Ribosomal_S8 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosomal protein S8, putative

Species:

Leishmania major

UniProt:

Q4QDW2_LEIMA

TriTrypDb:

LmjF.18.0800 , LMJLV39_180013500 , LMJSD75_180013400

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005840	ribosome	5	11
GO:0020023	kinetoplast	2	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4QDW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDW2

PDB structure(s): 7ane_c

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.273
CLV_NRD_NRD_1	267	269	PF00675	0.282
CLV_NRD_NRD_1	4	6	PF00675	0.600
CLV_NRD_NRD_1	56	58	PF00675	0.628
CLV_NRD_NRD_1	96	98	PF00675	0.692
CLV_PCSK_KEX2_1	167	169	PF00082	0.461
CLV_PCSK_KEX2_1	196	198	PF00082	0.272
CLV_PCSK_KEX2_1	267	269	PF00082	0.282
CLV_PCSK_KEX2_1	4	6	PF00082	0.600
CLV_PCSK_KEX2_1	56	58	PF00082	0.462
CLV_PCSK_KEX2_1	75	77	PF00082	0.596
CLV_PCSK_KEX2_1	96	98	PF00082	0.692
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.461
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.282
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.611
CLV_PCSK_SKI1_1	136	140	PF00082	0.436
CLV_PCSK_SKI1_1	212	216	PF00082	0.327
CLV_PCSK_SKI1_1	4	8	PF00082	0.668
CLV_PCSK_SKI1_1	51	55	PF00082	0.638
DEG_APCC_DBOX_1	77	85	PF00400	0.467
DEG_Nend_Nbox_1	1	3	PF02207	0.566
DEG_SPOP_SBC_1	23	27	PF00917	0.683
DOC_CKS1_1	177	182	PF01111	0.391
DOC_CYCLIN_RxL_1	208	216	PF00134	0.586
DOC_MAPK_gen_1	195	201	PF00069	0.482
DOC_MAPK_gen_1	227	236	PF00069	0.419
DOC_PP1_RVXF_1	134	140	PF00149	0.462
DOC_PP2B_PxIxI_1	242	248	PF00149	0.562
DOC_SPAK_OSR1_1	197	201	PF12202	0.496
DOC_USP7_MATH_1	23	27	PF00917	0.741
DOC_USP7_UBL2_3	167	171	PF12436	0.573
DOC_WW_Pin1_4	176	181	PF00397	0.390
DOC_WW_Pin1_4	259	264	PF00397	0.482
LIG_14-3-3_CanoR_1	96	105	PF00244	0.598
LIG_deltaCOP1_diTrp_1	172	178	PF00928	0.516
LIG_FHA_1	17	23	PF00498	0.641
LIG_FHA_1	172	178	PF00498	0.462
LIG_FHA_1	242	248	PF00498	0.482
LIG_FHA_1	33	39	PF00498	0.483
LIG_FHA_2	149	155	PF00498	0.519
LIG_FHA_2	255	261	PF00498	0.482
LIG_FHA_2	69	75	PF00498	0.525
LIG_LIR_Apic_2	151	155	PF02991	0.446
LIG_LIR_Gen_1	172	182	PF02991	0.500
LIG_LIR_Nem_3	172	178	PF02991	0.472
LIG_NRBOX	80	86	PF00104	0.498
LIG_SH2_NCK_1	152	156	PF00017	0.465
LIG_SH2_SRC	152	155	PF00017	0.472
LIG_SH2_STAT5	238	241	PF00017	0.482
LIG_SH2_STAT5	282	285	PF00017	0.482
LIG_SH2_STAT5	42	45	PF00017	0.533
LIG_SH3_1	110	116	PF00018	0.637
LIG_SH3_1	127	133	PF00018	0.400
LIG_SH3_3	110	116	PF00018	0.551
LIG_SH3_3	127	133	PF00018	0.418
LIG_SH3_3	174	180	PF00018	0.425
LIG_SH3_3	196	202	PF00018	0.482
LIG_UBA3_1	291	299	PF00899	0.513
MOD_CDK_SPK_2	259	264	PF00069	0.482
MOD_CK1_1	25	31	PF00069	0.768
MOD_CK1_1	32	38	PF00069	0.651
MOD_CK2_1	148	154	PF00069	0.528
MOD_CK2_1	200	206	PF00069	0.482
MOD_CK2_1	254	260	PF00069	0.476
MOD_CK2_1	68	74	PF00069	0.571
MOD_CK2_1	97	103	PF00069	0.503
MOD_Cter_Amidation	54	57	PF01082	0.519
MOD_GlcNHglycan	107	110	PF01048	0.580
MOD_GlcNHglycan	99	102	PF01048	0.670
MOD_GSK3_1	200	207	PF00069	0.482
MOD_GSK3_1	22	29	PF00069	0.760
MOD_GSK3_1	30	37	PF00069	0.778
MOD_NEK2_1	105	110	PF00069	0.476
MOD_PK_1	44	50	PF00069	0.452
MOD_PKA_1	4	10	PF00069	0.466
MOD_PKA_1	96	102	PF00069	0.607
MOD_PKA_2	4	10	PF00069	0.480
MOD_PKA_2	96	102	PF00069	0.607
MOD_PKB_1	187	195	PF00069	0.496
MOD_PKB_1	57	65	PF00069	0.438
MOD_Plk_1	171	177	PF00069	0.527
MOD_Plk_1	68	74	PF00069	0.571
MOD_Plk_2-3	249	255	PF00069	0.492
MOD_Plk_4	59	65	PF00069	0.480
MOD_ProDKin_1	176	182	PF00069	0.386
MOD_ProDKin_1	259	265	PF00069	0.482
MOD_SUMO_rev_2	229	239	PF00179	0.482
MOD_SUMO_rev_2	249	257	PF00179	0.496
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.550
TRG_ER_diArg_1	195	198	PF00400	0.473
TRG_ER_diArg_1	266	268	PF00400	0.482
TRG_ER_diArg_1	3	5	PF00400	0.606
TRG_ER_diArg_1	43	46	PF00400	0.591
TRG_ER_diArg_1	56	59	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I854	Leptomonas seymouri	80%	100%
A0A1X0P6W5	Trypanosomatidae	70%	100%
A0A3S7WUX4	Leishmania donovani	94%	100%
A0A422P1R7	Trypanosoma rangeli	68%	100%
A4H9J1	Leishmania braziliensis	84%	83%
A4HXV4	Leishmania infantum	94%	100%
C9ZZU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ARL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
V5DN42	Trypanosoma cruzi	67%	100%