Putative ethanolamine phosphotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ethanolamine phosphotransferase, putative

Species:

Leishmania major

UniProt:

Q4QDW1_LEIMA

TriTrypDb:

LmjF.18.0810 , LMJLV39_180013600 , LMJSD75_180013500

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QDW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDW1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006646	phosphatidylethanolamine biosynthetic process	6	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0019637	organophosphate metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	11
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046337	phosphatidylethanolamine metabolic process	6	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004307	ethanolaminephosphotransferase activity	6	6
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	11
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.482
CLV_NRD_NRD_1	142	144	PF00675	0.282
CLV_NRD_NRD_1	258	260	PF00675	0.581
CLV_NRD_NRD_1	283	285	PF00675	0.360
CLV_NRD_NRD_1	410	412	PF00675	0.576
CLV_PCSK_KEX2_1	142	144	PF00082	0.282
CLV_PCSK_KEX2_1	258	260	PF00082	0.610
CLV_PCSK_KEX2_1	283	285	PF00082	0.319
CLV_PCSK_KEX2_1	410	412	PF00082	0.528
CLV_PCSK_SKI1_1	201	205	PF00082	0.304
CLV_PCSK_SKI1_1	209	213	PF00082	0.364
DEG_Nend_UBRbox_4	1	3	PF02207	0.537
DEG_SCF_FBW7_1	107	112	PF00400	0.307
DEG_SCF_FBW7_1	15	22	PF00400	0.685
DEG_SPOP_SBC_1	343	347	PF00917	0.355
DOC_AGCK_PIF_2	34	39	PF00069	0.628
DOC_CKS1_1	106	111	PF01111	0.393
DOC_CKS1_1	16	21	PF01111	0.663
DOC_CYCLIN_yClb5_NLxxxL_5	113	122	PF00134	0.219
DOC_MAPK_FxFP_2	332	335	PF00069	0.348
DOC_MAPK_gen_1	258	268	PF00069	0.339
DOC_PP2B_LxvP_1	97	100	PF13499	0.426
DOC_PP4_FxxP_1	113	116	PF00568	0.362
DOC_PP4_FxxP_1	332	335	PF00568	0.348
DOC_USP7_MATH_1	23	27	PF00917	0.561
DOC_USP7_MATH_1	231	235	PF00917	0.447
DOC_USP7_MATH_1	249	253	PF00917	0.369
DOC_USP7_MATH_1	320	324	PF00917	0.439
DOC_USP7_MATH_1	343	347	PF00917	0.355
DOC_USP7_MATH_1	378	382	PF00917	0.382
DOC_USP7_MATH_1	5	9	PF00917	0.670
DOC_WW_Pin1_4	100	105	PF00397	0.371
DOC_WW_Pin1_4	112	117	PF00397	0.298
DOC_WW_Pin1_4	15	20	PF00397	0.582
DOC_WW_Pin1_4	8	13	PF00397	0.586
LIG_14-3-3_CanoR_1	209	214	PF00244	0.537
LIG_14-3-3_CanoR_1	283	289	PF00244	0.582
LIG_14-3-3_CanoR_1	360	366	PF00244	0.631
LIG_APCC_ABBA_1	308	313	PF00400	0.528
LIG_APCC_ABBA_1	33	38	PF00400	0.548
LIG_Clathr_ClatBox_1	399	403	PF01394	0.401
LIG_CSL_BTD_1	224	227	PF09270	0.408
LIG_FHA_1	106	112	PF00498	0.432
LIG_FHA_1	145	151	PF00498	0.482
LIG_FHA_1	16	22	PF00498	0.617
LIG_FHA_1	160	166	PF00498	0.377
LIG_FHA_1	233	239	PF00498	0.426
LIG_FHA_1	252	258	PF00498	0.382
LIG_FHA_1	273	279	PF00498	0.402
LIG_FHA_1	362	368	PF00498	0.582
LIG_FHA_2	210	216	PF00498	0.622
LIG_LIR_Apic_2	112	116	PF02991	0.247
LIG_LIR_Apic_2	8	12	PF02991	0.640
LIG_LIR_Gen_1	30	39	PF02991	0.606
LIG_LIR_Nem_3	223	228	PF02991	0.342
LIG_LIR_Nem_3	251	256	PF02991	0.432
LIG_LIR_Nem_3	30	36	PF02991	0.581
LIG_LIR_Nem_3	333	337	PF02991	0.282
LIG_LYPXL_yS_3	334	337	PF13949	0.334
LIG_MYND_1	100	104	PF01753	0.357
LIG_NRBOX	302	308	PF00104	0.430
LIG_PTB_Apo_2	398	405	PF02174	0.423
LIG_SH2_CRK	37	41	PF00017	0.564
LIG_SH2_SRC	153	156	PF00017	0.482
LIG_SH2_SRC	37	40	PF00017	0.619
LIG_SH2_STAP1	37	41	PF00017	0.529
LIG_SH2_STAT3	39	42	PF00017	0.625
LIG_SH2_STAT5	130	133	PF00017	0.335
LIG_SH2_STAT5	153	156	PF00017	0.482
LIG_SH2_STAT5	256	259	PF00017	0.364
LIG_SH2_STAT5	267	270	PF00017	0.283
LIG_SH2_STAT5	31	34	PF00017	0.557
LIG_SH2_STAT5	327	330	PF00017	0.335
LIG_SH2_STAT5	39	42	PF00017	0.543
LIG_SH3_3	377	383	PF00018	0.379
LIG_SH3_3	9	15	PF00018	0.572
LIG_SH3_3	98	104	PF00018	0.332
LIG_SH3_5	35	39	PF00018	0.629
LIG_SUMO_SIM_anti_2	301	307	PF11976	0.410
LIG_SUMO_SIM_anti_2	65	71	PF11976	0.368
LIG_SUMO_SIM_par_1	65	71	PF11976	0.368
LIG_TRFH_1	327	331	PF08558	0.471
LIG_WRC_WIRS_1	110	115	PF05994	0.374
MOD_CK1_1	112	118	PF00069	0.300
MOD_CK1_1	163	169	PF00069	0.335
MOD_CK1_1	234	240	PF00069	0.417
MOD_CK1_1	251	257	PF00069	0.548
MOD_CK1_1	60	66	PF00069	0.484
MOD_CK1_1	8	14	PF00069	0.595
MOD_CK2_1	209	215	PF00069	0.389
MOD_CK2_1	86	92	PF00069	0.547
MOD_GlcNHglycan	21	24	PF01048	0.603
MOD_GlcNHglycan	62	65	PF01048	0.434
MOD_GlcNHglycan	79	82	PF01048	0.550
MOD_GSK3_1	105	112	PF00069	0.440
MOD_GSK3_1	15	22	PF00069	0.584
MOD_GSK3_1	159	166	PF00069	0.321
MOD_GSK3_1	268	275	PF00069	0.470
MOD_GSK3_1	294	301	PF00069	0.401
MOD_GSK3_1	338	345	PF00069	0.354
MOD_GSK3_1	58	65	PF00069	0.376
MOD_N-GLC_1	249	254	PF02516	0.512
MOD_NEK2_1	122	127	PF00069	0.466
MOD_NEK2_1	164	169	PF00069	0.329
MOD_NEK2_1	173	178	PF00069	0.321
MOD_NEK2_1	180	185	PF00069	0.294
MOD_NEK2_1	193	198	PF00069	0.342
MOD_NEK2_1	220	225	PF00069	0.344
MOD_NEK2_1	67	72	PF00069	0.369
MOD_PIKK_1	102	108	PF00454	0.441
MOD_PK_1	145	151	PF00069	0.433
MOD_PKA_1	145	151	PF00069	0.335
MOD_Plk_1	249	255	PF00069	0.560
MOD_Plk_4	109	115	PF00069	0.421
MOD_Plk_4	145	151	PF00069	0.361
MOD_Plk_4	160	166	PF00069	0.331
MOD_Plk_4	188	194	PF00069	0.372
MOD_Plk_4	220	226	PF00069	0.388
MOD_Plk_4	23	29	PF00069	0.397
MOD_Plk_4	242	248	PF00069	0.539
MOD_Plk_4	274	280	PF00069	0.372
MOD_Plk_4	298	304	PF00069	0.326
MOD_Plk_4	345	351	PF00069	0.336
MOD_Plk_4	44	50	PF00069	0.464
MOD_Plk_4	5	11	PF00069	0.561
MOD_Plk_4	51	57	PF00069	0.360
MOD_Plk_4	62	68	PF00069	0.218
MOD_Plk_4	86	92	PF00069	0.524
MOD_ProDKin_1	100	106	PF00069	0.462
MOD_ProDKin_1	112	118	PF00069	0.357
MOD_ProDKin_1	15	21	PF00069	0.472
MOD_ProDKin_1	8	14	PF00069	0.476
TRG_DiLeu_BaEn_2	199	205	PF01217	0.355
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.424
TRG_ENDOCYTIC_2	31	34	PF00928	0.467
TRG_ENDOCYTIC_2	334	337	PF00928	0.333
TRG_ENDOCYTIC_2	37	40	PF00928	0.396
TRG_ER_diArg_1	257	259	PF00400	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V7	Leptomonas seymouri	63%	95%
A0A0S4J4C6	Bodo saltans	39%	100%
A0A1X0P7R6	Trypanosomatidae	48%	99%
A0A3Q8IJQ4	Leishmania donovani	94%	100%
A0A3R7N2B7	Trypanosoma rangeli	47%	100%
A4H9J2	Leishmania braziliensis	77%	100%
A4HXV5	Leishmania infantum	93%	100%
C9ZZU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ARL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%