Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QDV5_LEIMA

TriTrypDb:

LmjF.18.0870 , LMJLV39_180014200 , LMJSD75_180014100

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0051286	cell tip	3	2
GO:0060187	cell pole	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QDV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	377	381	PF00656	0.737
CLV_C14_Caspase3-7	384	388	PF00656	0.682
CLV_NRD_NRD_1	239	241	PF00675	0.518
CLV_NRD_NRD_1	299	301	PF00675	0.500
CLV_NRD_NRD_1	405	407	PF00675	0.621
CLV_NRD_NRD_1	417	419	PF00675	0.699
CLV_NRD_NRD_1	437	439	PF00675	0.592
CLV_NRD_NRD_1	506	508	PF00675	0.609
CLV_NRD_NRD_1	51	53	PF00675	0.651
CLV_PCSK_KEX2_1	239	241	PF00082	0.562
CLV_PCSK_KEX2_1	404	406	PF00082	0.654
CLV_PCSK_KEX2_1	417	419	PF00082	0.753
CLV_PCSK_KEX2_1	432	434	PF00082	0.458
CLV_PCSK_KEX2_1	506	508	PF00082	0.604
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.559
CLV_PCSK_PC7_1	502	508	PF00082	0.487
CLV_PCSK_SKI1_1	263	267	PF00082	0.443
CLV_PCSK_SKI1_1	320	324	PF00082	0.590
CLV_PCSK_SKI1_1	417	421	PF00082	0.756
CLV_PCSK_SKI1_1	502	506	PF00082	0.446
CLV_PCSK_SKI1_1	62	66	PF00082	0.412
CLV_PCSK_SKI1_1	81	85	PF00082	0.431
CLV_Separin_Metazoa	260	264	PF03568	0.309
DEG_APCC_DBOX_1	496	504	PF00400	0.446
DEG_Nend_UBRbox_3	1	3	PF02207	0.521
DEG_SPOP_SBC_1	423	427	PF00917	0.672
DOC_ANK_TNKS_1	505	512	PF00023	0.524
DOC_CYCLIN_RxL_1	105	117	PF00134	0.607
DOC_MAPK_gen_1	105	114	PF00069	0.614
DOC_MAPK_gen_1	497	505	PF00069	0.483
DOC_MAPK_HePTP_8	7	19	PF00069	0.476
DOC_MAPK_MEF2A_6	10	19	PF00069	0.475
DOC_MAPK_MEF2A_6	149	156	PF00069	0.512
DOC_MAPK_MEF2A_6	254	261	PF00069	0.412
DOC_MAPK_MEF2A_6	30	37	PF00069	0.336
DOC_MAPK_MEF2A_6	351	360	PF00069	0.472
DOC_MAPK_MEF2A_6	362	369	PF00069	0.478
DOC_PP1_RVXF_1	500	506	PF00149	0.577
DOC_PP4_FxxP_1	527	530	PF00568	0.430
DOC_USP7_MATH_1	104	108	PF00917	0.586
DOC_USP7_MATH_1	205	209	PF00917	0.719
DOC_USP7_MATH_1	345	349	PF00917	0.735
DOC_USP7_MATH_1	378	382	PF00917	0.656
DOC_USP7_MATH_1	422	426	PF00917	0.615
DOC_USP7_MATH_1	60	64	PF00917	0.431
DOC_USP7_UBL2_3	439	443	PF12436	0.693
DOC_USP7_UBL2_3	514	518	PF12436	0.497
DOC_WW_Pin1_4	100	105	PF00397	0.583
DOC_WW_Pin1_4	174	179	PF00397	0.353
DOC_WW_Pin1_4	201	206	PF00397	0.686
DOC_WW_Pin1_4	213	218	PF00397	0.634
DOC_WW_Pin1_4	492	497	PF00397	0.542
DOC_WW_Pin1_4	52	57	PF00397	0.733
LIG_14-3-3_CanoR_1	110	115	PF00244	0.685
LIG_14-3-3_CanoR_1	188	195	PF00244	0.463
LIG_14-3-3_CanoR_1	239	244	PF00244	0.539
LIG_14-3-3_CanoR_1	254	258	PF00244	0.359
LIG_14-3-3_CanoR_1	280	289	PF00244	0.493
LIG_14-3-3_CanoR_1	3	8	PF00244	0.505
LIG_14-3-3_CanoR_1	404	410	PF00244	0.793
LIG_14-3-3_CanoR_1	412	420	PF00244	0.661
LIG_14-3-3_CanoR_1	438	447	PF00244	0.595
LIG_14-3-3_CanoR_1	91	95	PF00244	0.562
LIG_Actin_WH2_2	69	87	PF00022	0.411
LIG_BIR_III_4	169	173	PF00653	0.472
LIG_BRCT_BRCA1_1	78	82	PF00533	0.441
LIG_BRCT_BRCA1_1	91	95	PF00533	0.537
LIG_CtBP_PxDLS_1	218	222	PF00389	0.548
LIG_CtBP_PxDLS_1	4	8	PF00389	0.446
LIG_EH1_1	470	478	PF00400	0.451
LIG_FHA_1	169	175	PF00498	0.461
LIG_FHA_1	254	260	PF00498	0.439
LIG_FHA_1	284	290	PF00498	0.522
LIG_FHA_1	291	297	PF00498	0.534
LIG_FHA_1	32	38	PF00498	0.331
LIG_FHA_1	353	359	PF00498	0.415
LIG_FHA_1	523	529	PF00498	0.360
LIG_FHA_2	155	161	PF00498	0.461
LIG_FHA_2	377	383	PF00498	0.660
LIG_LIR_Apic_2	524	530	PF02991	0.420
LIG_LIR_Gen_1	123	133	PF02991	0.584
LIG_LIR_Nem_3	123	129	PF02991	0.586
LIG_LIR_Nem_3	79	83	PF02991	0.449
LIG_MYND_3	509	513	PF01753	0.516
LIG_NRBOX	499	505	PF00104	0.530
LIG_PDZ_Class_1	531	536	PF00595	0.452
LIG_PTAP_UEV_1	341	346	PF05743	0.474
LIG_SH2_CRK	22	26	PF00017	0.479
LIG_SH2_CRK	80	84	PF00017	0.396
LIG_SH2_STAP1	166	170	PF00017	0.478
LIG_SH2_STAP1	523	527	PF00017	0.359
LIG_SH2_STAT5	251	254	PF00017	0.439
LIG_SH2_STAT5	28	31	PF00017	0.450
LIG_SH2_STAT5	36	39	PF00017	0.411
LIG_SH2_STAT5	523	526	PF00017	0.345
LIG_SH3_3	339	345	PF00018	0.580
LIG_SUMO_SIM_anti_2	258	263	PF11976	0.297
LIG_SUMO_SIM_anti_2	355	361	PF11976	0.413
LIG_SUMO_SIM_par_1	160	167	PF11976	0.325
LIG_SUMO_SIM_par_1	255	260	PF11976	0.401
LIG_SUMO_SIM_par_1	529	534	PF11976	0.371
LIG_TYR_ITIM	20	25	PF00017	0.481
MOD_CDK_SPK_2	100	105	PF00069	0.583
MOD_CDK_SPK_2	492	497	PF00069	0.495
MOD_CDK_SPK_2	52	57	PF00069	0.667
MOD_CDK_SPxK_1	201	207	PF00069	0.627
MOD_CDK_SPxxK_3	492	499	PF00069	0.521
MOD_CK1_1	121	127	PF00069	0.750
MOD_CK1_1	136	142	PF00069	0.534
MOD_CK1_1	144	150	PF00069	0.548
MOD_CK1_1	194	200	PF00069	0.632
MOD_CK1_1	213	219	PF00069	0.620
MOD_CK1_1	228	234	PF00069	0.689
MOD_CK1_1	318	324	PF00069	0.610
MOD_CK1_1	352	358	PF00069	0.448
MOD_CK1_1	408	414	PF00069	0.776
MOD_CK1_1	452	458	PF00069	0.662
MOD_CK1_1	478	484	PF00069	0.484
MOD_CK1_1	55	61	PF00069	0.648
MOD_CK1_1	99	105	PF00069	0.493
MOD_CK2_1	242	248	PF00069	0.514
MOD_CK2_1	365	371	PF00069	0.655
MOD_CK2_1	428	434	PF00069	0.519
MOD_Cter_Amidation	436	439	PF01082	0.568
MOD_GlcNHglycan	135	138	PF01048	0.672
MOD_GlcNHglycan	143	146	PF01048	0.627
MOD_GlcNHglycan	227	230	PF01048	0.767
MOD_GlcNHglycan	323	326	PF01048	0.683
MOD_GlcNHglycan	347	350	PF01048	0.559
MOD_GlcNHglycan	477	480	PF01048	0.404
MOD_GlcNHglycan	98	101	PF01048	0.498
MOD_GSK3_1	110	117	PF00069	0.663
MOD_GSK3_1	124	131	PF00069	0.496
MOD_GSK3_1	150	157	PF00069	0.508
MOD_GSK3_1	187	194	PF00069	0.459
MOD_GSK3_1	201	208	PF00069	0.594
MOD_GSK3_1	213	220	PF00069	0.700
MOD_GSK3_1	221	228	PF00069	0.759
MOD_GSK3_1	242	249	PF00069	0.485
MOD_GSK3_1	31	38	PF00069	0.331
MOD_GSK3_1	314	321	PF00069	0.705
MOD_GSK3_1	324	331	PF00069	0.674
MOD_GSK3_1	340	347	PF00069	0.506
MOD_GSK3_1	407	414	PF00069	0.759
MOD_GSK3_1	418	425	PF00069	0.710
MOD_GSK3_1	62	69	PF00069	0.458
MOD_GSK3_1	96	103	PF00069	0.573
MOD_N-GLC_1	222	227	PF02516	0.538
MOD_N-GLC_1	492	497	PF02516	0.477
MOD_N-GLC_1	60	65	PF02516	0.688
MOD_NEK2_1	114	119	PF00069	0.697
MOD_NEK2_1	135	140	PF00069	0.702
MOD_NEK2_1	154	159	PF00069	0.451
MOD_NEK2_1	221	226	PF00069	0.555
MOD_NEK2_1	281	286	PF00069	0.497
MOD_NEK2_1	390	395	PF00069	0.680
MOD_NEK2_1	400	405	PF00069	0.654
MOD_NEK2_1	469	474	PF00069	0.390
MOD_NEK2_1	477	482	PF00069	0.385
MOD_PIKK_1	144	150	PF00454	0.653
MOD_PIKK_1	290	296	PF00454	0.501
MOD_PK_1	405	411	PF00069	0.539
MOD_PKA_1	239	245	PF00069	0.320
MOD_PKA_1	405	411	PF00069	0.649
MOD_PKA_1	438	444	PF00069	0.587
MOD_PKA_2	104	110	PF00069	0.647
MOD_PKA_2	187	193	PF00069	0.422
MOD_PKA_2	239	245	PF00069	0.511
MOD_PKA_2	253	259	PF00069	0.352
MOD_PKA_2	388	394	PF00069	0.770
MOD_PKA_2	405	411	PF00069	0.546
MOD_PKA_2	428	434	PF00069	0.682
MOD_PKA_2	90	96	PF00069	0.538
MOD_PKB_1	108	116	PF00069	0.646
MOD_PKB_1	436	444	PF00069	0.573
MOD_Plk_1	121	127	PF00069	0.705
MOD_Plk_1	222	228	PF00069	0.535
MOD_Plk_1	31	37	PF00069	0.327
MOD_Plk_1	60	66	PF00069	0.550
MOD_Plk_2-3	328	334	PF00069	0.619
MOD_Plk_4	121	127	PF00069	0.570
MOD_Plk_4	150	156	PF00069	0.510
MOD_Plk_4	181	187	PF00069	0.386
MOD_Plk_4	217	223	PF00069	0.739
MOD_Plk_4	3	9	PF00069	0.465
MOD_Plk_4	522	528	PF00069	0.393
MOD_Plk_4	90	96	PF00069	0.629
MOD_ProDKin_1	100	106	PF00069	0.585
MOD_ProDKin_1	174	180	PF00069	0.357
MOD_ProDKin_1	201	207	PF00069	0.691
MOD_ProDKin_1	213	219	PF00069	0.634
MOD_ProDKin_1	492	498	PF00069	0.535
MOD_ProDKin_1	52	58	PF00069	0.730
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.491
TRG_ENDOCYTIC_2	22	25	PF00928	0.421
TRG_ENDOCYTIC_2	80	83	PF00928	0.401
TRG_ER_diArg_1	108	111	PF00400	0.585
TRG_ER_diArg_1	206	209	PF00400	0.720
TRG_ER_diArg_1	238	240	PF00400	0.545
TRG_ER_diArg_1	404	406	PF00400	0.623
TRG_ER_diArg_1	496	499	PF00400	0.599
TRG_ER_diArg_1	505	507	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ2	Leptomonas seymouri	52%	92%
A0A3Q8IB16	Leishmania donovani	94%	100%
A4H9J5	Leishmania braziliensis	74%	99%
A4HXW1	Leishmania infantum	95%	100%
C9ZZU2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ARM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%