Putative cyclosporin 16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclosporin 16, putative

Species:

Leishmania major

UniProt:

Q4QDV4_LEIMA

TriTrypDb:

LmjF.18.0880 , LMJLV39_180014300 , LMJSD75_180014200

Length:

1020

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005681	spliceosomal complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QDV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QDV4

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0018193	peptidyl-amino acid modification	5	9
GO:0018208	peptidyl-proline modification	6	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	9
GO:0003824	catalytic activity	1	9
GO:0016853	isomerase activity	2	9
GO:0016859	cis-trans isomerase activity	3	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.622
CLV_C14_Caspase3-7	743	747	PF00656	0.557
CLV_C14_Caspase3-7	91	95	PF00656	0.714
CLV_NRD_NRD_1	171	173	PF00675	0.672
CLV_NRD_NRD_1	24	26	PF00675	0.452
CLV_NRD_NRD_1	295	297	PF00675	0.579
CLV_NRD_NRD_1	318	320	PF00675	0.565
CLV_NRD_NRD_1	325	327	PF00675	0.499
CLV_NRD_NRD_1	344	346	PF00675	0.550
CLV_NRD_NRD_1	408	410	PF00675	0.647
CLV_NRD_NRD_1	539	541	PF00675	0.661
CLV_NRD_NRD_1	54	56	PF00675	0.619
CLV_NRD_NRD_1	553	555	PF00675	0.730
CLV_NRD_NRD_1	570	572	PF00675	0.579
CLV_NRD_NRD_1	636	638	PF00675	0.642
CLV_NRD_NRD_1	662	664	PF00675	0.603
CLV_NRD_NRD_1	824	826	PF00675	0.673
CLV_NRD_NRD_1	88	90	PF00675	0.714
CLV_NRD_NRD_1	886	888	PF00675	0.385
CLV_PCSK_KEX2_1	171	173	PF00082	0.664
CLV_PCSK_KEX2_1	295	297	PF00082	0.579
CLV_PCSK_KEX2_1	318	320	PF00082	0.565
CLV_PCSK_KEX2_1	325	327	PF00082	0.499
CLV_PCSK_KEX2_1	408	410	PF00082	0.647
CLV_PCSK_KEX2_1	539	541	PF00082	0.659
CLV_PCSK_KEX2_1	54	56	PF00082	0.619
CLV_PCSK_KEX2_1	553	555	PF00082	0.709
CLV_PCSK_KEX2_1	636	638	PF00082	0.642
CLV_PCSK_KEX2_1	824	826	PF00082	0.673
CLV_PCSK_KEX2_1	88	90	PF00082	0.687
CLV_PCSK_KEX2_1	886	888	PF00082	0.325
CLV_PCSK_SKI1_1	172	176	PF00082	0.575
CLV_PCSK_SKI1_1	296	300	PF00082	0.657
CLV_PCSK_SKI1_1	380	384	PF00082	0.626
CLV_PCSK_SKI1_1	39	43	PF00082	0.559
CLV_PCSK_SKI1_1	637	641	PF00082	0.609
CLV_PCSK_SKI1_1	664	668	PF00082	0.519
CLV_PCSK_SKI1_1	841	845	PF00082	0.496
DEG_APCC_DBOX_1	294	302	PF00400	0.576
DEG_APCC_DBOX_1	628	636	PF00400	0.623
DEG_Nend_UBRbox_4	1	3	PF02207	0.470
DEG_ODPH_VHL_1	873	884	PF01847	0.367
DEG_SCF_FBW7_1	194	200	PF00400	0.596
DEG_SCF_FBW7_1	843	848	PF00400	0.556
DEG_SPOP_SBC_1	769	773	PF00917	0.610
DEG_SPOP_SBC_1	784	788	PF00917	0.639
DEG_SPOP_SBC_1	796	800	PF00917	0.605
DEG_SPOP_SBC_1	813	817	PF00917	0.739
DOC_CDC14_PxL_1	480	488	PF14671	0.563
DOC_CKS1_1	194	199	PF01111	0.546
DOC_CKS1_1	374	379	PF01111	0.572
DOC_CKS1_1	667	672	PF01111	0.585
DOC_CYCLIN_RxL_1	661	669	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	843	849	PF00134	0.709
DOC_MAPK_gen_1	25	33	PF00069	0.481
DOC_MAPK_gen_1	315	323	PF00069	0.590
DOC_MAPK_gen_1	408	414	PF00069	0.678
DOC_MAPK_gen_1	459	467	PF00069	0.597
DOC_MAPK_HePTP_8	113	125	PF00069	0.602
DOC_MAPK_HePTP_8	857	869	PF00069	0.325
DOC_MAPK_MEF2A_6	116	125	PF00069	0.604
DOC_MAPK_MEF2A_6	459	467	PF00069	0.606
DOC_MAPK_MEF2A_6	860	869	PF00069	0.325
DOC_PP1_RVXF_1	317	324	PF00149	0.611
DOC_PP1_RVXF_1	890	896	PF00149	0.385
DOC_PP2B_LxvP_1	843	846	PF13499	0.702
DOC_PP4_FxxP_1	133	136	PF00568	0.660
DOC_PP4_FxxP_1	667	670	PF00568	0.636
DOC_PP4_FxxP_1	964	967	PF00568	0.385
DOC_USP7_MATH_1	163	167	PF00917	0.620
DOC_USP7_MATH_1	228	232	PF00917	0.726
DOC_USP7_MATH_1	393	397	PF00917	0.641
DOC_USP7_MATH_1	43	47	PF00917	0.607
DOC_USP7_MATH_1	495	499	PF00917	0.610
DOC_USP7_MATH_1	524	528	PF00917	0.610
DOC_USP7_MATH_1	532	536	PF00917	0.610
DOC_USP7_MATH_1	706	710	PF00917	0.534
DOC_USP7_MATH_1	769	773	PF00917	0.653
DOC_USP7_MATH_1	814	818	PF00917	0.769
DOC_WW_Pin1_4	1005	1010	PF00397	0.325
DOC_WW_Pin1_4	159	164	PF00397	0.708
DOC_WW_Pin1_4	190	195	PF00397	0.628
DOC_WW_Pin1_4	373	378	PF00397	0.554
DOC_WW_Pin1_4	525	530	PF00397	0.641
DOC_WW_Pin1_4	590	595	PF00397	0.696
DOC_WW_Pin1_4	649	654	PF00397	0.511
DOC_WW_Pin1_4	666	671	PF00397	0.546
DOC_WW_Pin1_4	785	790	PF00397	0.717
DOC_WW_Pin1_4	841	846	PF00397	0.687
DOC_WW_Pin1_4	94	99	PF00397	0.680
LIG_14-3-3_CanoR_1	139	147	PF00244	0.618
LIG_14-3-3_CanoR_1	164	168	PF00244	0.601
LIG_14-3-3_CanoR_1	236	240	PF00244	0.621
LIG_14-3-3_CanoR_1	255	264	PF00244	0.662
LIG_14-3-3_CanoR_1	295	299	PF00244	0.639
LIG_14-3-3_CanoR_1	402	412	PF00244	0.736
LIG_14-3-3_CanoR_1	431	435	PF00244	0.642
LIG_14-3-3_CanoR_1	539	548	PF00244	0.629
LIG_14-3-3_CanoR_1	560	567	PF00244	0.641
LIG_14-3-3_CanoR_1	636	645	PF00244	0.615
LIG_14-3-3_CanoR_1	714	722	PF00244	0.699
LIG_14-3-3_CanoR_1	740	745	PF00244	0.569
LIG_14-3-3_CanoR_1	892	896	PF00244	0.385
LIG_APCC_ABBA_1	1	6	PF00400	0.564
LIG_APCC_ABBA_1	465	470	PF00400	0.632
LIG_BIR_III_4	16	20	PF00653	0.521
LIG_BIR_III_4	757	761	PF00653	0.600
LIG_BRCT_BRCA1_1	129	133	PF00533	0.588
LIG_BRCT_BRCA1_1	28	32	PF00533	0.524
LIG_BRCT_BRCA1_1	385	389	PF00533	0.609
LIG_BRCT_BRCA1_1	959	963	PF00533	0.291
LIG_CaM_IQ_9	453	468	PF13499	0.505
LIG_DLG_GKlike_1	740	748	PF00625	0.538
LIG_FHA_1	108	114	PF00498	0.549
LIG_FHA_1	120	126	PF00498	0.598
LIG_FHA_1	281	287	PF00498	0.505
LIG_FHA_1	295	301	PF00498	0.681
LIG_FHA_1	422	428	PF00498	0.570
LIG_FHA_1	431	437	PF00498	0.535
LIG_FHA_1	583	589	PF00498	0.683
LIG_FHA_1	616	622	PF00498	0.597
LIG_FHA_1	759	765	PF00498	0.637
LIG_FHA_1	790	796	PF00498	0.767
LIG_FHA_1	813	819	PF00498	0.690
LIG_FHA_1	842	848	PF00498	0.563
LIG_FHA_2	122	128	PF00498	0.660
LIG_FHA_2	144	150	PF00498	0.600
LIG_FHA_2	308	314	PF00498	0.648
LIG_FHA_2	33	39	PF00498	0.461
LIG_FHA_2	439	445	PF00498	0.673
LIG_FHA_2	598	604	PF00498	0.680
LIG_FHA_2	605	611	PF00498	0.606
LIG_FHA_2	722	728	PF00498	0.620
LIG_FHA_2	73	79	PF00498	0.519
LIG_FHA_2	828	834	PF00498	0.601
LIG_FHA_2	912	918	PF00498	0.385
LIG_Integrin_RGD_1	910	912	PF01839	0.385
LIG_LIR_Apic_2	130	136	PF02991	0.652
LIG_LIR_Gen_1	271	279	PF02991	0.568
LIG_LIR_Gen_1	329	338	PF02991	0.507
LIG_LIR_Gen_1	386	395	PF02991	0.593
LIG_LIR_Gen_1	454	463	PF02991	0.582
LIG_LIR_Gen_1	547	556	PF02991	0.653
LIG_LIR_Gen_1	878	889	PF02991	0.321
LIG_LIR_Gen_1	894	903	PF02991	0.228
LIG_LIR_Nem_3	271	275	PF02991	0.557
LIG_LIR_Nem_3	329	335	PF02991	0.507
LIG_LIR_Nem_3	386	392	PF02991	0.518
LIG_LIR_Nem_3	450	455	PF02991	0.595
LIG_LIR_Nem_3	547	551	PF02991	0.715
LIG_LIR_Nem_3	573	579	PF02991	0.646
LIG_LIR_Nem_3	585	589	PF02991	0.527
LIG_LIR_Nem_3	878	884	PF02991	0.370
LIG_LIR_Nem_3	894	898	PF02991	0.244
LIG_LIR_Nem_3	932	937	PF02991	0.316
LIG_LIR_Nem_3	960	966	PF02991	0.291
LIG_MAD2	714	722	PF02301	0.578
LIG_MLH1_MIPbox_1	959	963	PF16413	0.291
LIG_PCNA_yPIPBox_3	128	141	PF02747	0.572
LIG_PDZ_Class_2	1015	1020	PF00595	0.420
LIG_Pex14_1	385	389	PF04695	0.480
LIG_Pex14_1	60	64	PF04695	0.594
LIG_SH2_CRK	64	68	PF00017	0.604
LIG_SH2_CRK	862	866	PF00017	0.385
LIG_SH2_CRK	890	894	PF00017	0.291
LIG_SH2_PTP2	455	458	PF00017	0.580
LIG_SH2_PTP2	480	483	PF00017	0.583
LIG_SH2_SRC	180	183	PF00017	0.602
LIG_SH2_STAP1	410	414	PF00017	0.489
LIG_SH2_STAP1	517	521	PF00017	0.563
LIG_SH2_STAP1	597	601	PF00017	0.623
LIG_SH2_STAP1	701	705	PF00017	0.549
LIG_SH2_STAT5	232	235	PF00017	0.630
LIG_SH2_STAT5	272	275	PF00017	0.617
LIG_SH2_STAT5	455	458	PF00017	0.580
LIG_SH2_STAT5	480	483	PF00017	0.583
LIG_SH2_STAT5	64	67	PF00017	0.596
LIG_SH3_3	1003	1009	PF00018	0.291
LIG_SH3_3	185	191	PF00018	0.647
LIG_SH3_3	204	210	PF00018	0.542
LIG_SH3_3	283	289	PF00018	0.515
LIG_SH3_3	478	484	PF00018	0.502
LIG_SUMO_SIM_anti_2	1013	1019	PF11976	0.385
LIG_SUMO_SIM_anti_2	683	692	PF11976	0.644
LIG_SUMO_SIM_anti_2	987	993	PF11976	0.385
LIG_SUMO_SIM_par_1	1008	1013	PF11976	0.455
LIG_SUMO_SIM_par_1	119	124	PF11976	0.681
LIG_SUMO_SIM_par_1	683	692	PF11976	0.644
LIG_TRAF2_1	124	127	PF00917	0.615
LIG_TRAF2_1	724	727	PF00917	0.734
LIG_TRAF2_1	75	78	PF00917	0.521
LIG_TRAF2_1	830	833	PF00917	0.586
LIG_TRFH_1	480	484	PF08558	0.519
LIG_TYR_ITIM	270	275	PF00017	0.553
LIG_UBA3_1	31	39	PF00899	0.556
LIG_WRC_WIRS_1	384	389	PF05994	0.527
MOD_CDK_SPK_2	159	164	PF00069	0.689
MOD_CDK_SPK_2	666	671	PF00069	0.574
MOD_CDK_SPxxK_3	373	380	PF00069	0.575
MOD_CK1_1	193	199	PF00069	0.603
MOD_CK1_1	214	220	PF00069	0.605
MOD_CK1_1	290	296	PF00069	0.633
MOD_CK1_1	527	533	PF00069	0.621
MOD_CK1_1	534	540	PF00069	0.553
MOD_CK1_1	582	588	PF00069	0.621
MOD_CK1_1	688	694	PF00069	0.539
MOD_CK1_1	97	103	PF00069	0.746
MOD_CK2_1	121	127	PF00069	0.620
MOD_CK2_1	307	313	PF00069	0.607
MOD_CK2_1	590	596	PF00069	0.650
MOD_CK2_1	597	603	PF00069	0.604
MOD_CK2_1	604	610	PF00069	0.516
MOD_CK2_1	72	78	PF00069	0.506
MOD_CK2_1	721	727	PF00069	0.708
MOD_CK2_1	827	833	PF00069	0.599
MOD_CK2_1	911	917	PF00069	0.337
MOD_CMANNOS	317	320	PF00535	0.623
MOD_Cter_Amidation	293	296	PF01082	0.577
MOD_GlcNHglycan	141	144	PF01048	0.662
MOD_GlcNHglycan	213	216	PF01048	0.602
MOD_GlcNHglycan	258	261	PF01048	0.593
MOD_GlcNHglycan	265	268	PF01048	0.558
MOD_GlcNHglycan	28	31	PF01048	0.616
MOD_GlcNHglycan	292	295	PF01048	0.623
MOD_GlcNHglycan	45	48	PF01048	0.641
MOD_GlcNHglycan	470	474	PF01048	0.671
MOD_GlcNHglycan	534	537	PF01048	0.673
MOD_GlcNHglycan	576	579	PF01048	0.778
MOD_GlcNHglycan	649	652	PF01048	0.549
MOD_GlcNHglycan	676	679	PF01048	0.653
MOD_GlcNHglycan	680	683	PF01048	0.680
MOD_GlcNHglycan	692	696	PF01048	0.716
MOD_GlcNHglycan	708	711	PF01048	0.438
MOD_GlcNHglycan	772	775	PF01048	0.630
MOD_GlcNHglycan	789	792	PF01048	0.593
MOD_GlcNHglycan	799	802	PF01048	0.711
MOD_GlcNHglycan	847	850	PF01048	0.608
MOD_GlcNHglycan	917	920	PF01048	0.337
MOD_GlcNHglycan	99	102	PF01048	0.640
MOD_GSK3_1	139	146	PF00069	0.727
MOD_GSK3_1	159	166	PF00069	0.653
MOD_GSK3_1	186	193	PF00069	0.595
MOD_GSK3_1	228	235	PF00069	0.647
MOD_GSK3_1	280	287	PF00069	0.680
MOD_GSK3_1	290	297	PF00069	0.609
MOD_GSK3_1	326	333	PF00069	0.594
MOD_GSK3_1	394	401	PF00069	0.649
MOD_GSK3_1	524	531	PF00069	0.621
MOD_GSK3_1	574	581	PF00069	0.643
MOD_GSK3_1	674	681	PF00069	0.630
MOD_GSK3_1	687	694	PF00069	0.641
MOD_GSK3_1	783	790	PF00069	0.743
MOD_GSK3_1	841	848	PF00069	0.576
MOD_GSK3_1	911	918	PF00069	0.291
MOD_LATS_1	558	564	PF00433	0.635
MOD_N-GLC_1	349	354	PF02516	0.589
MOD_N-GLC_1	604	609	PF02516	0.534
MOD_N-GLC_1	94	99	PF02516	0.744
MOD_N-GLC_1	957	962	PF02516	0.291
MOD_NEK2_1	186	191	PF00069	0.751
MOD_NEK2_1	253	258	PF00069	0.673
MOD_NEK2_1	383	388	PF00069	0.476
MOD_NEK2_1	421	426	PF00069	0.518
MOD_NEK2_1	447	452	PF00069	0.679
MOD_NEK2_1	579	584	PF00069	0.641
MOD_NEK2_1	685	690	PF00069	0.690
MOD_NEK2_1	847	852	PF00069	0.586
MOD_NEK2_1	937	942	PF00069	0.343
MOD_NEK2_1	962	967	PF00069	0.282
MOD_NEK2_2	107	112	PF00069	0.629
MOD_NEK2_2	294	299	PF00069	0.619
MOD_NEK2_2	597	602	PF00069	0.602
MOD_NEK2_2	814	819	PF00069	0.635
MOD_NEK2_2	861	866	PF00069	0.321
MOD_NEK2_2	977	982	PF00069	0.291
MOD_PIKK_1	394	400	PF00454	0.684
MOD_PIKK_1	579	585	PF00454	0.641
MOD_PIKK_1	639	645	PF00454	0.510
MOD_PIKK_1	957	963	PF00454	0.291
MOD_PK_1	993	999	PF00069	0.270
MOD_PKA_1	539	545	PF00069	0.627
MOD_PKA_2	127	133	PF00069	0.557
MOD_PKA_2	163	169	PF00069	0.604
MOD_PKA_2	235	241	PF00069	0.615
MOD_PKA_2	294	300	PF00069	0.576
MOD_PKA_2	430	436	PF00069	0.634
MOD_PKA_2	53	59	PF00069	0.605
MOD_PKA_2	539	545	PF00069	0.627
MOD_PKA_2	87	93	PF00069	0.789
MOD_PKA_2	891	897	PF00069	0.385
MOD_Plk_1	410	416	PF00069	0.550
MOD_Plk_1	517	523	PF00069	0.529
MOD_Plk_2-3	271	277	PF00069	0.623
MOD_Plk_2-3	726	732	PF00069	0.680
MOD_Plk_4	740	746	PF00069	0.570
MOD_Plk_4	758	764	PF00069	0.484
MOD_Plk_4	929	935	PF00069	0.448
MOD_Plk_4	977	983	PF00069	0.291
MOD_ProDKin_1	1005	1011	PF00069	0.325
MOD_ProDKin_1	159	165	PF00069	0.709
MOD_ProDKin_1	190	196	PF00069	0.628
MOD_ProDKin_1	373	379	PF00069	0.554
MOD_ProDKin_1	525	531	PF00069	0.641
MOD_ProDKin_1	590	596	PF00069	0.695
MOD_ProDKin_1	649	655	PF00069	0.502
MOD_ProDKin_1	666	672	PF00069	0.551
MOD_ProDKin_1	785	791	PF00069	0.717
MOD_ProDKin_1	841	847	PF00069	0.689
MOD_ProDKin_1	94	100	PF00069	0.678
MOD_SUMO_for_1	601	604	PF00179	0.564
MOD_SUMO_rev_2	1001	1007	PF00179	0.287
MOD_SUMO_rev_2	642	648	PF00179	0.563
TRG_DiLeu_BaEn_4	730	736	PF01217	0.644
TRG_DiLeu_BaLyEn_6	587	592	PF01217	0.608
TRG_ENDOCYTIC_2	272	275	PF00928	0.523
TRG_ENDOCYTIC_2	455	458	PF00928	0.580
TRG_ENDOCYTIC_2	480	483	PF00928	0.620
TRG_ENDOCYTIC_2	64	67	PF00928	0.608
TRG_ENDOCYTIC_2	862	865	PF00928	0.385
TRG_ENDOCYTIC_2	890	893	PF00928	0.291
TRG_ER_diArg_1	171	173	PF00400	0.679
TRG_ER_diArg_1	317	319	PF00400	0.634
TRG_ER_diArg_1	325	328	PF00400	0.565
TRG_ER_diArg_1	408	410	PF00400	0.647
TRG_ER_diArg_1	458	461	PF00400	0.586
TRG_ER_diArg_1	538	540	PF00400	0.659
TRG_ER_diArg_1	54	57	PF00400	0.488
TRG_ER_diArg_1	552	554	PF00400	0.716
TRG_ER_diArg_1	635	637	PF00400	0.642
TRG_ER_diArg_1	87	89	PF00400	0.716
TRG_NES_CRM1_1	987	1001	PF08389	0.319
TRG_Pf-PMV_PEXEL_1	539	544	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	714	718	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF65	Leptomonas seymouri	50%	85%
A0A3Q8IB03	Leishmania donovani	94%	100%
A0A3R7RS09	Trypanosoma rangeli	29%	100%
A4H9J6	Leishmania braziliensis	76%	97%
A4HXW2	Leishmania infantum	94%	100%
C9ZZU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ARM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%