW6_LEIMA

TriTrypDb:

LmjF.18.0760 , LMJLV39_180013100 , LMJSD75_180013000

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QDW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDW6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	8
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046914	transition metal ion binding	5	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	44	46	PF00675	0.599
CLV_NRD_NRD_1	73	75	PF00675	0.504
CLV_PCSK_KEX2_1	44	46	PF00082	0.601
CLV_PCSK_KEX2_1	73	75	PF00082	0.513
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.605
DOC_MAPK_gen_1	73	81	PF00069	0.457
DOC_MAPK_RevD_3	61	75	PF00069	0.518
DOC_PP4_FxxP_1	19	22	PF00568	0.558
DOC_USP7_MATH_1	5	9	PF00917	0.699
DOC_WW_Pin1_4	6	11	PF00397	0.600
DOC_WW_Pin1_4	61	66	PF00397	0.594
LIG_Actin_WH2_2	75	90	PF00022	0.555
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_FHA_2	62	68	PF00498	0.460
LIG_LIR_Apic_2	18	22	PF02991	0.377
LIG_LIR_Gen_1	66	77	PF02991	0.565
LIG_LIR_Nem_3	14	20	PF02991	0.619
LIG_LIR_Nem_3	66	72	PF02991	0.566
LIG_SH2_CRK	20	24	PF00017	0.523
LIG_SH2_STAT5	20	23	PF00017	0.480
LIG_TRAF2_1	90	93	PF00917	0.598
MOD_CK2_1	87	93	PF00069	0.532
MOD_GlcNHglycan	3	6	PF01048	0.759
MOD_GlcNHglycan	46	49	PF01048	0.481
MOD_GlcNHglycan	91	96	PF01048	0.558
MOD_GSK3_1	1	8	PF00069	0.681
MOD_GSK3_1	11	18	PF00069	0.590
MOD_GSK3_1	87	94	PF00069	0.615
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	28	33	PF00069	0.544
MOD_PIKK_1	28	34	PF00454	0.428
MOD_PKA_1	44	50	PF00069	0.485
MOD_PKA_2	44	50	PF00069	0.499
MOD_Plk_4	15	21	PF00069	0.577
MOD_ProDKin_1	6	12	PF00069	0.597
MOD_ProDKin_1	61	67	PF00069	0.588
MOD_SUMO_rev_2	85	90	PF00179	0.697
TRG_ENDOCYTIC_2	20	23	PF00928	0.531
TRG_ER_diArg_1	72	74	PF00400	0.457
TRG_NLS_MonoExtC_3	43	49	PF00514	0.629
TRG_NLS_MonoExtN_4	41	48	PF00514	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P725	Trypanosomatidae	57%	91%
A0A3Q8I9Z0	Leishmania donovani	91%	100%
A4H9I7	Leishmania braziliensis	76%	87%
A4HXV0	Leishmania infantum	90%	100%
E9ARL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BM68	Trypanosoma cruzi	51%	100%