Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Periodic tryptophan protein 2 homolog, putative

Species:

Leishmania major

UniProt:

Q4QDV9_LEIMA

TriTrypDb:

LmjF.18.0830 , LMJLV39_180013800 , LMJSD75_180013700

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0030684	preribosome	3	2
GO:0032040	small-subunit processome	4	2
GO:0032991	protein-containing complex	1	12
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	2
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	12
GO:0005730	nucleolus	5	10

Expansion

Sequence features

Q4QDV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDV9

Function

Biological processes
Term	Name	Level	Count
GO:0000028	ribosomal small subunit assembly	7	2
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043933	protein-containing complex organization	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.477
CLV_C14_Caspase3-7	465	469	PF00656	0.508
CLV_NRD_NRD_1	231	233	PF00675	0.412
CLV_NRD_NRD_1	274	276	PF00675	0.504
CLV_NRD_NRD_1	595	597	PF00675	0.333
CLV_NRD_NRD_1	633	635	PF00675	0.489
CLV_NRD_NRD_1	723	725	PF00675	0.500
CLV_NRD_NRD_1	741	743	PF00675	0.402
CLV_NRD_NRD_1	797	799	PF00675	0.322
CLV_NRD_NRD_1	826	828	PF00675	0.239
CLV_PCSK_KEX2_1	128	130	PF00082	0.499
CLV_PCSK_KEX2_1	231	233	PF00082	0.433
CLV_PCSK_KEX2_1	276	278	PF00082	0.484
CLV_PCSK_KEX2_1	595	597	PF00082	0.314
CLV_PCSK_KEX2_1	723	725	PF00082	0.500
CLV_PCSK_KEX2_1	741	743	PF00082	0.402
CLV_PCSK_KEX2_1	797	799	PF00082	0.280
CLV_PCSK_KEX2_1	826	828	PF00082	0.239
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.458
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.484
CLV_PCSK_PC1ET2_1	741	743	PF00082	0.455
CLV_PCSK_SKI1_1	148	152	PF00082	0.414
CLV_PCSK_SKI1_1	232	236	PF00082	0.412
CLV_PCSK_SKI1_1	270	274	PF00082	0.480
CLV_PCSK_SKI1_1	301	305	PF00082	0.335
CLV_PCSK_SKI1_1	309	313	PF00082	0.346
CLV_PCSK_SKI1_1	327	331	PF00082	0.376
CLV_PCSK_SKI1_1	385	389	PF00082	0.296
CLV_PCSK_SKI1_1	514	518	PF00082	0.338
CLV_PCSK_SKI1_1	621	625	PF00082	0.464
CLV_PCSK_SKI1_1	724	728	PF00082	0.611
CLV_PCSK_SKI1_1	86	90	PF00082	0.368
CLV_PCSK_SKI1_1	900	904	PF00082	0.336
CLV_PCSK_SKI1_1	906	910	PF00082	0.273
DEG_APCC_DBOX_1	231	239	PF00400	0.437
DEG_APCC_DBOX_1	274	282	PF00400	0.573
DEG_APCC_DBOX_1	722	730	PF00400	0.552
DEG_APCC_DBOX_1	85	93	PF00400	0.405
DEG_Nend_UBRbox_3	1	3	PF02207	0.387
DEG_SPOP_SBC_1	462	466	PF00917	0.356
DOC_CYCLIN_RxL_1	382	391	PF00134	0.312
DOC_MAPK_gen_1	275	283	PF00069	0.443
DOC_MAPK_gen_1	325	332	PF00069	0.296
DOC_MAPK_gen_1	779	787	PF00069	0.389
DOC_MAPK_gen_1	826	837	PF00069	0.298
DOC_MAPK_MEF2A_6	781	789	PF00069	0.451
DOC_MAPK_MEF2A_6	830	837	PF00069	0.298
DOC_PP1_RVXF_1	127	134	PF00149	0.432
DOC_PP1_RVXF_1	648	654	PF00149	0.453
DOC_PP1_RVXF_1	73	80	PF00149	0.288
DOC_PP1_SILK_1	297	302	PF00149	0.256
DOC_PP2B_LxvP_1	727	730	PF13499	0.471
DOC_PP4_FxxP_1	323	326	PF00568	0.406
DOC_PP4_FxxP_1	485	488	PF00568	0.455
DOC_USP7_MATH_1	115	119	PF00917	0.280
DOC_USP7_MATH_1	378	382	PF00917	0.282
DOC_USP7_MATH_1	506	510	PF00917	0.277
DOC_USP7_MATH_1	757	761	PF00917	0.374
DOC_USP7_MATH_1	829	833	PF00917	0.274
DOC_USP7_MATH_1	839	843	PF00917	0.226
DOC_USP7_MATH_1	96	100	PF00917	0.290
DOC_USP7_UBL2_3	179	183	PF12436	0.625
DOC_WW_Pin1_4	103	108	PF00397	0.277
DOC_WW_Pin1_4	20	25	PF00397	0.294
DOC_WW_Pin1_4	263	268	PF00397	0.664
DOC_WW_Pin1_4	28	33	PF00397	0.271
DOC_WW_Pin1_4	483	488	PF00397	0.425
DOC_WW_Pin1_4	60	65	PF00397	0.344
DOC_WW_Pin1_4	651	656	PF00397	0.353
LIG_14-3-3_CanoR_1	129	134	PF00244	0.448
LIG_14-3-3_CanoR_1	287	295	PF00244	0.427
LIG_14-3-3_CanoR_1	650	654	PF00244	0.361
LIG_14-3-3_CanoR_1	701	709	PF00244	0.415
LIG_14-3-3_CanoR_1	790	796	PF00244	0.427
LIG_14-3-3_CanoR_1	927	936	PF00244	0.577
LIG_AP2alpha_1	559	563	PF02296	0.429
LIG_BIR_III_4	628	632	PF00653	0.313
LIG_BRCT_BRCA1_1	335	339	PF00533	0.332
LIG_BRCT_BRCA1_1	841	845	PF00533	0.254
LIG_deltaCOP1_diTrp_1	375	379	PF00928	0.374
LIG_FHA_1	117	123	PF00498	0.215
LIG_FHA_1	145	151	PF00498	0.340
LIG_FHA_1	238	244	PF00498	0.471
LIG_FHA_1	336	342	PF00498	0.361
LIG_FHA_1	416	422	PF00498	0.426
LIG_FHA_1	445	451	PF00498	0.415
LIG_FHA_1	457	463	PF00498	0.415
LIG_FHA_1	520	526	PF00498	0.353
LIG_FHA_1	581	587	PF00498	0.444
LIG_FHA_1	684	690	PF00498	0.353
LIG_FHA_1	765	771	PF00498	0.378
LIG_FHA_1	791	797	PF00498	0.384
LIG_FHA_1	817	823	PF00498	0.453
LIG_FHA_1	98	104	PF00498	0.495
LIG_FHA_2	149	155	PF00498	0.394
LIG_FHA_2	203	209	PF00498	0.455
LIG_FHA_2	228	234	PF00498	0.388
LIG_FHA_2	440	446	PF00498	0.404
LIG_FHA_2	623	629	PF00498	0.332
LIG_FHA_2	756	762	PF00498	0.311
LIG_FHA_2	790	796	PF00498	0.497
LIG_GBD_Chelix_1	112	120	PF00786	0.255
LIG_Integrin_RGD_1	373	375	PF01839	0.327
LIG_Integrin_RGDW_4	373	376	PF00362	0.321
LIG_IRF3_LxIS_1	354	361	PF10401	0.328
LIG_LIR_Apic_2	321	326	PF02991	0.395
LIG_LIR_Gen_1	375	384	PF02991	0.296
LIG_LIR_Gen_1	646	655	PF02991	0.445
LIG_LIR_Gen_1	665	674	PF02991	0.165
LIG_LIR_Nem_3	27	33	PF02991	0.423
LIG_LIR_Nem_3	375	379	PF02991	0.298
LIG_LIR_Nem_3	646	651	PF02991	0.460
LIG_LIR_Nem_3	665	671	PF02991	0.175
LIG_LIR_Nem_3	842	848	PF02991	0.239
LIG_LIR_Nem_3	878	883	PF02991	0.404
LIG_LIR_Nem_3	914	919	PF02991	0.239
LIG_NRBOX	353	359	PF00104	0.336
LIG_NRBOX	383	389	PF00104	0.311
LIG_Pex14_1	668	672	PF04695	0.267
LIG_Pex14_2	559	563	PF04695	0.429
LIG_Pex14_2	623	627	PF04695	0.340
LIG_SH2_CRK	123	127	PF00017	0.309
LIG_SH2_CRK	30	34	PF00017	0.286
LIG_SH2_NCK_1	123	127	PF00017	0.309
LIG_SH2_PTP2	111	114	PF00017	0.278
LIG_SH2_SRC	295	298	PF00017	0.525
LIG_SH2_SRC	406	409	PF00017	0.298
LIG_SH2_STAP1	302	306	PF00017	0.344
LIG_SH2_STAP1	609	613	PF00017	0.339
LIG_SH2_STAP1	81	85	PF00017	0.330
LIG_SH2_STAT5	111	114	PF00017	0.278
LIG_SH2_STAT5	123	126	PF00017	0.302
LIG_SH2_STAT5	15	18	PF00017	0.290
LIG_SH2_STAT5	295	298	PF00017	0.427
LIG_SH2_STAT5	36	39	PF00017	0.269
LIG_SH2_STAT5	397	400	PF00017	0.322
LIG_SH2_STAT5	678	681	PF00017	0.409
LIG_SH2_STAT5	916	919	PF00017	0.242
LIG_SH2_STAT5	921	924	PF00017	0.234
LIG_SH3_3	18	24	PF00018	0.380
LIG_SH3_3	481	487	PF00018	0.461
LIG_SH3_3	774	780	PF00018	0.375
LIG_SUMO_SIM_anti_2	351	356	PF11976	0.374
LIG_SUMO_SIM_par_1	356	361	PF11976	0.307
LIG_SUMO_SIM_par_1	503	510	PF11976	0.299
LIG_SUMO_SIM_par_1	575	584	PF11976	0.305
LIG_SUMO_SIM_par_1	832	838	PF11976	0.222
LIG_TRAF2_1	602	605	PF00917	0.466
LIG_TRAF2_1	792	795	PF00917	0.421
LIG_TRFH_1	60	64	PF08558	0.365
LIG_UBA3_1	234	242	PF00899	0.404
LIG_WRC_WIRS_1	130	135	PF05994	0.461
LIG_WRC_WIRS_1	440	445	PF05994	0.404
LIG_WRC_WIRS_1	620	625	PF05994	0.333
MOD_CDK_SPK_2	265	270	PF00069	0.647
MOD_CDK_SPxxK_3	103	110	PF00069	0.282
MOD_CDK_SPxxK_3	263	270	PF00069	0.644
MOD_CK1_1	268	274	PF00069	0.608
MOD_CK1_1	335	341	PF00069	0.371
MOD_CK1_1	451	457	PF00069	0.483
MOD_CK1_1	53	59	PF00069	0.321
MOD_CK1_1	544	550	PF00069	0.514
MOD_CK2_1	227	233	PF00069	0.364
MOD_CK2_1	268	274	PF00069	0.492
MOD_CK2_1	419	425	PF00069	0.433
MOD_CK2_1	439	445	PF00069	0.404
MOD_CK2_1	483	489	PF00069	0.362
MOD_CK2_1	604	610	PF00069	0.306
MOD_CK2_1	755	761	PF00069	0.315
MOD_CK2_1	789	795	PF00069	0.482
MOD_CK2_1	928	934	PF00069	0.489
MOD_Cter_Amidation	593	596	PF01082	0.330
MOD_Cter_Amidation	739	742	PF01082	0.433
MOD_DYRK1A_RPxSP_1	483	487	PF00069	0.453
MOD_GlcNHglycan	196	199	PF01048	0.394
MOD_GlcNHglycan	288	291	PF01048	0.488
MOD_GlcNHglycan	335	338	PF01048	0.327
MOD_GlcNHglycan	360	363	PF01048	0.364
MOD_GlcNHglycan	380	383	PF01048	0.335
MOD_GlcNHglycan	421	424	PF01048	0.290
MOD_GlcNHglycan	435	438	PF01048	0.344
MOD_GlcNHglycan	450	453	PF01048	0.239
MOD_GlcNHglycan	455	458	PF01048	0.199
MOD_GlcNHglycan	499	503	PF01048	0.371
MOD_GlcNHglycan	543	546	PF01048	0.236
MOD_GlcNHglycan	549	552	PF01048	0.236
MOD_GlcNHglycan	567	570	PF01048	0.560
MOD_GlcNHglycan	592	595	PF01048	0.373
MOD_GlcNHglycan	640	643	PF01048	0.416
MOD_GlcNHglycan	83	86	PF01048	0.313
MOD_GSK3_1	144	151	PF00069	0.405
MOD_GSK3_1	20	27	PF00069	0.442
MOD_GSK3_1	207	214	PF00069	0.360
MOD_GSK3_1	291	298	PF00069	0.300
MOD_GSK3_1	310	317	PF00069	0.480
MOD_GSK3_1	411	418	PF00069	0.315
MOD_GSK3_1	444	451	PF00069	0.432
MOD_GSK3_1	452	459	PF00069	0.436
MOD_GSK3_1	46	53	PF00069	0.309
MOD_GSK3_1	463	470	PF00069	0.452
MOD_GSK3_1	543	550	PF00069	0.396
MOD_GSK3_1	586	593	PF00069	0.411
MOD_GSK3_1	604	611	PF00069	0.192
MOD_GSK3_1	619	626	PF00069	0.327
MOD_GSK3_1	835	842	PF00069	0.222
MOD_GSK3_1	894	901	PF00069	0.354
MOD_N-GLC_1	53	58	PF02516	0.323
MOD_N-GLC_1	565	570	PF02516	0.594
MOD_N-GLC_1	701	706	PF02516	0.524
MOD_N-GLC_1	928	933	PF02516	0.607
MOD_N-GLC_1	96	101	PF02516	0.386
MOD_NEK2_1	116	121	PF00069	0.291
MOD_NEK2_1	13	18	PF00069	0.301
MOD_NEK2_1	310	315	PF00069	0.485
MOD_NEK2_1	358	363	PF00069	0.326
MOD_NEK2_1	467	472	PF00069	0.512
MOD_NEK2_1	50	55	PF00069	0.378
MOD_NEK2_1	586	591	PF00069	0.347
MOD_NEK2_1	619	624	PF00069	0.478
MOD_NEK2_1	719	724	PF00069	0.581
MOD_NEK2_1	755	760	PF00069	0.302
MOD_NEK2_1	771	776	PF00069	0.299
MOD_NEK2_1	79	84	PF00069	0.338
MOD_NEK2_1	898	903	PF00069	0.273
MOD_NEK2_1	928	933	PF00069	0.520
MOD_OFUCOSY	52	59	PF10250	0.424
MOD_PIKK_1	24	30	PF00454	0.368
MOD_PIKK_1	488	494	PF00454	0.370
MOD_PIKK_1	507	513	PF00454	0.173
MOD_PIKK_1	672	678	PF00454	0.311
MOD_PKA_1	741	747	PF00069	0.412
MOD_PKA_2	286	292	PF00069	0.427
MOD_PKA_2	649	655	PF00069	0.385
MOD_PKA_2	741	747	PF00069	0.412
MOD_PKA_2	789	795	PF00069	0.558
MOD_PKA_2	829	835	PF00069	0.303
MOD_Plk_1	116	122	PF00069	0.322
MOD_Plk_1	291	297	PF00069	0.402
MOD_Plk_1	350	356	PF00069	0.319
MOD_Plk_1	488	494	PF00069	0.367
MOD_Plk_1	53	59	PF00069	0.321
MOD_Plk_1	604	610	PF00069	0.291
MOD_Plk_1	816	822	PF00069	0.303
MOD_Plk_4	188	194	PF00069	0.493
MOD_Plk_4	268	274	PF00069	0.465
MOD_Plk_4	291	297	PF00069	0.419
MOD_Plk_4	350	356	PF00069	0.326
MOD_Plk_4	46	52	PF00069	0.317
MOD_Plk_4	619	625	PF00069	0.400
MOD_Plk_4	840	846	PF00069	0.287
MOD_Plk_4	868	874	PF00069	0.247
MOD_ProDKin_1	103	109	PF00069	0.276
MOD_ProDKin_1	20	26	PF00069	0.294
MOD_ProDKin_1	263	269	PF00069	0.661
MOD_ProDKin_1	28	34	PF00069	0.274
MOD_ProDKin_1	483	489	PF00069	0.429
MOD_ProDKin_1	60	66	PF00069	0.345
MOD_ProDKin_1	651	657	PF00069	0.353
MOD_SUMO_for_1	241	244	PF00179	0.553
MOD_SUMO_for_1	602	605	PF00179	0.354
MOD_SUMO_rev_2	268	278	PF00179	0.595
MOD_SUMO_rev_2	422	429	PF00179	0.292
TRG_DiLeu_BaEn_1	656	661	PF01217	0.413
TRG_DiLeu_BaLyEn_6	903	908	PF01217	0.384
TRG_ENDOCYTIC_2	111	114	PF00928	0.278
TRG_ENDOCYTIC_2	30	33	PF00928	0.282
TRG_ENDOCYTIC_2	405	408	PF00928	0.316
TRG_ENDOCYTIC_2	474	477	PF00928	0.303
TRG_ENDOCYTIC_2	479	482	PF00928	0.328
TRG_ENDOCYTIC_2	916	919	PF00928	0.251
TRG_ER_diArg_1	275	278	PF00400	0.488
TRG_ER_diArg_1	595	597	PF00400	0.333
TRG_ER_diArg_1	779	782	PF00400	0.493
TRG_ER_diArg_1	796	798	PF00400	0.312
TRG_ER_diArg_1	825	827	PF00400	0.239
TRG_NES_CRM1_1	351	363	PF08389	0.338
TRG_Pf-PMV_PEXEL_1	724	728	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	900	904	PF00026	0.255
TRG_Pf-PMV_PEXEL_1	906	910	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE02	Leptomonas seymouri	88%	100%
A0A0S4J1U6	Bodo saltans	62%	99%
A0A1X0P754	Trypanosomatidae	71%	100%
A0A3S5H735	Leishmania donovani	97%	100%
A0A422P1S2	Trypanosoma rangeli	70%	100%
A4H9J4	Leishmania braziliensis	92%	100%
A4HXV7	Leishmania infantum	97%	100%
C9ZZU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ARM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P25635	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P91341	Caenorhabditis elegans	28%	100%
Q15269	Homo sapiens	31%	100%
Q54PE0	Dictyostelium discoideum	28%	100%
Q5RFQ3	Pongo abelii	31%	100%
Q8BU03	Mus musculus	31%	100%
Q8VYZ5	Arabidopsis thaliana	29%	100%
Q9C1X1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q9C270	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	33%	100%
V5B6K0	Trypanosoma cruzi	69%	100%