Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDV6_LEIMA

TriTrypDb:

LmjF.18.0860 , LMJLV39_180014100 , LMJSD75_180014000

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.821
CLV_C14_Caspase3-7	358	362	PF00656	0.569
CLV_C14_Caspase3-7	535	539	PF00656	0.529
CLV_C14_Caspase3-7	674	678	PF00656	0.707
CLV_C14_Caspase3-7	840	844	PF00656	0.783
CLV_C14_Caspase3-7	912	916	PF00656	0.551
CLV_NRD_NRD_1	242	244	PF00675	0.631
CLV_NRD_NRD_1	465	467	PF00675	0.717
CLV_NRD_NRD_1	477	479	PF00675	0.615
CLV_NRD_NRD_1	501	503	PF00675	0.601
CLV_NRD_NRD_1	627	629	PF00675	0.636
CLV_NRD_NRD_1	69	71	PF00675	0.504
CLV_NRD_NRD_1	690	692	PF00675	0.635
CLV_NRD_NRD_1	83	85	PF00675	0.518
CLV_NRD_NRD_1	874	876	PF00675	0.692
CLV_PCSK_FUR_1	463	467	PF00082	0.713
CLV_PCSK_FUR_1	688	692	PF00082	0.570
CLV_PCSK_FUR_1	872	876	PF00082	0.569
CLV_PCSK_KEX2_1	242	244	PF00082	0.631
CLV_PCSK_KEX2_1	465	467	PF00082	0.725
CLV_PCSK_KEX2_1	476	478	PF00082	0.612
CLV_PCSK_KEX2_1	501	503	PF00082	0.641
CLV_PCSK_KEX2_1	627	629	PF00082	0.636
CLV_PCSK_KEX2_1	690	692	PF00082	0.569
CLV_PCSK_KEX2_1	82	84	PF00082	0.557
CLV_PCSK_KEX2_1	874	876	PF00082	0.692
CLV_PCSK_PC7_1	497	503	PF00082	0.638
CLV_PCSK_SKI1_1	477	481	PF00082	0.614
CLV_PCSK_SKI1_1	592	596	PF00082	0.668
DEG_APCC_DBOX_1	476	484	PF00400	0.614
DEG_APCC_DBOX_1	81	89	PF00400	0.541
DEG_Nend_Nbox_1	1	3	PF02207	0.496
DEG_SCF_FBW7_1	158	165	PF00400	0.787
DEG_SCF_TRCP1_1	729	735	PF00400	0.699
DEG_SPOP_SBC_1	128	132	PF00917	0.741
DEG_SPOP_SBC_1	254	258	PF00917	0.603
DEG_SPOP_SBC_1	270	274	PF00917	0.630
DEG_SPOP_SBC_1	593	597	PF00917	0.552
DEG_SPOP_SBC_1	733	737	PF00917	0.771
DEG_SPOP_SBC_1	909	913	PF00917	0.705
DOC_CKS1_1	10	15	PF01111	0.534
DOC_CKS1_1	389	394	PF01111	0.613
DOC_CKS1_1	446	451	PF01111	0.560
DOC_CYCLIN_RxL_1	714	725	PF00134	0.628
DOC_MAPK_DCC_7	243	253	PF00069	0.665
DOC_MAPK_gen_1	188	197	PF00069	0.604
DOC_MAPK_gen_1	21	31	PF00069	0.553
DOC_MAPK_gen_1	301	311	PF00069	0.480
DOC_MAPK_gen_1	444	453	PF00069	0.569
DOC_MAPK_gen_1	82	90	PF00069	0.570
DOC_MAPK_MEF2A_6	245	253	PF00069	0.635
DOC_MAPK_MEF2A_6	444	453	PF00069	0.569
DOC_PP2B_LxvP_1	252	255	PF13499	0.774
DOC_PP2B_LxvP_1	561	564	PF13499	0.652
DOC_PP4_FxxP_1	139	142	PF00568	0.550
DOC_USP7_MATH_1	121	125	PF00917	0.701
DOC_USP7_MATH_1	128	132	PF00917	0.721
DOC_USP7_MATH_1	241	245	PF00917	0.641
DOC_USP7_MATH_1	255	259	PF00917	0.664
DOC_USP7_MATH_1	261	265	PF00917	0.451
DOC_USP7_MATH_1	271	275	PF00917	0.538
DOC_USP7_MATH_1	340	344	PF00917	0.763
DOC_USP7_MATH_1	43	47	PF00917	0.717
DOC_USP7_MATH_1	458	462	PF00917	0.504
DOC_USP7_MATH_1	539	543	PF00917	0.532
DOC_USP7_MATH_1	593	597	PF00917	0.657
DOC_USP7_MATH_1	598	602	PF00917	0.655
DOC_USP7_MATH_1	667	671	PF00917	0.700
DOC_USP7_MATH_1	835	839	PF00917	0.637
DOC_USP7_MATH_1	908	912	PF00917	0.705
DOC_USP7_MATH_1	98	102	PF00917	0.647
DOC_USP7_UBL2_3	21	25	PF12436	0.558
DOC_WW_Pin1_4	158	163	PF00397	0.714
DOC_WW_Pin1_4	244	249	PF00397	0.685
DOC_WW_Pin1_4	274	279	PF00397	0.729
DOC_WW_Pin1_4	29	34	PF00397	0.482
DOC_WW_Pin1_4	378	383	PF00397	0.742
DOC_WW_Pin1_4	388	393	PF00397	0.564
DOC_WW_Pin1_4	421	426	PF00397	0.576
DOC_WW_Pin1_4	445	450	PF00397	0.558
DOC_WW_Pin1_4	508	513	PF00397	0.586
DOC_WW_Pin1_4	578	583	PF00397	0.703
DOC_WW_Pin1_4	675	680	PF00397	0.746
DOC_WW_Pin1_4	805	810	PF00397	0.796
DOC_WW_Pin1_4	9	14	PF00397	0.528
LIG_14-3-3_CanoR_1	154	162	PF00244	0.723
LIG_14-3-3_CanoR_1	169	179	PF00244	0.779
LIG_14-3-3_CanoR_1	188	197	PF00244	0.517
LIG_14-3-3_CanoR_1	39	43	PF00244	0.621
LIG_14-3-3_CanoR_1	492	496	PF00244	0.700
LIG_14-3-3_CanoR_1	592	602	PF00244	0.651
LIG_14-3-3_CanoR_1	717	722	PF00244	0.647
LIG_14-3-3_CanoR_1	872	880	PF00244	0.755
LIG_BRCT_BRCA1_1	135	139	PF00533	0.557
LIG_EVH1_2	162	166	PF00568	0.777
LIG_FHA_1	117	123	PF00498	0.761
LIG_FHA_1	24	30	PF00498	0.552
LIG_FHA_1	277	283	PF00498	0.651
LIG_FHA_1	330	336	PF00498	0.657
LIG_FHA_1	365	371	PF00498	0.718
LIG_FHA_1	441	447	PF00498	0.591
LIG_FHA_1	515	521	PF00498	0.571
LIG_FHA_1	529	535	PF00498	0.584
LIG_FHA_1	721	727	PF00498	0.749
LIG_FHA_1	734	740	PF00498	0.543
LIG_FHA_1	752	758	PF00498	0.592
LIG_FHA_1	894	900	PF00498	0.728
LIG_FHA_2	356	362	PF00498	0.656
LIG_FHA_2	388	394	PF00498	0.621
LIG_FHA_2	57	63	PF00498	0.541
LIG_FHA_2	672	678	PF00498	0.707
LIG_FHA_2	815	821	PF00498	0.716
LIG_FHA_2	910	916	PF00498	0.550
LIG_IBAR_NPY_1	352	354	PF08397	0.764
LIG_LIR_Apic_2	136	142	PF02991	0.553
LIG_LIR_Gen_1	192	201	PF02991	0.632
LIG_LIR_Gen_1	393	404	PF02991	0.571
LIG_LIR_Gen_1	58	67	PF02991	0.552
LIG_LIR_Gen_1	854	864	PF02991	0.600
LIG_LIR_Nem_3	192	197	PF02991	0.623
LIG_LIR_Nem_3	213	217	PF02991	0.549
LIG_LIR_Nem_3	351	357	PF02991	0.676
LIG_LIR_Nem_3	393	399	PF02991	0.577
LIG_LIR_Nem_3	556	561	PF02991	0.563
LIG_LIR_Nem_3	854	859	PF02991	0.600
LIG_MYND_1	224	228	PF01753	0.707
LIG_PCNA_yPIPBox_3	619	628	PF02747	0.604
LIG_PCNA_yPIPBox_3	712	722	PF02747	0.627
LIG_PDZ_Class_1	918	923	PF00595	0.787
LIG_Pex14_2	210	214	PF04695	0.591
LIG_Pex14_2	751	755	PF04695	0.600
LIG_PTAP_UEV_1	344	349	PF05743	0.600
LIG_RPA_C_Fungi	185	197	PF08784	0.623
LIG_RPA_C_Fungi	79	91	PF08784	0.543
LIG_SH2_CRK	303	307	PF00017	0.638
LIG_SH2_NCK_1	357	361	PF00017	0.655
LIG_SH2_SRC	695	698	PF00017	0.777
LIG_SH2_STAP1	191	195	PF00017	0.595
LIG_SH2_STAT5	354	357	PF00017	0.689
LIG_SH2_STAT5	540	543	PF00017	0.561
LIG_SH2_STAT5	55	58	PF00017	0.555
LIG_SH2_STAT5	610	613	PF00017	0.612
LIG_SH2_STAT5	767	770	PF00017	0.679
LIG_SH3_2	176	181	PF14604	0.764
LIG_SH3_3	10	16	PF00018	0.534
LIG_SH3_3	173	179	PF00018	0.653
LIG_SH3_3	342	348	PF00018	0.745
LIG_SH3_3	386	392	PF00018	0.642
LIG_SH3_3	411	417	PF00018	0.626
LIG_SH3_3	42	48	PF00018	0.793
LIG_SH3_3	443	449	PF00018	0.575
LIG_SH3_3	506	512	PF00018	0.604
LIG_SH3_3	561	567	PF00018	0.721
LIG_SH3_3	579	585	PF00018	0.708
LIG_SH3_3	760	766	PF00018	0.617
LIG_SUMO_SIM_anti_2	367	372	PF11976	0.644
LIG_SUMO_SIM_par_1	118	124	PF11976	0.761
LIG_SUMO_SIM_par_1	717	725	PF11976	0.597
LIG_TRAF2_1	131	134	PF00917	0.546
LIG_WRC_WIRS_1	57	62	PF05994	0.533
MOD_CDC14_SPxK_1	581	584	PF00782	0.682
MOD_CDK_SPxK_1	578	584	PF00069	0.679
MOD_CDK_SPxK_1	9	15	PF00069	0.532
MOD_CDK_SPxxK_3	421	428	PF00069	0.682
MOD_CK1_1	112	118	PF00069	0.731
MOD_CK1_1	124	130	PF00069	0.644
MOD_CK1_1	153	159	PF00069	0.719
MOD_CK1_1	167	173	PF00069	0.721
MOD_CK1_1	244	250	PF00069	0.726
MOD_CK1_1	256	262	PF00069	0.695
MOD_CK1_1	272	278	PF00069	0.630
MOD_CK1_1	343	349	PF00069	0.697
MOD_CK1_1	381	387	PF00069	0.767
MOD_CK1_1	424	430	PF00069	0.603
MOD_CK1_1	468	474	PF00069	0.496
MOD_CK1_1	508	514	PF00069	0.526
MOD_CK1_1	596	602	PF00069	0.640
MOD_CK1_1	612	618	PF00069	0.561
MOD_CK1_1	662	668	PF00069	0.783
MOD_CK1_1	698	704	PF00069	0.621
MOD_CK1_1	720	726	PF00069	0.741
MOD_CK1_1	735	741	PF00069	0.548
MOD_CK1_1	834	840	PF00069	0.705
MOD_CK1_1	847	853	PF00069	0.615
MOD_CK1_1	9	15	PF00069	0.532
MOD_CK2_1	128	134	PF00069	0.667
MOD_CK2_1	387	393	PF00069	0.691
MOD_CK2_1	873	879	PF00069	0.745
MOD_GlcNHglycan	100	103	PF01048	0.758
MOD_GlcNHglycan	111	114	PF01048	0.615
MOD_GlcNHglycan	143	146	PF01048	0.721
MOD_GlcNHglycan	166	169	PF01048	0.728
MOD_GlcNHglycan	191	194	PF01048	0.612
MOD_GlcNHglycan	201	204	PF01048	0.599
MOD_GlcNHglycan	418	421	PF01048	0.687
MOD_GlcNHglycan	534	537	PF01048	0.593
MOD_GlcNHglycan	596	599	PF01048	0.749
MOD_GlcNHglycan	611	614	PF01048	0.614
MOD_GlcNHglycan	659	662	PF01048	0.729
MOD_GlcNHglycan	664	667	PF01048	0.749
MOD_GlcNHglycan	697	700	PF01048	0.700
MOD_GlcNHglycan	729	732	PF01048	0.671
MOD_GlcNHglycan	739	742	PF01048	0.576
MOD_GlcNHglycan	833	836	PF01048	0.702
MOD_GlcNHglycan	837	840	PF01048	0.711
MOD_GlcNHglycan	853	856	PF01048	0.507
MOD_GlcNHglycan	889	892	PF01048	0.716
MOD_GSK3_1	109	116	PF00069	0.740
MOD_GSK3_1	123	130	PF00069	0.611
MOD_GSK3_1	149	156	PF00069	0.652
MOD_GSK3_1	158	165	PF00069	0.704
MOD_GSK3_1	167	174	PF00069	0.770
MOD_GSK3_1	21	28	PF00069	0.556
MOD_GSK3_1	262	269	PF00069	0.745
MOD_GSK3_1	270	277	PF00069	0.753
MOD_GSK3_1	29	36	PF00069	0.538
MOD_GSK3_1	324	331	PF00069	0.678
MOD_GSK3_1	343	350	PF00069	0.799
MOD_GSK3_1	381	388	PF00069	0.766
MOD_GSK3_1	412	419	PF00069	0.570
MOD_GSK3_1	467	474	PF00069	0.530
MOD_GSK3_1	528	535	PF00069	0.589
MOD_GSK3_1	592	599	PF00069	0.688
MOD_GSK3_1	655	662	PF00069	0.807
MOD_GSK3_1	667	674	PF00069	0.675
MOD_GSK3_1	733	740	PF00069	0.693
MOD_GSK3_1	789	796	PF00069	0.767
MOD_GSK3_1	810	817	PF00069	0.684
MOD_GSK3_1	821	828	PF00069	0.740
MOD_GSK3_1	831	838	PF00069	0.706
MOD_GSK3_1	847	854	PF00069	0.485
MOD_N-GLC_1	618	623	PF02516	0.656
MOD_NEK2_1	35	40	PF00069	0.533
MOD_NEK2_1	355	360	PF00069	0.708
MOD_NEK2_1	366	371	PF00069	0.588
MOD_NEK2_1	399	404	PF00069	0.580
MOD_NEK2_1	467	472	PF00069	0.722
MOD_NEK2_1	513	518	PF00069	0.554
MOD_NEK2_1	56	61	PF00069	0.565
MOD_NEK2_1	571	576	PF00069	0.679
MOD_NEK2_1	594	599	PF00069	0.546
MOD_NEK2_1	609	614	PF00069	0.582
MOD_NEK2_1	751	756	PF00069	0.601
MOD_PIKK_1	129	135	PF00454	0.767
MOD_PIKK_1	16	22	PF00454	0.553
MOD_PIKK_1	43	49	PF00454	0.709
MOD_PIKK_1	458	464	PF00454	0.569
MOD_PIKK_1	838	844	PF00454	0.786
MOD_PIKK_1	893	899	PF00454	0.800
MOD_PKA_1	21	27	PF00069	0.557
MOD_PKA_1	465	471	PF00069	0.698
MOD_PKA_1	789	795	PF00069	0.798
MOD_PKA_2	14	20	PF00069	0.552
MOD_PKA_2	153	159	PF00069	0.730
MOD_PKA_2	168	174	PF00069	0.534
MOD_PKA_2	189	195	PF00069	0.646
MOD_PKA_2	199	205	PF00069	0.570
MOD_PKA_2	241	247	PF00069	0.628
MOD_PKA_2	343	349	PF00069	0.625
MOD_PKA_2	38	44	PF00069	0.620
MOD_PKA_2	465	471	PF00069	0.704
MOD_PKA_2	491	497	PF00069	0.721
MOD_PKA_2	831	837	PF00069	0.789
MOD_PKA_2	868	874	PF00069	0.668
MOD_PKB_1	463	471	PF00069	0.700
MOD_PKB_1	657	665	PF00069	0.696
MOD_Plk_1	133	139	PF00069	0.557
MOD_Plk_1	618	624	PF00069	0.663
MOD_Plk_1	821	827	PF00069	0.558
MOD_Plk_2-3	491	497	PF00069	0.591
MOD_Plk_4	222	228	PF00069	0.672
MOD_Plk_4	276	282	PF00069	0.600
MOD_Plk_4	366	372	PF00069	0.643
MOD_Plk_4	399	405	PF00069	0.566
MOD_Plk_4	505	511	PF00069	0.636
MOD_Plk_4	821	827	PF00069	0.734
MOD_ProDKin_1	158	164	PF00069	0.717
MOD_ProDKin_1	244	250	PF00069	0.690
MOD_ProDKin_1	274	280	PF00069	0.726
MOD_ProDKin_1	29	35	PF00069	0.482
MOD_ProDKin_1	378	384	PF00069	0.742
MOD_ProDKin_1	388	394	PF00069	0.559
MOD_ProDKin_1	421	427	PF00069	0.568
MOD_ProDKin_1	445	451	PF00069	0.557
MOD_ProDKin_1	508	514	PF00069	0.579
MOD_ProDKin_1	578	584	PF00069	0.705
MOD_ProDKin_1	675	681	PF00069	0.745
MOD_ProDKin_1	805	811	PF00069	0.795
MOD_ProDKin_1	9	15	PF00069	0.532
MOD_SUMO_rev_2	649	655	PF00179	0.771
TRG_DiLeu_BaEn_1	475	480	PF01217	0.698
TRG_DiLeu_BaEn_2	212	218	PF01217	0.592
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.593
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.606
TRG_DiLeu_LyEn_5	475	480	PF01217	0.465
TRG_ENDOCYTIC_2	694	697	PF00928	0.721
TRG_ENDOCYTIC_2	767	770	PF00928	0.679
TRG_ENDOCYTIC_2	777	780	PF00928	0.690
TRG_ER_diArg_1	188	191	PF00400	0.622
TRG_ER_diArg_1	197	200	PF00400	0.648
TRG_ER_diArg_1	242	245	PF00400	0.595
TRG_ER_diArg_1	463	466	PF00400	0.712
TRG_ER_diArg_1	476	478	PF00400	0.552
TRG_ER_diArg_1	501	503	PF00400	0.641
TRG_ER_diArg_1	626	628	PF00400	0.630
TRG_ER_diArg_1	688	691	PF00400	0.574
TRG_ER_diArg_1	82	84	PF00400	0.560
TRG_ER_diArg_1	872	875	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.633
TRG_PTS1	920	923	PF00515	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBC4	Leptomonas seymouri	51%	100%
A0A3Q8IB49	Leishmania donovani	90%	100%
A0A422P1W2	Trypanosoma rangeli	26%	100%
A4H9S5	Leishmania braziliensis	76%	100%
A4HXW0	Leishmania infantum	90%	100%
E9ARM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%